Ken Grauer, MD
NOVEMBER 15, 2024
Today's case was contributed by Dr. Magnus Nossen ( from Fredrikstad, Norway ). Dr. Nossen was at his computer — reviewing ECGs from patients recently admitted to his group's hospital service. He came across the ECG shown in Figure-1 — obtained from a woman in her 70s who was admitted to the hospital for new CP ( C hest P ain ). QUESTION: How would YOU interpret the ECG in Figure-1 ?
HCPLive
NOVEMBER 15, 2024
IL-18 levels were consistently lower across participants with different SARDs, remission status, and COVID-19 disease characteristics.
Journal of Clinical Investigation - Cardiology
NOVEMBER 15, 2024
Glioblastoma (GBM), an aggressive brain malignancy with a cellular hierarchy dominated by GBM stem cells (GSCs), evades antitumor immunity through mechanisms that remain incompletely understood. Like most cancers, GBMs undergo metabolic reprogramming toward glycolysis to generate lactate. Here, we show that lactate production by patient-derived GSCs and microglia/macrophages induces tumor cell epigenetic reprogramming through histone lactylation, an activating modification that leads to immunosu
Science Daily - Heart Disease
NOVEMBER 15, 2024
More time spent sitting, reclining or lying down during the day may increase the risk of cardiovascular disease (CVD) and death, according to a new study. More than roughly 10-and-a-half hours of sedentary behavior per day was significantly linked with future heart failure (HF) and cardiovascular (CV) death, even among people meeting recommended levels of exercise.
CTVS
NOVEMBER 15, 2024
This Thanksgiving, 39-year-old Cherith Satterfield has much to be grateful for as she gathers with her family. The wife, mother of five, three grown and two at home, was unexpectedly diagnosed with a rare, aggressive form of lung cancer earlier this year. For Cherith, the journey has been a powerful reminder to take your health seriously.
Med Page Today
NOVEMBER 15, 2024
(MedPage Today) -- Higher mean blood pressure (BP) levels were associated with faster rates of visual field progression in patients with glaucoma, according to a retrospective cohort study. Among 985 patients, the interaction terms of higher mean.
Dr. Paddy Barrett
NOVEMBER 15, 2024
Being overweight is a major risk factor for heart disease and also an early death. But even if you have excess weight, there are many things you can do to seriously reduce that risk without focusing on weight loss itself. So, if you struggle with excess weight, you need to know what else you can do to reduce your future risk. The Life Essential 8 are a set of factors that significantly influence your risk of heart disease and early death, including: Regular Physical Activity.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Becker's Hospital Review - Cardiology
NOVEMBER 15, 2024
Somerville, Mass.-based Mass General Brigham has appointed Patrick Ellinor, MD, PhD, as the inaugural executive director of the system's Heart and Vascular Institute.
Physiologically Speaking
NOVEMBER 15, 2024
Greetings! Welcome to the Physiology Friday newsletter. Details about the sponsors of this newsletter including FSTFUEL electrolytes, Examine.com , and my book “VO2 Max Essentials ” can be found at the end of the post or on a brand-new page on my website where I list all of the products I use and enjoy. Physiologically Speaking is a reader-supported publication.
The New England Journal of Medicine
NOVEMBER 15, 2024
In patients with heart failure with preserved ejection fraction and obesity, treatment with tirzepatide led to a lower risk of death from cardiovascular causes or worsening heart-failure events than placebo.
HCPLive
NOVEMBER 15, 2024
Once-daily aprocitentan is indicated to help lower blood pressure in adult patients with hypertension who are inadequately controlled on other medications.
JAMA Cardiology
NOVEMBER 15, 2024
In this case series study, pulmonary artery systolic, diastolic, and mean pressures of 2 participants with obesity and heart failure with preserved ejection fraction were measured at zero gravity during parabolic flight to assess the effect of external constraint on left ventricular filling pressures.
