Physiologically Speaking

JULY 26, 2024

Welcome to the Physiology Friday newsletter. We talk about the ketogenic diet as a metabolic therapy for type 1 diabetes. Physiologically Speaking is a reader-supported publication. This irregular sleep pattern misaligns circadian rhythms and disrupts physiology. “The shorter your sleep, the shorter your life.”

Chronic Disease 64

Chronic Disease Physiology Atrial Flutter Atrial Fibrillation 64

Physiologically Speaking

AUGUST 9, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Details about the sponsors of this newsletter including Examine.com and my book “VO2 Max Essentials ” can be found at the end of the post! That’s a sweet conclusion.

Physiology 69

Physiology Diet Cholesterol Biomarkers 69

Medical Xpress - Cardiology

JUNE 14, 2024

Fatty liver disease (SLD) is increasingly causing failure of the liver as a vital organ.

Physiology 81

Physiology Diabetes Research 81

Physiologically Speaking

OCTOBER 18, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Research has linked circadian rhythm disruptions to a wide range of health issues, including cardiovascular disease, diabetes, obesity, and even certain cancers.

Physiology 64

Physiology Diet Research Exercise 64

Cardiometabolic Health Congress

MAY 24, 2024

Furthermore, physiological factors such as peripheral blood perfusion, hematocrit levels, partial pressure of oxygen (pO2), triglycerides, bilirubin, and uric acid levels can influence the results. Environmental factors like temperature, humidity, altitude, and electromagnetic radiation also impact these readings.

Diabetes 98

Diabetes Technology Congenital Outcomes 98

Physiologically Speaking

DECEMBER 15, 2023

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Blood glucose control Resistance exercise training can reduce fasting glucose by 2–5 mg/dL in adults with prediabetes and type 2 diabetes but doesn’t seem to reduce blood glucose in healthy adults (not surprising).

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52

Physiologically Speaking

DECEMBER 15, 2023

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Blood glucose control Resistance exercise training can reduce fasting glucose by 2–5 mg/dL in adults with prediabetes and type 2 diabetes but doesn’t seem to reduce blood glucose in healthy adults (not surprising).

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52

Physiologically Speaking

JUNE 7, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Lastly, insufficient sleep is also a massive health liability, leading to cardiovascular disease, diabetes, and cognitive decline. To receive new posts and support my work, consider becoming a free or paid subscriber.

Physiology 52

Physiology Exercise Blood Pressure Outcomes 52

Physiologically Speaking

JANUARY 10, 2024

Our body’s physiological processes oscillate on a 24-hour cycle known as the circadian rhythm. Day-night oscillations in the release of hormones, body temperature, and a range of other important physiological events orchestrate the complex system that is us. Every process in our body happens rhythmically.

Blood Pressure 131

Blood Pressure Physiology Cardiovascular Disease Obesity 131

Physiologically Speaking

NOVEMBER 1, 2023

In this week's post, we take a deep dive into the latest study showing that red meat intake is associated with type 2 diabetes…one that caused quite a stir in the media. Physiologically Speaking is a reader-supported publication. More meat, more diabetes? Could red meat intake be causing diabetes? Read more

Diabetes 52

Diabetes BMI Nursing Diet 52

Physiologically Speaking

MARCH 8, 2024

Welcome to the Physiology Friday newsletter. On Wednesday, I published a post on the philosophy and physiology of an “exercise pill.” Physiologically Speaking is a reader-supported publication. To receive new posts and support my work, consider becoming a free or paid subscriber. Acute sleep loss is also insidious.

Physiology 52

Physiology Exercise Diet Research 52

DAIC

JUNE 7, 2024

Such fibrils are associated with major human diseases including Alzheimer’s and Parkinson’s diseases, diabetes, and heart diseases such as atherosclerosis and calcific aortic valve disease. “We

Aortic valve 105

Aortic valve Aortic Heart Valves Pharmacology 105

Physiologically Speaking

MARCH 27, 2024

Physiologically Speaking is a reader-supported publication. Tl;dr: Continuous glucose monitors can be extremely insightful to use for a month or two, but unless you have diabetes or are at a high risk of having diabetes, it’s probably not something you need to use all the time. Do you follow an 80-20 routine with a bike?

Physiology 52

Physiology Exercise Diabetes Download 52

Frontiers in Cardiovascular Medicine

DECEMBER 13, 2023

Cancer, atrial fibrillation (AF) and coronary artery disease share some common factors and interact with each other, such as obesity, aging, diabetes, and inflammation, but the potential specific mechanism is still unclear. A growing number of studies have elucidated the association between cancer and CVD.

