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Dementia Risk Factors Stroke 
Science Daily - Stroke
SEPTEMBER 17, 2024
Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.
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Science Daily - Stroke
APRIL 3, 2025
In a new extensive systematic review, researchers identified 17 modifiable risk factors that are shared by stroke, dementia, and late-life depression. Modifying any one of them can reduce your risk of all three conditions. The findings provide evidence to inform novel tools such as the Brain Care Score.
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Science Daily - Heart Disease
OCTOBER 23, 2024
In middle-aged people, having risk factors like blood pressure, blood sugar and cholesterol that are not well-controlled combined with not following certain healthy habits including exercise, diet and sleep, are linked to a higher risk of stroke, dementia or depression later in life, according to a new study.
123 
Frontiers in Cardiovascular Medicine
APRIL 3, 2025
BackgroundNon-valvular atrial fibrillation (NVAF) significantly increases ischemic stroke and systemic embolism (SE) risks. Despite the proven efficacy of oral anticoagulants (OAC) in reducing these risks, their underutilization highlights a gap in clinical practice. for stroke/SE-specific, p-value<0.001).
American College of Cardiology
FEBRUARY 5, 2024
Hypertension represents a major modifiable risk factor for coronary artery disease (CAD), heart failure (HF), stroke, chronic kidney disease (CKD), and dementia.
75 
Dr. Paddy Barrett
AUGUST 30, 2024
Poor Sleep Might Eliminate The Benefits Of Exercise & Dementia. High levels of aerobic fitness are closely linked to lower rates of future dementia 1. Regular physical activity is arguably one of the biggest factors preventing dementia. When it comes to preventing dementia, this could not be truer.
111 
Hypertension Journal
SEPTEMBER 21, 2023
Cerebral small vessel disease is common in older adults and increases the risk of stroke, cognitive impairment, and dementia. While often attributed to midlife vascular risk factors such as hypertension, factors from earlier in life may contribute to later small vessel disease risk.
40 
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP269-AWP269, February 1, 2025. Introduction:All-cause dementia remains a significant public health concern, with stroke recognized as a key risk factor. This study included patients aged 20+ who experienced their first stroke (any type) in 2018 (baseline).
40 
Journal of the American Heart Association
FEBRUARY 13, 2024
BackgroundIt is uncertain whether rareNOTCH3variants are associated with stroke and dementia in the general population and whether they lead to alterations in cognitive function. For the follow‐up analysis, 1007 participants were included in the stroke analysis, and 870 participants in the dementia analysis.
40 
Science Daily - Stroke
DECEMBER 20, 2023
Signs of injury to the brain's white matter called white matter hyperintensities, as seen on brain scans, may be tied more strongly to vascular risk factors, brain shrinkage, and other markers of dementia in former tackle football players than in those who did not play football.
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWMP16-AWMP16, February 1, 2024. Background:Individual magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD) are associated with impaired cognition and dementia but may not reflect the overall burden of CSVD. Over a median follow-up time of 6.4 years (Q1-Q3: 4.6-11.3),
40 
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ADP22-ADP22, February 1, 2025. Introduction:Covert brain infarcts (CBIs) are associated with risk of stroke and dementia. It is unknown whether surveillance for CBIs and medical management can mitigate this risk. Results:Among 1,290 included patients, 237 (18.4%) had CBI.
40 
Journal of the American Heart Association
DECEMBER 29, 2023
The authors tested the hypothesis that suboptimal sleep duration is associated with poorer neuroimaging brain health profiles in asymptomatic middle‐aged adults.Methods and ResultsThe authors conducted a prospective magnetic resonance neuroimaging study in middle‐aged individuals without stroke or dementia enrolled in the UK Biobank.
40 
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP33-ATP33, February 1, 2025. (1) The risk factors for cerebral MB and cSS and their relationship with cognitive decline are not well known.(2) The risk factors for cerebral MB and cSS and their relationship with cognitive decline are not well known.(2)
40 
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
cSVD accounts for approximately 25% of ischemic strokes and the vast majority of spontaneous intracerebral hemorrhage and is also the most important vascular contributor to dementia. Despite its high prevalence and potentially long therapeutic window, there are still no mechanism-based treatments.
