Stroke survivors face much higher odds for dementia, research finds
Medical Xpress - Cardiology
DECEMBER 6, 2024
Stroke survivors have an 80% increased risk of dementia compared to people who've never suffered a stroke, a new study finds.
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Biomarker tied to premature cell aging may signal stroke, dementia, late-life depression
Science Daily - Stroke
JANUARY 30, 2025
Shorter protective caps on chromosomes called telomeres, a proposed marker of accelerated biological cell aging, may be associated with an increased risk of stroke, dementia and late-life depression, according to an analysis of more than 356,000 people in the United Kingdom.
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Midlife Choices May Offset Genetic Risk for Dementia, Stroke, Late-Life Depression
Med Page Today
NOVEMBER 8, 2024
(MedPage Today) -- Healthier lifestyle behaviors in midlife were linked with better outcomes in people with genetic predisposition for age-related brain diseases, longitudinal data from the U.K. Biobank showed. Over about 12 years of follow-up.
Does Early Rhythm Control for Atrial Fibrillation Reduce Dementia Risk in Patients with Prior Stroke?
NEJM Journal Watch - Cardiology
MAY 22, 2024
Observational data from South Korea show an association between early rhythm control and lower risk for dementia in stroke survivors.
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The heart health, dementia link: 7 things to know
Becker's Hospital Review - Cardiology
OCTOBER 10, 2024
Addressing heart health earlier in life may affect and even deter dementia risk later in life, according to research published by The American Heart Association Oct. 10 in Stroke.
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Our Brains Are Getting Bigger, MRIs Show
Med Page Today
MARCH 28, 2024
From the 1930s to 1970s, brain volumes and cortical surface area of people who had neither dementia nor stroke became progressively larger, reported Charles. (MedPage Today) -- Human brains appeared to be getting bigger, temporal trends showed.
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Study finds high prevalence of hidden brain changes in people with heart disease
Science Daily - Heart Disease
MARCH 26, 2024
A new analysis involving over 13,000 people has found changes to blood vessels in the brain that can increase the risk of stroke and dementia are common in people with a range of heart conditions, regardless of whether they have experienced a stroke.
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Reliability and Validity of Self‐Reported Risk Factors for Stroke and Dementia
Journal of the American Heart Association
MARCH 21, 2025
BackgroundStroke and dementia are leading causes of mortality and can be prevented through risk factor management. Reliability was assessed using F1 scores, and used surveyweighted Coxproportional hazards models evaluated associations with stroke or dementiarelated mortality. Journal of the American Heart Association, Ahead of Print.
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Live well, think well: Research shows healthy habits tied to brain health
Science Daily - Heart Disease
OCTOBER 23, 2024
In middle-aged people, having risk factors like blood pressure, blood sugar and cholesterol that are not well-controlled combined with not following certain healthy habits including exercise, diet and sleep, are linked to a higher risk of stroke, dementia or depression later in life, according to a new study.
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Atrial fibrillation: A review
Science Daily - Heart Disease
DECEMBER 16, 2024
Significant complications associated with this condition include ischemic stroke, heart failure, myocardial infarction, chronic kidney disease, dementia and mortality. In the U.S., In a new review article scientists summarize the current evidence regarding the epidemiology, pathophysiology, diagnosis and management of AF.
Predicting cardiac arrhythmia 30 minutes before it happens
Science Daily - Heart Disease
APRIL 22, 2024
This irregular heartbeat is associated with increased risks of heart failure, dementia and stroke. Atrial fibrillation is the most common cardiac arrhythmia worldwide with around 59 million people concerned in 2019. It constitutes a significant burden to healthcare systems, making its early detection and treatment a major goal.
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LDL Cholesterol Lowering: Is There a Risk for Dementia and Hemorrhagic Stroke?
