Sun.Mar 10, 2024

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Tapinarof Cream Significantly Improves Atopic Dermatitis Regardless of Skin Color

HCPLive

In a phase 3 trial that featured approximately half of participants with skin of color, tapinarof cream 1.0% provided consistent benefit for patients identified as White, Black, or Asian.

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Recent advances of myotubularin-related (MTMR) protein family in cardiovascular diseases

Frontiers in Cardiovascular Medicine

Belonging to a lipid phosphatase family containing 16 members, myotubularin-related proteins (MTMRs) are widely expressed in a variety of tissues and organs. MTMRs preferentially hydrolyzes phosphatidylinositol 3-monophosphate and phosphatidylinositol (3,5) bis-phosphate to generate phosphatidylinositol and phosphatidylinositol 5-monophosphate, respectively.

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Brian Kim, MD: Pushing Dermatology Forward and Alys Pharmaceuticals

HCPLive

Kim discusses the state of dermatology innovation and applied care, as well as his involvement in a new company in the space.

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Study on the related factors of TCM constitution and hemodynamics in patients with coronary heart disease

Frontiers in Cardiovascular Medicine

Background The concepts of “individualization” and “preventive treatment” should be incorporated into the precise diagnosis and treatment of coronary heart disease (CHD). Both hemodynamics and Chinese medicine constitution studies align with these two concepts. Methods This study utilized data from 81 patients with CHD, including 12 patients with balanced constitution (BC), 20 patients with blood stasis constitution (BSC), 17 patients with phlegm-dampness constitution (PDC), 15 patients with qi-

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Discussing New Phase 2 Findings on Lutikizumab for Hidradenitis Suppurativa with Alexa Kimball, MD, MPH

HCPLive

Kimball discusses her team’s new late-breaking data regarding the safety and effectiveness of lutikizumab in treating the symptoms of moderate-to-severe HS in adult non-responders to anti-TNF therapy.

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Habituation: “Give me a pain that I’m used to!”

Heart Sisters

How I realized that I’d not yet become habituated to new arthritis pain in the way I’d already become habituated to my longstanding cardiac pain.

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Brett King, MD, PhD: Baricitinib Impact on Regrowth of Scalp, Eyebrow, Eyelash Hair with Alopecia Areata

HCPLive

These phase 3 findings from AAD 2024 suggest patients treated with baricitinib may continue to see scalp, eyelash, and eyebrow hair regrowth with specific dosing regimens.

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Martina J. Porter, MD: New Findings on Efficacy, Safety of Ruxolitinib Cream Among Patients with HS

HCPLive

In this interview at AAD 2024, Porter discussed her team’s phase 2 findings on hidradenitis suppurativa the impact of ruxolitinib cream among those with Hurley Stage I and II.

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Estimation of aortic stiffness by finger photoplethysmography using enhanced pulse wave analysis and machine learning

Frontiers in Cardiovascular Medicine

Introduction Aortic stiffness plays a critical role in the evolution of cardiovascular diseases, but the assessment requires specialized equipment. Photoplethysmography (PPG) and single-lead electrocardiogram (ECG) are readily available in healthcare and wearable devices. We studied whether a brief PPG registration, alone or in combination with single-lead ECG, could be used to reliably estimate aortic stiffness.

Aortic 59
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Ruxolitinib Cream Improves Itch, Sleep, Skin Pain in Children with Atopic Dermatitis

HCPLive

A secondary analysis from TRuE-AD3 shows ruxolitinib cream significantly benefits pediatric atopic dermatitis patient-reported outcomes.

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Temporary pacing following cardiac surgery – a reference guide for surgical teams

Journal of Cardiothoracic Surgery

Temporary pacing wires are often used following cardiac surgery to optimise the heart rhythm. Although setting and checking temporary pacemakers is typically undertaken by anaesthetists, intensivists, and nurs.

