Fri.Nov 15, 2024

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How You Can Reduce The Risk Of Heart Disease Without Losing Weight.

Dr. Paddy Barrett

Being overweight is a major risk factor for heart disease and also an early death. But even if you have excess weight, there are many things you can do to seriously reduce that risk without focusing on weight loss itself. So, if you struggle with excess weight, you need to know what else you can do to reduce your future risk. The Life Essential 8 are a set of factors that significantly influence your risk of heart disease and early death, including: Regular Physical Activity.

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Running After Heart Surgery: A Comprehensive Guide

MIBHS

Undergoing heart surgery can be a life-changing experience, especially for those with coronary artery disease or other heart conditions. Minimally invasive or bloodless heart surgery techniques have made recovery more manageable and less daunting. However, as patients emerge from this journey, many are eager to return to their normal activities, including running.

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Sitting too long can harm heart health, even for active people

Science Daily - Heart Disease

More time spent sitting, reclining or lying down during the day may increase the risk of cardiovascular disease (CVD) and death, according to a new study. More than roughly 10-and-a-half hours of sedentary behavior per day was significantly linked with future heart failure (HF) and cardiovascular (CV) death, even among people meeting recommended levels of exercise.

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IL-18 Levels Associated With Long COVID Risk in People With Rheumatic Diseases

HCPLive

IL-18 levels were consistently lower across participants with different SARDs, remission status, and COVID-19 disease characteristics.

COVID-19 126
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Bridging Innovation & Patient Care: The Growing Role of AI

Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.

AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!

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Higher BP Linked to Faster Visual Field Progression in Glaucoma

Med Page Today

(MedPage Today) -- Higher mean blood pressure (BP) levels were associated with faster rates of visual field progression in patients with glaucoma, according to a retrospective cohort study. Among 985 patients, the interaction terms of higher mean.

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Mass General Brigham names Heart and Vascular Institute leader

Becker's Hospital Review - Cardiology

Somerville, Mass.-based Mass General Brigham has appointed Patrick Ellinor, MD, PhD, as the inaugural executive director of the system's Heart and Vascular Institute.

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Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity

The New England Journal of Medicine

In patients with heart failure with preserved ejection fraction and obesity, treatment with tirzepatide led to a lower risk of death from cardiovascular causes or worsening heart-failure events than placebo.

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Heart Failure in Zero Gravity—External Constraint and Cardiac Hemodynamics

JAMA Cardiology

In this case series study, pulmonary artery systolic, diastolic, and mean pressures of 2 participants with obesity and heart failure with preserved ejection fraction were measured at zero gravity during parabolic flight to assess the effect of external constraint on left ventricular filling pressures.

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Telehealth Could Address HCV Care Barriers, Expand Treatment for People Who Inject Drugs

HCPLive

Zoi Papalamprakopoulou, MD, explains telehealth’s potential to aid HCV treatment in high-risk populations and how patients perceive this care modality.

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Parkin paves the path to antitumor immunity: Expanding Parkin’s role as a tumor suppressor

Journal of Clinical Investigation - Cardiology

Parkin, a ring-between-ring-type E3 ubiquitin ligase, first shown to play a critical role in autosomal recessive juvenile Parkinsonism, has recently emerged as a key player in cancer biology. Parkin is now known to serve as a tumor suppressor, and its deregulation frequently promotes tumorigenesis. In this issue of the JCI, Perego et al. expand that role by showing that Parkin expression stimulated an interferon (IFN) response to modulate CD8+ T cell activity.

Cancer 54
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Idorsia Launches Aprocitentan (TRYVIO) in US For Treatment of Hypertension

HCPLive

Once-daily aprocitentan is indicated to help lower blood pressure in adult patients with hypertension who are inadequately controlled on other medications.

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Exercise Training in HCM Patients Without LVOT Obstruction

American College of Cardiology

What is the effect of exercise training on left ventricular (LV) filling pressure measured during exercise in patients with hypertrophic cardiomyopathy (HCM) without left ventricular outflow tract (LVOT) obstruction?

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FDA Accepts Resubmitted sBLA for Dupilumab Treatment of Chronic Spontaneous Urticaria

HCPLive

The announcement of the resubmission by Regeneron and Sanofi follows LIBERTY-CUPID phase 3 clinical findings on dupilumab for patients with CSU.

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The association between the stress hyperglycaemia ratio and mortality in cardiovascular disease: a meta-analysis and systematic review

Cardiovascular Diabetology

A raised stress hyperglycaemia ratio (SHR) has been associated with all-cause mortality and may better discriminate than an absolute glucose value. The aim of this meta analysis and systematic review is to syn.

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Glucocorticosteroid Use for Rheumatoid Arthritis Increases CVD, Infection Mortality Risk Even After Cessation

HCPLive

People who used GC for over 2 years and 3 years had elevated risks of CVD and infection-related mortality, respectively, that never returned to pre-GC use levels.

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FDA warns of arterial bypass device safety concerns: 5 things to know

Becker's Hospital Review - Cardiology

"FDA warns of safety concerns and supply issues for Getinge/Maquet's VasoView HemoPro Endoscopic Vessel Harvesting Systems used in endoscopic arterial bypass su

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John Stone, MD, MPH: Inebilizumab Efficacious for IgG4-Related Disease in MITIGATE Study

HCPLive

Stone discussed findings from the first randomized, double-blind, placebo-controlled trial for IgG4-related disease.

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Artificial heart saves 4th patient

Becker's Hospital Review - Cardiology

Surgeons at Cincinnati-based The Christ Hospital performed a successful human implantation of the BiVACOR Total Artificial Heart, marking the fourth hospital in the U.S. to complete the procedure as part of the FDA's early feasibility study.

