Fri.Dec 20, 2024

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Can the heart heal itself? New study says it can

Science Daily - Heart Disease

Physician-scientists found that a subset of artificial heart patients can regenerate heart muscle, which may open the door to new ways to treat and perhaps someday cure heart failure.

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Sedentary Behavior Linked to Increased Gout Risk Even Without Hyperuricemia

HCPLive

A study found the association between sedentary behavior and gout remained strong even when adjusting for physical activity.

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Using an AI tool, researchers find poor vascular health accelerates brain aging

Medical Xpress - Cardiology

Using an AI tool, researchers at Karolinska Institutet have analyzed brain images from 70-year-olds and estimated their brains' biological age. They found that factors detrimental to vascular health, such as inflammation and high glucose levels, are associated with an older-looking brain, while healthy lifestyles were linked to brains with a younger appearance.

Research 109
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CagriSema Achieves 22.7% Weight Loss in Phase 3 REDEFINE 1 Trial

HCPLive

CagriSema, a fixed dose of cagrilintide 2.4 mg and semaglutide 2.4 mg, achieved statistically significant weight loss after 68 weeks versus placebo.

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Best Supplements For Heart Health.

Dr. Paddy Barrett

As a cardiologist, I am frequently asked about supplements and heart health. In general, I am not a fan. Personally, I take two supplements. Whey protein for hitting my daily protein targets. Creatine for improving exercise performance and muscle mass. Neither of these supplements is for improving ‘heart health’ During the winter months, I will occasionally take vitamin D if my levels are low, but generally, if I get enough time outside, even during the winter months, I do not need t

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Are Antibiotics Linked to Dementia? New Study Weighs In

Med Page Today

(MedPage Today) -- Antibiotic use didn't raise the risk of dementia in healthy older adults, a prospective study suggested. Over about 5 years of follow-up, antibiotic use was not tied to higher dementia incidence (HR 1.03, 95% CI 0.84-1.25) compared.

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First dual chamber leadless pacemaker implanted in a child

Science Daily - Heart Disease

Pediatric cardiologists have implanted a dual chamber leadless pacemaker in a child.

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First dual chamber leadless pacemaker implanted in a child

Medical Xpress - Cardiology

UC Davis Director of Pediatric Electrophysiology Dan Cortez has set another world record: He is the first to implant a dual chamber leadless pacemaker in a child. His case report was published this week in the journal Pacing and Clinical Electrophysiology.

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Harmonizing Optimal Strategy for Treatment of Coronary Artery Stenosis–Extended Antiplatelet Monotherapy

American College of Cardiology

The goal of the HOST-EXAM trial was to assess the safety and efficacy of clopidogrel vs. aspirin monotherapy among patients who had completed the required duration of dual antiplatelet therapy (DAPT) therapy postdrug-eluting stent (DES) percutaneous coronary intervention (PCI).

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Genetic predisposition to nephropathy and associated cardiovascular disease in people with type 1 diabetes: role of the angiotensinI-converting enzyme (ACE), and beyond; a narrative review

Cardiovascular Diabetology

Hypertension, cardiovascular disease and kidney failure are associated with persistent hyperglycaemia and the subsequent development of nephropathy in people with diabetes. Diabetic nephropathy is associated w.

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FDA Approves Tirzepatide for Obstructive Sleep Apnea in Obesity

HCPLive

Tirzepatide's approval marks the first and only prescription medicine available for adults with moderate-to-severe obstructive sleep apnea and obesity.

Obesity 64
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Chlorthalidone vs. Hydrochlorothiazide and Kidney Outcomes

American College of Cardiology

Is chlorthalidone superior to hydrochlorothiazide in preventing kidney outcomes when used for hypertension treatment?

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New Data Supports Liver Retransplantation for Patients with PSC Recurrence

HCPLive

Retransplantation outcomes were similar or better in patients with PSC compared with patients with other liver disease etiologies.

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Estimated potassium intake and major adverse cardiovascular events in individuals with type 2 diabetes: a prospective cohort study with trans-ethnic validation

Cardiovascular Diabetology

Data on the relationship between potassium intake and major cardiovascular events (MACE) in patients with diabetes are scarce. We aim to study the association between estimated potassium intake and risk of MAC.