HCPLive
NOVEMBER 15, 2024
The announcement of the resubmission by Regeneron and Sanofi follows LIBERTY-CUPID phase 3 clinical findings on dupilumab for patients with CSU.
Cardiovascular Diabetology
NOVEMBER 15, 2024
A raised stress hyperglycaemia ratio (SHR) has been associated with all-cause mortality and may better discriminate than an absolute glucose value. The aim of this meta analysis and systematic review is to syn.
HCPLive
NOVEMBER 15, 2024
People who used GC for over 2 years and 3 years had elevated risks of CVD and infection-related mortality, respectively, that never returned to pre-GC use levels.
CardiacWire
NOVEMBER 15, 2024
Eli Lilly’s GLP-1 tirzepatide has triumphed yet again, as the full SURMOUNT-1 trial showed that the drug kept nearly 99% of prediabetic patients diabetes-free over 3 years, while improving cardiometabolic metrics. Tirzepatide (Mounjaro / Zepbound) is used to promote weight loss and treat Type 2 diabetes through the GIP and GLP-1 receptor pathways. Like Novo Nordisk’s semaglutide, evidence of tirzepatide’s cardiometabolic and cardiovascular benefits continue to mount.
Cassling
NOVEMBER 15, 2024
Healthcare professionals use ultrasound machines for several purposes, including diagnostic exams, cardiac assessments, pregnancy evaluation, guiding procedures and numerous other areas of patient care. However, the cost of an ultrasound machine can vary significantly depending on the type of machine and configuration. In this article, we'll review some of the differences that influence ultrasound machine cost, including diagnostic capabilities, AI features, transducers, mobility, and ergonomics
Becker's Hospital Review - Cardiology
NOVEMBER 15, 2024
Surgeons at Cincinnati-based The Christ Hospital performed a successful human implantation of the BiVACOR Total Artificial Heart, marking the fourth hospital in the U.S. to complete the procedure as part of the FDA's early feasibility study.
DAIC
NOVEMBER 15, 2024
tim.hodson Fri, 11/15/2024 - 11:04 The deadline for early bird discounts for HIMSS25 is rapidly approaching. Register by December 15 to save up to $500 on your pass for the HIMSS Global Health Conference & Exhibition. HIMSS Global Health Conference & Exhibition will take place in Las Vegas, March 3-6, 2025. For more information, please visit www.himssconference.
Journal of Clinical Investigation - Cardiology
NOVEMBER 15, 2024
Lung megakaryocytes (Mks) are largely extravascular with an immune phenotype (1). Because bone marrow (BM) Mks are short lived, it has been assumed that extravascular lung Mks are constantly “seeded” from the BM. To investigate lung Mk origins and how origin affects their functions, we developed methods to specifically label lung Mks using CFSE dye and biotin delivered via the oropharyngeal route.
HCPLive
NOVEMBER 15, 2024
Panelists discuss how disease severity in chronic spontaneous urticaria (CSU) is assessed using tools such as the Urticaria Activity Score over 7 days (UAS7) and the Urticaria Control Test (UCT), while also addressing the frequency of delayed diagnoses and the significant implications for condition management and patient quality of life.
Journal of Clinical Investigation - Cardiology
NOVEMBER 15, 2024
The sensory cells that transduce the signals for hearing and balance are highly specialized mechanoreceptors called hair cells that together with supporting cells comprise the sensory epithelia of the inner ear. Loss of hair cells from toxin exposure and age can cause balance disorders and is essentially irreversible due to the inability of mammalian vestibular organs to regenerate physiologically active hair cells.
HCPLive
NOVEMBER 15, 2024
Panelists discuss the factors influencing the development of treatment goals for chronic spontaneous urticaria (CSU) from both patient and physician perspectives, highlighting current international guidelines that recommend antihistamines as first-line treatment, with options for updosing, and outlining second-line therapies such as omalizumab and third-line options like cyclosporine, along with the recommendation to adjust treatment based on disease control levels.
