Wed.Mar 06, 2024

article thumbnail

CVD Risks Tied to Teeny-Tiny Plastics Lodged in Atherosclerotic Plaque

Med Page Today

(MedPage Today) -- It was common for tiny plastic particles from the environment to infiltrate people's vascular lesions, foreshadowing future cardiovascular disease in patients who underwent carotid endarterectomy, an observational study showed.

Plaque 138
article thumbnail

Bodyport Presents Preliminary Analysis of SCALE-HF 1 Study on Remote Heart Failure Monitoring at Technology and Heart Failure Therapeutics (THT) Conference

DAIC

Bodyport Inc., a biomarker-guided predictive care company, has presented data showing its FDA-cleared, non-invasive, biomarker-based technology for remote heart failure monitoring detected twice as many heart failure events as compared to the weight-based standard of care. Data from a preliminary analysis of Bodyport’s SCALE-HF 1 study were presented on the final day of the Cardiovascular Research Foundation’s third annual Technology and Heart Failure Therapeutics (THT) conference being held in

article thumbnail

FDA Clears First OTC Continuous Glucose Monitor

Med Page Today

(MedPage Today) -- The first over-the-counter continuous glucose monitor (CGM) was cleared for use by adults with or without diabetes, the FDA announced on Tuesday. The Dexcom Stelo Glucose Biosensor System is an integrated CGM (iCGM) that will.

Diabetes 111
article thumbnail

More than half of American Indian youth may have abnormal or high cholesterol

Science Daily - Heart Disease

More than 70% of American Indian young adults aged 20-39 and 50% of American Indian teens have cholesterol levels or elevated fat in the blood that put them at risk for cardiovascular disease, a new study suggests. In some cases, these levels -- specifically high low-density lipoprotein (LDL) cholesterol, often thought of as 'bad cholesterol,' -- were linked to plaque buildup and cardiovascular events, such as heart attack and stroke.

article thumbnail

FDA Rejects sNDA of Tasimelteon for Treating Insomnia

HCPLive

FDA issued a Complete Response Letter to Vanda Pharmaceuticals stating tasimelteon for treating insomnia cannot be approved in its current form due to identified deficiencies.

105
105
article thumbnail

Ensight-AI Awarded FDA’s Breakthrough Device Designation for Its ECGVision-TTR Technology for Early Detection of ATTR-Cardiomyopathy

DAIC

Getty Images milla1cf Wed, 03/06/2024 - 18:45 March 6, 2024 — Ensight-AI , a Yale start-up and leader in AI -based cardiovascular diagnostics, announces the receipt of the U.S. Food and Drug Administration’s ( FDA ) Breakthrough Device Designation for their ECGvision-TTR Technology for early detection of ATTR-Cardiomyopathy. Ensight-AI is leveraging the newly launched U.S.

article thumbnail

Semaglutide Reduced Inflammatory Biomarkers in HIV Patients With Lipohypertrophy

Med Page Today

(MedPage Today) -- DENVER -- People with HIV who received semaglutide (Ozempic, Wegovy) had reduced levels of several inflammatory biomarkers associated with cardiovascular disease, a randomized controlled trial showed. After 32 weeks, interleukin.

More Trending

article thumbnail

Instructors' Collection ECG: Regular Really Wide QRS Tachycardia

ECG Guru

The Patient: Unfortunately, this is an old tracing, and we do not have patient information, other than the list of medications the patient has been taking, (Lasix, Capoten, Ntg, and Procardia). Lasix (furosemide) is a potassium – wasting diuretic. Capoten (captopril) is an ACE inhibitor. Ntg is presumably sublingual nitroglycerine used for angina.

article thumbnail

Cleerly Receives FDA Breakthrough Device Designation for Heart Disease Risk Staging System

