CardiacWire
FEBRUARY 12, 2025
Just a couple weeks after the full trial results of AZALEA TIMI 71 were released, Novartis agreed to acquire Anthos Therapeutics for $925M upfront and another $2.15B in milestone payments, signaling that the pharma titan may have renewed confidence in abelacimab and the Factor XI inhibition segment. Novartis spun out the testing and development of abelacimab and formed Anthos Therapeutics back in 2019.
Heart BMJ
FEBRUARY 12, 2025
Background Atrial arrhythmias (AA) and heart failure (HF) are major causes of hospitalisation in adult congenital heart disease (ACHD). This study aimed to evaluate the temporal relationship between AA and HF onset, the association between HF and the success of radiofrequency ablation (RFA), and how HF influences outcomes in patients with AA. Methods In this single-centre retrospective cohort study, data from 3995 patients with ACHD were analysed.
Frontiers in Cardiovascular Medicine
FEBRUARY 12, 2025
BackgroundCurrent evidence suggests that cardiovascular disease (CVD) plays a role in the progression of chronic obstructive pulmonary disease (COPD). However, the relationship between CVD and the severity of COPD remains inadequately understood. Therefore, this study aims to elucidate the association between CVD and the severity of COPD.MethodsIn this cross-sectional study involving 7,152 individuals with COPD., Logistic regression, subgroup and sensitivity analyses were employed to evaluate th
Heart BMJ
FEBRUARY 12, 2025
In adults with congenital heart disease (ACHD patients), atrial arrhythmias (AA) and heart failure (HF) are common. Of these, AA is one of the leading causes for hospital admissions in ACHD care. 1 Factors related to congenital heart disease, such as underlying anatomy, surgical repair technique and scars, can all be considered as AA substrates. Scar-related re-entrant atrial tachycardias and atrial fibrillation (AF) are the most common types of AA, but focal atrial tachycardias, atrioventricula
Speaker: Simran Kaur, Co-founder & CEO at Tattva.Health
AI is transforming clinical trials—accelerating drug discovery, optimizing patient recruitment, and improving data analysis. But its impact goes far beyond research. As AI-driven innovation reshapes the clinical trial process, it’s also influencing broader healthcare trends, from personalized medicine to patient outcomes. Join this new webinar featuring Simran Kaur for an insightful discussion on what all of this means for the future of healthcare!
Frontiers in Cardiovascular Medicine
FEBRUARY 12, 2025
BackgroundInflammation, as the basic pathogenic mechanism of atherosclerosis, promotes the development of atherosclerosis (AS) and atherosclerotic cardiovascular disease (ASCVD). In numerous experiments based on animal and cellular models, sodium tanshinone IIA sulfonate (STS) injection has been found to reduce the levels of pro-inflammatory cytokines, adhesion molecules, and chemokines in patients with AS and ASCVD, exerting an anti-inflammatory effect to treat the disease.ObjectivesThis study
Heart BMJ
FEBRUARY 12, 2025
Background Bicuspid aortic valve (BAV) is the most common congenital heart defect in adults, often leading to complications such as thoracic aortic aneurysms and aortic stenosis. While BAV is frequently associated with 22q11.2 deletion syndrome (22q11.2DS), the contribution of rare copy number variants (CNVs) in this region to non-syndromic BAV is less clear.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Heart BMJ
FEBRUARY 12, 2025
Fabry disease (FD) is a rare X-linked genetic lysosomal storage disorder characterised by glycosphingolipid accumulation leading to multiorgan involvement including the heart typically in the second to fourth decades of life. Cardiomyopathy is a primary determinant of prognosis in FD and typically presents as a heart failure (HF) with a preserved ejection fraction phenotype. 1 Early identification and treatment are essential to mitigate disease progression leading to proposals for clinical stagi
HCPLive
FEBRUARY 12, 2025
A study found distinct DNA methylation patterns at birth linked to early-onset atopic dermatitis by age 2. Findings will be presented at AAAAI 2025.
Medical Xpress - Cardiology
FEBRUARY 12, 2025
Can telemedicine and exercise apps improve the health of people with type 2 diabetes and coronary heart disease? A large study led by the Technical University of Munich (TUM) shows that the positive effects are minimal. Study leader Prof. Martin Halle views the results as clear evidence of misplaced priorities in medical care. Direct care from medical professionals remains crucial.
American Heart News - Heart News
FEBRUARY 12, 2025
Research Highlights: A data analysis projected that South Asian adults living in the United Kingdom may experience elevated blood pressure nine years earlier than East Asian adults on average. The largest blood pressure disparities between South Asian.
Medical Xpress - Cardiology
FEBRUARY 12, 2025
Certain hormonal contraceptives are associated with a higher stroke and heart attack risk, finds a large study from Denmark in The BMJ that draws on prescription records to give more precise estimates for different products than previous studies.
HCPLive
FEBRUARY 12, 2025
A study found 1 in 7 children with anaphylaxis experience biphasic reactions after epinephrine, with no recurrences after 4 hours, highlighting corticosteroid impact.
Medical Xpress - Cardiology
FEBRUARY 12, 2025
Researchers at McMaster University have made a discovery in the field of hematology, providing an explanation for spontaneous and unusual blood-clotting that continues to occur despite treatment with full-dose blood thinners.
