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The biggest and most comprehensive analysis of glucagon-like peptide-1 (GLP-1) receptor agonists on kidney and cardiovascular outcomes shows they have significant benefits in people with and without diabetes.
Obesity is a complex, chronic condition that significantly impacts cardiometabolic health and overall well-being. 1 Dietary Modifications: Evidence-Based Approaches Low-Fat vs. Low-Carb Diets A meta-analysis of 48 randomized controlled trials (RCTs) revealed no significant difference in weight loss outcomes between low-fat and low-carb diets.
Starting with the good news, GLP-1s lowered risks for 42 health outcomes while increasing risks for 19 outcomes. Its also worth noting that the data came from military veterans who were older and mainly white, so the outcomes might not apply to other populations. year follow-up.
What are the effects of semaglutide across a broad range of outcomes in people with obesity-related heart failure with preserved ejection fraction (HFpEF) with and without diabetes, and consistency across key patient subgroups?
In a randomized, controlled trial, semaglutide resulted in greater weight loss, improved symptoms, and fewer serious adverse events compared with placebo.
We have previously shown an association between metabolic syndrome (MS) and heart failure (HF) outcomes in patients with implanted defibrillators (ICD) and cardiac resynchronization therapy (CRT-D). However, the role of MS and diabetes in predicting HF outcomes was not assessed in non-obese patients.
The goal of the SELECT trial was to determine the association of subcutaneous semaglutide, a glucagon-like peptide-1 receptor agonist (GLP-1 RA), with cardiovascular (CV) events in a secondary prevention cohort of patients with overweight or obesity and prior CV disease (CVD) without diabetes mellitus (DM).
In a trial in patients with cardiovascular disease and overweight or obesity but no diabetes, semaglutide was superior to placebo in lowering the risk of major adverse cardiovascular events at a mean follow-up of 39.8
Background and aims Pre-eclampsia complicates 3–5% of pregnancies worldwide and is associated with adverse outcomes for the mother and the offspring. Pre-eclampsia and heart failure have common risk factors, including hypertension, obesity and diabetes.
A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8
Obesity is common in the heart failure (HF) population and is regarded as an important risk factor for developing HF. Greater skeletal muscle mass has shown to be the underlying protective factor against cardi.
Obesity significantly increases AF risk, both directly and indirectly, through related conditions, like hypertension, diabetes, and heart failure. In particular, expanding epicardial adipose tissue during obesity has been suggested as a key driver of AF via paracrine signaling and direct infiltration.
The associations between obesity and hypertension are widely known, but a new JACC study reveals that weight-reducing gastric bypass surgery has a significant and lasting impact on patients’ need for antihypertensives. The GATEWAY trial assigned 100 participants (76% women, 43.8 of them achieved BPs below 130/80 mm Hg (vs.
Neha Agarwal, PhD, Clinical Director at Cardiometabolic Health Congress , Informa Connect, recently presented significant findings at the 84th American Diabetes Association (ADA) Scientific Sessions. Competence in selecting treatments for long-term obesity management rose from 43% pre-test to 95% post-test.
Pregnancy complications such as preeclampsia and gestational diabetes have recently been associated with a higher risk of developing heart disease later in life. But a new study has found obesity before or during pregnancy is the actual root cause of future cardiovascular disease. “We
Practical, Future-Focused Education Cardiorenal and metabolic diseases, fueled by poor lifestyle choices and health conditions, lead to type 2 diabetes, cardiovascular disease, and chronic kidney disease. The robust conference agenda begins with FDA updates and advancements in cardiorenal metabolic care.
As a leader in the field of research-based cardiometabolic health education, CMHC is proud to present its CME education outcomes study at ADA (American Diabetes Association) 2024 Scientific Sessions, which offers its education-focused agenda to a wide number of healthcare practitioners from all areas of the U.S.
Increasing severity of obesity is associated with multiple characteristics that may contribute to the development or worsening of heart failure (HF) with preserved ejection fraction (HFpEF). Echocardiography demonstrated increased CO with obesity, but not estimated right atrial (RA) pressure or E/e′. Overall, 60.9%
Less than two weeks after Novo Nordisk’s weight-loss drug Wegovy gained expanded FDA approval for cardiovascular event risk reduction, CMS issued a new Medicare Part D guidance that allows coverage of obesity drugs for senior patients with “an additional medically accepted indication”… like cardiovascular disease.
Somers, MD, PhD , a consultant in cardiovascular medicine from the Mayo Clinic, discusses how sleep impacts both cardiovascular and metabolic outcomes. There is a clear relationship between sleep deprivation and the development of conditions like obesity, diabetes, and hypertension. In this week’s CMHC Pulse Blog Post, Virend K.
Wegovy’s expanded FDA approval now supports its use for the reduction of major adverse cardiovascular events in obese or overweight adults with established CVD. Semeglutide was already approved for diabetes (via Ozempic) and weight loss (via Wegovy), although payors have largely resisted covering non-diabetic patients.
One such syndrome that has been associated with poor outcomes is cognitive frailty: the simultaneous presence of cognitive impairment, without evidence of dementia, and physical frailty, which results in decreased cognitive reserve.
Introduction:The paucity of large-scale data exploring the effect of prior bariatric surgery on recurrent stroke outcomes in elderly obese stroke survivors led us to address the gap, with an emphasis on the risk of recurrent stroke and its trends.Methods:A retrospective study was conducted using National Inpatient Sample data from 2016-2019.
