Dr. Paddy Barrett

FEBRUARY 14, 2025

low cholesterol), the total score can easily be taken to greater than 10 with other risk factors, including high blood pressure, obesity, inactivity, smoking etc. Overweight but not obese and a systolic blood pressure of 135 mmHg (Not very high but certainly not ideal). Non-smoker, doesn’t have diabetes and is on no medications.

Cholesterol 113

Cholesterol Heart Disease Heart Attack Heart attacks 113

Cardiometabolic Health Congress

JULY 25, 2023

Can you please explain the concept of an obesity paradox? Salvatore Carbone, PhD: First, I’d like to point out that obesity is a major risk factor for cardiometabolic disease. 2, 3] This association is more pronounced for those with class I obesity, which is a body mass index (BMI) between 30-35 kg/m2.

Obesity 52

Obesity BMI Heart Failure Cardiovascular Disease 52

Journal of the American Heart Association

DECEMBER 29, 2023

AF increases the risk of stroke, heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both directly and indirectly, through related conditions, like hypertension, diabetes, and heart failure. However, studies on how obesity affects pharmacologic or interventional AF treatments are limited.

Obesity 45

Obesity Atrial Fibrillation Heart Failure Pharmacology 45

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionRecombinant tissue plasminogen activator (rtPA) is the only approved treatment for acute ischemic stroke (AIS) patients, however, only a minuscule percentage of patients receive rtPA [1, 2].

Obesity 40

Obesity Stroke Strokes Risk Factors 40

DAIC

MARCH 26, 2025

2 Most are balancing multiple comorbidities, such as obesity, diabetes, hypertension and chronic kidney disease (CKD). A Trial to Learn How Well Finerenone Works and How Safe it is in Adult Participants With Non-diabetic Chronic Kidney Disease (FIND-CKD). Diabetes Care. 4 Approximately 6.7 million adults in the U.S.

Heart Failure 52

Heart Failure Preserved Ejection Fraction Kidney Disease ACE Inhibitor 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A13-A13, February 1, 2024. Elderly obese stroke survivors (> 65 years) having a recurrent acute ischemic stroke (AIS), with or without prior bariatric surgery (PBS), were identified using ICD-10 codes. vs. 61.6%), diabetes mellitus (60% vs. 52.2%), tobacco use (37.5%

Obesity 40

Obesity Inpatient Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page A51-A51, February 1, 2025. Background:Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have shown a reduction in major adverse cardiovascular events (MACE) among patients with type 2 diabetes mellitus (T2DM). 0.96),P<0.001), and nonfatal stroke by 13% (OR, 0.87(95%CI:

Heart Failure 40

Heart Failure Obesity Stroke Strokes 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page ATP262-ATP262, February 1, 2024. Background:Obesity has been associated with an increase in the risk of stroke and poor outcomes. Meanwhile, Metabolically healthy obesity (MHO) trends are understudied in association with stroke. p<0.001) compared to the MHO+ve cohort.

Obesity 40

Obesity Hospital Stroke Strokes 40

Dr. Paddy Barrett

AUGUST 29, 2023

It all comes down to: What your priorities are What your objectives are Your risk tolerance Your ability to update that risk model Where you draw the line of ‘risk’ equating to ‘causation’ The same is true when it comes to the question of statins ‘causing’ diabetes. What to do? Let’s dive in.

Diabetes 52

Diabetes Risk Factors Heart Attack Heart attacks 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A21-A21, February 1, 2024. Introduction:Ischemic stroke (IS) is a pressing global health concern. Diabetes mellitus not only heightens the risk of IS but also aggravates its outcomes. db/db mice were used to model type 2 diabetes and obesity, while db/+ mice served as euglycemic controls.

Diabetes 40

Diabetes Stroke Strokes Obesity 40

DAIC

SEPTEMBER 11, 2024

Atrial fibrillation, a rapid, irregular heart beat that can lead to stroke or sudden death, is three times more common than previously thought, affecting nearly 5 percent of the population, or 10.5 Studies have shown that people with A-Fib are up to 5 times more likely to have a stroke. tim.hodson Wed, 09/11/2024 - 15:40 Sept.

Atrial Fibrillation 92

Atrial Fibrillation Quality of Life Myocardial Infarction Kidney Disease 92

European Journal of Heart Failure

DECEMBER 7, 2023

Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF). Echocardiography demonstrated increased CO with obesity, but not estimated right atrial (RA) pressure or E/e′. Overall, 60.9%

Preserved Ejection Fraction 40

Preserved Ejection Fraction Obesity Heart Failure BMI 40

Dr. Paddy Barrett

AUGUST 30, 2024

Insulin resistance is a precursor condition to metabolic syndrome and type 2 diabetes, both major drivers of heart disease. Obesity is one of the biggest global health concerns we face today. Obesity is also a key driver of risk for cardiovascular disease. Poor Sleep Increases The Rate Of Heart Attacks & Stroke.

