Physiologically Speaking
MARCH 21, 2025
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CardiacWire
MARCH 21, 2025
Its not surprising that Alnylams Amvuttra (vutrisiran) received FDA approval for ATTR-CM last week, but what shocked many was Alnylams choice to price the drug at nearly half a million dollars per year in a segment where its incumbent competitors cost half as much. Amvuttra is now the third FDA-approved therapy for ATTR-CM, following Pfizers Vyndaqel and BridgeBios Attruby/Beyonttra.
Medical Xpress - Cardiology
MARCH 21, 2025
The coffee from most of the coffee machines in workplaces contains relatively high levels of cholesterol-elevating substances. There is a big difference in comparison to coffee made in regular paper filter coffee makers, which filter out most of these substances.
Med Page Today
MARCH 21, 2025
(MedPage Today) -- For people with atrial fibrillation (Afib or AF), stopping oral anticoagulation (OAC) after a "successful" catheter ablation left them exposed to increased risk, according to a Japanese hospital's dataset. At Nagoya University.
Speaker: Simran Kaur, Co-founder & CEO at Tattva Health Inc.
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Journal of the American Heart Association
MARCH 21, 2025
Journal of the American Heart Association, Ahead of Print.
American College of Cardiology
MARCH 21, 2025
Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease affecting approximately 0.3-1.2% of the population, though underdiagnosis is common due to challenges in recognition and reporting.
Cardiovascular Update brings together the best content for cardiovascular medicine professionals from the widest variety of industry thought leaders.
Med Page Today
MARCH 21, 2025
(MedPage Today) -- Gene-silencing therapy vutrisiran (Amvuttra) graduated to a broad indication in treatment of transthyretin amyloidosis cardiomyopathy, as Alnylam Pharmaceuticals announced expanded FDA approval. Vutrisiran, a transthyretin-directed.
Cardiovascular Diabetology
MARCH 21, 2025
Mineralocorticoid receptor antagonists (MRAs) are often underutilized in patients with heart failure (HF), particularly those with diabetes and/or chronic kidney disease (CKD). However, the impact of concurren.
HCPLive
MARCH 21, 2025
Counting down the most impactful news at major medical meetings, its the HCPLive Five! This episode focuses on 5 key allergy updates from the 2025 American Academy of Allergy, Asthma, and Immunology (AAAAI) annual meeting.
American College of Cardiology
MARCH 21, 2025
In this podcast hosts highlight the 2023 Guideline updates and the importance of a patient centered cardiac care team approach to AFib diagnosis, management, and treatment.
HCPLive
MARCH 21, 2025
These data highlight differences and similarities among dermatologists globally in their decisions related to the treatment of mild-to-moderate atopic dermatitis.
Cardiovascular Diabetology
MARCH 21, 2025
Heart failure (HF) with preserved ejection fraction (HFpEF) is increasingly prevalent worldwide due to aging and comorbidities. Epicardial adipose tissue (EAT), favored by diabetes and obesity, was shown to co.
Journal of Cardiothoracic Surgery
MARCH 21, 2025
In valve-sparing aortic root replacement procedure, leaflet prolapse can be corrected by shortening the length of the free margin. But precisely determining the extent of the reduction remains a problem. This.
Cardiovascular Diabetology
MARCH 21, 2025
Glycemic control is critical for managing transcatheter aortic valve replacement (TAVR) patients, especially those in intensive care units (ICUs).
HCPLive
MARCH 21, 2025
A new cross-sectional study found that the odds of having bronchodilator responsiveness declined by 8% per hour during the working day.
American College of Cardiology
MARCH 21, 2025
Among at-risk patients undergoing elective coronary angiography (CAG) or PCI, delayed remote ischemic preconditioning (RIPC) reduces the incidence of contrast-associated acute kidney injury (CA-AKI) compared with sham preconditioning.
HCPLive
MARCH 21, 2025
Bhatt previews 3 late-breaking clinical trials being presented at this year's American College of Cardiology Annual Scientific Sessions.
The New England Journal of Medicine
MARCH 21, 2025
When his mother is diagnosed with what medicine calls heart failure, an epidemiologist identifies harmful flaws in both the term and communication with patients and families.
HCPLive
MARCH 21, 2025
By year 5, COPD exacerbations occurred in 81.3% of the PPV23 group and 23.6% of the PCV13 group.
Journal of the American Heart Association
MARCH 21, 2025
Journal of the American Heart Association, Ahead of Print.
HCPLive
MARCH 21, 2025
A panelist discusses how finding an effective treatment for their condition has dramatically improved their mental health and quality of life by restoring their confidence and reducing anxiety about their appearance, allowing them to participate more fully in social activities and giving them a renewed sense of hope and normalcy.
