Tue.Dec 03, 2024

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Tiny, daily bursts of vigorous incidental physical activity could almost halve cardiovascular risk in middle-aged women

Science Daily - Heart Disease

An average of four minutes of incidental vigorous physical activity a day could almost halve the risk of major cardiovascular events, such as heart attacks, for middle-aged women who do not engage in structured exercise, according to new research.

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Cognitive Performance Falls as Metal Exposure Rises

Med Page Today

(MedPage Today) -- Traces of nine essential metals and non-essential metals in urine were linked with lower cognitive performance and the risk of future dementia, a large prospective study showed. The study assessed concentrations of the essential.

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Esperion Presents New Data from CLEAR Outcomes Trial Highlighting Value of NEXLETOL

DAIC

tim.hodson Tue, 12/03/2024 - 16:52 Nov. 18, 2024 — In November, Esperion presented an analysis from the CLEAR Outcomes study focused on patients with Peripheral Artery Disease (PAD) who were unable or unwilling to take statin medications. These data were presented at the 2024 American Heart Association Scientific Sessions, in Chicago, IL. Additionally, two exploratory analyses from the CLEAR Outcomes trial and a real-world analysis of bempedoic acid usage were presented at the conference.

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Daily Chores May Provide Cardiovascular Protection in Women Who Don't Exercise

Med Page Today

(MedPage Today) -- Short, intense bouts of physical activity during daily life were associated with a lower risk of major adverse cardiovascular events (MACE) in non-exercising women, according to an observational study. A median 3.4 minutes of.

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What can you find with continuous ST monitoring in the ED?

Dr. Smith's ECG Blog

This was written by one of our fine residents, who will soon be an EMS fellow: Michael Perlmutter Case A mid-50s male came to the ED with a burning sensation that was acutely worse while at home. He had recently returned from overseas travel where these symptoms had been intermittently bothersome over the preceding weeks and had been attributed to heartburn.

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EM Quick Hits 61 TEE in Cardiac Arrest, Nebulized Ketamine, Cellulitis Update, SQ Insulin for DKA, Medicolegal DDx Documentation Tips

ECG Cases

On this month's EM Quick Hits podcast: Ross Prager on TEE in cardiac arrest, Justin Morgenstern on nebulized ketamine for analgesia in the ED, Hans Rosenberg & Krishin Yadav on standardizing cellulitis management, Mathew McArther on latest studies on subcutaneous insulin protocols in DKA, Jennifer C. Tang on documenting differential diagnoses medicolegal tips.

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Allergy Month in Review | November 2024

HCPLive

In this iteration of the Month in Review series, a list of highlighted stories in the allergy and immunology space covered in the month of November is provided.

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This Year in Medicine 2024: Stories that Defined Healthcare

HCPLive

An overview and landing page for future installments from HCPLive's 8th annual This Year in Medicine Series.

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M*-powered patients & Fearsome doctors !

Dr. S. Venkatesan MD

The following thought, is in response to a spate of violent attacks by patients on the doctors in my state. One of my ex-colleagues, an Oncologist was stabbed with a knife by a son of an elderly mother in his clinic room, apparently agitated with the side effects of the chemotherapeutic drugs she was receiving for end-stage Hodgkin’s lymphoma.

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Intra-Cellular Therapies Submits sNDA to FDA for Lumateperone as an MDD Adjunctive Therapy

HCPLive

Intra-Cellular Therapies announced they submitted a supplemental New Drug Application to the FDA for lumateperone (CAPLYTA) as an adjunctive therapy to antidepressants for MDD.

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Prevalence and prognostic significance of pulmonary hypertension in adults with left ventricular diastolic dysfunction

Open Heart

Aims Pulmonary hypertension (PHT) appears to be very common in heart failure with preserved ejection fraction but details on its prevalence, severity and prognostic implications have not been well defined. We, therefore, aimed to document PHT and its impact on mortality among adults with left ventricular (LV) diastolic dysfunction (LVDD). Methods We analysed the profile and outcomes of 16 058 adults with LVDD (and with preserved LV ejection fraction, >50%) from the National Echocardiography

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Timelier U.S. Guidelines; Spouse's Personality & CVD; 'Hostile' Cardiologists Out

Med Page Today

(MedPage Today) -- To facilitate more timely guideline updates, the American College of Cardiology and the American Heart Association have committed to annual guideline "maintenance" and single recommendation updating. (Journal of the American.

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5 NYC Health hospitals are hypertension control 'champions'

Becker's Hospital Review - Cardiology

The CDC and CMS added four NYC Health + Hospitals' facilities to the Million Hearts Hypertension Control Champion list in 2024, which recognizes hospitals who have achieved blood pressure control for at least 80% of adult hypertension patients.