Heart Disease 111

Heart Disease Dementia Obesity Heart Attack 111

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWMP106-AWMP106, February 1, 2025. Introduction:An elevated urinary albumin-to-creatinine ratio (UACR), a marker of renal dysfunction, has been linked to an increased incidence of stroke. Those with elevated UACR (top tertile) had a higher incidence of stroke (4.6% 1.66, p=0.011).

Stroke 40

Stroke Strokes Obesity Education 40

Frontiers in Cardiovascular Medicine

DECEMBER 5, 2024

The molecular mechanisms underlying the impaired effects of altered lipoproteins have been studied in numerous in vitro and in vivo studies, and have been extensively analyzed in coronary atherosclerosis, especially in the context of pathologies such as dyslipidemia, diabetes, obesity, and metabolic syndrome.

Circulation 40

Circulation Stroke Strokes Atherosclerosis 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP268-ATP268, February 1, 2025. Introduction:Xylitol, a sugar alcohol with a global market estimated at 161,500 metric tons, has been linked to increased thrombosis and risk of stroke and heart attack.

Thrombosis 40

Thrombosis Obesity Stroke Strokes 40

MIBHS

MARCH 15, 2025

Studies show that repeated binge drinking can contribute to spikes in blood pressure, increasing the likelihood of stroke, heart attack, and heart failure. Additionally, alcohol contributes to weight gain, as many alcoholic beverages are high in empty calories, leading to an increased risk of obesity and its associated heart complications.

Blood Pressure 52

Blood Pressure Heart Rhythm Blood Clot Heart Disease 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP235-AWP235, February 1, 2024. Introduction:Amid the rising prevalence of cannabis use disorder (CUD) in older adults and with surveys reporting ~85% of overlapping use for medicinal and recreational purposes in American cannabis users, the link between CUD and stroke is paramount. vs. 28.4%).

Inpatient 45

Inpatient Stroke Strokes Obesity 45

Stroke Journal

DECEMBER 19, 2024

Stroke, Ahead of Print. The latest research on socioeconomic status (SES) and stroke continues to demonstrate that individuals with low SES are at a higher risk of stroke, receive lower-quality care, and experience poorer outcomes. Addressing stroke inequalities requires an interdisciplinary approach.

Stroke 40

Stroke Strokes Risk Factors Hypertension 40

Cardiology Update

JANUARY 24, 2024

Growing Global Burden of Cardiometabolic Risks: The 2023 World Obesity Atlas projects a significant rise in global overweight and obesity levels by 2035, leading to a surge in diabetes cases. Strategies promoting healthy aging globally are crucial to mitigate the impact of population aging.

Cardiovascular Disease 119

Cardiovascular Disease Research Blood Pressure Public Health 119

MIBHS

FEBRUARY 28, 2025

Arrhythmias: Genetic mutations can also predispose individuals to irregular heart rhythms, such as atrial fibrillation or long QT syndrome, which may increase the risk of stroke or sudden cardiac arrest. Mutations in specific genes often cause hypertrophic cardiomyopathy and dilated cardiomyopathy.

Genetic predisposition 52

Genetic predisposition Heart Disease Cholesterol Blood Pressure 52

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP319-ATP319, February 1, 2025. Census tract stroke prevalence was estimated using 2021 CDC PLACES data. Stroke prevalence was 1.59% (95% CI:1.50-1.69) Stroke prevalence was also higher in tracts with declining investment (1.40%; 95% CI: 1.18-1.63%)

Stroke 40

Stroke Strokes Obesity Diabetes 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page AWP141-AWP141, February 1, 2025. Background:A recent prospective study reported that myocardial infarction (MI) was present in nearly half of ischemic stroke patients with substantially elevated troponin, with 1 in 5 having a type 1 MI. In suspected stroke patients, 26.1% (95% CI, 20.9-32.2%)

Stroke 40

Stroke Strokes Chest Pain Myocardial Infarction 40

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A96-A96, February 1, 2024. Introduction:While ischemic stroke (IS) in the young (18-55) is thought to have different etiologies than in older patients, a rise in vascular risk factors (VRFs) among young adults may translate to an IS risk profile similar to the older population. p <0.001).VRF

Risk Factors 40

Risk Factors Stroke Strokes Coronary Artery Disease 40

Circulation

NOVEMBER 11, 2024

Aim:This study investigates the prevalence of isolated interventricular membranous septal (IVMS) aneurysms detected via echocardiography and assesses the associated stroke risk without other classical risk factors.Methods:We searched the echocardiography database at Mount Sinai Morningside from January 2017 to September 2023.

