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Can the Recent Stanford Vegan vs. Omnivore Twin Study Inform Us about the “Optimal” Diet for Cardiometabolic Health?

Physiologically Speaking

The quest to determine whether plant-based diets surpass omnivorous diets in their heart healthfulness has been ongoing for decades, yielding inconclusive results despite dedicated research endeavors. Both observational and clinical studies have suggested potential advantages associated with plant-based diets.

Diet 69
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Heart Disease and Stroke Could Affect at Least 60% of Adults in U.S. by 2050, According to American Heart Association Advisories

DAIC

A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8

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Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050—Prevalence of Risk Factors and Disease: A Presidential Advisory From the American Heart Association

Circulation

We projected through 2050, overall and by age and race and ethnicity, accounting for changes in disease prevalence and demographics.RESULTS:We estimate that among adults, prevalence of hypertension will increase from 51.2% to 26.8%) and obesity (43.1% in 2020 to 61.0% Diabetes (16.3% Prevalences of coronary disease (7.8%

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Can the Recent Stanford Vegan vs. Omnivore Twin Study Inform Us about the “Optimal” Diet for Cardiometabolic Health?

Physiologically Speaking

The quest to determine whether plant-based diets surpass omnivorous diets in their heart healthfulness has been ongoing for decades, yielding inconclusive results despite dedicated research endeavors. Both observational and clinical studies have suggested potential advantages associated with plant-based diets.

Diet 52
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Obese Male Mice Exposed to Early Life Stress Display Sympathetic Activation and Hypertension Independent of Circulating Angiotensin II

Journal of the American Heart Association

BackgroundWe have previously reported that male mice exposed to maternal separation and early weaning (MSEW), a model of early life stress, show sympathetic activation and increased blood pressure in response to a chronic high‐fat diet. At weaning, both control and MSEW offspring were placed on a low‐fat diet or a high‐fat diet for 20 weeks.

Obesity 40
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Expert Perspective: The Obesity Paradox with Salvatore Carbone, PhD

Cardiometabolic Health Congress

Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.

Obesity 52
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Abstract 4139791: A short version of HFD/L-NAME mouse model enabling time-effective proof of concept studies to evaluate drugs targeting the cardiometabolic and mild hypertension associated HFpEF phenotype.

Circulation

Empagliflozin (EMPA), the clinical benchmark, was used to confirm the relevance of the model.Methods:To induce obesity/metabolic syndrome, mild and HFpEF, C57BL6N mice were fed HFD (60% Kcal from fat) and water with L-NAME (0.5g/l) We evaluated the presence of HFpEF hallmark and corroborated our data with literature. l) for 8 weeks.