Mon.Jan 08, 2024

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UH Harrington Heart and Vascular Institute First in World to Implant Penditure Clip Using Minimally Invasive Approach

DAIC

milla1cf Mon, 01/08/2024 - 14:35 January 8, 2024 — University Hospitals (UH) Harrington Heart & Vascular Institute recently became the first center in the world to implant Medtronic’s Penditure Left Atrial Appendage (LAA) Exclusion System through a minimally invasive approach during a mitral valve repair procedure. This was also the first time this device and approach were used simultaneously in a human.

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Transgender Individuals Report Isolation, Concerns Related to Gender Expression Due to Acne

HCPLive

These findings highlight the real access barriers faced by TGD individuals as well as the necessity of additional research to promote evidence-based hormonal acne treatments.

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Stereotaxis Announces First Patients Successfully Treated Using MAGiC Ablation Catheter

DAIC

Physicians at Vilnius University. milla1cf Mon, 01/08/2024 - 14:26 January 8, 2024 — Stereotaxis , a pioneer in surgical robotics for minimally invasive endovascular intervention, announced that the first patients have been successfully treated using its Magnetic Interventional Ablation Catheter, MAGiC. Assoc. Prof. Gediminas Račkauskas Stereotaxis’ MAGiC catheter is a robotically navigated magnetic ablation catheter designed to perform minimally invasive cardiac ablation procedures.

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Omadacycline Shows Promise as Safe, Effective C Diff Antibiotic Compared to Vancomycin

HCPLive

Participants given omadacycline had high fecal concentrations with a distinct microbiome profile compared to those in the vancomycin group, with study results calling attention to the importance of antibiotics’ impact on the gut microbiome.

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GE HealthCare Announces Agreement to Acquire MIM Software

DAIC

Getty Images milla1cf Mon, 01/08/2024 - 11:32 January 8, 2023 — GE HealthCare announced it has entered into an agreement to acquire MIM Software , a global provider of medical imaging analysis and artificial intelligence (AI) solutions for the practice of radiation oncology , molecular radiotherapy, diagnostic imaging, and urology at imaging centers, hospitals, specialty clinics, and research organizations worldwide.

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Impact of Early Versus Late CRRT Initiation in Children and Young Adults, with Katja Gist, DO

HCPLive

We sat down with Katja Gist, DO, for further insight into the use of continuous renal replacement therapy in children and young adults, spotlighting the importance of timing to therapy initiation.

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Cardiovascular and renal diseases in type 2 diabetes patients: 5-year cumulative incidence of the first occurred manifestation and hospitalization cost: a cohort within the French SNDS nationwide claims database

Cardiovascular Diabetology

Myocardial infarction (MI), stroke, peripheral arterial disease (PAD), heart failure (HF) and chronic kidney disease (CKD) are common cardiovascular renal diseases (CVRD) manifestations for type 2 diabetes. Th.

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Systematic review and meta-analysis of early aortic valve replacement versus conservative therapy in patients with asymptomatic aortic valve stenosis with preserved left ventricle systolic function

Open Heart

Background A quarter of patients with severe aortic stenosis (AS) were asymptomatic, and only a third of them survived at the end of 4 years. Only a select subset of these patients was recommended for aortic valve replacement (AVR) by the current American College of Cardiology/American Heart Association guidelines. We intended to study the effect of early AVR (eAVR) in this subset of asymptomatic patients with preserved left ventricle function.

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Positive Response Observed in HS Patients Having Failed Anti-TNF Therapy Treated with Lutikizumab

HCPLive

These phase 2 data on hidradenitis suppurativa patients highlight new information on the use of lutikizumab as a treatment alternative.

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Self-Measured Blood Pressure–Guided Pharmacotherapy: A Systematic Review and Meta-Analysis of US-Based Telemedicine Trials

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:The optimal approach to implementing telemedicine hypertension management in the United States is unknown.METHODS:We examined telemedicine hypertension management versus the effect of usual clinic-based care on blood pressure (BP) and patient/clinician-related heterogeneity in a systematic review/meta-analysis.

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Dextromethorphan-bupropion for Treatment of Major Depressive Disorder

HCPLive

Dr Greg Mattingly explains the mechanism of action of dextromethorphan-bupropion, a new agent to treat Major Depressive Disorder.

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New program for psoriasis patients highlights cardiovascular risk

Medical Xpress - Cardiology

Almost 30% of the patients in a pilot program for those with psoriasis that was devised by researchers from the Perelman School of Medicine at the University of Pennsylvania were identified as having undiagnosed, elevated risk for cardiovascular disease. Those patients were then able to be given more individualized care over the next year, but all participants received extra care and guidance.