Med Page Today
FEBRUARY 12, 2025
(MedPage Today) -- Various hormonal contraceptives were linked to incident cardiovascular disease in an analysis of Denmark's nationwide records. From a pool of over 2 million women of reproductive age, users of most methods of hormonal contraception.
Medical Xpress - Cardiology
FEBRUARY 12, 2025
The RNA inhibitor olpasiran significantly reduces a type of "bad cholesterol" that's associated with a high risk of cardiovascular events, according to results from an analysis by a Mount Sinai researcher of a Phase II trial.
HCPLive
FEBRUARY 12, 2025
Bruckner discusses her teams long-term data on the safety and efficacy of birch bark extract, also known as Oleogel-S10, for those with epidermolysis bullosa.
Medical Xpress - Cardiology
FEBRUARY 12, 2025
Among simple congenital heart diseases (CHD), patent foramen ovale (PFO) is associated with a significantly higher risk for epilepsy, according to a study published in the February issue of CNS Neuroscience & Therapeutics.
The New England Journal of Medicine
FEBRUARY 12, 2025
In a randomized trial involving patients with acute myocardial infarction, colchicine did not decrease the risk of major adverse cardiovascular events over a median follow-up period of 3 years.
Science Daily - Heart Disease
FEBRUARY 12, 2025
South Asian adults in the United Kingdom may face high blood pressure-related heart risks earlier in life, while East Asian adults see risks rise in later years, according to a new study.
American College of Cardiology
FEBRUARY 12, 2025
In a contemporary population of patients with transthyretin amyloid cardiomyopathy (ATTR-CM) treated with tafamidis, long-term mortality was relatively high, according to a multicenter study published Feb. 11.
HCPLive
FEBRUARY 12, 2025
In the final segments of this 4-part episode, the discussion focuses on the use of HCEs in different kidney disease trials.
American College of Cardiology
FEBRUARY 12, 2025
A novel causal machine learning algorithm can determine which patients with atrial fibrillation (AFib) are more likely to benefit from left atrial appendage occlusion (LAAO) compared with direct-acting oral anticoagulant (DOAC) therapy, according to a study published Feb. 12.
HCPLive
FEBRUARY 12, 2025
In this quiz, we test your knowledge of evidence-based management strategies, recommended epinephrine doses, and evolving guidance on patient follow-up and discharge planning for anaphylaxis.
Medical Xpress - Cardiology
FEBRUARY 12, 2025
South Asian and East Asian adults living in the United Kingdom may have distinct trajectories to develop high blood pressure over their life course, according to new research published in Hypertension.
HCPLive
FEBRUARY 12, 2025
The Phase 2b RENOIR trial met its primary endpoint and key secondary endpoints in patients with RA in new 12-week data.
American College of Cardiology
FEBRUARY 12, 2025
Patients with significant tricuspid regurgitation (TR) at intermediate disease stage were more likely to survive at one year when treated via tricuspid transcatheter edge-to-edge-repair (T-TEER) when compared to patients treated conservatively, according to a study published Feb. 10.
HCPLive
FEBRUARY 12, 2025
In these new findings, investigators highlight phase 1 research into ritlecitinib for patients aged 6 to 12 years with alopecia areata.
American College of Cardiology
FEBRUARY 12, 2025
Additional rhythm-control strategies are frequently continued after index ablation for atrial fibrillation (AFib), according to a study published Feb. 12 in JACC: Clinical Electrophysiology.
HCPLive
FEBRUARY 12, 2025
New 2-year data from the BE HEARD program shed further light on the role bimekizumab in treatment algorithms for HS.
Cardiovascular Diabetology
FEBRUARY 12, 2025
Clonal hematopoiesis of indeterminate potential (CHIP) was associated with diabetes and cardiovascular diseases (CVD). However, the effect of CHIP on CVD have not been evaluated among patients with diabetes, a.
Journal of Cardiothoracic Surgery
FEBRUARY 12, 2025
Percutaneous coronary intervention (PCI) can effectively restore myocardial perfusion in patients with ST-segment elevation myocardial infarction (STEMI). Nevertheless, STEMI patients may still experience a n.
HCPLive
FEBRUARY 12, 2025
In part 2 of 4 from this episode, the discussion focuses on hierarchical composite endpoints and their use in nephrology trials and research.
Medical Xpress - Cardiology
FEBRUARY 12, 2025
A research team has revealed that cadmium, a toxic heavy metal, increases the synthesis of hyaluronan in vascular endothelial cells. Their study has also identified that this process is mediated by the induction of hyaluronan synthase 3 (HAS3) expression.
HCPLive
FEBRUARY 12, 2025
In part 3 of 4 from this episode, the discussion focuses on potential limitations to HCEs and addressing skepticism around their use in nephrology.
American College of Cardiology
FEBRUARY 12, 2025
In this weeks View, Dr. Eagle looks at tighter blood pressure control in patients who are postpartum.
HCPLive
FEBRUARY 12, 2025
These findings were from a 52-week analysis of a Phase-2 trial in participants with chronic spontaneous urticaria.
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