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Findings from an observational analysis of ARISE-HF trial participants, newly-published in the Journal of the American College of Cardiology, JACC, shed light on the racial and ethnic disparities in diabetic cardiomyopathy (DbCM), which researchers note may have the potential to inform clinical practice, interventions, and policies.
Recent over-the-counter (OTC) approvals for CGM systems are transforming diabetes management and lifestyle management for those without diabetes, making this an exciting time for healthcare professionals and their patients. These enhancements offer benefits beyond diabetes management, including support for women across the lifespan.
The primary outcome was atherothrombotic major adverse cardiovascular events as a composite outcome of cardiovascular mortality, nonfatal stroke, and nonfatal myocardial infarction. Patients were propensity matched in a 1:1 ratio using a caliper distance of 0.2 without replacement.
With molecular surveillance we can monitor organ health while avoiding the inconvenience and discomfort of unnecessary biopsies, said Dr. Brian Feingold, Medical Director, Pediatric Heart Transplantation, UPMC Childrens Hospital of Pittsburgh. 5 As with other organ transplants, the organs are at risk of rejection. Clin Transplant.
We aim to examine the real-world effectiveness of early versus delayed post-discharge SGLT2 inhibitor initiation in people with acute heart failure and type 2 diabetes. The primary outcome was hospitalization for heart failure (HHF) or cardiovascular mortality as a composite. Follow-up started from discharge for maximum 1 year.
Introduction:Clinical characteristics of patients with in-hospital onset stroke (IHOS) compared to those with out-of-hospital onset stroke are reported to be late detection of stroke onset, less use of rt-PA, presence of atrial fibrillation, and poor outcome. Patients under 18 years and discharged within 24 hours were excluded.
Background There is increasing awareness that patients without standard modifiable risk factors (SMuRFs; diabetes, hypercholesterolaemia, hypertension and smoking) may represent a unique subset of patients with acute coronary syndrome (ACS). The primary outcome was 30-day mortality. Patients with coronary artery disease were excluded.
Brittany Weber, MD, PhD , of Brigham and Women’s Hospital, is the 2024 YIA winner for her abstract, "The Frequency, Prevalence, And Outcomes Of Incidentally Detected Coronary Artery Calcium Using Artificial Intelligence Analysis Among Patients With Immune Mediated Inflammatory Diseases.”
The international ARISE-HF trial was designed to test the effectiveness of the investigational drug AT-001 at stabilizing exercise capacity in patients with diabetic cardiomyopathy. Patients had had Type 2 diabetes for an average of 14 years. Decline in exercise ability is a hallmark of progression to overt heart failure.
Introduction:The transitional period from hospital discharge to the community for stroke survivors is a vulnerable time as patients navigate healthcare systems with their new impairments. The intervention group had a significantly lower rate of 1 year hospital readmission due to any cause (62.1% vs 69.3%, p=0.04).
Background:Heart failure (HF) is one of the leading causes of hospitalizations in the States. Results:We included 4,454,273 weighted hospitalizations due to HF for which 380,446 patients (8.5%) had a concurrent diagnosis of hyperkalemia. Further studies can investigate whether novel potassium binders may improve outcomes.
Sodium-glucose co-transporter 2 inhibitors (SGLT2i), a novel class of antidiabetic drugs, have shown a promising impact in reducing cardiovascular events in diabetic and nondiabetic heart failure (HF) patients. To evaluate the effects of SGLT2i on preventing AF recurrence following CA and its impact on other cardiovascular outcomes.
As a low-volume PCI centre in the Middle East, we wanted to find out if the outcomes of our PCI procedures are different from those of high-volume PCI centres in the UK and the Western world. Prospectively collected data of all comers for PCI (urgent and elective) were retrospectively analysed. Mean age was 60.9 ± 9.4
This study assesses the impact of SGLT2i on AF recurrence and clinical outcomes in HFrEF patients undergoing CBA. Secondary endpoints included all-cause mortality and heart failure (HF)-related hospitalizations. vs. 14.9%, p =0.039) and HF hospitalizations (16.9% Results The median follow-up period was 347 days.
