Exploring Hematoma Expansion Shift With Recombinant Factor VIIa: A Pooled Analysis of 4 Randomized Controlled Trials
Stroke Journal
OCTOBER 7, 2023
Stroke, Volume 54, Issue 12 , Page 2990-2998, December 1, 2023. BACKGROUND:Hematoma expansion shift (HES) analysis can be used to assess the biological effect of a hemostatic therapy for intracerebral hemorrhage. In this study, we applied HES analysis to individual patient data from 4 randomized controlled trials evaluating rFVIIa (recombinant factor VIIa) 80 μg/kg to placebo.METHODS:We generated polychotomous strata of HES using absolute growth thresholds (≤0/<6/≥6 mL) and quintiles of p
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