Sun.Jan 28, 2024

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Impact of untreated CAD on TAVR outcomes

Cardiology Update

The optimal management of concomitant chronic obstructive coronary artery disease (CAD) in transcatheter aortic valve replacement (TAVR) recipients remains a debated topic. While some advocate for pre-TAVR percutaneous coronary intervention, others adopt an expectant approach. In a recent study published in the European Heart Journal, researchers investigated the influence of varying degrees and extent of untreated chronic obstructive CAD on TAVR outcomes and longer-term results.

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Cold weather = worse angina symptoms!

Heart Sisters

If you live with heart disease, it’s important to know the surprising effects of COLD TEMPERATURES on your heart health.

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The effect of an initial catheter ablation with an adjunctive ethanol infusion into the vein of Marshall on persistent atrial fibrillation

Journal of Cardiovascular Electrophysiology

Abstract Introduction Some previous studies have reported that a first-step ethanol infusion into the vein of Marshall (EIVOM) with touch-up radiofrequency (RF) ablation can facilitate mitral isthmus (MI) block and improves the ablation outcomes in persistent atrial fibrillation (PeAF) patients. However, the effect of an initial RF ablation with an adjunctive EIVOM has not been fully investigated.

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Vascepa’s ACS Advantage

CardiacWire

Amarin’s fish oil-based Vascepa (icosapent ethyl, aka IPE) made its mark in 2018’s REDUCE-IT trial after achieving a 25% MACE reduction among high-risk statin users, and new post hoc analysis of the same data suggests that IPE might have an even greater benefit among patients who recently had acute coronary syndrome (ACS). Researchers analyzed 840 REDUCE-IT participants (10.3% of total trial) who experienced ACS within 12 months of trial randomization, finding that most patients who received IPE

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The effects of flip angle and gadolinium contrast agent on single breath-hold compressed sensing cardiac magnetic resonance cine for biventricular global strain assessment

Frontiers in Cardiovascular Medicine

Background Due to its potential to significantly reduce scanning time while delivering accurate results for cardiac volume function, compressed sensing (CS) has gained traction in cardiovascular magnetic resonance (CMR) cine. However, further investigation is necessary to explore its feasibility and impact on myocardial strain results. Materials and methods A total of 102 participants [75 men, 46.5 ± 17.1 (SD) years] were included in this study.

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STS Congenital Heart Surgery Database Shapes Comprehensive Study of Post-Arterial Switch Operations

Society of Thoracic Surgeons - Adult Cardiac

A recent multicenter study on post-arterial switch operations (ASO) revealed improved survival rates for adolescent and adult patients. However, it also highlighted an increased likelihood of these patients requiring cardiac reoperations to address arterial switch-related complications later in life.

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Effect of sacubitril/valsartan on sinus rhythm maintenance after catheter ablation in patients with persistent atrial fibrillation without reduced ejection fraction heart failure: a study protocol for a multi-center, open-label, randomized, controlled, superiority clinical trial

Frontiers in Cardiovascular Medicine

Introduction A high recurrence rate of atrial fibrillation was monitored after catheter ablation for persistent atrial fibrillation. Sacubitril/valsartan can improve outcomes for patients with heart failure and ventricular tachycardia, but few studies examined whether it can reduce recurrence or improve cardiovascular outcomes in patients with persistent atrial fibrillation after catheter ablation.

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Transcriptomic analysis reveals the lipid metabolism-related gene regulatory characteristics and potential therapeutic agents for myocardial ischemia-reperfusion injury

Frontiers in Cardiovascular Medicine

Background Impaired energy balance caused by lipid metabolism dysregulation is an essential mechanism of myocardial ischemia-reperfusion injury (MI/RI). This study aims to explore the lipid metabolism-related gene (LMRG) expression patterns in MI/RI and to find potential therapeutic agents. Methods Differential expression analysis was performed to screen the differentially expressed genes (DEGs) and LMRGs in the MI/RI-related dataset GSE61592.

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Surgical LAA Closure Rises to the Top in STS Guideline for Afib

Med Page Today

(MedPage Today) -- SAN ANTONIO -- The Society of Thoracic Surgeons (STS) made a big push for left atrial appendage (LAA) occlusion in updated guidelines for the surgical treatment of atrial fibrillation (Afib). In this document, concomitant.

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Identification of 4 autophagy-related genes in heart failure by bioinformatics analysis and machine learning

Frontiers in Cardiovascular Medicine

Introduction Autophagy refers to the process of breaking down and recycling damaged or unnecessary components within a cell to maintain cellular homeostasis. Heart failure (HF) is a severe medical condition that poses a serious threat to the patient's life. Autophagy is known to play a pivotal role in the pathogenesis of HF. However, our understanding of the specific mechanisms involved remains incomplete.

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FDA Adverse Events Reporting System Shows Rise in Alopecia Cases, Use of Monoclonal Antibodies

HCPLive

These data represent a significant step toward finding a causal connection for drug-induced alopecia, though further controlled studies may be necessary to isolate certain variables.