Journal of Clinical Investigation - Cardiology
NOVEMBER 15, 2024
Canonically PD-L1 functions as the inhibitory immune checkpoint on cell surface. Recent studies have observed PD-L1 expression in the nucleus of cancer cells. But the biological function of nuclear PD-L1 (nPD-L1) in tumor growth and antitumor immunity is unclear. Here we enforced nPD-L1 expression and established stable cells. nPD-L1 suppressed tumorigenesis and aggressiveness in vitro and in vivo.
HCPLive
NOVEMBER 15, 2024
Panelists discuss how, given that approximately 49% of patients with chronic spontaneous urticaria (CSU) consult general practitioners, while only approximately 19% see dermatologists, there is a compelling case for more patients to be referred to dermatologists, as CSU is an internally driven disease that may benefit from specialized expertise.
Journal of Clinical Investigation - Cardiology
NOVEMBER 15, 2024
Effective psychotherapy of post-traumatic stress disorder (PTSD) remains challenging owing to the fragile nature of fear extinction, for which the ventral hippocampal CA1 (vCA1) region is considered as a central hub. However, neither the core pathway nor the cellular mechanisms involved in implementing extinction are known. Here, we unveil a direct pathway, where layer 2a fan cells in the lateral entorhinal cortex (LEC) target parvalbumin-expressing interneurons (PV-INs) in the vCA1 region to pr
HCPLive
NOVEMBER 15, 2024
Panelists discuss the challenges and limitations of using second-generation H1 antihistamines as first-line therapy for chronic spontaneous urticaria (CSU), including recommended increased dosages for nonresponding patients and the complexities of cycling through antihistamines. They also explore the appropriate circumstances for considering combination therapies, the role of steroids in management, necessary precautions when using systemic steroids, and the factors influencing the decision to e
Journal of Clinical Investigation - Cardiology
NOVEMBER 15, 2024
The high rate of recurrence after radiation therapy in triple-negative breast cancer (TNBC) indicates that novel approaches and targets are needed to enhance radiosensitivity. Here, we report that neuropilin-2 (NRP2), a receptor for vascular endothelial growth factor (VEGF) that is enriched on subpopulations of TNBC cells with stem cell properties, is an effective therapeutic target for sensitizing TNBC to radiotherapy.
MIBHS
NOVEMBER 15, 2024
Undergoing heart surgery can be a life-changing experience, especially for those with coronary artery disease or other heart conditions. Minimally invasive or bloodless heart surgery techniques have made recovery more manageable and less daunting. However, as patients emerge from this journey, many are eager to return to their normal activities, including running.
HCPLive
NOVEMBER 15, 2024
HCPLive spoke with Okuno at NASPGHAN 2024 about a study examining changes in parent stress levels and mental health symptoms after a child completes weaning off tube feeding.
Becker's Hospital Review - Cardiology
NOVEMBER 15, 2024
"FDA warns of safety concerns and supply issues for Getinge/Maquet's VasoView HemoPro Endoscopic Vessel Harvesting Systems used in endoscopic arterial bypass su
HCPLive
NOVEMBER 15, 2024
In this analysis in Thailand, video education’s impact on patient guardians’ knowledge was assessed with the aim of reducing eczema severity.
The New England Journal of Medicine
NOVEMBER 15, 2024
In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 American Heart Association Scientific Sessions.
HCPLive
NOVEMBER 15, 2024
In this cross-sectional survey analysis, new insights were explored regarding clinical practice patterns and treatment outcomes within dermatology practices in the US.
The New England Journal of Medicine
NOVEMBER 15, 2024
In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 American Heart Association Scientific Sessions.
HCPLive
NOVEMBER 15, 2024
Zoi Papalamprakopoulou, MD, explains telehealth’s potential to aid HCV treatment in high-risk populations and how patients perceive this care modality.
The New England Journal of Medicine
NOVEMBER 15, 2024
In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 American Heart Association Scientific Sessions.
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