Sun.Sep 01, 2024

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Wearable heart monitor increases diagnosis of irregular heart rhythm

Science Daily - Stroke

Wearable, long-term continuous heart monitors helped identify 52% more cases of atrial fibrillation compared to usual care, but that did not lead to a reduction in hospitalizations due to stroke, according to a new study.

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Are you one of the “Top Grateful Patients” at your hospital?

Heart Sisters

After my book was published, the hospital that had sent me home in mid-heart attack with an acid reflux misdiagnosis invited me to be the guest speaker at a fundraising campaign they were about to launch.

Hospital 109
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Stenting, TAVR Make Sense Packaged Together for Some Patients

Med Page Today

(MedPage Today) -- LONDON -- Some individuals already undergoing transcatheter aortic valve replacement (TAVR, also TAVI) might as well get coronary lesions revascularized around the same time, according to the NOTION-3 randomized trial. Clinical.

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Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk

The New England Journal of Medicine

In this phase 3 trial involving patients with persistant chylomicronemia, plozasiran, a short interfering RNA that targets APOC3, reduced triglyceride levels and the incidence of pancreatitis.

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What We Have Learned About Reducing Low-Density Lipoprotein Cholesterol and Coronary Plaques

JAMA Cardiology

After the introduction of statins in 1987 and the publication of the landmark Scandinavian Simvastatin Survival Trial in 1996, extraordinarily robust evidence has accumulated demonstrating that lowering levels of low-density lipoprotein cholesterol (LDL-C) is associated with a major reduction in cardiovascular morbidity and mortality. Determining how the reduction in LDL-C results in these benefits has been the subject of intense scientific interest during the last 4 decades.

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FINEARTS-HF: Finerenone Could Find Role as Second Pillar in HFmrEF/HFpEF

HCPLive

FINEARTS-HF results suggest finerenone may join SGLT2 inhibitors as a second pillar in treating HFmrEF/HFpEF, cutting total heart failure events by 16%.

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Lesion-Level Effects of LDL-C–Lowering Therapy in Patients With Acute Myocardial Infarction

JAMA Cardiology

This post hoc analysis of a randomized clinical trial analyzes imaging data for atheroma volume at the lesion level from patients who received intensive lipid-lowering therapy with alirocumab plus statin compared with a statin alone.

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Diagnostic value of miR-34a in Mycoplasma pneumoniae pneumonia in children and its correlation with rehabilitation effect

Journal of Cardiothoracic Surgery

Mycoplasma pneumoniae pneumonia (MPP) is responsible for 20 to 40% of all cases of pneumonia acquired by children and shows an increasing incidence year by year. The aim of this study was to investigate the ex.

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Long-Term Data from ESC 2024 Reinforces Safety, Efficacy Profile of Mavacamten in oHCM

HCPLive

MAVA-LTE trial data show mavacamten's sustained benefits in symptomatic obstructive HCM, with long-term improvements in LVOT, NT-proBNP, and quality of life.

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Mechanism of KLF2 in young mice with pneumonia induced by Streptococcus pneumoniae

Journal of Cardiothoracic Surgery

Streptococcus pneumoniae (Spn) is a major causative agent of pneumonia, which can disseminate to the bloodstream and brain. Pneumonia remains a leading cause of death among children aged 1–59 months worldwide. Th.

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Matthew Cavender, MD, MPH: Evolving Landscape of Risk Scores in Cardiology

HCPLive

Matthew Cavender, MD, MPH, discusses a study he led at ESC Congress examining utility of the SCORE2-Diabetes risk score using clinical trial data.

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Nonsteroidal MRA Improves Outcomes in HFpEF, HFmrEF

Med Page Today

(MedPage Today) -- LONDON -- The nonsteroidal mineralocorticoid receptor antagonist (MRA) finerenone (Kerendia) improved outcomes driven by soft endpoints in patients with heart failure and mildly reduced or preserved ejection fraction (HFmrEF.

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OCEANIC-AF: Asundexian Nearly Quadruples Stroke, Embolism Risk vs Apixaban

HCPLive

Asundexian failed to prove noninferiority to apixaban for its primary efficacy outcome in the phase 3 OCEANIC-AF trial.