Aneurysm 40

Aneurysm Stroke Strokes Atrial Fibrillation 40

CardiacWire

OCTOBER 27, 2024

Heart Disease in 2050 – The AHA warned of massive heart disease increases by 2050, spanning CVD (+60%), diabetes (+100%), obesity (+70%), hypertension (+44%), heart failure (+66%), and stroke (+100%). Add all that up and the cost of treating adult CVD and stroke patients will increase by 195% to $1.85

AFIB 59

AFIB Hypertension Kidney Disease Heart Disease 59

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWP280-AWP280, February 1, 2024. Introduction:Veterans represent a unique population who may be at higher risk of developing stroke. Logistical regression models were created to explore the association between Veteran status and stroke. vs. 3.6%, p<0.001). weighted, Table).

Risk Factors 40

Risk Factors Stroke Strokes Obesity 40

AMS Cardiology

NOVEMBER 21, 2024

Plus, these stressors can increase the risk of heart attack, stroke or retention of extra fluid and heart failure , explains Dr. Tarditi. Heavier drinking may increase the risk for scarring, electrical abnormalities, heart attack and stroke.

Heart Attack 52

Heart Attack Heart attacks Heart Failure Blood Pressure 52

Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page A52-A52, February 1, 2024. Background/Purpose:Stroke imposes a substantial healthcare burden, with ischemic stroke (IS) mortality rising from 2.04 million (1990) to 3.29 million (2019) and projected to reach 4.90 million by 2030 according to the Global Burden of Disease Study.

Inpatient 40

Inpatient Stroke Strokes Coronary Artery Disease 40

ADN Center of Excellence

SEPTEMBER 2, 2024

This miscommunication can cause blood to pool in the atria, increasing the risk of clot formation, which can then lead to strokes. AFib is associated with a fivefold increased risk of stroke, and it is also linked to heart failure, chronic fatigue, and other serious health issues.

AFIB 59

AFIB Atrial Fibrillation Innovation Heart Rhythm 59

Clinical Trial Results

DECEMBER 18, 2024

Disclosures: TBD

Diabetes 60

Diabetes Stroke Strokes Obesity 60

Circulation

NOVEMBER 11, 2024

Patients with a history of prior hemorrhagic stroke were excluded from this analysis. vs. 72.8%, p<0.001), had higher rates of diabetes (49.1% vs. 43.6%, p=0.007), and were less often obese (34.0% Circulation, Volume 150, Issue Suppl_1 , Page A4141940-A4141940, November 12, 2024. vs. 42.2%, p=0.009).

Atrial Fibrillation 40

Atrial Fibrillation Embolism Stroke Strokes 40

ADN Center of Excellence

SEPTEMBER 2, 2024

This miscommunication can cause blood to pool in the atria, increasing the risk of clot formation, which can then lead to strokes. AFib is associated with a fivefold increased risk of stroke, and it is also linked to heart failure, chronic fatigue, and other serious health issues.

AFIB 52

AFIB Atrial Fibrillation Innovation Heart Rhythm 52

DAIC

FEBRUARY 29, 2024

24 will focus on the following three current guideline updates: American College of Cardiology (ACC)/American Heart Association (AHA) Guidelines 2023 Atrial Fibrillation Guideline - Pharmacology II: Strokes vs. Bleeds, What Do the Guidelines Tell Us About Practical Management in A-fib? The Guidelines Sessions at ACC.24 12:15 p.m.

Aortic valve 103

Aortic valve Myocardial Infarction Aortic Blood Pressure 103

Circulation

NOVEMBER 11, 2024

Age-standardized prevalence rates were calculated for eight conditions, including hypertension, type 2 diabetes, alcohol use, smoking, physical inactivity, overweight/obesity, short sleep (< 7 hours), and CVD (defined as having coronary heart disease, heart attack, or stroke). p< 0.001) and alcohol use (AAPC: 2.3%,p<

Risk Factors 40

Risk Factors Cardiovascular Disease Obesity Heart Attack 40

DAIC

SEPTEMBER 11, 2024

Atrial fibrillation, a rapid, irregular heart beat that can lead to stroke or sudden death, is three times more common than previously thought, affecting nearly 5 percent of the population, or 10.5 Studies have shown that people with A-Fib are up to 5 times more likely to have a stroke. tim.hodson Wed, 09/11/2024 - 15:40 Sept.

Atrial Fibrillation 52

Atrial Fibrillation Quality of Life Myocardial Infarction Kidney Disease 52

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. We aimed to investigate the safety of intravenous tissue plasminogen activator (IV tPA) and mechanical thrombectomy (MT) for acute ischemic stroke (AIS), and compare the functional outcome in cardiomyopathy patients with and without HF.

Heart Failure 40

Heart Failure Cardiomyopathy Inpatient Stroke 40