Stroke survivors face much higher odds for dementia, research finds
Medical Xpress - Cardiology
DECEMBER 6, 2024
Stroke survivors have an 80% increased risk of dementia compared to people who've never suffered a stroke, a new study finds.
Genetic risk-factor overlap between Alzheimer's disease, and all-cause and vascular dementias
Science Daily - Stroke
SEPTEMBER 17, 2024
Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.
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Midlife Choices May Offset Genetic Risk for Dementia, Stroke, Late-Life Depression
Med Page Today
NOVEMBER 8, 2024
(MedPage Today) -- Healthier lifestyle behaviors in midlife were linked with better outcomes in people with genetic predisposition for age-related brain diseases, longitudinal data from the U.K. Biobank showed. Over about 12 years of follow-up.
The heart health, dementia link: 7 things to know
Becker's Hospital Review - Cardiology
OCTOBER 10, 2024
Addressing heart health earlier in life may affect and even deter dementia risk later in life, according to research published by The American Heart Association Oct. 10 in Stroke.
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Does Early Rhythm Control for Atrial Fibrillation Reduce Dementia Risk in Patients with Prior Stroke?
NEJM Journal Watch - Cardiology
MAY 22, 2024
Observational data from South Korea show an association between early rhythm control and lower risk for dementia in stroke survivors.
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Our Brains Are Getting Bigger, MRIs Show
Med Page Today
MARCH 28, 2024
From the 1930s to 1970s, brain volumes and cortical surface area of people who had neither dementia nor stroke became progressively larger, reported Charles. (MedPage Today) -- Human brains appeared to be getting bigger, temporal trends showed.
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Study finds high prevalence of hidden brain changes in people with heart disease
Science Daily - Heart Disease
MARCH 26, 2024
A new analysis involving over 13,000 people has found changes to blood vessels in the brain that can increase the risk of stroke and dementia are common in people with a range of heart conditions, regardless of whether they have experienced a stroke.
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AF and Dementia
Dr. Sanjay Gupta
JANUARY 17, 2022
The big risk of AF is thought to be an increased risk of strokes and therefore when we see patients above the age of 65, or patients who carry comorbidities we recommend lifelong anticoagulation and as long as the patient is anticoagulated, we feel that the patient is safe. We never really think beyond the risk of stroke.
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Study finds high prevalence of hidden brain changes in people with heart disease
Medical Xpress - Cardiology
MARCH 26, 2024
A new analysis involving over 13,000 people has found changes to blood vessels in the brain that can increase the risk of stroke and dementia are common in people with a range of heart conditions, regardless of whether they have experienced a stroke.
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Cerebral Small Vessel Disease, Hypertension, and Vascular Contributions to Cognitive Impairment and Dementia: Dementia Series
Hypertension Journal
NOVEMBER 29, 2023
It is the main cause of lacunar stroke and a major source of vascular contributions to cognitive impairment and dementia. Strongly associated with age and hypertension, small vessel disease is found at autopsy in over 50% of people aged ≥65 years, with a spectrum of clinical manifestations.
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Heart failure, atrial fibrillation and coronary heart disease linked to cognitive impairment
Medical Xpress - Cardiology
OCTOBER 10, 2024
Three common cardiovascular diseases in adults—heart failure, atrial fibrillation and coronary heart disease—are linked to cognitive impairment and increased risk of dementia, according to "Cardiac Contributions to Brain Health," a new scientific statement from the American Heart Association published today in the journal, Stroke.
LDL Cholesterol Lowering: Is There a Risk for Dementia and Hemorrhagic Stroke?
American College of Cardiology
MAY 22, 2024
Reduction in low-density lipoprotein cholesterol (LDL-C) levels has consistently demonstrated a reduced risk of atherosclerotic cardiovascular disease (ASCVD). There is extensive evidence from randomized trials that demonstrates the effectiveness of lipid-lowering agents in reducing ASCVD-related events.