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DOAC Monotherapy Bests Dual Antithrombotic Therapy for Afib Plus Coronary Disease

Med Page Today

(MedPage Today) -- LONDON -- For patients with atrial fibrillation (Afib) and stable coronary artery disease (CAD), edoxaban (Savaysa) monotherapy improved net outcomes weighing together bleeding and ischemic events as compared with dual antithrombotic.

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The pseudo-superiority of pPCI is exposed one more time … but it will thrive!

Dr. S. Venkatesan MD

CAPTIM trial was published in 2002, which left a gospel truth in the science of myocardial reperfusion (two decades gone now). It is a sad academic story ,most of the interventional cardiology community shrugged it off as a non-event. After CAPTIM , there were several other studies that tried to reiterate the same. The fact of the matter is, in the art and science of reperfusion, all that glitters may not be gold at the myocardium level.

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SCOFF: Is Fasting Prior to Cath Lab Procedures Necessary?

American College of Cardiology

Fasting prior to cath lab procedures requiring conscious sedation may not be needed, based on findings from the SCOFF trial presented at ESC Congress 2024 in London.

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Echoes of Concern—AI and Moral Agency in Medicine

JAMA Cardiology

This essay describes concerns that use of artificial intelligence (AI) as a replacement rather than a supplement in the provision of medical care may lead to loss of the art of medicine and the collaborative partnership between physician and patient.

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2024 ESC Guidelines for Management of Chronic Coronary Syndromes: Key Points

American College of Cardiology

The following are key points to remember from the 2024 European Society of Cardiology (ESC) guidelines for the management of chronic coronary syndromes (CCS).

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The protective effect of Ghrelin peptide on doxorubicin hydrochloride induced heart failure in rats

Journal of Cardiothoracic Surgery

To investigate the protective effect and mechanism of Ghrelin on Doxorubicin (Dox) hydrochloride induced heart failure (HF) and myocardial injury in rats.

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SENIOR-RITA, STROKESTOP II and EARTH-STEMI: CV Management in Frail Adults

American College of Cardiology

An invasive treatment strategy involving coronary angiography and revascularization plus medical therapy did not significantly lower the composite risk of cardiovascular death or nonfatal myocardial infarction (MI) compared with a conservative strategy of medical therapy alone in older adults with NSTEMI, according to findings from the SENIOR-RITA trial presented at ESC Congress 2024 in London and simultaneously published in The New England Journal of Medicine.

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Relationship of Different Left Bundle Branch Pacing Sites and Clinical Outcomes in Heart Failure Patients

HeartRhythm

Left bundle branch pacing (LBBP) is a novel physiological pacing modality. However, whether it delivers comparable efficacy with different capture sites in heart failure (HF) patients remains unclear.

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Asundexian Versus Apixaban in Patients With Atrial Fibrillation

American College of Cardiology

The goal of the OCEANIC-AF trial was to determine whether asundexian, a direct and selective factor XIa inhibitor, is 1) noninferior in preventing stroke or systemic thromboembolism, and 2) superior with respect to major bleeding risk compared with apixaban in patients with atrial fibrillation (AF) requiring oral anticoagulant therapy.

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Paclitaxel-Coated Balloon Versus Uncoated Balloon Angioplasty For Coronary In-Stent Restenosis: A Systematic Review And Meta-Analysis Of Randomized Controlled Trials

The American Journal of Cardiology

Publication date: Available online 31 August 2024 Source: The American Journal of Cardiology Author(s): Ahmad Al-Abdouh, Dealla Samadi, Fares Sukhon, Mohammed Mhanna, Ahmad Jabri, Laith Alhuneafat, Taqwa Alabduh, Anas Bizanti, Luai Madanat, Mohammad Alqarqaz, Timir K Paul, Amartya Kundu

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Edoxaban Versus Edoxaban With Antiplatelet Agent in Patients With Atrial Fibrillation and Chronic Stable Coronary Artery Disease

American College of Cardiology

The goal of the EPIC-CAD trial was to evaluate edoxaban monotherapy compared with edoxaban/antiplatelet therapy among patients with atrial fibrillation (AF) and chronic coronary disease.

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NEJM at ESC — Plozasiran for Managing Persistent Chylomicronemia and Pancreatitis Risk

The New England Journal of Medicine

In this audio interview, Editor-in-Chief Eric Rubin and Deputy Editor Jane Leopold discuss research being presented at the 2024 European Society of Cardiology annual meeting.