American College of Cardiology
MAY 22, 2024
Reduction in low-density lipoprotein cholesterol (LDL-C) levels has consistently demonstrated a reduced risk of atherosclerotic cardiovascular disease (ASCVD). There is extensive evidence from randomized trials that demonstrates the effectiveness of lipid-lowering agents in reducing ASCVD-related events.
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Study finds high prevalence of hidden brain changes in people with heart disease
Medical Xpress - Cardiology
MARCH 26, 2024
A new analysis involving over 13,000 people has found changes to blood vessels in the brain that can increase the risk of stroke and dementia are common in people with a range of heart conditions, regardless of whether they have experienced a stroke.
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Heart failure, atrial fibrillation and coronary heart disease linked to cognitive impairment
Medical Xpress - Cardiology
OCTOBER 10, 2024
Three common cardiovascular diseases in adults—heart failure, atrial fibrillation and coronary heart disease—are linked to cognitive impairment and increased risk of dementia, according to "Cardiac Contributions to Brain Health," a new scientific statement from the American Heart Association published today in the journal, Stroke.
AF and Dementia
Dr. Sanjay Gupta
JANUARY 17, 2022
The big risk of AF is thought to be an increased risk of strokes and therefore when we see patients above the age of 65, or patients who carry comorbidities we recommend lifelong anticoagulation and as long as the patient is anticoagulated, we feel that the patient is safe. We never really think beyond the risk of stroke.
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The Potential Risks of GLP-1s
CardiacWire
JANUARY 22, 2025
As expected, GLP-1s reduced MI risk by 9%, cardiac arrest by 22%, incident HF by 11%, ischemic stroke by 7%, and hemorrhagic stroke by 14%. GLP-1s also led to an 8% lower risk of dementia and 12% lower risk of Alzheimer’s disease. The less good news? Theres still no free lunch in healthcare.
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Abstract WP269: Predicting post-stroke all-cause dementia incidence using machine learning models and electronic health record data
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP269-AWP269, February 1, 2025. Introduction:All-cause dementia remains a significant public health concern, with stroke recognized as a key risk factor. This study included patients aged 20+ who experienced their first stroke (any type) in 2018 (baseline). The sample was 48.4%
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Abstract WP319: Reliability and validity of self-reported risk factors for stroke and dementia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP319-AWP319, February 1, 2025. Introduction:Stroke and dementia are among the leading causes of mortality globally. This can be mitigated through targeting modifiable risk factors.
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High biological age may increase the risk of dementia and stroke
Science Daily - Stroke
NOVEMBER 6, 2023
People who have a higher biological age than their actual chronological age have a significantly increased risk of stroke and dementia, especially vascular dementia.
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Protein ADM Mediates Loneliness’ Association With CVD, Stroke, Mortality
HCPLive
JANUARY 6, 2025
A study found that the protein ADM significantly mediates loneliness' link to cardiovascular disease, stroke, dementia, and mortality, emphasizing loneliness health risks.
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Research finds risk of dementia nearly three times higher the first year after a stroke
Medical Xpress - Cardiology
FEBRUARY 1, 2024
Having a stroke may significantly increase the risk of developing dementia. The risk of dementia was the highest in the first year after a stroke and remained elevated over a period of 20 years, according to preliminary research presented at the American Stroke Association's International Stroke Conference 2024, held in Phoenix, Feb.
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Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia: Dementia Series
Hypertension Journal
NOVEMBER 29, 2023
It is the main cause of lacunar stroke and a major source of vascular contributions to cognitive impairment and dementia. Strongly associated with age and hypertension, small vessel disease is found at autopsy in over 50% of people aged ≥65 years, with a spectrum of clinical manifestations.
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64 Association of Rare NOTCH3 Variants With Prevalent and Incident Stroke and Dementia in the General Population
Journal of the American Heart Association
FEBRUARY 13, 2024
BackgroundIt is uncertain whether rareNOTCH3variants are associated with stroke and dementia in the general population and whether they lead to alterations in cognitive function. For the follow‐up analysis, 1007 participants were included in the stroke analysis, and 870 participants in the dementia analysis.