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Heart failure with preserved ejection fraction and atrial fibrillation: clinical management in the context of recent therapeutic advances in heart failure and electrophysiology

Frontiers in Cardiovascular Medicine

Heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF) have emerged as major age-related epidemics within cardiology. Both conditions carry overlapping symptomatology, and delineating between AF and HFpEF from a diagnostic standpoint is challenging as echocardiographic and biomarker assessments used to diagnose HFpEF may be impacted by AF.

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Selective Retina Therapy Aids Real-World Outcomes in Central Serous Chorioretinopathy

HCPLive

Over 24 months in a real-world study, selective retina therapy with real-time feedback-controlled technology achieved anatomical improvements in eyes with CSC.

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The Future of Pediatric and Adult Heart Transplantation: Perspective From the United States

Circulation

Circulation, Volume 149, Issue 5 , Page 339-341, January 30, 2024.

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Angus Worthing, MD: 2024 Trends and Predictions in Rheumatology

HCPLive

Angus Worthing, MD, discusses the recent developments in rheumatology and his predictions for the future of treatment moving into 2024 and beyond.

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Predictors of Non-Pulmonary Vein Triggers for Atrial Fibrillation: A Clinical Risk Score

HeartRhythm

Targeting non-pulmonary vein triggers (NPVTs) after pulmonary vein isolation may reduce atrial fibrillation (AF) recurrence. Isoproterenol infusion and cardioversion of spontaneous or induced AF can provoke NPVTs but typically require vasopressor support and increased procedure time.

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STS Annual Meeting Late-Breaking Research: 2023 STS/AATS Joint Expert Consensus Document on the Management of the Small Aortic Root

Society of Thoracic Surgeons - Research

Press Release STS Annual Meeting Late-Breaking Research: 2023 STS/AATS Joint Expert Consensus Document on the Management of the Small Aortic Root January 29, 2024 KCummings Sun, 01/28/2024 - 14:06 SAN ANTONIO (January 28, 2024) — The Society of Thoracic Surgeons and the American Association for Thoracic Surgery released a late-breaking study on a new risk model for isolated tricuspid valve surgery at the 2024 Annual Meeting taking place January 27 - 29 in San Antonio.

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Disputation on the Power and Efficacy of Phenotypical Classification in Arrhythmogenic Cardiomyopathy: Time for a Reformation?!

HeartRhythm

Representing the spark that lit the Protestant Reformation, on the 31st of October Anno Domini 1517 Reverend Martin Luther sent the manuscript entitled “Disputation on the Power and Efficacy of Indulgences” to the Archbishop of Mainz for academic disputation or, as it would be called today, external peer review. This document challenged well-established religious beliefs of the time, leading to massive changes across a society ripe for transformation yet deeply entrenched into outdated believes.

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CLOSE protocol versus lower ablation index value for paroxysmal atrial fibrillation: A randomized noninferior clinical trial

Journal of Cardiovascular Electrophysiology

Abstract Introduction The optimized ablation index (AI) value for catheter ablation of atrial fibrillation (AF) remains to be defined. We aimed to compare the efficacy and safety of CLOSE protocol and lower AI protocol in paroxysmal AF. Methods and Results Patients with symptomatic, drug-resistant paroxysmal AF for first ablation were prospectively enrolled from September 2020 to January 2022.

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Minimally Invasive Epicardial Surgical Left Atrial Appendage Exclusion for Atrial Fibrillation Patients at High Risk of Stroke and of Bleeding

HeartRhythm

Atrial fibrillation (AF) patients at high risk for stroke and also at high risk for bleeding may be unsuitable for either oral anticoagulation or endocardial left atrial appendage (LAA) occlusion. However, minimally invasive, epicardial LAA exclusion (LAAE) may be an option.

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Slow conduction velocity predicts atrial fibrillation recurrence after radiofrequency ablation

Journal of Cardiovascular Electrophysiology

Abstract Objective To evaluate the progression of electrophysiological phenomena in atrial fibrillation (AF) and elucidate the association between the left atrial conduction velocity (LACV) and AF recurrence after pulmonary vein isolation. Methods A total of 188 AF patients (121 paroxysmal AF and 67 persistent AF) who underwent PVI for the first time were enrolled in this prospective study.

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LDL-C–Lowering Therapies for Adults and Children With Homozygous Familial Hypercholesterolemia: Challenges and Successes

Circulation

Circulation, Volume 149, Issue 5 , Page 363-366, January 30, 2024.

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Predictors of first pass isolation of the pulmonary veins in real world ablations: An analysis of 2671 patients from the REAL?AF registry

Journal of Cardiovascular Electrophysiology

Abstract Introduction During atrial fibrillation ablation (AFA), achievement of first pass isolation (FPI) reflects effective lesion formation and predicts long-term freedom from arrhythmia recurrence. We aim to determine the clinical and procedural predictors of pulmonary vein FPI. Methods We reviewed AFA procedures in a multicenter prospective registry of AFA (REAL-AF).

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Palpitations and Recurrent Syncope in a Young Woman

Circulation

Circulation, Volume 149, Issue 5 , Page 402-405, January 30, 2024.