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The Potential Risks of GLP-1s

CardiacWire

As expected, GLP-1s reduced MI risk by 9%, cardiac arrest by 22%, incident HF by 11%, ischemic stroke by 7%, and hemorrhagic stroke by 14%. That said, it could serve as an early look into the long-term health outcomes of using GLP-1s to treat obesity and T2D. The less good news? Theres still no free lunch in healthcare.

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Heart Disease and Stroke Could Affect at Least 60% of Adults in U.S. by 2050, According to American Heart Association Advisories

DAIC

A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 This includes a doubling of stroke rates. Obesity rates are expected to climb from 43.1% The diabetes rate is expected to rise from 16.3%

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Joint assessment of abdominal obesity and non-traditional lipid parameters for primary prevention of cardiometabolic multimorbidity: insights from the China health and retirement longitudinal study 2011–2018

Cardiovascular Diabetology

Obesity and abnormal lipid metabolism increase the risk of various cardiometabolic diseases, including diabetes, heart disease, and stroke. However, the impact of abdominal obesity (AO) and non-traditional lip.

Obesity 52
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Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050—Prevalence of Risk Factors and Disease: A Presidential Advisory From the American Heart Association

Circulation

BACKGROUND:Cardiovascular disease and stroke are common and costly, and their prevalence is rising. Diabetes (16.3% to 26.8%) and obesity (43.1% to 3.8%), stroke (3.9% Circulation, Ahead of Print. in 2020 to 61.0% to 60.6%) will increase, whereas hypercholesterolemia will decline (45.8% to 9.2%), heart failure (2.7%

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Impact of Obesity on Atrial Fibrillation Pathogenesis and Treatment Options

Journal of the American Heart Association

AF increases the risk of stroke, heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both directly and indirectly, through related conditions, like hypertension, diabetes, and heart failure. However, studies on how obesity affects pharmacologic or interventional AF treatments are limited.

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Abstract 258: Comorbidities Associated with Exclusion from rtPA in Obese Ischemic Stroke Patients with History of Smoking

Stroke: Vascular and Interventional Neurology

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionRecombinant tissue plasminogen activator (rtPA) is the only approved treatment for acute ischemic stroke (AIS) patients, however, only a minuscule percentage of patients receive rtPA [1, 2].

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Abstract 13: Prior Bariatric Surgery is Associated With Reduced Risk of Recurrent Stroke Among Elderly Obese Stroke Survivors: A National Inpatient Sample Study (2016-2019)

Stroke Journal

Stroke, Volume 55, Issue Suppl_1 , Page A13-A13, February 1, 2024. Elderly obese stroke survivors (> 65 years) having a recurrent acute ischemic stroke (AIS), with or without prior bariatric surgery (PBS), were identified using ICD-10 codes. vs. 61.6%), diabetes mellitus (60% vs. 52.2%), tobacco use (37.5%

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