Remove Dementia Remove Stenosis Remove Strokes
article thumbnail

Epidemiology, Pathophysiology, and Imaging of Atherosclerotic Intracranial Disease

Stroke Journal

Stroke, Volume 55, Issue 2 , Page 311-323, February 1, 2024. Intracranial atherosclerotic disease (ICAD) is one of the most common causes of stroke worldwide. In addition to stroke, ICAD increases the risk of dementia and cognitive decline, magnifying ICAD societal burden.

article thumbnail

Abstract TP215: Impact of Carotid Stenosis on Cerebral Glucose Metabolism

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATP215-ATP215, February 1, 2025. Background:Carotid stenosis has been associated with stroke and cognitive impairment. It remains unclear if hypometablism, a marker for neurodegeneration, may be in the mechanistic pathway in the association between carotid stenosis and cognitive decline.

article thumbnail

Randomized Secondary Prevention Trials in Participants With Symptomatic Intracranial Atherosclerotic Stenosis

Stroke Journal

Stroke, Volume 55, Issue 2 , Page 324-334, February 1, 2024. Intracranial atherosclerotic stenosis is a prevalent cause of ischemic stroke worldwide. This review focuses on randomized secondary prevention trials involving antithrombotic therapy, endovascular treatment, open surgical therapy, and remote ischemic conditioning.

article thumbnail

Abstract WP383: Targeting CD38 to Alleviate Brain Endothelial Cell Dysfunction and Cognitive Impairment in Vascular Dementia

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page AWP383-AWP383, February 1, 2025. Background and purpose:Vascular dementia (VaD) is one of the most common causes of cognitive decline, primarily resulting from cerebrovascular damage. CBF, BBB permeability, and cognitive function were evaluated.

article thumbnail

Abstract TP248: Factors associated with Silent Brain Infarcts after the Middle Cerebral Artery Stenting or Balloon Angioplasty

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATP248-ATP248, February 1, 2025. Objective:Silent brain infarctions (SBIs), which appear as dot-like lesions on diffusion-weighted imaging (DWI) after endovascular procedures, are associated with an increased risk of subsequent stroke, dementia and cognitive decline. 14.74], p=0.012).

article thumbnail

Abstract TP349: Deleted NLRP3 inflammasome improves functional outcome and improves cerebral blood flow in an experimental model of Vascular Cognitive Impairment and Dementia

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATP349-ATP349, February 1, 2025. Background:Inflammation, a key player in both acute and chronic cerebral ischemia, is activated in brain tissues by bilateral carotid stenosis (BCAS)- induced chronic cerebral hypoperfusion.

article thumbnail

Abstract TP229: Comparison of 30-Day Readmission Rates in Elective and Nonelective Carotid Endarterectomy and Carotid Artery Stenting: A Nationwide Cohort Study

Stroke Journal

Stroke, Volume 56, Issue Suppl_1 , Page ATP229-ATP229, February 1, 2025. Frequently, carotid artery stenosis is found during stroke workup and these patients undergo revascularization during the same nonelective admission.