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Subacute hemorrhagic pericardial tamponade after COVID-19 infection mimicking carcinomatous pericarditis: a case report

Frontiers in Cardiovascular Medicine

Background Coronavirus disease (COVID-19)-associated acute pericarditis has recently received much attention owing to its high frequency associated with pericardial tamponade (PT), showing unfavorable prognosis. However, early diagnosis and treatment remain challenging in cases of non-specific signs and symptoms. Case presentation A 64-year-old man was admitted to our hospital for acute osteomyelitis of the toes and was properly treated with antimicrobial agents.

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Ohio hospital first to combine new heart clip with minimally invasive procedure

Becker's Hospital Review - Cardiology

Cleveland-based University Hospitals Harrington Heart & Vascular Institute became the first in the world to implant Medtronic's Penditure left atrial appendage exclusion system through a minimally invasive approach.

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What do you suspect from this ECG in this 40-something with SOB and Chest pain?

Dr. Smith's ECG Blog

I was reviewing ECGs for a study, and came across this one, and was able to get all the clinical information: What do you think? The Queen diagnosed "OMI with high confidence" due to the ST Elevation in V1-V3. Smith interpretation: This is highly likely to be due to extreme right heart strain and is nearly diagnostic of pulmonary embolism. Let me tell you about her hospitalization, discharged 1 day prior, but it was at another hospital (I wish I had the ECG from that hospitalization): The patien

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Iron Deficiency Linked to Elevated HbA1c, Worsening Glucose Control in Diabetes

HCPLive

A study of more than 140 adults with diabetes is providing additional insight into the prevalence of anemia among these patients as well as its association with changes in glycemic control.

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Challenges in the Cardiovascular Evaluation and Management of Patients With Obesity

American College of Cardiology

Obesity is a multifaceted disease that is directly and indirectly implicated in atherosclerotic cardiovascular disease (CVD), heart failure (HF), atrial fibrillation (AF), and multiple CVD risk factors, including dyslipidemia, hypertension, type 2 diabetes mellitus (DM), and sleep disorders.

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Health Record Trigger Boosted Screening for Primary Aldosteronism

Med Page Today

(MedPage Today) -- An electronic health record (EHR) best-practice advisory helped identify candidates for primary aldosteronism (PA) screening, a prospective quality improvement study found. Out of a pool of 57,334 adults with hypertension seen.

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TENS Treatment Improves Pressure Pain Thresholds in Fibromyalgia

HCPLive

Results indicate the potential relevance of pressure pain thresholds for understanding the mechanisms that contribute to pain in fibromyalgia.

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Melatonin attenuates diabetic cardiomyopathy by increasing autophagy of cardiomyocytes via regulation of VEGF-B/GRP78/PERK signaling pathway

Cardiovascular Diabetology

Diabetic cardiomyopathy (DCM) is a major cause of mortality in patients with diabetes, and the potential strategies for treating DCM are insufficient.

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Update on mechanisms and management of atrial fibrillation

Medical Xpress - Cardiology

Atrial fibrillation (AF) is a major global health concern impacting millions and causing symptoms like palpitations, dyspnea, fatigue, dizziness, and chest discomfort. Furthermore, these symptoms reduce patients' quality of life and lead to increased mortality and morbidity.

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Comparison of left ventricular deformation abnormalities by echocardiography with cardiac magnetic resonance imaging in patients with acute myocarditis and preserved left ventricular ejection fraction

Frontiers in Cardiovascular Medicine

Purpose Cardiac magnetic resonance imaging (cMRI) represents the gold standard to detect myocarditis. Left ventricular (LV) deformation imaging provides additional diagnostic options presumably exceeding conventional transthoracic echocardiography (TTE). The present study aimed to analyze the feasibility to detect myocarditis in patients (pts) with preserved LV ejection fraction (LVEF) by TTE compared to cMRI.

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AZURE: Treat-and-Extend Aflibercept for nAMD Noninferior to Fixed Dosing

HCPLive

Results of the 76-week trial suggest that a treat-and-extend aflibercept regimen yields similar functional and anatomic outcomes as fixed dosing every 8 weeks among patients with nAMD.