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Research finds risk of dementia nearly three times higher the first year after a stroke
Medical Xpress - Cardiology
FEBRUARY 1, 2024
Having a stroke may significantly increase the risk of developing dementia. The risk of dementia was the highest in the first year after a stroke and remained elevated over a period of 20 years, according to preliminary research presented at the American Stroke Association's International Stroke Conference 2024, held in Phoenix, Feb.
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40 Association of Rare NOTCH3 Variants With Prevalent and Incident Stroke and Dementia in the General Population
Journal of the American Heart Association
FEBRUARY 13, 2024
BackgroundIt is uncertain whether rareNOTCH3variants are associated with stroke and dementia in the general population and whether they lead to alterations in cognitive function. For the follow‐up analysis, 1007 participants were included in the stroke analysis, and 870 participants in the dementia analysis.
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High biological age may increase the risk of dementia and stroke
Science Daily - Stroke
NOVEMBER 6, 2023
People who have a higher biological age than their actual chronological age have a significantly increased risk of stroke and dementia, especially vascular dementia.
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Do Statins Cause Dementia?
Dr. Paddy Barrett
SEPTEMBER 19, 2023
I am going to start with the answer to the question of whether statins cause dementia and then provide the details backing up my answer. Statins do not cause dementia. But if you are someone who thinks that statins do cause dementia and you need to see the evidence to refute that claim, then read on. The answer is: No.
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Predicting cardiac arrhythmia 30 minutes before it happens
Science Daily - Heart Disease
APRIL 22, 2024
This irregular heartbeat is associated with increased risks of heart failure, dementia and stroke. Atrial fibrillation is the most common cardiac arrhythmia worldwide with around 59 million people concerned in 2019. It constitutes a significant burden to healthcare systems, making its early detection and treatment a major goal.
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Live well, think well: Research shows healthy habits tied to brain health
Science Daily - Heart Disease
OCTOBER 23, 2024
In middle-aged people, having risk factors like blood pressure, blood sugar and cholesterol that are not well-controlled combined with not following certain healthy habits including exercise, diet and sleep, are linked to a higher risk of stroke, dementia or depression later in life, according to a new study.
Abstract TMP92: Dementia and Cognitive Impairment in Stroke: A Systematic Review and Meta-Analysis of Reperfusion Treatment Outcomes
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATMP92-ATMP92, February 1, 2024. Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. EVT in dementia patients in one study found only increased odds of ICH (adjusted OR 1.57
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Impact of Sleep Disorders and Disturbed Sleep on Brain Health: A Scientific Statement From the American Heart Association
Stroke Journal
JANUARY 18, 2024
Stroke, Ahead of Print. Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease–related dementias.
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Cerebral Small Vessel Disease: Early-Life Antecedents and Long-Term Implications for the Brain, Aging, Stroke, and Dementia: Dementia Series
Hypertension Journal
SEPTEMBER 21, 2023
Cerebral small vessel disease is common in older adults and increases the risk of stroke, cognitive impairment, and dementia. While often attributed to midlife vascular risk factors such as hypertension, factors from earlier in life may contribute to later small vessel disease risk.
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Atrial fibrillation: A review
Science Daily - Heart Disease
DECEMBER 16, 2024
Significant complications associated with this condition include ischemic stroke, heart failure, myocardial infarction, chronic kidney disease, dementia and mortality. In the U.S., In a new review article scientists summarize the current evidence regarding the epidemiology, pathophysiology, diagnosis and management of AF.
2023 ESH Hypertension Guideline Update: Bringing Us Closer Together Across the Pond
American College of Cardiology
FEBRUARY 5, 2024
Hypertension represents a major modifiable risk factor for coronary artery disease (CAD), heart failure (HF), stroke, chronic kidney disease (CKD), and dementia.
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Suboptimal Sleep Duration Is Associated With Poorer Neuroimaging Brain Health Profiles in Middle?Aged Individuals Without Stroke or Dementia
Journal of the American Heart Association
DECEMBER 29, 2023
The authors tested the hypothesis that suboptimal sleep duration is associated with poorer neuroimaging brain health profiles in asymptomatic middle‐aged adults.Methods and ResultsThe authors conducted a prospective magnetic resonance neuroimaging study in middle‐aged individuals without stroke or dementia enrolled in the UK Biobank.
