Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

We demonstrate that reducing ghrelin — by ghrelin gene knockout (GKO), conditional ghrelin cell ablation, or high-fat diet (HFD) feeding — was associated with increased mean islet size (up to 62%), percentage of large islets (up to 854%), and β cell cross-sectional area (up to 51%).

Ablation 139

Ablation Diet Obesity Diabetes 139

Physiologically Speaking

DECEMBER 27, 2023

The quest to determine whether plant-based diets surpass omnivorous diets in their heart healthfulness has been ongoing for decades, yielding inconclusive results despite dedicated research endeavors. Both observational and clinical studies have suggested potential advantages associated with plant-based diets.

Diet 69

Diet Cardiovascular Disease Research Diabetes 69

Frontiers in Cardiovascular Medicine

JANUARY 21, 2024

The aim of this study was to investigate the effects of Totum-070 on cholesterol levels in an animal model of diet-induced hypercholesterolemia. Methods C57BL/6JOlaHsd male mice were fed a Western diet and received Totum-070, or not, by daily gavage (1g/kg and 3g/kg body weight) for 6 weeks.

Diet 59

Diet Cholesterol Obesity Risk Factors 59

Medical Xpress - Cardiology

MARCH 22, 2024

Diet-induced metabolic abnormalities including obesity, hyperglycemia, dyslipidemia, insulin resistance (IR), and non-alcoholic fatty liver disease are considered atherogenic risk factors. Atherosclerosis is the major contributor to cardiovascular mortality worldwide.

Atherosclerosis 86

Atherosclerosis Diet Obesity Risk Factors 86

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

How these conditions are linked mechanistically remains unclear, especially two of these: obesity and elevated blood pressure. Pharmacological prevention of lipid droplet formation reverses the suppression of NO production in cell culture and in vivo and blunts blood pressure elevation in response to a high-fat diet.

Blood Pressure 105

Blood Pressure Obesity Pharmacology Diet 105

DAIC

JUNE 18, 2024

A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8

Heart Disease 105

Heart Disease Blood Pressure Strokes Stroke 105

Dr. Paddy Barrett

JULY 19, 2024

But What Diet Should You Eat? Multiple trials have shown that when you control for calories, the type of diet you eat doesn’t really matter when it comes to weight loss 1. Secondly, it's not that any of these diets don’t work. Obesity medications are tools. I repeat MUST be in a calorie deficit. Mediterrean?

Exercise 111

Exercise Diet Obesity Risk Factors 111

MIBHS

FEBRUARY 15, 2025

Here are actionable steps to protect your heart and keep your blood pressure under control: Adopt a Heart-Healthy Diet : Follow the DASH (Dietary Approaches to Stop Hypertension) diet, which emphasizes fruits, vegetables, whole grains, lean proteins, and low-fat dairy products.

Blood Pressure 52

Blood Pressure Hypertension Chest Pain ACE Inhibitor 52

Physiologically Speaking

DECEMBER 27, 2023

The quest to determine whether plant-based diets surpass omnivorous diets in their heart healthfulness has been ongoing for decades, yielding inconclusive results despite dedicated research endeavors. Both observational and clinical studies have suggested potential advantages associated with plant-based diets.

Diet 52

Diet Cardiovascular Disease Research Diabetes 52

Physiologically Speaking

FEBRUARY 7, 2024

The consumption of ultraprocessed foods is increasing worldwide, and damning evidence implicates these “foods” in the diseases of civilization — type 2 diabetes, obesity, and cardiovascular disease. There’s no denying it — diet quality worldwide has declined dramatically in the last few decades.

Diet 98

Diet Public Health Obesity Diabetes 98

AMS Cardiology

MARCH 31, 2025

Obesity : Excess weight increases the risk of heart-related issues, including AFib. Healthy Diet : Consuming a balanced diet rich in fruits, vegetables, and lean proteins supports heart health. Coronary Artery Disease : Blocked arteries can affect heart function and rhythm.

Atrial Fibrillation 52

Atrial Fibrillation AFIB Heart Rhythm Blood Pressure 52

Journal of the American Heart Association

DECEMBER 29, 2023

BackgroundWe have previously reported that male mice exposed to maternal separation and early weaning (MSEW), a model of early life stress, show sympathetic activation and increased blood pressure in response to a chronic high‐fat diet. At weaning, both control and MSEW offspring were placed on a low‐fat diet or a high‐fat diet for 20 weeks.

Obesity 40

Obesity Blood Pressure Diet Circulation 40

Medical Xpress - Cardiology

MARCH 18, 2025

People with cardiometabolic disorderssuch as obesity, diabetes and heart diseasecould increase their chances of living longer by adopting a healthy plant-based diet, according to a study being presented at the American College of Cardiology's Annual Scientific Session (ACC.25).

Diet 54

Diet Obesity Diabetes 54

Physiologically Speaking

AUGUST 9, 2024

The debate over whether carbohydrates or sugar are the true culprits behind modern health issues has long stirred controversy among nutrition experts, diet enthusiasts, and the general public alike. This has led to widespread recommendations to drastically reduce "free sugars" in the diet.