Atrial Fibrillation 64

Atrial Fibrillation Cancer Embolism Coronary Artery Disease 64

Dr. Paddy Barrett

AUGUST 23, 2024

V02 Max V02 Max is a measure of the maximum amount of oxygen your body can use during exercise and is best measured in a specialised sports physiology lab as part of a cardiopulmonary exercise test. Those with the very highest levels of fitness have almost nonexistent rates of type 2 diabetes 4. The relationship is clear.

Exercise 116

Exercise Dementia Cancer Chronic Disease 116

DAIC

JULY 1, 2024

Dr. Adamson earned his MD with distinction from the University of Oklahoma College of Medicine and MSc in physiology from the University of Oklahoma. Diabetes Care, Mardil Medical, and Catheter Robotics. He will begin his employment at CVRx on May 23, 2024. She has also held clinical leadership roles at POPS!

Reimbursement 105

Reimbursement RN Heart Failure Laboratory 105

Circulation

NOVEMBER 11, 2024

Endothelial cell (EC) sensing of elevated fluid shear stress (FSS) from blood flow induces vessel outward remodeling to restore physiological FSS, but mechanisms are poorly understood.

Physiology 40

Physiology Ischemia Diabetes Circulation 40

Frontiers in Cardiovascular Medicine

JANUARY 22, 2024

The etiological risk factors of CVDs are widely known and include dyslipidemia, obesity, diabetes, and chronic cigarette consumption. However, one component that is often underestimated is exposure to heavy metals. The biological perspective explains that different metals play different roles.

Cardiovascular Disease 64

Cardiovascular Disease Risk Factors Physiology Obesity 64

Hypertension Journal

DECEMBER 7, 2023

ET (endothelin) is a powerful vasoconstrictor 21-amino acid peptide present in many tissues, which exerts many physiological functions across the body and participates as a mediator in many pathological conditions. Hypertension, Ahead of Print.

Kidney Disease 45

Kidney Disease Hypertension Pulmonary Atherosclerosis 45

Physiologically Speaking

MARCH 6, 2024

But the rising trends of obesity, diabetes, and cardiovascular disease and the falling trend of activity levels lead me to a dark conclusion: things probably aren’t going to get any better. I’m an exercise scientist by training. We can promote exercise until we’re red in the face. Unfortunately, this isn’t possible.

Exercise 92

Exercise Blood Pressure Risk Factors Physiology 92

Physiologically Speaking

OCTOBER 9, 2024

Both lactate and BHB naturally increase in response to physiological stresses—lactate during intense exercise and BHB during prolonged fasting or low-carbohydrate diets. This could make LaKe an attractive option for weight management or as part of a dietary intervention for metabolic disorders like obesity and type 2 diabetes.

Exercise 75

Exercise Physiology Diet Obesity 75

Open Heart

DECEMBER 15, 2022

Combination nutraceutical regimens providing physiologically meaningful doses of several of these agents, capable of activating Sirt1 in complementary ways, may have considerable potential for health promotion.

Physiology 52

Physiology Diabetes 52

Dr. S. Venkatesan MD

MAY 26, 2024

LDL is potrayed as villian de-chief of atheroscerlois and CAD.But, LDL of about 100 to 160 mg concentration is in constant circulation, in a smooth manner serving other physiological vascular functions. The associated diabetic basement membrane dysfuntion.? accelerated caveolae formation , or 2.The The shear stress of flowing BP or 3.The

Pharmacology 45

Pharmacology Cholesterol Physiology Diabetes 45

Dr. Smith's ECG Blog

JANUARY 5, 2024

Written by Willy Frick A 46 year old man with a history of type 2 diabetes mellitus presented to urgent care with complaint of "chest burning." The documentation does not describe any additional details of the history. The following ECG was obtained. ECG 1 What do you think? The ECG shows sinus bradycardia but is otherwise normal.

Angina 121

Angina Plaque Document Stents 121

Stroke Journal

JANUARY 30, 2025

SPRINT originally randomized 9,361 hypertensive individuals without diabetes into two groups: intensive treatment (SBP<120 mmHg, n=4,678) and standard treatment (SBP<140 mmHg, n=4,683). This framework could be valuable for simulating RCTs that target continuous and highly heritable physiological variables.

Coronary Artery Disease 40

Coronary Artery Disease Myocardial Infarction Physiology Diabetes 40

MIBHS

MAY 15, 2024

While factors like high blood pressure, high cholesterol, obesity, and smoking affect both men and women, certain conditions like diabetes, metabolic syndrome, and mental stress tend to pose a higher risk for women. Hormonal changes, particularly during menopause, also play a significant role, altering women’s cardiovascular health.