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TNIK regulation of interferon signaling and endothelial cell response to virus infection

Frontiers in Cardiovascular Medicine

Background Traf2 and Nck-interacting kinase (TNIK) is known for its regulatory role in various processes within cancer cells. However, its role within endothelial cells (ECs) has remained relatively unexplored. Methods Leveraging RNA-seq data and Ingenuity Pathway Analysis (IPA), we probed the potential impact of TNIK depletion on ECs. Results Examination of RNA-seq data uncovered more than 450 Differentially Expressed Genes (DEGs) in TNIK-depleted ECs, displaying a fold change exceeding 2 with

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ACC CardiaCast: Heart Vision: Challenges and Opportunities in Multimodality Imaging

American College of Cardiology

In this first “Heart Vision” episode, Drs. Purvi Parwani and Jamieson Bourque are joined by Dr. Ron Blankstein, current Chair of Cardiovascular Imaging Section Leadership Council.

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Wrong lessons in lipidology : Eradicating LDL is not our goal !

Dr. S. Venkatesan MD

Preamble 15 % of body weight is fat. (10kg) Out of which just 250 mg of cholesterol is streaming in blood. We must understand Fat, lipid and cholesterol are different entities. LDL is obviously a target against atherosclerosis. While the total body seems to do little in determining cholesterol levels, what is more scientifically shocking is slope of the curve between blood LDL levels and plaque burden is rarely linear.

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Remnant cholesterol and the risk of aortic valve calcium progression: insights from the MESA study

Cardiovascular Diabetology

Remnant cholesterol (RC) is implicated in the risk of cardiovascular disease. However, comprehensive population-based studies elucidating its association with aortic valve calcium (AVC) progression are limited.

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Identification of M2 Macrophage-Related Key Genes in Advanced Atherosclerotic Plaques by Network Based Analysis

Journal of Cardiovascular Pharmacology

Atherosclerotic plaque accounts for major adverse cardiovascular events due to its vulnerability. The M1 and M2 macrophages are implicated in progression and regression of plaque, respectively. However, the therapeutic targets related M2 macrophages still remain largely elusive. In this study, CIBERSORT and WGCNA algorithms were employed to establish a weighted gene co-expression network for identifying M2 macrophage-related hub genes using GSE43292 dataset.

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The translational potential of miR-26 in atherosclerosis and development of agents for its target genes ACC1/2, COL1A1, CPT1A, FBP1, DGAT2, and SMAD7

Cardiovascular Diabetology

Atherosclerosis is one of the leading causes of death worldwide. miR-26 is a potential biomarker of atherosclerosis. Standardized diagnostic tests for miR-26 (MIR26-DX) have been developed, but the fastest pro.

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New insights of platelet endocytosis and its implication for platelet function

Frontiers in Cardiovascular Medicine

Endocytosis constitutes a cellular process in which cells selectively encapsulate surface substances into endocytic vesicles, also known as endosomes, thereby modulating their interaction with the environment. Platelets, as pivotal hematologic elements, play a crucial role not only in regulating coagulation and thrombus formation but also in facilitating tumor invasion and metastasis.

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Kudos to our Austin Monthly Top Doctors for 2024

CTVS

We are humbled and honored to begin the new year with recognition from our peers in the local Austin medical community. CTVS is pleased to share that several members of our team of our board-certified cardiothoracic and vascular surgeons have been named to Austin Monthly magazine’s Top Doctors list for 2024.

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Glutamatergic Signaling and New Mechanisms of Action for Treatment of Depression

HCPLive

Dr Andrew Cutler and Dr Greg Mattingly discuss newer mechanisms of action to treat patients with Major Depressive Disorder, in particular those with glutamatergic agents.

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FDA Update: Agency Facilitates Broader Adoption of Vaporized Hydrogen Peroxide to Sterilize Medical Devices

American College of Cardiology

The U.S. Food and Drug Administration (FDA) announced on Jan. 8 that vaporized hydrogen peroxide is now considered an established method of sterilization for medical devices, pointing out its long history of safety and efficacy.

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Higher Disease Activity in Early RA Predicts Increased Cardiovascular Disease Risk

HCPLive

Serum-COMP was linked to an increased risk of both cardiovascular disease and coronary artery disease.

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Cedars-Sinai launches aorta clinic

Becker's Hospital Review - Cardiology

Discover the new Aortic Surveillance Clinic at Smidt Heart Institute, providing comprehensive evaluation and monitoring for aortic disorders in Los Angeles.

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Colchicine Demonstrates Lack of Effect on Atrial Arrhythmia Recurrence

HCPLive

Randomized trial data shows colchicine administered following catheter ablation did not reduce atrial arrhythmia recurrence or associated clinical events.

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Tufts breaks regional heart transplant record

Becker's Hospital Review - Cardiology

Boston-based Tufts Medical Center broke the New England regional adult heart transplant record with 61 transplants in 2023.