Physiology 69

Physiology Diet Cholesterol Biomarkers 69

Circulation

NOVEMBER 11, 2024

In this study, we investigated whether a novel, non-steroidal selective MR blocker, esaxerenone, ameliorates the development of metabolic disorders in obese mice models and examined the underlying mechanism.Methods:Esaxerenone (3 mg/kg/day) was orally administered to high-fat diet (HFD)-fed C57BL/6J or normal chow-fed db/db mice.

Obesity 40

Obesity Blood Pressure Diet Diabetes 40

Cardiometabolic Health Congress

JANUARY 28, 2025

Obesity management beyond diet and exercise. Sleep and Cardiometabolic Health The Impact on Obesity Studies indicate that 19.3% of adults experience insufficient sleep (6 hours), which is linked to higher obesity rates. Practical Takeaway Encourage fiber-rich diets to promote microbiome diversity.

Obesity 52

Obesity Diet Exercise Education 52

Circulation

JUNE 4, 2024

to 26.8%) and obesity (43.1% The prevalences of poor diet, inadequate physical activity, and smoking are estimated to improve over time, whereas inadequate sleep will worsen. in 2020 to 61.0% Diabetes (16.3% to 60.6%) will increase, whereas hypercholesterolemia will decline (45.8%

Risk Factors 81

Risk Factors Cardiovascular Disease Strokes Stroke 81

Dr. Paddy Barrett

JANUARY 24, 2025

I am a fan of using low-carb diets for both weight loss and improving metabolic health. Low-carb diets have consistently shown benefits in improving these parameters 1. In the early 1970’s a group of 106 severely obese patients were put on a diet that resulted in an average weight loss of 63 Kg (139 lbs) over about one year 2.

Diet 52

Diet Obesity Diabetes Cholesterol 52

Journal of Clinical Investigation - Cardiology

OCTOBER 1, 2024

Gpr75–/– mice displayed reduced food intake under high-fat diet (HFD) feeding, and pair-feeding normalized their body weight. Using random germline mutagenesis in mice, we identified a missense allele (Thinner) of Gpr75 that resulted in a lean phenotype and verified the decreased body weight and fat weight in Gpr75-knockout (Gpr75–/–) mice.

BMI 53

BMI Diet Obesity 53

Frontiers in Cardiovascular Medicine

AUGUST 2, 2024

Here, we combined the single-cell RNA sequencing technique with cell metabolic and functional assays on major WAT ATM subpopulations using a diet-induced atherosclerosis mouse model (Apoe-null). We also identified lipid-associated macrophages (LAM), which were previously described in obesity. Interestingly, LAM increased 8.4-fold

Diet 52

Diet Atherosclerosis Obesity 52

Physiologically Speaking

JANUARY 31, 2025

” Panel members noted that athletes can obtain omega-3 fatty acids through diet or supplements. In the last decade, we’ve all read 100s of articles about processed foods, and how they are contributing to obesity and illness rates. Hall performs strictly-controlled obesity research at the National Institutes of Health.

Physiology 85

Physiology Exercise Article Research 85

Cardiometabolic Health Congress

JUNE 27, 2024

Competence in selecting treatments for long-term obesity management rose from 43% pre-test to 95% post-test. Neha Agarwal, PhD, Clinical Director at Cardiometabolic Health Congress , Informa Connect, recently presented significant findings at the 84th American Diabetes Association (ADA) Scientific Sessions.

CME 59

CME Diabetes Obesity Education 59

Journal of the American Heart Association

FEBRUARY 19, 2025

The aim of this study was to examine the effect of daily avocado intake for 26 weeks on LE8 in adults with abdominal obesity.Methods and ResultsAn ancillary analysis including participants (n=969; aged 5114 years) from the HAT (Habitual Diet and Avocado Trial), a randomized controlled trial, was conducted.

Diet 40

Diet Blood Pressure Obesity 40

Frontiers in Cardiovascular Medicine

DECEMBER 17, 2023

These conditions have an increasing share in the health burden worldwide due to worsening endemic of hypertension, obesity, and diabetes. In contrast, inactivation of Trp53inp2 ameliorated cardiac dysfunction induced by combined stresses of high fat diet and moderate pressure overload (Cardiometabolic Disorder Model).

Heart Failure 64

Heart Failure Diet Obesity Diabetes 64

Journal of Clinical Investigation - Cardiology

DECEMBER 15, 2023

Both germline and conditional ghrelin-knockout mice associated with increased islet size, which was further exacerbated by older age and diet-induced obesity. These findings suggest that modulation of ghrelin may open a therapeutic window to prevent or treat diabetes.

Pharmacology 45

Pharmacology Diet Obesity Diabetes 45

Dr. Paddy Barrett

AUGUST 16, 2024

Overweight/Obesity. Falling into the class of obesity with a BMI of greater than 30 makes this more likely, but so also does having excess visceral fat deposition with significant metabolic consequences at a BMI less than 30. They are not crash diets to fit into your swimwear. All diets work. For a while.