Insulin resistance is a precursor condition to metabolic syndrome and type 2 diabetes, both major drivers of heart disease. Obesity is one of the biggest global health concerns we face today. Obesity is also a key driver of risk for cardiovascular disease. Obesity (Silver Spring). hour sleep-per-night group.
This year’s theme, “Advancing Cardiovascular Care for All” brings the latest practice-changing breakthroughs, along with top experts debating and discussing outcomes of highly-anticipated clinical trials. 24 from April 6 - 8, 2024 in Atlanta, GA at the Georgia World Congress Center.
Malnutrition is common in stroke patients and leads to worse outcomes. Body mass index (BMI) is a widely available marker of nutrition status, however studies on BMI and post-ICH outcomes are limited and have conflicting results. There was no association between BMI and ICH volume in patients with deep or lobar hemorrhage.
Untangling the Statins and Diabetes Link : Dr. Savitha Subtamaniam explored the incidence of diabetes associated with statin use, noting that the mechanism is unclear. She also highlighted uncertainty regarding whether statins worsen glycemic management in individuals with pre-existing diabetes.
Semaglutide reduced cardiovascular events by 20% in adults with overweight or obesity and established cardiovascular disease who do not have diabetes, according to new research. In the trial, patients treated with semaglutide lost an average of 9.4%
Diabetes mellitus not only heightens the risk of IS but also aggravates its outcomes. db/db mice were used to model type 2 diabetes and obesity, while db/+ mice served as euglycemic controls. Stroke, Volume 55, Issue Suppl_1 , Page A21-A21, February 1, 2024.
Peripheral artery disease (PAD) continues to increase in prevalence worldwide due to risk factors such as advanced age, diabetes mellitus, and obesity. This paper presents a brief overview of the structure of the multidisciplinary team with key components and functions of such a team to optimize treatment outcomes for PAD and CLTI.
The focus will be on the intricate interplay between cardiorenal and metabolic conditions, such as type 2 diabetes, cardiovascular disease, and chronic kidney disease, driven by lifestyle and health factors. Attendees will gain valuable clinical insights and explore cutting-edge therapies aimed at improving overall health outcomes. “Dr.
These factors include obesity, dyslipidemia, hypertension, and insulin resistance — also known as metabolic syndrome. Numerous pharmacological and non-pharmacological interventions have been developed to control and improve clinical outcomes, and all these aspects involve cardiometabolic diseases.
Factors such as aging populations, rising rates of obesity, hypertension, and other cardiovascular conditions contribute to this increase. Regular screening, especially in high-risk populations, can lead to earlier intervention and better outcomes. By 2050, the number of individuals affected by AFib is expected to more than double.
BackgroundMultimorbidity is common among patients with atrial fibrillation (AF) and is associated with worse outcomes. Multimorbidity was defined as 2 comorbidities (heart failure, hypertension, diabetes, coronary heart disease, kidney dysfunction, moderate or severe mitral valve regurgitation, or obesity).
IntroductionThe Appalachia region of North America is known to have significant health disparities, specifically, worse risk factors and outcomes for stroke. These subjects underwent MT for ELVO, and during the procedure, carotid arterial blood samples were acquired and subsequently sent for proteomic analysis.
Factors such as aging populations, rising rates of obesity, hypertension, and other cardiovascular conditions contribute to this increase. Regular screening, especially in high-risk populations, can lead to earlier intervention and better outcomes. By 2050, the number of individuals affected by AFib is expected to more than double.
Age-standardized prevalence rates were calculated for eight conditions, including hypertension, type 2 diabetes, alcohol use, smoking, physical inactivity, overweight/obesity, short sleep (< 7 hours), and CVD (defined as having coronary heart disease, heart attack, or stroke). p< 0.001) and alcohol use (AAPC: 2.3%,p<
Overweight/Obesity. Falling into the class of obesity with a BMI of greater than 30 makes this more likely, but so also does having excess visceral fat deposition with significant metabolic consequences at a BMI less than 30. Weight Loss Potential With Obesity Medications. ” here is what I tell them.
The throng of epidemiological evidence hasn’t helped either — one week “butter is back” and the next, red meat is giving us diabetes. While individuals adhering to plant-based diets may exhibit better health outcomes than their meat-eating counterparts, attributing this solely to dietary choices is jumping the gun.
2023, the American Heart Association (AHA) issued a presidential advisory on the urgency of this systemic disorder involving heart disease, kidney disease, diabetes and obesity. The virtual, self-paced Foundations of Cardiometabolic Health Certificate Course is the first step to attaining the CCHP credential.
Cardiometabolic conditions – specifically obesity, diabetes and heart disease – disproportionately affect the 60 million people in the U.S. Dr. Rodriguez presents to hundreds of practitioners of women's health on using digital tools and community intervention to improve outcomes in underserved ethnic populations. Register Now
The latest research on socioeconomic status (SES) and stroke continues to demonstrate that individuals with low SES are at a higher risk of stroke, receive lower-quality care, and experience poorer outcomes.
National Inpatient Sample (NIS) database from 2009 to 2020, evaluating patients who presented with stroke from ICAD and were treated with angioplasty and stenting and analyzed presenting co-morbidities and patient outcomes. vs 7.9%), diabetes (33.6% vs 4.6%), obesity (26.4%
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