DAIC

milla1cf Wed, 03/06/2024 - 18:48 March 6, 2024 — Cleerly , the company on a mission to create a new standard of care to aid in the diagnosis of heart disease, has been granted Breakthrough Device Designation by the U.S. Food and Drug Administration ( FDA ) for its Coronary Artery Disease ( CAD ) Staging System. The CAD Staging System is a noninvasive imaging-based investigational software device that analyzes important and actionable features of coronary atherosclerosis, stenosis and ischemia.

article thumbnail

Cognitive Evaluation Necessary Among Children with Eczema, Comorbid Neurodevelopmental Disorders

HCPLive

These data suggest that, among children with atopic dermatitis and ADHD or other learning disabilities, an assessment for impairment of their cognitive abilities may need prioritization.

98
article thumbnail

As Cyberattack Jeopardizes Physician Practices, AMA Demands Action

DAIC

Getty Images milla1cf Wed, 03/06/2024 - 18:50 March 6, 2024 — As the cyber-takedown of Change Healthcare has forced medical practices to go without revenue for a twelfth day, the American Medical Association ( AMA ) urged U.S. Department of Health and Human Services ( HHS ) Secretary Xavier Becerra to use all its available authorities to ensure that physician practices can continue to function, and patients can continue to receive the care that they need.

Medicare 105
article thumbnail

"Exercise in a Pill": The Next Biohack or a Far-off Fantasy?

Physiologically Speaking

Plenty of people love to exercise. If you’re reading this post, you might be one of them. But the disheartening truth is that most people don’t enjoy exercise. A third or less of adults meet the minimum recommendations for aerobic and strength exercise each week. As a result, much of the global disease burden can be attributed to physical in activity — 6–10% based on some estimations.

article thumbnail

Cardiac memory: a phenomenon with important clinical implications

Nature Reviews - Cardiology

Nature Reviews Cardiology, Published online: 07 March 2024; doi:10.1038/s41569-024-01008-y Rebecca Gilchrist discusses the study that demonstrated the long-term modulation of ventricular repolarization by the sequence of electrical activation in the human heart and established the concept of cardiac memory.

93
article thumbnail

This injectable hydrogel mitigates damage to the right ventricle of the heart

Science Daily - Heart Disease

An injectable hydrogel can mitigate damage to the right ventricle of the heart with chronic pressure overload, according to a new study. In 2019, this same hydrogel was shown to be safe in humans through an FDA-approved Phase 1 trial in people who suffered a heart attack. As a result of the new preclinical study, the FDA approved an investigational new drug application to start a clinical trial with the hydrogel in pediatric patients in the coming months, once institutional approvals are receive

article thumbnail

The Prospect of Pz-cel in RDEB Treatment, with Peter Marinkovich, MD

HCPLive

Marinkovich discusses how the investigative cell-based graft therapy may serve a key role in the emerging DEB treatment paradigm.

98
article thumbnail

Fractional flow reserve and instantaneous wave-free ratio in coronary artery bypass grafting: a meta-analysis and practice review

Frontiers in Cardiovascular Medicine

Objective Fractional flow reserve (FFR) and instantaneous wave-free ratio (iFR) are invasive methods to assess the functional significance of intermediate severity coronary lesions. Both indexes have been extensively validated in clinical trials in guiding revascularisation in patients with stable ischaemic heart disease undergoing percutaneous coronary intervention (PCI) with improved clinical outcomes.

article thumbnail

Revealing a hidden threat: Researchers show viral infections pose early heart risks

Science Daily - Heart Disease

In a potentially game-changing development, scientists have revealed a new understanding of sometimes fatal viral infections that affect the heart. Traditionally, the focus has been on heart inflammation known as myocarditis, which is often triggered by the body's immune response to a viral infection. However, a new study sheds new light on this notion, revealing that the virus itself creates potentially dangerous conditions in the heart before inflammation sets in.

article thumbnail

Plastics, Fossil Carbon, and the Heart

The New England Journal of Medicine

Plastics have enabled extraordinary advances in virtually every area of medicine and have made our lives immeasurably more convenient. Multiple lines of evidence now indicate, however, that plastics are neither as safe nor as inexpensive as they seem. The benefits of plastics come at great and increasingly visible costs to.