Abstract Aims In VERTIS CV, ertugliflozin was associated with a 30% risk reduction for adjudication-confirmed, first and total hospitalizations for heart failure (HHF) in participants with type 2 diabetes and atherosclerotic cardiovascular disease.
Circulation: Cardiovascular Quality and Outcomes, Ahead of Print. Background:Patients with type 2 diabetes are at risk of heart failure hospitalization. Accounting for all-cause mortality, we obtained the incidence for heart failure hospitalization at 5 years follow-up; overall and in each SDI group.
When compared with placebo, glucagon-like peptide-1 receptor agonists such as once-weekly semaglutide (semaglutide OW T2D) improve cardiovascular outcomes in people with type 2 diabetes (T2D), whereas dipeptidyl peptidase-4 inhibitors (DPP-4is) do not. Stroke, Volume 55, Issue Suppl_1 , Page AWP229-AWP229, February 1, 2024.
Future work is needed to examine if enhanced syphilis screening practices in acute stroke hospitalizations can be used to inform stroke management and improve patient outcomes. Younger and racial minority patients are more likely to be screened.
Kidney Week 2023 emphasized the need to address disparities in nephrology to improve patient outcomes and equitable care. Depression symptoms linked to increased hospitalization rates in patients with CKD. Depressive symptoms in patients with chronic kidney disease (CKD) are associated with an increased risk of hospitalization.
A 56 year old male with a history of diabetes, dyslipidemia, hypertension, and coronary artery disease presented to the emergency department with sudden onset weakness, fatigue, lethargy, and confusion. He was admitted to the hospital for evaluation of these symptoms — but no ECG was done at that time. No ECG was ordered on Day #1.
Background:The STRACK project aims to improve post-stroke patient management and the transition from acute to primary care thanks to improvements in patient pathways and monitoring cardiovascular risk factors: heart failure, diabetes, atrial fibrillation, dyslipidemia and hypertension.
This study examines prognostic factors in a multiethnic Latin American cohort with CCAD, aiming to identify key predictors of outcomes in this diverse population.Methods:We conducted a 6-month follow-up study, assessing clinical outcomes in patients diagnosed with CCAD. At hospital discharge, the median of mRS was 3 (IQR: 2.00, 45.7%
I was texted these ECGs by a recent residency graduate after they had all been recorded, along with the following clinical information: A 50-something with no cardiac history, but with h/o Diabetes, was doing physical work when he collapsed. The outcome measure was whether the patient ultimately had an OMI or not.
However, its postoperative complications can have a significant effect on long-term patient outcomes. AUC, or area under the receiver operating characteristic curve, quantifies the ability of a model to distinguish between positive and negative outcomes.
AF increases the risk of stroke, heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both directly and indirectly, through related conditions, like hypertension, diabetes, and heart failure. ABSTRACTAtrial fibrillation (AF) is the most common cardiac arrhythmia.
ABSTRACT Background Atrioventricular block (AVB) is a cardiac conduction disorder that can lead to significant clinical outcomes, particularly in resource-limited and conflict-affected regions. Conclusion AVB prevalence in the Syrian ED setting is high, with age, IHD, and diabetes as significant predictors. p <0.001), IHD (OR: 1.9,
Aims Heart failure (HF) is associated with comorbidities which independently influence treatment response and outcomes. Methods Patients acted as their own controls, with outcomes compared for equal periods (for each patient) pre (HF MDT) versus post-MDT (multispecialty) meeting. Results 334 patients (mean age 72.5±11
A retrospective analysis was conducted on clinical, operative, and outcome data from 1070 patients (mean age: 59 ± 9.8& The outcome variable was prolonged length of stay LOS in the CICU stay (> 3 nights after CABG). This study aimed to evaluate these risk factors.
Demographic and clinical characteristics were described at baseline, and incidence rates of IS, intracranial bleeding, and bleeding leading to hospitalization with sensitivity analyses at different time points were calculated.Results:Overall, 203,757 patients were included in the study, 97,481 from MarketScan, 106,276 from CDM.
Introduction:Effective care transition for ischemic or hemorrhagic stroke patients post-hospital discharge is critical. Ensuring a follow-up neurology appointment within two weeks is vital to managing stroke risk factors like hypertension, diabetes, and atrial fibrillation.