Journal of the American Heart Association
MARCH 21, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundPatients hospitalized with COVID19 from socioeconomically vulnerable communities are at risk for inhospital cardiovascular events. However, the association of socioeconomic vulnerability and outcomes after hospitalization is uncertain.Methods and ResultsAmerican Heart Association COVID19 Cardiovascular Disease Registry hospitalizations between March 1, 2020, and June 30, 2022, linked with Medicare feeforservice claims, were ana
HCPLive
MARCH 21, 2025
A panelist discusses how Brea's patient journey involved a gradual recognition of unusual hair loss patterns, followed by an emotional diagnostic process for alopecia areata, which significantly impacted her quality of life through decreased self-confidence, social withdrawal, and psychological distress before finding effective treatment options.
Journal of the American Heart Association
MARCH 21, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundEssential hypertension (EH) is a global health issue. Despite extensive research, much of EH heritability remains unexplained. We investigated the genetic basis of EH in Africanderived individuals from partially isolated quilombo populations in Vale do Ribeira (So Paulo, Brazil).Methods and ResultsSamples from 431 individuals (167 affected, 261 unaffected, 3 unknown) were genotyped using a 650 000 singlenucleotide polymorphism
HCPLive
MARCH 21, 2025
Experts discuss the JAK/STAT signaling pathways critical role in immune response, highlighting the involvement of JAK enzymes in atopic dermatitis (AD) pathogenesis and how JAK inhibitors effectively reduce itch and inflammation, improving symptoms and skin clearance in AD.
Journal of the American Heart Association
MARCH 21, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundThe best use of cardiac imaging to guide preventive coronary heart disease (CHD) treatment is debated. Current guidelines recommend the pooled cohort equation, followed by computed tomography for coronary artery calcification (CAC) assessment. We evaluated if this approach could be simplified using a selfreport risk algorithm instead of the pooled cohort equation.MethodsA gradient boosting machine model was trained on selfrepor
HCPLive
MARCH 21, 2025
Experts discuss the significance of using selective JAK1 inhibitors for atopic dermatitis (AD), noting their targeted action compared with nonselective JAK inhibitors, and how JAK1 selectivity enhances both the efficacy and safety of these agents in treating AD.
Journal of the American Heart Association
MARCH 21, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundIt is imperative to maintain the use of sodiumglucose cotransporter2 inhibitors (SGLT2is) in patients with diabetes both after the index diagnosis of heart failure (HF) and even prior to the index diagnosis of HF. We aimed to investigate whether timing of SGLT2 is before the index diagnosis of HF, and second, adherence to SGLT2is in the form of the proportion of days covered metric matter in patients with HF and diabetes.Method
Circulation: Heart Failure
MARCH 21, 2025
Circulation: Heart Failure, Ahead of Print.
Journal of the American Heart Association
MARCH 21, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundCarotid intimamedia thickness (CIMT) and carotid distensibility are markers of arterial change; however, little is known of the association with incident heart failure (HF). We aimed to assess this.MethodsThis was a longitudinal analysis of data from the British Regional Heart Study, a prospective cohort study.
Circulation: Cardiovascular Imaging
MARCH 21, 2025
Circulation: Cardiovascular Imaging, Ahead of Print.
Journal of the American Heart Association
MARCH 21, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundThe clinical utility of the polygenic risk score in predicting cardiovascular events in patients with atrial fibrillation (AF) has not yet been established. This study aimed to determine whether the polygenic risk score for AF might be useful in the risk stratification of AFrelated cardiovascular events.Methods and ResultsThis study included 9597 oral anticoagulationnaive patients with AF with a CHA2DS2VA (congestive heart fail
Circulation: Cardiovascular Imaging
MARCH 21, 2025
Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:Tricuspid regurgitation (TR) is associated with increased mortality and is often underdiagnosed due to limitations in imaging modalities. While routine 2-dimensional echocardiography (2DE) demonstrates frequent disagreement with cardiac magnetic resonance imaging (CMR) in classifying TR severity, the incremental value of 3-dimensional echocardiography (3DE) remains unknown also due to the lack of a generalizable grading scheme acros
Journal of the American Heart Association
MARCH 21, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundCurrent guidelines and expert consensus recommend lifelong single antiplatelet therapy for patients undergoing transcatheter aortic valve replacement who have no indication for anticoagulation or dual antiplatelet therapy. However, there is no direct evidence from randomized controlled trials supporting this practice.
Circulation: Cardiovascular Imaging
MARCH 21, 2025
Circulation: Cardiovascular Imaging, Ahead of Print. BACKGROUND:Patients with paradoxical low-flow, low-gradient severe aortic stenosis exhibit low transvalvular flow rate (Q), while maintaining preserved left ventricular ejection fraction. Severe mitral regurgitation (MR) also causes a low-flow state, adding complexity to diagnosis and management. This study aimed to examine the impact of severe MR on outcomes in paradoxical low-flow, low-gradient severe aortic stenosis.METHODS:Data from an ins
Journal of the American Heart Association
MARCH 21, 2025
Journal of the American Heart Association, Ahead of Print. BackgroundWe aimed to reevaluate randomized controlled trial data on outcomes of cerebral embolic protection device use during transcatheter aortic valve implantation. A conventional metaanalysis followed by trial sequential analysis was conducted to evaluate the strength of the current evidence.Methods and ResultsDatabases were searched for randomized controlled trials.
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