76
article thumbnail

Ovariectomy-Induced Arterial Stiffening Differs From Vascular Aging and Is Reversed by GPER Activation

Hypertension Journal

Hypertension, Ahead of Print. BACKGROUND:Arterial stiffness is a cardiovascular risk factor and dramatically increases as women transition through menopause. The current study assessed whether a mouse model of menopause increases arterial stiffness in a similar manner to aging and whether activation of the G-protein–coupled estrogen receptor could reverse stiffness.METHODS:Female C57Bl/6J mice were ovariectomized at 10 weeks of age or aged to 52 weeks, and some mice were treated with G-protein–c

article thumbnail

Microplastics and Nanoplastics in Atheromas and Cardiovascular Events

The New England Journal of Medicine

Patients with evidence of microplastics and nanoplastics in carotid artery plaque, as compared with patients without, had a greater risk of adverse cardiovascular events at 34 months of follow-up.

Plaque 76
article thumbnail

Compression-Only or Standard Cardiopulmonary Resuscitation for Trained Laypersons in Out-of-Hospital Cardiac Arrest: A Nationwide Randomized Trial in Sweden

Circulation: Cardiovascular Quality & Outcomes

Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. BACKGROUND:The ongoing TANGO2 (Telephone Assisted CPR. AN evaluation of efficacy amonGst cOmpression only and standard CPR) trial is designed to evaluate whether compression-only cardiopulmonary resuscitation (CPR) by trained laypersons is noninferior to standard CPR in adult out-of-hospital cardiac arrest.

article thumbnail

Dyslipidemia in American Indian Adolescents and Young Adults: Strong Heart Family Study

Journal of the American Heart Association

Journal of the American Heart Association, Ahead of Print. BackgroundAlthough many studies on the association between dyslipidemia and cardiovascular disease (CVD) exist in older adults, data on the association among adolescents and young adults living with disproportionate burden of cardiometabolic disorders are scarce.Methods and ResultsThe SHFS (Strong Heart Family Study) is a multicenter, family‐based, prospective cohort study of CVD in an American Indian populations, including 12 communitie

Plaque 75
article thumbnail

Medical Debt Linked to Worse Health Status, Greater Mortality Rates in US

HCPLive

A study found a 1-percentage point increase in the population with medical debt was associated with 18.3 more physically unhealthy days and 17.9 more mentally unhealthy days per 1000 people for 30 days.

64
article thumbnail

Oklahoma hospital opens state's 1st pediatric heart transplant program

Becker's Hospital Review - Cardiology

Oklahoma City-based Oklahoma Children's Hospital is the first in the state to open a pediatric heart transplant program, ABC affiliate KOCO reported March 5.

article thumbnail

GATEWAY: Bariatric Surgery Effective to Control Hypertension, Polypharmacy in Patients With Obesity

American College of Cardiology

Bariatric surgery is effective in controlling hypertension (HTN) and polypharmacy in patients with obesity, according to results from the GATEWAY clinical trial published Feb. 5 in JACC.

Obesity 69
article thumbnail

Amy Paller, MD: What Pz-cel, B-VEC Each Bring to Recessive DEB

HCPLive

Gene and cell therapies are reaching patients with the severe forms of epidermolysis bullosa. An expert explains their differing benefits and strengths.

69
article thumbnail

Krüpple-like factors in cardiomyopathy: emerging player and therapeutic opportunities

Frontiers in Cardiovascular Medicine

Cardiomyopathy, a heterogeneous pathological condition characterized by changes in cardiac structure or function, represents a significant risk factor for the prevalence and mortality of cardiovascular disease (CVD). Research conducted over the years has led to the modification of definition and classification of cardiomyopathy. Herein, we reviewed seven of the most common types of cardiomyopathies, including Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC), diabetic cardiomyopathy, Dilate

article thumbnail

Benzoyl Peroxide Acne Products Shown to Contain High Levels of Benzene

HCPLive

This analysis concluded that the carcinogen known as benzene can be broadly found in concerning levels within benzoyl peroxide (BPO) acne treatment products.

