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Andrew is a research scientist at Sansum Diabetes Research Institute, where he’s investigating metabolic therapies for health and disease. His mission is to optimize metabolic health and patient outcomes for people living with type 1 diabetes. Andrew is unique because he himself has type 1 diabetes.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Finally, having dyslipidemia (abnormal levels of blood lipids) and diabetes were associated with a higher age acceleration. ” Details can be found at the end of the post! The early bird gets the worm.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. The debate over whether carbohydrates or sugar are the true culprits behind modern health issues has long stirred controversy among nutrition experts, diet enthusiasts, and the general public alike.
More contentious is whether ketogenic diets have any utility for exercise performance, especially among high-level athletes. Ketogenic diets are characterized as being very low in carbohydrates (less than 50 grams per day), modest in protein, and high in fat (more than 80% of total energy intake). What are ketones?
Welcome to the Physiology Friday newsletter. We talk about the ketogenic diet as a metabolic therapy for type 1 diabetes. Physiologically Speaking is a reader-supported publication. This irregular sleep pattern misaligns circadian rhythms and disrupts physiology. on Tuesday, and 7 on Wednesday.
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Many people carefully adjust their diets, follow specific exercise routines, and track their sleep with wearable devices, all in the pursuit of becoming the healthiest version of themselves. How can you apply these findings?
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Blood glucose control Resistance exercise training can reduce fasting glucose by 2–5 mg/dL in adults with prediabetes and type 2 diabetes but doesn’t seem to reduce blood glucose in healthy adults (not surprising).
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. Blood glucose control Resistance exercise training can reduce fasting glucose by 2–5 mg/dL in adults with prediabetes and type 2 diabetes but doesn’t seem to reduce blood glucose in healthy adults (not surprising).
In this week's post, we take a deep dive into the latest study showing that red meat intake is associated with type 2 diabetes…one that caused quite a stir in the media. Physiologically Speaking is a reader-supported publication. More meat, more diabetes? Could red meat intake be causing diabetes? Read more
Welcome to the Physiology Friday newsletter. On Wednesday, I published a post on the philosophy and physiology of an “exercise pill.” Physiologically Speaking is a reader-supported publication. When consumed via the diet (or used as a supplement), creatine increases our body’s phosphocreatine (PCr) stores.
Physiologically Speaking is a reader-supported publication. Tl;dr: Continuous glucose monitors can be extremely insightful to use for a month or two, but unless you have diabetes or are at a high risk of having diabetes, it’s probably not something you need to use all the time. Do you follow an 80-20 routine with a bike?
Both lactate and BHB naturally increase in response to physiological stresses—lactate during intense exercise and BHB during prolonged fasting or low-carbohydrate diets. At the same time, BHB levels rise more gradually, paralleling the ketogenic state induced by fasting or ketogenic diets.
Physiologically Speaking is a reader-supported publication. Selecting the optimal diet. For example, here’s a piece focusing on the findings from an analysis of 400+ diet books going back to the 1860s. Another study found that they don’t get diabetes and kidney diseases (the ninth leading cause of death).
Welcome to the Physiology Friday newsletter. Physiologically Speaking is a reader-supported publication. The weekend warrior activity pattern was associated with a 23% lower risk for hypertension, a 43% lower risk for diabetes, a 45% lower risk for obesity, and a 43% lower risk for sleep apnea.
Welcome to the Physiology Friday newsletter. ICYMI On Wednesday, I published a post discussing the different metabolic effects of the ketogenic diet and exogenous ketones during exercise. Physiologically Speaking is a reader-supported publication.
Focusing your efforts on preventing type 2 diabetes, however, is arguably one of the best strategies you can use and is likely to have the biggest gains. When I say diabetes, I am referring to type 2 diabetes, not type 1 diabetes. Having diabetes is very likely to shorten your life. Here’s why. That is huge!
These indirect and direct factors can lead to obesity, hypertension, hyperlipidemia, diabetes, ischemia with no obstructive coronary artery disease (INOCA), CAD, myocardial infarction (MI), and stroke via the hypothalamic-pituitary-adrenal axis, sympathetic-adrenal-medullary system, sympathetic nervous system, and hypoestrogenemia.
6 [link] Insufficient sleep has been linked to a greater risk for several health conditions including obesity, diabetes, hypertension, and cognitive decline. 21 22 23 It is worth noting that the literature here is still in its infancy, as research into sex differences is currently an emerging area in physiology.
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