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Med Page Today
DECEMBER 26, 2023
(MedPage Today) -- Four new risk factors for young-onset dementia were identified in the prospective U.K. Orthostatic hypotension, vitamin D deficiency, high C-reactive protein (CRP) levels, and social isolation emerged as new risk. Biobank study.
142 
Science Daily - Stroke
SEPTEMBER 17, 2024
Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.
119 
Medical Xpress - Cardiology
JUNE 26, 2024
Dementia risk factors associated with cardiovascular health may have increased over time compared to factors such as smoking and having less education, finds a new study led by UCL researchers.
98 
Med Page Today
MAY 23, 2024
(MedPage Today) -- Lifestyle and other dementia risk factors were linked with cognitive changes independently of genetic risks for Alzheimer's disease, a French prospective study found. Across nearly 5,200 people in three French cities, worse.
144 
Dr. Paddy Barrett
AUGUST 9, 2024
More than heart disease or cancer, the risk of dementia often creates much greater anxiety in the patients I see. And given that dementia is routinely in the top 5 leading causes of death, this concern is dually warranted. But can dementia be prevented? 14 Ways To Prevent Dementia. 14 Ways To Prevent Dementia.
115 
Med Page Today
JULY 31, 2024
(MedPage Today) -- PHILADELPHIA -- The Lancet Commission on dementia prevention, intervention, and care has raised the number of modifiable risk factors definitively linked to cognitive loss to 14, based on research conducted since its last update.
126 
Med Page Today
DECEMBER 14, 2023
(MedPage Today) -- Sleep regularity in midlife and at older ages may be a novel dementia risk factor, data from 88,000 people in Great Britain suggested. Day-to-day consistency in sleep-wake patterns showed a U-shaped association with incident.
128 
Physiologically Speaking
NOVEMBER 22, 2024
Insulin resistance and impaired glucose metabolism are risk factors for Alzheimer's disease, hence why the disease is sometimes referred to as ‘type 3 diabetes.’ And while lifestyle factors play a crucial role in mitigating the risk of dementia, our genetic makeup also plays a part. Moderate: 24.1–31.1
110 
Dr. Paddy Barrett
SEPTEMBER 13, 2024
Insulin resistance is a major risk factor for the leading causes of death, the leading one being cardiovascular disease. Understanding where you sit on this continuum is a key part of defining your future risk of heart disease but also dementia, and many cancers. The key is to identify risk much earlier.
105 
NEJM Journal Watch - Cardiology
OCTOBER 9, 2024
After adjustment for known risk factors, ICAD was associated with elevated dementia risk at 5 years.
75 
Med Page Today
JANUARY 30, 2025
(MedPage Today) -- An online intervention targeting modifiable dementia risk factors improved cognition over 3 years, a randomized controlled trial of 6,100 older adults in Australia showed. The primary outcome of change in global cognitive composite.
124 
Science Daily - Heart Disease
OCTOBER 23, 2024
In middle-aged people, having risk factors like blood pressure, blood sugar and cholesterol that are not well-controlled combined with not following certain healthy habits including exercise, diet and sleep, are linked to a higher risk of stroke, dementia or depression later in life, according to a new study.
120 
Cardiometabolic Health Congress
AUGUST 23, 2024
The 2024 report from the Lancet Standing Commission on Dementia Prevention, Intervention, and Care brings promising developments for healthcare professionals and public health advocates. Key Takeaways: Up to 50% of all dementia cases could potentially be prevented or substantially delayed.
52 
Stroke Journal
JANUARY 30, 2025
Introduction:Stroke and dementia are among the leading causes of mortality globally. This can be mitigated through targeting modifiable risk factors. Identification of those at-risk through screening tools could be facilitated by inclusion of self-reported risk factors rather than reliance on clinical data.
40 
Dr. Sanjay Gupta
JANUARY 17, 2022
However over the past few years there have been several studies which have studied AF patients and discovered patients with AF have a significantly higher prevalence of cognitive impairment and dementia and as we do not have any clinical guidelines as yet, we have to try and work out for ourselves as to why there is this association.
