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Desire for Subspecialization For physicians who already have a general specialty, such as cardiology or internal medicine, a fellowship offers a route to subspecialization. For example, transitioning from generalcardiology to interventional cardiology or electrophysiology.
Though this effect has also been documented with statin therapy, monotherapy using PCSK9 inhibitors or ezetimibe have not been associated with similar reduction in biomarkers of inflammation. Bempedoic Acid and Cardiovascular Outcomes in Statin-Intolerant Patients. at 6 months compared to placebo. N Engl J Med. Epub 2023 Mar 4.
Rationale and design of the DIGIT-HF trial (DIGitoxin to Improve ouTcomes in patients with advanced chronic Heart Failure): a randomized, double-blind, placebo-controlled study. 2021 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. Eur Heart J. 2021 Sep 21;42(36):3599-3726. doi: 10.1093/eurheartj/ehab368.
The study documented that catheter ablation for AF in patients with heart failure was associated with a significantly lower rate of a composite endpoint of death from any cause or hospitalization for worsening heart failure, than medical therapy. The study was stopped for efficacy at the third interim analysis after a median of 5.1
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