Obesity 52

Obesity Blood Pressure Diet Exercise 52

Journal of the American Heart Association

DECEMBER 20, 2024

We assessed CVH metrics by individual scores for 4 health behaviors (diet, physical activity, nicotine exposure, and body mass index) and 3 health factors (blood lipids, glucose, and pressure). These scores were subsequently combined to calculate the CVH score, health behavior score, and health factor score.

Diet 45

Diet Obesity Outcomes 45

Circulation: Cardiovascular Quality & Outcomes

APRIL 14, 2025

Poor sleep health is associated with cardiometabolic disease and related risk factors, including heart disease, stroke, elevated blood pressure and lipid levels, inflammation, glucose intolerance, obesity, physical inactivity, poor diet, unhealthy substance use, poor mental health, and increased all-cause and cardiovascular mortality, and is associated (..)

Health Disparities 40

Health Disparities Blood Pressure Diet Obesity 40

Circulation

NOVEMBER 11, 2024

Empagliflozin (EMPA), the clinical benchmark, was used to confirm the relevance of the model.Methods:To induce obesity/metabolic syndrome, mild and HFpEF, C57BL6N mice were fed HFD (60% Kcal from fat) and water with L-NAME (0.5g/l) We evaluated the presence of HFpEF hallmark and corroborated our data with literature. l) for 8 weeks.

Preserved Ejection Fraction 40

Preserved Ejection Fraction Hypertension Blood Pressure Obesity 40

Cardiometabolic Health Congress

JUNE 7, 2024

They highlighted that the non-HDL/HDL ratio is a better predictor of ASCVD and that triglycerides (TG) are a sensitive indicator of diet and exercise, emphasizing the importance of lifestyle factors in lipid management and cardiovascular risk reduction. The interplay of Obesity, Dyslipidemia, and CVD : Dr. Harold E.

Cardiovascular Disease 59

Cardiovascular Disease Obesity Heart Disease Risk Factors 59

ADN Center of Excellence

SEPTEMBER 2, 2024

Factors such as aging populations, rising rates of obesity, hypertension, and other cardiovascular conditions contribute to this increase. Risk Factor Management: Controlling risk factors such as hypertension, diabetes, obesity, and sleep apnea is essential in managing AFib.

AFIB 59

AFIB Atrial Fibrillation Innovation Heart Rhythm 59

Physiologically Speaking

OCTOBER 9, 2024

Both lactate and BHB naturally increase in response to physiological stresses—lactate during intense exercise and BHB during prolonged fasting or low-carbohydrate diets. At the same time, BHB levels rise more gradually, paralleling the ketogenic state induced by fasting or ketogenic diets.

Exercise 75

Exercise Physiology Diet Obesity 75

GEMMS

NOVEMBER 22, 2023

Regular exercise, a balanced diet, and lifestyle choices such as not smoking and managing stress are all crucial for achieving and maintaining optimal cardiovascular health. The role of diet in cardiovascular health Diet plays a significant role in maintaining cardiovascular health.

Blood Pressure 52

Blood Pressure Cholesterol Diet Exercise 52

Circulation

JANUARY 23, 2024

High-cholesterol diet–fed ApoE–/–mice with AVCAPIR knockout were used to examine the role of AVCAPIR in aortic valve calcification (AVC). Gain- and loss-of-function assays were conducted to determine the role of AVCAPIR in the induced osteogenic differentiation of human valvular interstitial cells.

Aortic valve 45

Aortic valve Aortic Diet Cholesterol 45

Frontiers in Cardiovascular Medicine

JANUARY 4, 2024

A higher Zn/Cu ratio may protect against CVD, while elevated Cu levels are linked to obesity, fibrinogen levels, and HbA1C. Maintaining optimal levels of these trace elements, either through diet or supplementation, may help reduce CVD risk. The study reveals a link between Zn, Cu, and the Zn/Cu ratio and cardiovascular disease risk.

Cardiovascular Disease 59

Cardiovascular Disease Blood Pressure Diet Obesity 59

ADN Center of Excellence

SEPTEMBER 2, 2024

Factors such as aging populations, rising rates of obesity, hypertension, and other cardiovascular conditions contribute to this increase. Risk Factor Management: Controlling risk factors such as hypertension, diabetes, obesity, and sleep apnea is essential in managing AFib.

AFIB 52

AFIB Atrial Fibrillation Innovation Heart Rhythm 52

Physiologically Speaking

NOVEMBER 29, 2023

Exogenous ketones: a brief overview and physiological effects Ketones are produced by our liver during periods of fasting, low-carbohydrate dieting, and prolonged exercise. In non-exercise contexts, ketone ester supplementation has shown promise in improving cerebral blood flow and various cognitive aspects in adults with obesity.

Exercise 52

Exercise Diet Physiology Obesity 52