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The relative and combined ability of stress hyperglycemia ratio and N-terminal pro-B-type natriuretic peptide to predict all-cause mortality in diabetic patients with multivessel coronary artery disease

Cardiovascular Diabetology

Stress hyperglycemia ratio (SHR) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are independently associated with increased mortality risk in diabetic patients with coronary artery disease (CAD). Ho.

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Myocardial infarction due to coronary embolism after mechanical aortic valve replacement: a case report

Journal of Cardiothoracic Surgery

Prosthetic valve thrombosis (PVT) in aortic valve and its complication coronary embolism is a very rare condition. Diagnosis and treatment process is challenging. We present a young patient with acute myocardi.

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Underlying mechanisms and cardioprotective effects of SGLT2i and GLP-1Ra: insights from cardiovascular magnetic resonance

Cardiovascular Diabetology

Originally designed as anti-hyperglycemic drugs, Glucagon-Like Peptide-1 receptor agonists (GLP-1Ra) and Sodium-glucose cotransporter-2 inhibitors (SGLT2i) have demonstrated protective cardiovascular effects,

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Oral Upadacitinib Significantly Reduces Facial, Total Nonsegmental Vitiligo Through 52 Weeks

HCPLive

Thierry Passeron, MD, PhD, discusses the potential benefit of upadacitinib as an oral systemic therapy in patients with nonsegmental vitiligo.

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Prognostic significance of T lymphocyte subgroups (CD4 and CD8) in lung cancer patients after neoadjuvant chemotherapy

Journal of Cardiothoracic Surgery

The basis for current and future lung cancer immunotherapy depends on our knowledge of molecular mechanisms of interactions between tumor and immune system cells. Interactions that occur between different intr.

Cancer 40
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New Long-Term Data on Bimekizumab for Psoriasis with Mark Lebwohl, MD

HCPLive

This AAD 2024 interview features a discussion with Lebwohl on his team’s new late-breaking data, covering long-term findings on bimekizumab.

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18F-FDG PET/CT and radiolabeled leukocyte SPECT/CT imaging for the evaluation of cardiovascular infection in the multimodality context

HeartRhythm

This document on cardiovascular infection, including infective endocarditis, is the first in the American Society of Nuclear Cardiology Imaging Indications (ASNC I2) series to assess the role of radionuclide imaging in the multimodality context for the evaluation of complex systemic diseases with multi-societal involvement including pertinent disciplines.

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Preservative, Surfactant Allergens Frequently Found in Infant Skincare Products

HCPLive

Data presented at AAD 2024 hopes to clarify allergen exposure risks during infancy that may increase risk of allergic contact dermatitis.

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Novel Near-Field Detection algorithm-guided slow pathway ablation in atrioventricular nodal reentrant tachycardia

HeartRhythm

Catheter ablation for atrioventricular nodal(AVN) reentrant tachycardia(AVNRT), involving slow pathway(SP) ablation, is extensively practiced. However, the complete anatomical understanding of the AVN remains elusive. Recently, the utility of high-resolution mapping-guided slow pathway ablation has been increasingly reported.1,2 This study aims to visualize the SP using the Near-Field Detection algorithm.

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Mark Lebwohl, MD: Implications of 4 Year Data on Bimekizumab for Psoriasis Treatment

HCPLive

In this interview segment, Lebwohl discusses the implications of his team’s late-breaking data on bimekizumab for clinical practice.

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Provision of care in clinical cardiac electrophysiology during and after the COVID-19 pandemic: an open challenge for health care systems

HeartRhythm

The outbreak of COVID-19 pandemic was first reported in China between December 2019 and January 2020 and then spread to Europe, with Italy among the first countries with recognized clusters. Within a few weeks, the COVID-19 pandemic had reached all the western countries with such a dramatic course that it was recognized by the World Healthcare Organization (WHO) as a public health emergency of international concern.