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWMP13-AWMP13, February 1, 2024. Introduction:Associations between magnetic resonance imaging (MRI) markers of vascular pathology and dementia risk in older adults have been established, but it remains less clear how lifestyle factors may modify this association.
40 
Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionPatients with cognitive impairment often have a history of cardiovascular disease (CVD) or multiple cardiovascular risk factors (CRFs) such as hypertension, obesity, and hypercholesterolemia.
40 Stroke Journal
NOVEMBER 15, 2024
Stroke, Ahead of Print. As awareness of dementia increases, more individuals with minor cognitive complaints are requesting clinical assessment. Neuroimaging studies frequently identify incidental white matter hyperintensities, raising patient concerns about their brain health and future risk for dementia.
40 
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP117-AWMP117, February 1, 2025. Endothelial dysfunction, a key mechanism in COVID-19 illness, is also a major risk factor for vascular dementia (VaD). Introduction:SARS-CoV-2 causes various neurological sequelae in COVID-19 survivors including fatigue and cognitive dysfunction.
40 Journal of the American Heart Association
MARCH 8, 2024
Whether hs‐cTn is associated with domain‐specific cognitive decline and SVD burden in patients with stroke remains unknown.Methods and ResultsWe analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]‐Mechanisms of Dementia after Stroke) study.
40 
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWMP22-AWMP22, February 1, 2024. Background:Mild manifestations of individual cerebral small vessel disease (CSVD) markers are common and may not denote increased risk, but high CSVD burden identifies individuals at increased risk of stroke and dementia. years (Q1-Q3: 5.1-12.5)
40 
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP238-ATP238, February 1, 2024. Introduction:Stroke and transient ischemic attack (TIA) increase risk for cognitive impairment and dementia. Both subjects with stroke and subjects with TIA had increased serum PDGFRβ compared to those without history of CVA (6608.4 pg/mL and 5337.0
40 
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page A37-A37, February 1, 2024. The 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by motivating lifestyle changes (Fig 1).
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP44-AWP44, February 1, 2025. Background:Patent foramen ovale (PFO) is an independent risk factor for neurovascular injury such as stroke. We previously found that large PFO shunt is associated with increased long-term risk of vascular dementia.
40 
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP252-ATP252, February 1, 2025. Alzheimers Disease (AD) is the most common form of dementia and is characterized by progressive neurodegeneration and cognitive decline.
40 Journal of the American Heart Association
JANUARY 12, 2024
BackgroundInfection and inflammation are dementia risk factors in population‐based cohorts; however, studies in stroke are scarce. years; median National Institutes of Health Stroke Scale score 5 [range, minimum‐maximum, 0–30]), infection was present in 90 patients (35.3%) at mean 4.4 (SD,
40 
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page A10-A10, February 1, 2024. Background:Adherence to the American Heart Association's Life’s Essential 8 (LE8) reduces the risk of cardiovascular disease. Participants with prior stroke, transient ischemic attack (TIA) or myocardial infarction (MI) were excluded. 0.73; p<0.001).APOEε4
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A139-A139, February 1, 2025. Using Cox regression analyses, we compared the risk of incident SDH among the three groups after adjustment for demographics and comorbidities. In pre-specified sensitivity analyses, patients with a diagnosis of dementia at baseline were excluded.Results:Among 8.5
40 
Journal of the American Heart Association
NOVEMBER 28, 2023
BackgroundCerebral small vessel disease (cSVD) is a major contributing factor to ischemic stroke and dementia. However, longitudinal investigations into vascular stiffness and regulatory function as possible risk factors for cSVD remain warranted. However, the vascular pathologies of cSVD remain inconclusive.
40 
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ADP15-ADP15, February 1, 2025. Background:White matter hyperintensities (WMH) of presumed vascular origin can be associated with vascular cognitive impairment and dementia. However, WMH are also seen in asymptomatic subjects. FLAIR/T1 images were segmented to create WMH masks.
