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Obesity in heart failure with preserved ejection fraction: Insights from the REDUCE LAP?HF II trial

European Journal of Heart Failure

Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF). Obesity was associated with more first and recurrent heart failure events.

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Basic Science of Cardiac Contractility Modulation Therapy: Molecular and Electrophysiological Mechanisms

HeartRhythm

In heart failure with reduced ejection fraction and heart failure with preserved ejection fraction, profound cellular and molecular changes have recently been documented in the failing myocardium.These changes include altered calcium handling and metabolic efficiency of the cardiac myocyte, reactivation of the fetal gene program, changes in the electrophysiological (..)

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Neuromuscular manifestations of wild type transthyretin amyloidosis: a review and single center’s experience

Frontiers in Cardiovascular Medicine

ATTRwt was previously known as “senile amyloidosis” and causes cardiomyopathy which may lead to heart failure with a preserved ejection fraction, affecting predominantly elderly men. The exact prevalence of ATTRwt in the general population remains unclear, but its occurrence may be underestimated in women.

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Prevalence and prognostic significance of pulmonary hypertension in adults with left ventricular diastolic dysfunction

Open Heart

Aims Pulmonary hypertension (PHT) appears to be very common in heart failure with preserved ejection fraction but details on its prevalence, severity and prognostic implications have not been well defined.