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Parent Stress Reduces Over Time When Weaning Child Off Tube Feeding with Hide Okuno, MS

HCPLive

HCPLive spoke with Okuno at NASPGHAN 2024 about a study examining changes in parent stress levels and mental health symptoms after a child completes weaning off tube feeding.

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Diagnosis and Management of Kawasaki Disease: Key Points

American College of Cardiology

The following are key points to remember from an American Heart Association scientific statement on the diagnosis and management of Kawasaki disease.

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Video Education Program Reduced Severity Score of Atopic Dermatitis in Pediatric Patients

HCPLive

In this analysis in Thailand, video education’s impact on patient guardians’ knowledge was assessed with the aim of reducing eczema severity.

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Dual targeting macrophages and microglia is a therapeutic vulnerability in models of PTEN-deficient glioblastoma

Journal of Clinical Investigation - Cardiology

Tumor-associated macrophages and microglia (TAMs) are critical for tumor progression and therapy resistance in glioblastoma (GBM), a type of incurable brain cancer. We previously identified lysyl oxidase (LOX) and olfactomedin like-3 (OLFML3) as essential macrophage and microglia chemokines, respectively, in GBM. Here, single-cell transcriptomics and multiplex sequential immunofluorescence followed by functional studies demonstrate that macrophages negatively correlate with microglia in the GBM

Cancer 42
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Study Highlights Real-World Characteristics of Providers Treating Psoriasis in US

HCPLive

In this cross-sectional survey analysis, new insights were explored regarding clinical practice patterns and treatment outcomes within dermatology practices in the US.

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Cell-cycle machinery is critical in regulating uterine steroid hormone for embryo implantation and development

Journal of Clinical Investigation - Cardiology

Proper embryo implantation is necessary for a successful pregnancy. In this issue of the JCI, Aljubran et al. identified the cell cycle regulatory protein cyclin A2 (CCNA2) as a factor in supporting embryo implantation and embryo development. Endometrial stromal cells showed higher levels of CCNA2 in patients undergoing assisted reproductive technology who had successful pregnancies.

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Wei Zhang, MD, PhD: Optimizing Post-Liver Transplant Care for High-Risk Patients

HCPLive

Zhang describes how a novel multidisciplinary care clinic has helped reduce relapse after transplant in patients with alcohol-associated liver disease.

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NEJM at AHA — Tirzepatide for Heart Failure with Preserved Ejection Fraction and Obesity

The New England Journal of Medicine

In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 American Heart Association Scientific Sessions.

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VTP-300, Nivolumab Combination Shows Promise for Functional HBV Cure in Phase 2b Trial

HCPLive

New phase 2b data suggest a combination of VTP-300 and low-dose nivolumab can stimulate immune response and induce HBV functional cure.

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WMH Contributions to Cognitive Impairment: Rationale and Design of the Diverse VCID Study

Stroke Journal

Stroke, Ahead of Print. As awareness of dementia increases, more individuals with minor cognitive complaints are requesting clinical assessment. Neuroimaging studies frequently identify incidental white matter hyperintensities, raising patient concerns about their brain health and future risk for dementia. Moreover, current US demographics indicate that 50% of these individuals will be from diverse backgrounds by 2060.

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Seladelpar (Livdelzi) Demonstrates Long-Term Benefit for Primary Biliary Cholangitis

HCPLive

Findings from a 2.5-year interim analysis from the ongoing phase 3 ASSURE study highlight seladelpar’s sustained efficacy and long-term safety for PBC.

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The Impact of Coronary Ischemia Assessment on Outcomes in Those With Scar‐Dependent Ventricular Tachycardia

Journal of Cardiovascular Electrophysiology

Central illustration: In those presenting With monomorphic VT, undergoing coronary ischemia assessment was associated With improved 12-month event-free survival from the primary endpoint of VT recurrence, ICD therapy, heart failure hospitalization, and death. ABSTRACT Background Guidance and outcomes of coronary ischemia assessment (IA) in those with structural heart disease (SHD), presenting with monomorphic ventricular tachycardia (MMVT) is unclear.

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Disease Severity and Delays in Treatment in CSU

HCPLive

Panelists discuss how disease severity in chronic spontaneous urticaria (CSU) is assessed using tools such as the Urticaria Activity Score over 7 days (UAS7) and the Urticaria Control Test (UCT), while also addressing the frequency of delayed diagnoses and the significant implications for condition management and patient quality of life.

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NEJM at AHA — Left Atrial Appendage Closure after Ablation for Atrial Fibrillation

The New England Journal of Medicine

In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 American Heart Association Scientific Sessions.

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The Role of Dermatologists in Treating CSU

HCPLive

Panelists discuss how, given that approximately 49% of patients with chronic spontaneous urticaria (CSU) consult general practitioners, while only approximately 19% see dermatologists, there is a compelling case for more patients to be referred to dermatologists, as CSU is an internally driven disease that may benefit from specialized expertise.

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NEJM at AHA — Catheter Ablation or Antiarrhythmic Drugs for Ventricular Tachycardia

The New England Journal of Medicine

In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 American Heart Association Scientific Sessions.

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Impact of Atrial Fibrillation and Atrial Fibrillation Therapies on Sports Performance in Athletes

HeartRhythm

It has been hypothesized that both atrial fibrillation (AF) and medications for AF, are poorly tolerated in athletes.

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NEJM at AHA — Intensive Blood-Pressure Control in Patients with Type 2 Diabetes

The New England Journal of Medicine

In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 American Heart Association Scientific Sessions.