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Kimberly A. Davidow, MD: Elucidating Risk of Autoimmune Disease in Childhood Cancer Survivors

HCPLive

Davidow discussed how a new cohort study has helped support findings of an older European study and the need for a prospective trial to confirm the increased risk.

Cancer 59
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First Drug Approved for Familial Chylomicronemia Syndrome

Med Page Today

(MedPage Today) -- The FDA approved olezarsen (Tryngolza) as the first drug for adults with familial chylomicronemia syndrome, a rare genetic disorder that can cause triglyceride levels to reach the thousands. A first-in-class antisense oligonucleotide.

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CASPAR Criteria May Identify More Patients With Juvenile PsA Than ILAR Criteria

HCPLive

A prospective study also found that the presence of psoriasis and dactylitis at disease onset were the strongest predictors for the development of PsA.

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Cardiovascular Risk in Prostate Cancer: Key Points

American College of Cardiology

The following are key points to remember from a state-of-the-art review on cardiovascular (CV) risk in prostate cancer (PC).

Cancer 58
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Study Highlights Impact of Smoking on Surgical Outcomes for HS

HCPLive

In this analysis, investigators conducted a systematic review of studies evaluating the effects of smoking tobacco on surgical outcomes for those with hidradenitis suppurativa.

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Dyslipidemia and associated factors among adult type two diabetes mellitus patients in Felege Hiywot Refral, Hospital, Bahir Dar, Ethiopia, 2023

Frontiers in Cardiovascular Medicine

BackgroundDyslipidemia is a common condition in type two diabetic patients, and it is thought to have a significant role in moderating the cardiovascular risk associated with diabetes. Data on serum lipid profiles in type 2 diabetes patients from Bahir Dar, Ethiopia is limited. This study aimed to evaluate the prevalence of dyslipidemia among adult type 2 diabetes patients and to explore potential contributing factors.Method and materialsA facility-based cross-sectional study was conducted with

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FDA Issues CRL for Sotagliflozin in Type 1 Diabetes and CKD

HCPLive

The FDA's decision not to approve sotagliflozin as an adjunct in T1D and CKD comes less than 2 months after a negative advisory committee meeting for the application.

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Systematic literature review on early detection of postoperative delirium in adult patients after cardiac surgery

Journal of Cardiothoracic Surgery

Postoperative delirium (POD) is a cognitive decline and attention deficit that can occur in patients after cardiac surgery. Despite extensive research identifying the risk factors, POD often remains undiagnose.

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Study Shows a U-Shaped Association Between HDL-C, Major Adverse Cardiovascular Events

HCPLive

A study finds that individuals with low or high LDL cholesterol levels face a greater cardiovascular risk than those with medium levels.

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Evaluation of Ventricular Ectopic Beats

All About Cardiovascular System and Disorders

Most of the time ventricular ectopics are quite benign, especially if there is no associated structural heart disease. Occasionally they can be dangerous, mainly if associated with structural heart disease. Sometimes ventricular ectopy can be the forerunner of malignant ventricular arrhythmia.

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Belapectin Misses Primary Endpoint in Phase 3 MASH Cirrhosis, Portal Hypertension Trial

HCPLive

The phase 2b/3 NAVIGATE trial missed its primary endpoint for the prevention of varices in patients with MASH cirrhosis and portal hypertension.

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Resveratrol promotes cholesterol efflux from dendritic cells and controls costimulation and T-cell activation in high-fat and lipopolysaccharide-driven atherosclerotic mice

Frontiers in Cardiovascular Medicine

Cholesterol aggregation in dendritic cells (DCs) triggers an inflammatory response and accelerates the development of atherosclerosis (AS). Resveratrol (RES), a natural compound with anti-inflammatory and cholesterol metabolism regulatory properties, has been shown to influence the maturation and inflammatory functions of DCs. However, its relationship with cholesterol metabolism remains unclear.

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Study Highlights Necessity of Image Quality for Deep Learning Model Diagnostic Success

HCPLive

These data resulted from an investigation of the effect of varying image qualities on the diagnostic abilities of a convolutional neural network (CNN) model and clinicians.