64
article thumbnail

Hybrid stage 1 palliation for HLHS: the experience of a tertiary center in a developing country

Frontiers in Cardiovascular Medicine

Background Hypoplastic left heart syndrome (HLHS) accounts for 2.6% of congenital heart disease and is an invariably fatal cardiac anomaly if left untreated. Approximately 33,750 babies are born annually with HLHS in developing countries. Unfortunately, the majority will not survive due to the scarcity of resources and the limited availability of surgical management.

article thumbnail

Limited Alcohol Consumption May Be Safe in Early Stages of Steatotic Liver Disease

HCPLive

Although abstinence is the safest approach, patients with SLD at low risk for advanced fibrosis can safely consume < 7.4 g/day of alcohol, equivalent to half of a standard US drinking unit.

59
article thumbnail

The heart-mind relationship in women cardiovascular primary prevention: the role of depression, anxiety, distress and Type-D personality in the 10-years cardiovascular risk evaluation

Frontiers in Cardiovascular Medicine

Introduction Cardiovascular diseases are the leading cause of death among women. Prevention programmes underscore the need to address women-specific risk factors. Additionally, mental well-being is a significant aspect to consider when grappling with cardiovascular disease in women, particularly depression, anxiety, distress, and personality traits.

article thumbnail

Thyroidectomy, Radioactive Iodine Could Prevent More CV Events than Antithyroid Drugs

HCPLive

A study suggests that opting for thyroid surgery or radioactive iodine therapy could be better for reducing long-term cardiovascular risk in hyperthyroidism patients compared to medication alone.

59
article thumbnail

Lipoprotein(a) as a risk factor for atherosclerotic cardiovascular disease in patients in non-metropolitan area of Brandenburg, Germany

Frontiers in Cardiovascular Medicine

Background and aims In the non-metropolitan region of Brandenburg (Germany), which is characterized by high rates of cardiovascular diseases and underserved medical care, there is a lack of awareness regarding lipoprotein(a) [Lp(a)] as a risk factor. In addition, data from patients with atherosclerotic cardiovascular disease (ASCVD) in diverse regional backgrounds, including the understudied Brandenburg cohort, and various healthcare statuses remain insufficient.

article thumbnail

Endocrinology Month in Review: February 2024

HCPLive

In our endocrinology month in review for February 2024, we are spotlighting trending studies and new data in endocrinology, the latest news surrounding tirzepatide, and a recap of the 4 episodes of our flagship endocrinology podcast launched during the last month.

59
article thumbnail

TAVR or SAVR in Severe Aortic Stenosis and Small Aortic Annulus

American College of Cardiology

What are the hemodynamic and clinical outcomes after transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) among patients with severe aortic stenosis (AS) and a small aortic annulus?

TAVR 59
article thumbnail

One on One. with Hal Wolf, FHIMSS

DAIC

Industry trade shows and conferences seem to be making their comeback. The Healthcare Information and Management Systems Society (HIMSS) Global Conference and Exhibition was particularly poised to deliver the best of the best when it comes to digital transformation in both the delivery of healthcare and a quality experience for those in this demanding, rapidly evolving industry.

article thumbnail

Echocardiogram in Rheumatic Mitral and Aortic Regurgitation

All About Cardiovascular System and Disorders

Transcript of the video: This is an apical five chamber view and this is an apical four chamber view. You can see four chambers – RV, LV, RA, LA, and the transducer location is here. And this is five chamber because, in addition you are seeing the aorta also. Right atrium has not been labelled. In this view, you can see that mitral leaflets are thickened.