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MIRACLE-AF: Village Doctors Supported by Telemedicine Improved Reduced AFib Risks in Rural China

American College of Cardiology

Village doctors in rural China trained to manage the care of older adults with atrial fibrillation (AFib) and supported by AFib experts in tertiary hospitals through telemedicine lowered the risk of AFib-related adverse cardiovascular events by 36% over three years, based on findings from the MIRACLE-AF trial presented at ESC Congress 2024 in London.

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Dr. Frans Berend Mensink, Dr. Dirk-Jan van Genus and Dr. C Michael Gibson Discuss: Functional Improvement of non-infarcT relaTed coronary artery stenosis by Extensive LDL-C Reduction with a PCSK9 Antibody

Clinical Trial Results

ESC 2024 FITTER Late-breaking PDF slides (1) Download Disclosures: TBD

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Older Patients With Non–ST-Segment Elevation Myocardial Infarction Randomized Interventional Treatment

American College of Cardiology

The goal of the SENIOR-RITA trial was to evaluate routine invasive therapy compared with conservative therapy among older patients with non–ST-elevation myocardial infarction (NSTEMI).

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Dr. David Ferreira and Dr. C Michael Gibson Discuss: SCOFF – Fasting or no fasting before cardiac cauterization procedures

Clinical Trial Results

Copy of Ferreira_David SCOFF ESC 2024 Download Disclosures: TBD

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STEEER-AF: Targeted Education For Clinicians Improved Adherence to Guideline-Recommended AFib Care

American College of Cardiology

A short educational program for targeted at health care professionals in France, Germany, Italy, Poland, Spain and the UK increased patient-level adherence to guideline recommendations on atrial fibrillation (AFib) management, based on findings from the STEEER-AF trial presented at ESC Congress 2024 in London.

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Dr. Gianluca Campo and Dr. C Michael Gibson Discuss: EARTH-STEMI – Complete vs. culprit-only revascularization in older STEMI patients

Clinical Trial Results

Copy of Campo_Gianluca Download Disclosures: TBD

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OCEANIC-AF: Asundexian vs. Apixaban in Patients With AFib

American College of Cardiology

Asundexian was associated with a higher incidence of stroke or systemic embolism, but less major bleeding, compared with apixaban among patients with atrial fibrillation (AFib) who were at high risk for stroke, based on findings from the OCEANIC-AF trial presented at ESC Congress 2024 in London and simultaneously published in The New England Journal of Medicine.

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Dr. Rabea Asleh and Dr. C Michael Gibson Discuss: Gut Microbiota and Associated Metabolites Play a Key Role in the Pathogenesis of the Obesity Phenotype of Heart Failure With Preserved Ejection Fraction

Clinical Trial Results

Disclosures: TBD ESC 2024_Rabea_Asleh Download

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GUARD-AF: Does Screening For Undiagnosed AFib Reduce Bleeding and Stroke Risk?

American College of Cardiology

One-time screening for atrial fibrillation (AFib) using a 14-day, electrocardiographic (ECG) patch monitor in individuals aged ≥70 years did not reduce rates of bleeding or stroke, based on results from the GUARD-AF trial.

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Dr. Laust Dupont Rasmussen and Dr. C Michael Gibson Discuss: Assessment of the microvascular resistance reserve for predicting the effect of revascularization in patients with moderate coronary stenoses.

Clinical Trial Results

Rasmussen_Laust Download Disclosures: TBD

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New Research Explores Benefits of Finerenone in Patients With HFmrEF or HFpEF; More

American College of Cardiology

In patients with heart failure (HF) and mildly reduced or preserved ejection fraction (HFmrEF/HFpEF), finerenone had a significantly lower rate of worsening HF events and cardiovascular-related death than placebo, based on findings from theFINEARTS-HF trial.

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Dr. Gi-Byoung Nam, Dr. Dukwoo Park and Dr. C Michael Gibson Discuss: EPIC-CAD – Edoxaban monotherapy vs. dual antithrombotic therapy for atrial fibrillation and stable coronary artery disease

Clinical Trial Results

Copy of Park_DW Download Disclosures: TBD