We aimed to compare in-hospital mortality and predictors in stroke patients with secondary rheumatological conditions.Methods:Using the National Inpatient Sample (NIS), we identified patients ≥18 admitted for stroke (Jan 2019 - Dec 2020), stratified into RA, SLE, scleroderma, or vasculitides groups using ICD-10-CM codes.
Background:Mechanical thrombectomy has been associated with improved outcomes in patients with acute ischemic stroke. However, not all patients with successful reperfusion experience good functional outcomes. years, 54% were women, 87% had hypertension, 44% had diabetes mellitus, and 54% had hyperlipidemia. pg/ml vs. 39.520.6
National Inpatient Sample (NIS) database from 2009 to 2020, evaluating patients who presented with stroke from ICAD and were treated with angioplasty and stenting and analyzed presenting co-morbidities and patient outcomes. vs 7.9%), diabetes (33.6% There were significantly higher incidences in uncontrolled hypertension (28.2%
Background:Mortality doubles in stroke patients when Diabetes Mellitus (DM) is present. Target: Type 2 DiabetesSM(TT2DM) is an American Heart Association® (AHA) initiative focused on providing evidence-based guideline (EBG) resources to mitigate risk in hospitalized stroke patients with DM. 1, 2020-Dec.
Abstract Aims To evaluate the association between transcatheter edge-to-edge repair (TEER) and outcomes in patients with significant mitral regurgitation (MR) following acute myocardial infarction (MI), focusing on the aetiology of acute post-MI MR in high-risk surgical patients.
Aims Identifying clinical and echocardiographic parameters associated with improvement in systolic function in outpatients with heart failure with reduced ejection fraction (HFrEF) could lead to more targeted treatment improving systolic function and outcome. per 100 person years, p=0.012).
vs. 30.8%, p=0.001), and higher rates of diabetes (33.3% risk stratification for ICH patients is a critical gap in improving post-ICH outcomes. Socioeconomic deprivation was measured using the state-level Area Deprivation Index (ADI; high deprivation defined as ADI > 7). vs 12.8%, p=0.040). vs 7.7%, p=0.039) (Table 2).Conclusion:More
A prior history of the following comorbidities was considered: episodic or persistent atrial fibrillation ( n = 920), coronary artery disease ( n = 3732), diabetes ( n = 2171), and hypertension ( n = 3353). Outcomes were evaluated within each comorbidity group using a Bayesian hierarchical Weibull survival regression model.
Here, we aimed to develop a nomogram model utilizing multimodal data for the risk stratification of AF recurrence following catheter ablation in individuals diagnosed with PFO and new-onset PAF.Methods:Patients with PFO and PAF who underwent catheter ablation at our hospital from January 2018 to June 2020 were consecutively enrolled.
2023, the American Heart Association (AHA) issued a presidential advisory on the urgency of this systemic disorder involving heart disease, kidney disease, diabetes and obesity. In its advisory, the AHA stressed an interdisciplinary team approach emphasizing social determinants of health, shortcomings in current efforts, and knowledge gaps.
Accumulating evidence suggests that an imbalance of neuroprotective and neuroinflammatory cytokines may contribute to stroke outcomes. had diabetes mellitus, and 53.7% had diabetes mellitus, and 53.7% Accurate identification of stroke etiology is vital for secondary stroke prevention. were women, 87% had hypertension, 48.1%
1,2 The National Institute of Health Stroke Scale (NIHSS) cutoff for poor outcomes is lower in BAO compared to anterior circulation large vessel occlusions (LVO) due to the scale’s weighted scoring towards cortical signs.3,4 3,4 To bridge this gap, Alemseged et.al
Written by Jesse McLaren A 75 year-old patient with diabetes and end stage renal disease was sent to the ED after dialysis for three days of nausea, vomiting, loose stool, lightheadedness and fatigue. RR18 sat 99% HR 90 BP 90/60, afebrile. Below is the 15 lead ECG. What do you think? Circulation 2007 2. Khan et al.
IntroductionEndoscopic endonasal approach(EEA) techniques have been increasingly utilized and have been associated with development of cerebrospinal fluid(CSF) leak, meningitis, diabetes insipidus post‐operatively. Her neurological exam improved to baseline on hospital day(HD) 9.On CSF cultures were negative.
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