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ECG Cases 52 – The Art of Occlusion MI, part 1: Mirror Image

ECG Cases

In this month's ECG Cases Jesse McLaren takes us through 6 cases highlighting important mirror concepts in ECG interpretation including: which leads are reciprocal to each other, how to identify which is the main ST/T change and which is the mirror, reciprocal changes highlighting subtle inferior, lateral and posterior OMI, ST elevation in aVR as a mirror to widespread ST depression and more.

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Comparing the Latest Stool- Based and Blood-Based Colorectal Cancer Screening Tests

HCPLive

Vivek Kaul, MD, discusses the sensitivity and accuracy of the stool DNA test, providing relevant data, while also describing the role of blood-based tests in colorectal cancer screening and how they complement or differ from stool-based tests.

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Deadline Extended: Special Collection on Artificial Intelligence in Cardiovascular Health

International Journal of Cardiovascular Sciences

We would like to inform you that the deadline for submitting articles for the special collection on Artificial Intelligence in Cardiovascular Health has been extended to March 1, 2024. This special collection aims to explore advancements, applications, and challenges of artificial intelligence in the context of cardiovascular health, promoting the dissemination of knowledge and scientific innovations in the field.

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Protective effect of UDCA against IL-11- induced cardiac fibrosis is mediated by TGR5 signalling

Frontiers in Cardiovascular Medicine

IntroductionCardiac fibrosis occurs in a wide range of cardiac diseases and is characterised by the transdifferentiation of cardiac fibroblasts into myofibroblasts these cells produce large quantities of extracellular matrix, resulting in myocardial scar. The profibrotic process is multi-factorial, meaning identification of effective treatments has been limited.

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10 recent cardiology partnerships

Becker's Hospital Review - Cardiology

"Discover the latest cardiology partnerships, from a $700 million investment in cardiovascular care to international AI applications, in this article.

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Correlation between admission blood glucose, fibrinogen, and slow blood flow during primary PCI for acute ST segment elevation myocardial infarction

Frontiers in Cardiovascular Medicine

BackgroudCoronary slow flow (CSF) is a common phenomenon of coronary microcirculation dysfunction, and is closely related to elevated blood glucose and fibrinogen (FIB) levels. However, whether immediate blood glucose and FIB levels affect coronary blood flow during primary percutaneous coronary intervention (PCI) remains unclear.ObjectiveTo explore the correlation between admission blood glucose (ABG), fibrinogen (FIB) and slow blood flow during primary PCI for acute ST segment elevation myocar

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ACCEL Lite: Top Takeaways from 2024: Interventional Cardiology with Deepak L. Bhatt, MD, MPH, MBA, FACC

American College of Cardiology

In this interview, Deepak L Bhatt, MD, MPH, MBA, FACC, and Alison L. Bailey, MD FACC, discuss the Top Interventional Takeaways from 2024. Dr. Bhatt discusses the CLEAR SYNERGY, DanGer Shock, EARLY TAVR trials and more.

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Traditional Chinese medicine for cardiovascular disease: efficacy and safety

Frontiers in Cardiovascular Medicine

In China and other Asian nations, traditional medicine has long been utilized in the treatment of cardiovascular diseases (CVD). While Chinese authorities have incorporated traditional Chinese medicine (TCM) treatment experiences as a supplementary guide for CVD, its international recognition remains limited due to a scarcity of high-quality and reliable randomized controlled trials (RCTs) evidence.

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Anemia Negatively Impacts Right Ventricular Function in Patients with HFpEF

HCPLive

Anemia in heart failure with preserved ejection fraction was linked to right ventricular dysfunction in an analysis of more than 1000 patients in China.

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Case Report: A novel method of needle-free transseptal puncture

Frontiers in Cardiovascular Medicine

BackgroundIn the era of fluoroless catheter ablation (CA), achieving a successful transseptal puncture (TSP) presents a significant challenge. We introduce a novel technique for zero-fluoroscopy and cost-effective needle-free TSP.Case summaryWe describe two cases where a GMS-1 guidewire (0.025 inch, pigtail configuration; Toray Medical Co., Ltd., Japan) was utilized for TSP.

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Endoscopy in the Age of GLP-1 RAs: 2024 Sees New Risk-Based Perioperative Guidance

HCPLive

Previous ASA guidance recommended holding GLP-1 RAs in the perioperative period, but new 2024 multisociety guidance suggests a risk-based approach.

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The "Why" of Shared Decision-Making With Athletes: Highlights From the "Courtside with the Chair" Podcast

American College of Cardiology

Because of recent incidents of sudden cardiac arrest (SCA) among high-profile athletes, including Damar Hamlin and Bronny James, there has been greater scrutiny regarding the medical evaluation process for athletes.

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Dermatology Month in Review | November 2024

HCPLive

The November Month in Review features a set of dermatology news coverage highlights, including FDA news and developments in psoriasis.