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Cerebral Small Vessel Disease: Early-Life Antecedents and Long-Term Implications for the Brain, Aging, Stroke, and Dementia: Dementia Series
Hypertension Journal
SEPTEMBER 21, 2023
Cerebral small vessel disease is common in older adults and increases the risk of stroke, cognitive impairment, and dementia. While often attributed to midlife vascular risk factors such as hypertension, factors from earlier in life may contribute to later small vessel disease risk.
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Abstract TMP92: Dementia and Cognitive Impairment in Stroke: A Systematic Review and Meta-Analysis of Reperfusion Treatment Outcomes
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATMP92-ATMP92, February 1, 2024. Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. EVT in dementia patients in one study found only increased odds of ICH (adjusted OR 1.57
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Impact of Sleep Disorders and Disturbed Sleep on Brain Health: A Scientific Statement From the American Heart Association
Stroke Journal
JANUARY 18, 2024
Stroke, Ahead of Print. Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease–related dementias.
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90 Lab-grown 'small blood vessels' point to potential treatment for major cause of stroke and vascular dementia
Science Daily - Heart Disease
NOVEMBER 16, 2023
Scientists have grown small blood vessel-like models in the lab and used them to show how damage to the scaffolding that supports these vessels can cause them to leak, leading to conditions such as vascular dementia and stroke.
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Adverse Social Determinants of Health Linked to Treatment-resistant Hypertension in Black Americans
DAIC
MAY 16, 2024
Additionally, this risk was higher among Black American adults than white American adults, according to a study funded by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. Over a period of 9.5 years 24% of Black adults developed the condition compared with 15.9% of white adults.
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Do Statins Cause Dementia?
Dr. Paddy Barrett
SEPTEMBER 19, 2023
I am going to start with the answer to the question of whether statins cause dementia and then provide the details backing up my answer. Statins do not cause dementia. But if you are someone who thinks that statins do cause dementia and you need to see the evidence to refute that claim, then read on. The answer is: No.
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52 Abstract TP123: Physician perspectives on acute evaluation and determining goals of stroke care for people living with dementia or disability: Results from the SEED mixed-methods study
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP123-ATP123, February 1, 2025. Background:Around one in three strokes are experienced by people living with disability or dementia (PLWD), yet there is currently no consensus to guide physicians in evaluating baseline status in this patient population and determining goals of care.
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Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle?Aged Individuals Without Stroke or Dementia
Journal of the American Heart Association
DECEMBER 29, 2023
The authors tested the hypothesis that suboptimal sleep duration is associated with poorer neuroimaging brain health profiles in asymptomatic middle‐aged adults.Methods and ResultsThe authors conducted a prospective magnetic resonance neuroimaging study in middle‐aged individuals without stroke or dementia enrolled in the UK Biobank.
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2023 ESH Hypertension Guideline Update: Bringing Us Closer Together Across the Pond
American College of Cardiology
FEBRUARY 5, 2024
Hypertension represents a major modifiable risk factor for coronary artery disease (CAD), heart failure (HF), stroke, chronic kidney disease (CKD), and dementia.
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Five Things Every Middle Aged Adult Should Know About Sleep & Heart Disease.
Dr. Paddy Barrett
AUGUST 30, 2024
Poor Sleep Might Eliminate The Benefits Of Exercise & Dementia. High levels of aerobic fitness are closely linked to lower rates of future dementia 1. Regular physical activity is arguably one of the biggest factors preventing dementia. When it comes to preventing dementia, this could not be truer.
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Shorter Telomere Length Linked to Increased Risk of Stroke, Dementia, Depression
HCPLive
FEBRUARY 3, 2025
A study indicated that telomere length may not directly cause age-related brain diseases, but healthier lifestyles could counteract the harmful effects of shorter telomeres.
