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Case Report: Comprehensive evaluation of ECG phenotypes and genotypes in a family with Brugada syndrome carrying SCN5A-R376H

Frontiers in Cardiovascular Medicine

Background Brugada syndrome (BrS) is a channelopathy that can lead to sudden cardiac death in the absence of structural heart disease. Patients with BrS can be asymptomatic or present with symptoms secondary to polymorphic ventricular tachycardia or ventricular fibrillation. The patient did not have underlying diseases.

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Clinical presentations leading to arrhythmogenic left ventricular cardiomyopathy

Open Heart

Twenty-one (41%) had normal echocardiogram, 13 (25%) a hypokinetic non-dilated cardiomyopathy (HNDC) and 17 (33%) a dilated cardiomyopathy (DCM). Significant right ventricular involvement was an exclusion criterion. Results Fifty-two patients (63% males, age 45 years (31–53)) composed the study cohort.

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Association between implanted cardioverter-defibrillators and mortality for patients with left ventricular ejection fraction between 30% and 35%

Open Heart

Background Consensus guidelines support the use of implanted cardioverter-defibrillators (ICD) for primary prevention of sudden cardiac death in patients with either non-ischaemic or ischaemic cardiomyopathy with left ventricular ejection fraction (LVEF) ≤35%. A secondary analysis was performed for LVEF 36%–40%.

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Abstract 4139584: Serendipitously Discovered Wild-Type Transthyretin Cardiac Amyloidosis in the Setting of Familial Hypertrophic Obstructive Cardiomyopathy

Circulation

An external monitor revealed one episode of non-sustained supraventricular tachycardia, otherwise was unremarkable. Pre-stress echocardiogram revealed a sigmoid septum with septal wall thickness of 1.6 Post-stress echocardiogram revealed severe SAM with septal contact, LVOT gradient of 70 mmHg, as well as hypotension.

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Hyperthermia and ST Elevation

Dr. Smith's ECG Blog

Otherwise vitals after intubation were only notable for tachycardia. An initial EKG was obtained: Computer read: sinus tachycardia, early acute anterior infarct. A formal echocardiogram was completed the next day and again showed a normal ejection fraction without any focal wall motion abnormalities to suggest CAD.