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Impact of Smokeless Oral Nicotine Products on Cardiovascular Disease: Implications for Policy, Prevention, and Treatment: A Policy Statement From the American Heart Association

Circulation

Circulation, Ahead of Print. Smokeless oral nicotine products are addictive, and their use has potential adverse effects on some but not all biomarkers of cardiovascular risk. The use of some types of these products, for instance, is associated with an increased mortality risk in those with ischemic heart or cerebrovascular disease. Similarly, smokeless tobacco has the potential to increase the risk of oral cancer, but the risks depend on the chemical composition of the product.

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Denosumab Biosimilar Demonstrates Equivalent Efficacy, Safety in Phase 3 Trial

HCPLive

CT-P41 had similar rates of bone mineral density increases and adverse events in data presented at the ACR 2024 Convergence.

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Bare metal stent application to prevent limb occlusion in iliac arteries with severe tortuosity during an endovascular aneurysm repair: a cohort study

Frontiers in Cardiovascular Medicine

BackgroundThe risk of limb graft occlusion (LGO) after endovascular aneurysm repair (EVAR) is increased by severe tortuosity of the iliac artery. A bare metal stent (BMS) may protect LGO, according to the hypothesis of this single-center retrospective analysis.MethodsAll patients undergoing elective EVAR with a bifurcated stent graft between January 2012 and June 2022 were included in this cohort study.

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ACE2, From the Kidney to SARS-CoV-2: Donald Seldin Award Lecture 2023

Hypertension Journal

Hypertension, Ahead of Print. ACE2 (angiotensin-converting enzyme 2) is a monocarboxypeptidase that cleaves Ang II (angiotensin II) among other substrates. ACE2 is present in the cell membrane of many organs, most abundantly in epithelial cells of kidney proximal tubules and the small intestine, and also exists in soluble forms in plasma and body fluids.

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Risk of Bleeding, Thrombosis and Death among Atrial Fibrillation Patients Treated with Oral Anticoagulants Across Estimated Glomerular Filtration Rates

The American Journal of Cardiology

Publication date: Available online 2 December 2024 Source: The American Journal of Cardiology Author(s): Xinhai Huang, Donglin Xie, Jie Huang, Ruijuan Li, Qiaowei Zheng, Xiumei Liu, Hengfen Dai, Xiangsheng Lin, Yuxin Liu, Jun Su, Xiaomin Dong, Yanxian Lan, Cuifang You, Shuzheng Jiang, Jinhua Zhang

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HEART UK’s 37th AMSC 2024 – Hot topics in atherosclerosis and cardiovascular disease

The British Journal of Cardiology

HEART UK held its 37 th Annual Medical and Scientific Conference between 10 th –12 th July. This year, the cholesterol charity took on an international theme, looking at the global cardiovascular disease (CVD) prevention picture. There was also a particular focus on women and CVD disease, alongside a review of how familial hypercholesterolaemia (FH) care has advanced in recent decades.

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Anatomy of the aortic segmental arteries—the fundamentals of preventing spinal cord ischemia in aortic aneurysm repair

Frontiers in Cardiovascular Medicine

ObjectiveSpinal cord ischemia due to damage or occlusion of the orifices of aortic segmental arteries (ASA) is a serious complication of open and endovascular aortic repair. Our study aims to provide detailed descriptions of the proximal course of the ASAs and metric information on their origins.Materials and methodsInitially, 200 randomly selected, embalmed cadavers of human body donors were anatomically dissected and systematically examined.

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A tale of two hearts

The British Journal of Cardiology

A 74-year-old man with a heterotopic heart transplant experienced alternating episodes of sustained native heart ventricular tachycardia and prolonged asystole. These were managed with cardioversion, drug therapy and pacemaker insertion. The unique physiology in such patients lends itself to numerous clinical considerations that would otherwise be routine management for most.

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Correlation between thrombocytopenia and adverse outcomes in patients with atrial fibrillation: a systematic review and meta-analysis

Frontiers in Cardiovascular Medicine

BackgroundThrombocytopenia is often associated with adverse outcomes in patients with atrial fibrillation. Therefore, we conducted a meta-analysis to comprehensively assess the impact of thrombocytopenia on ischemic stroke/systemic embolism, major bleeding and all-cause mortality in patients with atrial fibrillation.MethodsTwo electronic databases, PubMed and Web of Science, were systematically searched from their inception to December 1, 2023, including the studies on the correlation between at

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A rare case of hypereosinophilic endomyocardial fibrosis due to PCM1-JAK2

The British Journal of Cardiology

Endomyocardial fibrosis is a common cause of restrictive cardiomyopathy worldwide, but rarely occurs in patients living outside tropical regions. 1 Herein is the first published case report of a 48-year-old woman with endomyocardial fibrosis due to hypereosinophilia secondary to a rare chromosome 8 and 9 PCM1-JAK2 translocation.

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FDA Authorizes Predetermined Change Control Plan for Sleep Wearable Dreem 3S

HCPLive

Dreem 3S is the first sleep wearable with an FDA-authorized Predetermined Change Control Plan.

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