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Abstract TP208: Pre-Existing Dementia Should Not Be Independently Associated Short-Term Functional Outcome in Patients With Acute Ischemic Stroke: A Sub-Analysis of the PASTA Registry Study
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP208-ATP208, February 1, 2024. Background:The aging of the population is associated with an increasing number of stroke patients with pre-existing dementia. PED was defined as any type of dementia that was present prior to the index stroke. women), 86 (17.4%) had PED.
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Cardiac Contributions to Brain Health: A Scientific Statement From the American Heart Association
Stroke Journal
OCTOBER 10, 2024
Stroke, Ahead of Print. The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Previous scientific statements have addressed the association between cardiac diseases and stroke.
Abstract TP298: Patterns of In-Hospital Prescribing of Post-Stroke Antidepressants in a Comprehensive Stroke Center
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP298-ATP298, February 1, 2025. Background:Post stroke depression (PSD) affects over 33% of stroke survivors with the highest incidence occurring in the first year after stroke. Predictors of PSD include stroke severity, cognitive impairment, age, and physical disability.
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Use of lipid-lowering therapy after ischaemic stroke and expected benefit from intensification of treatment
Open Heart
APRIL 22, 2022
We examined use of lipid-lowering therapy (LLT) following ischaemic stroke, and estimated benefits from guideline-based up-titration of LLT. Patients with prestroke dementia and cardioembolic stroke aetiology were less likely to receive LLT. Results At discharge, 92% received LLT (97% statin monotherapy). to –0.9)
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52 Abstract WP51: Non-Traumatic Intracranial Hemorrhage and Risk of Incident Dementia
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP51-AWP51, February 1, 2025. The outcome was an incident diagnosis of dementia. In the primary analysis, we used Cox regression to study the risk of dementia after any intracranial hemorrhage, after adjusting for demographics and comorbidities. During a median follow up of 5.6
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Epidemiology, Pathophysiology, and Imaging of Atherosclerotic Intracranial Disease
Stroke Journal
JANUARY 21, 2024
Stroke, Volume 55, Issue 2 , Page 311-323, February 1, 2024. Intracranial atherosclerotic disease (ICAD) is one of the most common causes of stroke worldwide. In addition to stroke, ICAD increases the risk of dementia and cognitive decline, magnifying ICAD societal burden.
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74 Non-Traumatic Intracranial Hemorrhage and Risk of Incident Dementia in U.S. Medicare Beneficiaries
Stroke Journal
JANUARY 30, 2025
Stroke, Ahead of Print. The outcome was a first-ever diagnosis of dementia. We excluded patients who had prevalent intracranial hemorrhage or dementia, to ensure that only incident cases were counted in our analyses. The cumulative incidence rate of dementia was 8.6% (IQR, 8.1-8.9) During a median follow up of 5.6
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Abstract TP22: Delirium, Infection, and Risk of Dementia in Patients With and Without Cerebral Small Vessel Disease
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP22-ATP22, February 1, 2024. Background:The increased risk of dementia after delirium and infection might be influenced by cerebral small vessel disease-SVD. Dementia was diagnosed using clinical/cognitive assessment, medical records and death certificates. vs. 3.41,1.91-6.09,
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Abstract 72: Association Between Stroke Subtype and Post-Stroke Cognitive Decline: A Pooled Cohort Analysis of Four Cohorts
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page A72-A72, February 1, 2024. Introduction:Associations between stroke subtype and post-stroke cognitive decline are unclear. Of the ischemic strokes, 22% were small-vessel occlusion, 8% large artery atherosclerosis, 21% cardioembolic, and 49% cryptogenic/other determined etiology.
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Abstract WMP18: The Association between Cerebral Microbleed Patterns and Incident Dementia: The ARIC-Neurocognitive Study
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP18-AWMP18, February 1, 2025. Background:Cerebral microbleeds (CMBs) are associated with incident dementia, but the impact of specific CMB patterns is unclear. Compared to individuals with no CMBs, presence of any CMBs was associated with an increased risk of dementia (Table 2).
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