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Prognostic value of the derived inflammatory marker SIRI in postmenopausal women with coronary artery disease

Frontiers in Cardiovascular Medicine

ObjectiveThe aim of this study was to explore the predictive value of the Systemic Inflammatory Response Index (SIRI) for the prognosis of older postmenopausal women with coronary artery disease (CAD).Patients and methodsThis retrospective cohort study included 617 postmenopausal female patients aged 50 years or older with a CAD diagnosis confirmed by coronary angiography seen at the First Affiliated Hospital of Zhengzhou University from January 2019 to December 2020.

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FDA Approves First Acellular Tissue Vessel Therapy for Extremity Vascular Trauma

HCPLive

The ATEV therapy, named Symvess, provides revascularization when autologous vein graft or implantation of a synthetic graft is not feasible.

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Association between asthma and cardiovascular disease: evidence from the national health and nutrition examination survey 1999–2018

Frontiers in Cardiovascular Medicine

BackgroundCardiovascular disease(CVD) remains a significant global challenge. Asthma, which is characterized by airway hyperresponsiveness and reversible and limited airflow, plays an important role in cardiovascular diseases. This study aimed to investigate the association between asthma and CVD.MethodsThis cross-sectional study included demographic, laboratory, and questionnaire data from the National Health and Nutrition Examination Survey (NHANES) 19992018.

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Advancing the Diagnostic Criteria for Multiple Sclerosis: A New Era of Early Detection and Precision

HCPLive

With new revisions of the MS diagnostic criteria being made, clinicians highlighted key updates and the broader implications it has for diagnosis, treatment, and healthcare practices worldwide.

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Case Report: A missed diagnosis of cardiac amyloidosis using echocardiography due to immunoglobulin light chain amyloidosis with normal wall thickness in the early stage

Frontiers in Cardiovascular Medicine

BackgroundCardiac amyloidosis (CA) is a challenging diagnosis, particularly when the classic signs, such as increased wall thickness in a non-dilated left ventricle (LV), are absent. This makes the diagnosis more difficult in patients with normal LV wall thickness. We present a case of CA without increased wall thickness and without the characteristic granular sparkling echotexture in a non-dilated LV.Case summaryA 50-year-old female patient presented with worsening breathlessness on exertion, p

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Yehuda Handelsman, MD: Key Highlights, Takeaways from WCIRDC 2024

HCPLive

Yehuda Handelsman, MD reflects on the WCIRDC 2024s comprehensive approach to advancing cardiometabolic care through multidisciplinary collaboration.

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Papillary Muscle Structural Abnormalities and Site of Origin of Arrhythmias

American College of Cardiology

Does the finding of structural abnormalities on the papillary muscles have an association with site of origin of arrhythmias? Can multimodality imaging be of benefit in planning ablation procedures?

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Effects of School‐Based Lifestyle Interventions on Cardiovascular Health in Chinese Children and Adolescents: A Post Hoc Analysis of a National Multicenter Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundWe evaluated the effects of a national schoolbased lifestyle intervention program against childhood obesity on improving cardiovascular health (CVH), assessed using the recently introduced Life's Essential 8 metric framework.Methods and ResultsOur post hoc analysis of the national schoolbased lifestyle intervention targeting diet and physical activity included 94 schools with eligible students aged 7 to 17 years (intervention g

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Activation of Imprinted Gene PW1 Promotes Cardiac Fibrosis After Ischemic Injury

Circulation

Circulation, Ahead of Print. BACKGROUND:Cardiac fibrosis, characterized by excessive extracellular matrix (ECM) deposition in the myocardium, is an important target for heart disease treatments.Pw1(paternally expressed gene 3) is an imprinted gene expressed from the paternal allele, and de novo purine biosynthesis (DNPB) is a crucial pathway for nucleotide synthesis.

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Changes in Blood Eosinophil Counts Predict the Death of Patients With Myocardial Infarction After Hospital Discharge

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundPreclinical studies demonstrate a cardioprotective role of eosinophils in acute myocardial infarction. Yet clinical studies show conflicting correlations between blood eosinophil counts and acute myocardial infarction risk and mortality. This study evaluates blood eosinophil counts of patients with acute myocardial infarction at hospital admission (EOSbaseline) and discharge (EOSpost) on allcause and cardiac mortalities.Methods