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Abstract TP22: Delirium, Infection, and Risk of Dementia in Patients With and Without Cerebral Small Vessel Disease
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP22-ATP22, February 1, 2024. Background:The increased risk of dementia after delirium and infection might be influenced by cerebral small vessel disease-SVD. Dementia was diagnosed using clinical/cognitive assessment, medical records and death certificates. vs. 3.41,1.91-6.09,
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40 Lab-grown 'small blood vessels' point to potential treatment for major cause of stroke and vascular dementia
Science Daily - Heart Disease
NOVEMBER 16, 2023
Scientists have grown small blood vessel-like models in the lab and used them to show how damage to the scaffolding that supports these vessels can cause them to leak, leading to conditions such as vascular dementia and stroke.
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Abstract TP208: Pre-Existing Dementia Should Not Be Independently Associated Short-Term Functional Outcome in Patients With Acute Ischemic Stroke: A Sub-Analysis of the PASTA Registry Study
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP208-ATP208, February 1, 2024. Background:The aging of the population is associated with an increasing number of stroke patients with pre-existing dementia. PED was defined as any type of dementia that was present prior to the index stroke. women), 86 (17.4%) had PED.
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Abstract WMP16: Multi-Marker Cerebral Small Vessel Disease Score and Risk of Incident Dementia in the Framingham Heart Study
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWMP16-AWMP16, February 1, 2024. Background:Individual magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD) are associated with impaired cognition and dementia but may not reflect the overall burden of CSVD. Over a median follow-up time of 6.4 years (Q1-Q3: 4.6-11.3),
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Five Things Every Middle Aged Adult Should Know About Sleep & Heart Disease.
Dr. Paddy Barrett
AUGUST 30, 2024
Poor Sleep Might Eliminate The Benefits Of Exercise & Dementia. High levels of aerobic fitness are closely linked to lower rates of future dementia 1. Regular physical activity is arguably one of the biggest factors preventing dementia. When it comes to preventing dementia, this could not be truer.
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105 New cause of Alzheimer's, vascular dementia
Science Daily - Stroke
SEPTEMBER 5, 2023
Researchers have discovered a new avenue of cell death in Alzheimer's disease and vascular dementia. The study reveals for the first time that a form of cell death known as ferroptosis -- caused by a buildup of iron in cells -- destroys microglia cells in cases of Alzheimer's and vascular dementia.
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40 Abstract WMP13: The Modifying Effects of Psychosocial Health on the Association Between Cerebrovascular Health and Dementia Risk: The Atherosclerosis Risk in Communities (ARIC) Neurocognitive Study
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWMP13-AWMP13, February 1, 2024. Introduction:Associations between magnetic resonance imaging (MRI) markers of vascular pathology and dementia risk in older adults have been established, but it remains less clear how lifestyle factors may modify this association. years) with ongoing surveillance.
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Adverse Social Determinants of Health Linked to Treatment-resistant Hypertension in Black Americans
DAIC
MAY 16, 2024
Additionally, this risk was higher among Black American adults than white American adults, according to a study funded by the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health. Over a period of 9.5 years 24% of Black adults developed the condition compared with 15.9% of white adults.
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Cardiac Contributions to Brain Health: A Scientific Statement From the American Heart Association
Stroke Journal
OCTOBER 10, 2024
Stroke, Ahead of Print. The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Previous scientific statements have addressed the association between cardiac diseases and stroke.
Epidemiology, Pathophysiology, and Imaging of Atherosclerotic Intracranial Disease
Stroke Journal
JANUARY 21, 2024
Stroke, Volume 55, Issue 2 , Page 311-323, February 1, 2024. Intracranial atherosclerotic disease (ICAD) is one of the most common causes of stroke worldwide. In addition to stroke, ICAD increases the risk of dementia and cognitive decline, magnifying ICAD societal burden.