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWP308-AWP308, February 1, 2024. Introduction:Respiratory disorders, including sleep apnea, are an independent risk factor for the development of cognitive dysfunction and dementia. Disordered breathing occurs frequently in patients with AD (Alzheimer’s Disease).
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Dr. Sanjay Gupta
JANUARY 17, 2022
The big risk of AF is thought to be an increased risk of strokes and therefore when we see patients above the age of 65, or patients who carry comorbidities we recommend lifelong anticoagulation and as long as the patient is anticoagulated, we feel that the patient is safe. We never really think beyond the risk of stroke.
52 Journal of the American Heart Association
MARCH 21, 2025
BackgroundStroke and dementia are leading causes of mortality and can be prevented through risk factor management. Risk factor assessment requires laboratory or physical measurements. Journal of the American Heart Association, Ahead of Print.
40 Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP319-AWP319, February 1, 2025. Introduction:Stroke and dementia are among the leading causes of mortality globally. This can be mitigated through targeting modifiable risk factors.
40 
Dr. Paddy Barrett
FEBRUARY 21, 2025
That is severe obstructive sleep apnea (OSA), and with that serious interruption to sleep quality also comes a doubling in the risk of future heart disease, particularly stroke 6. As a risk factor for cardiovascular disease and many of the major chronic diseases that result in an early death, avoiding type 2 diabetes is key.
81 
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP358-ATP358, February 1, 2025. Introduction:Stroke is a well-established independent risk factor for the development of dementia. Most dementia patients exhibit mixed brain pathologies, with histological evidence of ischemia and A plaque accumulation, observed at autopsy.
40 
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP18-AWMP18, February 1, 2025. Background:Cerebral microbleeds (CMBs) are associated with incident dementia, but the impact of specific CMB patterns is unclear. Compared to individuals with no CMBs, presence of any CMBs was associated with an increased risk of dementia (Table 2).
40 Stroke Journal
OCTOBER 10, 2024
Stroke, Ahead of Print. The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Emerging evidence shows that the heart and the brain, once considered unrelated organ systems, are interdependent and linked through shared risk factors.
Stroke Journal
DECEMBER 5, 2024
Stroke, Volume 56, Issue 1 , Page 65-73, January 1, 2025. BACKGROUND:Socioeconomic disparities exist in acute stroke care as well as in long-term stroke outcomes. We aimed to investigate whether socioeconomic status was associated with the rate of poststroke dementia (PSD).METHODS:This 1000 person-years).
40 
Dr. Paddy Barrett
MARCH 23, 2024
It’s not that they don’t get cardiovascular disease, cancer or dementia; they just get it way later than everyone else. When broken down by disease category, cardiovascular disease, cancer, dementia, stroke, osteoarthritis, hypertension and stroke, the pattern is the same. J Gerontol A Biol Sci Med Sci.
106 
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP285-AWP285, February 1, 2025. Introduction:Cerebral small vessel disease (CSVD) is linked to stroke and dementia risk, often predating clinical events for years to decades.
40 
Circulation
NOVEMBER 14, 2024
male) without cardiovascular disease and with proteomics measurements, we examined the primary composite outcome of fatal and nonfatal coronary heart disease, stroke, or heart failure (major adverse cardiovascular events), as well as additional secondary cardiovascular outcomes.
Stroke Journal
FEBRUARY 27, 2024
Stroke, Ahead of Print. Vascular contributions to cognitive impairment and dementia, specifically cerebral small vessel disease (CSVD), are the second most common cause of dementia. Currently, there are no specific pharmacological treatments for CSVD, and the use of conventional antidementia drugs is not recommended.
40 
Dr. Paddy Barrett
MAY 3, 2024
It usually takes many years of being exposed to an uncontrolled risk factor such as high blood pressure, high LDL cholesterol or diabetes. Even if they have controlled all of their known risk factors. However, it just happens way less often to those who have controlled their risk factors. Manage Risk.
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