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Voltage and propagation mapping: New tools to improve successful ablation of atrioventricular nodal reentry tachycardia

Journal of Cardiovascular Electrophysiology

Graphical abstract summurized four step of AVNRT ablation. Abstract Introduction Mapping system is useful in ablation of atrioventricular nodal reentry tachycardia (AVNRT) and localization of anatomic variances. Voltage mapping identifies a low voltage area in the Koch triangle called low-voltage-bridge (LVB); propagation mapping identifies the collision point (CP) of atrial wavefront convergence.

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Correction to: 2023 Scientific Sessions Abstract 18918

Circulation

Circulation, Volume 149, Issue 11 , Page e958-e958, March 12, 2024.

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First?in?man report of transsubclavian venous implantation of the Aveir leadless cardiac pacing system

Journal of Cardiovascular Electrophysiology

Abstract Introduction Transsubclavian venous implantation of the Aveir leadless cardiac pacemaker (LCP) has not been previously reported. Methods and Results Three cases of transsubclavian implantation of the Aveir LCP are reported. Two cases were postbilateral orthotopic lung transplant, without appropriate femoral or jugular access due to recent ECMO cannulation and jugular central venous catheters.

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Correction to: 2023 Scientific Sessions Abstract 18987

Circulation

Circulation, Volume 149, Issue 11 , Page e959-e959, March 12, 2024.

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Sex differences in the relationship between serum total bilirubin and risk of incident metabolic syndrome in community-dwelling adults: Propensity score analysis using longitudinal cohort data over 16 years

Cardiovascular Diabetology

Research on identifiable risks for metabolic syndrome (MetS) is ongoing, and growing evidence suggests that bilirubin is a potent antioxidant and cytoprotective agent against MetS. Ho.

Research 111
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Dual (Ischemic and Nonischemic) Cardiomyopathy: A Wolf in Sheep’s Clothing

Circulation

Circulation, Volume 149, Issue 11 , Page 822-824, March 12, 2024.

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Dropping the floor on QRS duration boundaries for CRT patient selection in 2024- effects of sex, race, height and heart size

HeartRhythm

Cardiac resynchronization therapy (CRT) improves clinical outcomes in selected heart failure (HF) patients. Does it reach all possible candidates - or are some missed?

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Nature and Magnitude of the Benefits of Dapagliflozin and Empagliflozin for Heart Failure

Circulation

Circulation, Volume 149, Issue 11 , Page 839-842, March 12, 2024.

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Antiarrhythmic Drug Therapy: Where Do We Go From Here?

Circulation

Circulation, Volume 149, Issue 11 , Page 801-803, March 12, 2024.

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Correction to: Development and Validation of the American Heart Association’s PREVENT Equations

Circulation

Circulation, Volume 149, Issue 11 , Page e956-e956, March 12, 2024.

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Correction to: 2023 Scientific Sessions Abstract 18890

Circulation

Circulation, Volume 149, Issue 11 , Page e957-e957, March 12, 2024.

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Response by Zimmermann et al to Letter Regarding Article, “Fractional Flow Reserve–Guided PCI or Coronary Bypass Surgery for 3-Vessel Coronary Artery Disease: 3-Year Follow-Up of the FAME 3 Trial”

Circulation

Circulation, Volume 149, Issue 11 , Page 896-896, March 12, 2024.

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Letter by Heuts et al Regarding Article, “Fractional Flow Reserve-Guided PCI or Coronary Bypass Surgery for 3-Vessel Coronary Artery Disease: 3-Year Follow-Up of the FAME 3 Trial”

Circulation

Circulation, Volume 149, Issue 11 , Page 892-893, March 12, 2024.

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Are Recommendations That Favor Other Agents Over Angiotensin-Converting Enzyme Inhibitors in Africans With Hypertension Justified?

Circulation

Circulation, Volume 149, Issue 11 , Page 804-806, March 12, 2024.

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End-Stage Heart Failure in Cardiac Sarcoidosis

Circulation

Circulation, Volume 149, Issue 11 , Page 885-887, March 12, 2024.