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Key cause of restricted blood flow to the brain in vascular dementia
Science Daily - Stroke
AUGUST 7, 2023
Researchers have uncovered a potential route to developing the first ever drug treatments for vascular dementia that directly target a cause of the condition. The research has shed light on how high blood pressure causes changes to arteries in the brain, a process that leads to the devastating condition.
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Abstract 72: Association Between Stroke Subtype and Post-Stroke Cognitive Decline: A Pooled Cohort Analysis of Four Cohorts
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page A72-A72, February 1, 2024. Introduction:Associations between stroke subtype and post-stroke cognitive decline are unclear. Of the ischemic strokes, 22% were small-vessel occlusion, 8% large artery atherosclerosis, 21% cardioembolic, and 49% cryptogenic/other determined etiology.
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Use of lipid-lowering therapy after ischaemic stroke and expected benefit from intensification of treatment
Open Heart
APRIL 22, 2022
We examined use of lipid-lowering therapy (LLT) following ischaemic stroke, and estimated benefits from guideline-based up-titration of LLT. Patients with prestroke dementia and cardioembolic stroke aetiology were less likely to receive LLT. Results At discharge, 92% received LLT (97% statin monotherapy). to –0.9)
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Living Past 100: Insights from Centenarians on a Long, Healthy Life
Dr. Paddy Barrett
MARCH 23, 2024
It’s not that they don’t get cardiovascular disease, cancer or dementia; they just get it way later than everyone else. When broken down by disease category, cardiovascular disease, cancer, dementia, stroke, osteoarthritis, hypertension and stroke, the pattern is the same. J Gerontol A Biol Sci Med Sci.
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Why Exercise Is The Key To A Longer Life
Dr. Paddy Barrett
AUGUST 23, 2024
While I have covered many of these fitness measures individually in previous posts, I wanted to summarise these metrics and how they relate to living longer and preventing major diseases such as cardiovascular disease, cancer and dementia. A higher daily step count is also linked to significantly lower cancer, stroke and heart disease rates.
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Abstract WMP22: Higher Burden of Cerebral Small Vessel Disease is Associated With Risk of Incident Stroke in Community-Dwelling Individuals
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWMP22-AWMP22, February 1, 2024. Background:Mild manifestations of individual cerebral small vessel disease (CSVD) markers are common and may not denote increased risk, but high CSVD burden identifies individuals at increased risk of stroke and dementia. Over a median follow-up of 8.2
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40 High?Sensitivity Cardiac Troponin T and Cognitive Function Over 12?Months After Stroke—Results of the DEMDAS Study
Journal of the American Heart Association
MARCH 8, 2024
Whether hs‐cTn is associated with domain‐specific cognitive decline and SVD burden in patients with stroke remains unknown.Methods and ResultsWe analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]‐Mechanisms of Dementia after Stroke) study.
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Abstract TP238: Blood Brain Barrier Injury Detected in the Serum of Patients With a History of Stroke and Transient Ischemic Attack
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP238-ATP238, February 1, 2024. Introduction:Stroke and transient ischemic attack (TIA) increase risk for cognitive impairment and dementia. Both subjects with stroke and subjects with TIA had increased serum PDGFRβ compared to those without history of CVA (6608.4 pg/mL and 5337.0
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Pathophysiology of cerebral small vessel disease: a journey through recent discoveries
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
cSVD accounts for approximately 25% of ischemic strokes and the vast majority of spontaneous intracerebral hemorrhage and is also the most important vascular contributor to dementia. Despite its high prevalence and potentially long therapeutic window, there are still no mechanism-based treatments.
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Abstract WP320: Microemboli Model of Vascular Cognitive Impairment/Dementia (VCID) Presents With Long-Term Brain Tissue Hypoxia: Relevance to Endothelin-1 (ET-1)
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWP320-AWP320, February 1, 2024. Diabetes doubles the risk of VCID but the underlying reasons remain unclear.
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