Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

How these conditions are linked mechanistically remains unclear, especially two of these: obesity and elevated blood pressure. Pharmacological prevention of lipid droplet formation reverses the suppression of NO production in cell culture and in vivo and blunts blood pressure elevation in response to a high-fat diet.

Blood Pressure 105

Blood Pressure Obesity Pharmacology Diet 105

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Conflicting studies in recent years report that genetic or pharmacological increases or decreases in ghrelin either increase or have no effect on islet size. Both germline and conditional ghrelin-knockout mice associated with increased islet size, which was further exacerbated by older age and diet-induced obesity.

Pharmacology 45

Pharmacology Diet Obesity Diabetes 45

ADN Center of Excellence

SEPTEMBER 2, 2024

Factors such as aging populations, rising rates of obesity, hypertension, and other cardiovascular conditions contribute to this increase. From advances in pharmacological treatments to innovative procedures like catheter ablation, the landscape of AFib treatment is continually evolving.

AFIB 59

AFIB Atrial Fibrillation Innovation Heart Rhythm 59

ADN Center of Excellence

SEPTEMBER 2, 2024

Factors such as aging populations, rising rates of obesity, hypertension, and other cardiovascular conditions contribute to this increase. From advances in pharmacological treatments to innovative procedures like catheter ablation, the landscape of AFib treatment is continually evolving.

AFIB 52

AFIB Atrial Fibrillation Innovation Heart Rhythm 52

Cardiometabolic Health Congress

JULY 25, 2023

Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.

Obesity 52

Obesity BMI Heart Failure Cardiovascular Disease 52

Cardiometabolic Health Congress

MAY 10, 2024

Results revealed that women are twice as likely to exhibit myocardial ischemia in response to mental stress compared to traditional stressors like exercise or pharmacologic stress. Inflammation plays a pivotal role in both depression and obesity, while stress elevates cortisol levels, often initiating this cycle.

Coronary Artery Disease 59

Coronary Artery Disease Obesity Chest Pain Ischemia 59

Journal of Clinical Investigation - Cardiology

MARCH 17, 2025

This was functionally important, as inhibition of LIPA genetically or pharmacologically resulted in lower plasma FFAs under lipolytic conditions. Furthermore, adipocyte LIPA deficiency impaired thermogenesis and oxygen consumption and rendered mice susceptible to diet-induced obesity.

Pharmacology 95

Pharmacology Diet Obesity 95