Heart Disease 52

Heart Disease Chest Pain Risk Factors Blood Pressure 52

Cardiometabolic Health Congress

JULY 10, 2024

Bakris’s distinguished career in medicine spanned over four decades, marked by significant contributions to the fields of diabetic kidney disease, hypertension, and nephropathy progression. A Pioneering Journey: The Life and Legacy of Dr. George L. Bakris Dr. George L. When I heard of his passing, I felt quite sad.

Hypertension 52

Hypertension Education Blood Pressure Kidney Disease 52

EMS 12-Lead

MAY 8, 2022

In today’s case the patient is suffering from diabetic ketoacidosis, which facilitates hydrogen ion shift into the cells in exchange for potassium. Physiology. Chapter 4: Cardiovascular Physiology. ACE inhibitors, or potassium-sparing diuretics), are particularly susceptible. Journal of Electrocardiology, 37 (3), 149-156. [3]

ACE Inhibitor 52

ACE Inhibitor Ischemia STEMI Physiology 52

EMS 12-Lead

MARCH 19, 2023

He denied any known medical history, specifically: coronary artery disease, hypertension, dyslipidemia, diabetes, heart failure, myocardial infarction, or any prior PCI/stent. Another factor to be considered, according to Chou’s textbook, is that many patients have dual AVN physiology and conduction is preferential down the fast pathway.

Myocardial Infarction 52

Myocardial Infarction STEMI Coronary Angiogram Coronary Artery Disease 52

Dr. Smith's ECG Blog

APRIL 20, 2018

female with HTN, HLD, diabetes, ESRD on dialysis is brought in by EMS with sudden onset, left -sided chest pain for the past four hours. Given her risk factors (HTN, HLD, ESRD from diabetes) I decided to obtain a broad cardiac workup for the patient: serial ECGs, labs, serial troponins, CXR and bedside cardiac ultrasound.

Chest Pain 40

Chest Pain Ultrasound Risk Factors STEMI 40

Physiologically Speaking

OCTOBER 4, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. The weekend warrior activity pattern was associated with a 23% lower risk for hypertension, a 43% lower risk for diabetes, a 45% lower risk for obesity, and a 43% lower risk for sleep apnea.

Exercise 105

Exercise Physiology Dementia Obesity 105

Physiologically Speaking

MAY 1, 2024

This dietary approach has been studied for weight loss, metabolic syndrome, type 2 diabetes, epilepsy, Alzheimer’s disease, and cancer. Burke - 2021 - The Journal of Physiology - Wiley Online Library Let’s transition to discussing how exogenous ketones impact metabolism and fuel use during exercise.

Diet 52

Diet Exercise Physiology Cancer 52

Physiologically Speaking

MAY 3, 2024

Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. ICYMI On Wednesday, I published a post discussing the different metabolic effects of the ketogenic diet and exogenous ketones during exercise. It’s been well-established that males and females respond differently to exercise.

Exercise 95

Exercise Physiology Research Kidney Disease 95

Dr. Smith's ECG Blog

APRIL 6, 2023

Medical history: History of Ischemic Heart Disease History of Congestive Heart Failure Diabetes Mellitus requiring treatment with insulin Pre-operative serum creatinine >2 mg/dL He had this ECG recorded: What do you think? This patient presented with complications of his dialysis fistula.

Arrhythmia 52

Arrhythmia Atrial Fibrillation AFIB Outpatient 52

Physiologically Speaking

FEBRUARY 26, 2024

Physiologically Speaking is a reader-supported publication. Another study found that they don’t get diabetes and kidney diseases (the ninth leading cause of death). Physiologically Speaking is a reader-supported publication. The Scarcity Loop has 3 parts: opportunity, unpredictable rewards, and quick repeatability.

Diet 52

Diet Cardiovascular Disease Exercise Research 52

Dr. Paddy Barrett

OCTOBER 24, 2023

Focusing your efforts on preventing type 2 diabetes, however, is arguably one of the best strategies you can use and is likely to have the biggest gains. When I say diabetes, I am referring to type 2 diabetes, not type 1 diabetes. Having diabetes is very likely to shorten your life. Here’s why. That is huge!

Diabetes 52

Diabetes Cancer Exercise Cardiovascular Disease 52

Cardiometabolic Health Congress

MAY 10, 2024

These indirect and direct factors can lead to obesity, hypertension, hyperlipidemia, diabetes, ischemia with no obstructive coronary artery disease (INOCA), CAD, myocardial infarction (MI), and stroke via the hypothalamic-pituitary-adrenal axis, sympathetic-adrenal-medullary system, sympathetic nervous system, and hypoestrogenemia.

Coronary Artery Disease 59

Coronary Artery Disease Obesity Chest Pain Ischemia 59