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Background and Purpose:Whether imaging markers of cerebral small vessel disease on computed tomography (CT-CSVD) relates to early clinical outcomes after intravenous thrombolysis for acute ischemic stroke remains not well understood. Stroke, Volume 56, Issue Suppl_1 , Page AWP6-AWP6, February 1, 2025. 1.02; score 2: OR 0.46, 95%CI 0.26-0.83;
While DM can reduce the effect of intravenous thrombolysis, metformin can have a positive outcome on AIS patients. The outcomes of stroke in diabetic patients receiving metformin is largely unexplored.
Introduction:Tenecteplase (TNK) is now an accepted alternative to Alteplase (ALT) for intravenous thrombolysis (IVT) in acute ischemic stroke (AIS). Hemorrhagic transformation (HT), a complication of IVT, is more frequent in acute hyperglycemia and diabetes (DM) and is associated with poor clinical outcomes.
Culprit lesion vessel size was associated with body surface area, diabetes, total ischemic time, postinterventional thrombolysis in myocardial infarction flow, and infarct size. Median culprit lesion vessel size was 3.1 (2.7–3.6) MVO and IMH were found in 299 (58%) and 182 (35%) patients.
For inclusion, patients must have been successfully recanalized by mechanical thrombectomy with or without intravenous thrombolytic and ultimate modified thrombolysis in cerebral infarction (mTICI) score 2B/2C/3. The multivariate model (area under curve = 0.93) had three significant predictors: diabetes mellitus (aOR 36.5,
BACKGROUNDIn patients with acute ischemic stroke secondary to large vessel occlusion, achieving modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 (excellent recanalization) over mTICI 2b is associated with improved functional outcomes. P=0.036), were less likely to have a history of diabetes (aOR, 0.42;P=0.050) P=0.012).
P = 0.016), and diabetes (18.2% P < 0.001) and more likelihood of achieving Thrombolysis in Cerebral Infarction 3 (79.5% Patients with mRS score 0–2 were less likely to have hypertension (61.4% versus 83.3%;P P = 0.01), hyperlipidemia (38.6% versus 62.1%;P versus 36.4%;P P = 0.040). versus 42.2%;P P < 0.001).
We present a complex case of NSTEMI with multi-vessel coronary artery disease treated with PCI via the Carlino technique.Case Description:A 60-year-old female with a history of hypertension, diabetes mellitus, and ischemic heart disease presented with severe chest pain that radiated to the neck and was associated with nausea and vomiting.
vs. 45.4%; p=0.01), had higher baseline NIHSS scores (17 [7] vs. 15 [9.5]; p=0.001), lower baseline ASPECTS (7 [3] vs. 8 [2]; p<0.001) and higher diabetes prevalence (45.9% Dexmedetomidine-treated patients were more often male (63.2% vs. 32.6%; p=0.045) compared to patients not exposed to dexmedetomidine. vs. 28.8%; p=0.24).
treatment window for thrombolysis. Patients with missed strokes were more likely female than those with accurate strokes (57% vs 39%, p<0.01), have a history of diabetes (43% vs 26%, p=0.03), and were more likely to receive recommendation for seizure workup (25% vs 8%, p<0.01).
link] A 62 year old man with a history of hypertension, type 2 diabetes mellitus, and carotid artery stenosis called 911 at 9:30 in the morning with complaint of chest pain. This is written by Willy Frick, an amazing cardiology fellow in St. He described it as "10/10" intensity, radiating across his chest from right to left.
Case submitted and written by Mazen El-Baba MD, with edits from Jesse McLaren and edits/comments by Smith and Grauer A 90-year old with a past medical history of atrial fibrillation, type-2 diabetes, hypertension, dyslipidemia, presented with acute onset chest/epigastric pain, nausea, and vomiting. BP was 110 and oxygen saturation was normal.
ConclusionA significant association has been observed between the risk of in-hospital death among AIS with AF individual undergoing intravenous thrombolysis and the SII. The SII is determined by taking the product of the platelet and neutrophil counts, followed by dividing this result by the lymphocyte count.
The new analysis of the trial results, led by UVA Health’s Andrew Southerland , MD, found that high blood sugar shortly after thrombolysis – opening blocked arteries in the brain with a clot-busting drug – was associated with greater risk for potentially deadly brain bleeds, particularly in older patients with more severe strokes.
IntroductionThe risk of tandem occlusion treatment in the setting of intravenous thrombolysis is unclear. Patients who received thrombolysis and subsequently underwent endovascular therapy for acute ischemic stroke between 2012 and 2022 were included. vs 55%, p=0.03). vs 40%, p=0.03) and lower rate of atrial fibrillation (12.1%
CADASIL patients had lower rates of hypertension, diabetes, and coronary artery disease (55.0% There was no difference in the rate of administration of IV thrombolysis (5.0% They received IV thrombolysis at an equal rate but EVT at a lower rate, likely due to the small vessel pathology of CADASIL. vs 38.9%, p<0.001; 3.3%
Outcomes included sICH, and inpatient mortality, adjusted for confounders which included age, gender, baseline NIHSS, perfusion grade (TICI) intravenous thrombolysis, history of diabetes and HBA1c.Results:A total of 224 patients (mean age was 68.7 years (±14.3); 44.2% were women) underwent endovascular treatment.
Cohorts were matched on age, sex, diabetes, atrial fibrillation, and hypertension. A greater proportion of the US cohort underwent IV thrombolysis (30.7% White matter hyperintensities (WMH) and intracranial volumes (ICV) were extracted from MRI images by training a deep learning model, and the softwares FreeSurfer and FSL.
Some of the latest strategies include: Innovations in Thrombolysis and Clot Retrieval : Techniques such as tissue plasminogen activator (tPA) injections and mechanical thrombectomy are significantly improving recovery rates for ischemic stroke patients.
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