52 
Dr. Paddy Barrett
JANUARY 23, 2024
The real question is what the Tsimane tribe's risk factor profile looks like. Because if we can understand that, we can attempt to emulate it and also considerably delay the onset of cardiovascular disease and our risk of an early death as a consequence of it. For the Tsimane tribe, dementia is rarely, if ever, an issue.
105 
Dr. Paddy Barrett
AUGUST 30, 2024
Poor Sleep Might Eliminate The Benefits Of Exercise & Dementia. High levels of aerobic fitness are closely linked to lower rates of future dementia 1. Regular physical activity is arguably one of the biggest factors preventing dementia. When it comes to preventing dementia, this could not be truer.
111 
American College of Cardiology
FEBRUARY 5, 2024
Hypertension represents a major modifiable risk factor for coronary artery disease (CAD), heart failure (HF), stroke, chronic kidney disease (CKD), and dementia.
75 
Science Daily - Stroke
DECEMBER 20, 2023
Signs of injury to the brain's white matter called white matter hyperintensities, as seen on brain scans, may be tied more strongly to vascular risk factors, brain shrinkage, and other markers of dementia in former tackle football players than in those who did not play football.
81 
Dr. Paddy Barrett
MARCH 23, 2024
It’s not that they don’t get cardiovascular disease, cancer or dementia; they just get it way later than everyone else. When broken down by disease category, cardiovascular disease, cancer, dementia, stroke, osteoarthritis, hypertension and stroke, the pattern is the same. Aggressively control the risk factors.
105 
Hypertension Journal
SEPTEMBER 21, 2023
Cerebral small vessel disease is common in older adults and increases the risk of stroke, cognitive impairment, and dementia. While often attributed to midlife vascular risk factors such as hypertension, factors from earlier in life may contribute to later small vessel disease risk.
40 
Stroke Journal
JANUARY 30, 2025
Background:Cerebral microbleeds (CMBs) are associated with incident dementia, but the impact of specific CMB patterns is unclear. This study investigates the association between CMB patterns and dementia risk in the community-based longitudinal Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS).Methods:All
40 
Hypertension Journal
SEPTEMBER 21, 2023
Recently, some randomized trials, including the SPRINT (Systolic Blood Pressure Intervention Trial), have suggested that improvements in cardiovascular risk factors may also slow cognitive decline and reduce the eventual development of dementia.
40 Hypertension Journal
SEPTEMBER 21, 2023
Dementia affects almost 50 million adults worldwide, and remains a major cause of death and disability. Hypertension is a leading risk factor for dementia, including Alzheimer disease and Alzheimer disease–related dementias. Hypertension, Ahead of Print.
40 Stroke Journal
FEBRUARY 1, 2024
Background:Individual magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD) are associated with impaired cognition and dementia but may not reflect the overall burden of CSVD. 3.69; p<0.001) and vascular risk factors (HR: 1.76; 95% CI: 1.10-2.81; Over a median follow-up time of 6.4
40 
Journal of the American Heart Association
FEBRUARY 13, 2024
BackgroundIt is uncertain whether rareNOTCH3variants are associated with stroke and dementia in the general population and whether they lead to alterations in cognitive function. For the follow‐up analysis, 1007 participants were included in the stroke analysis, and 870 participants in the dementia analysis.
40 
Stroke Journal
JANUARY 30, 2025
Introduction:All-cause dementia remains a significant public health concern, with stroke recognized as a key risk factor. Few studies have applied Machine Learning (ML) models to accurately predict cognitive impairment and dementia, yet none have specifically focused on post-stroke dementia risk prediction.
40 
Stroke Journal
JANUARY 30, 2025
The risk factors for cerebral MB and cSS and their relationship with cognitive decline are not well known.(2) 2) Objective:This study aimed to explore the risk factors for cerebral MBs and cSS and to examine their impact on cognitive function in a cohort of cognitively impaired patients.(3)
40 
Journal of Clinical Investigation - Cardiology
JANUARY 2, 2024
In Lewy body diseases (LBDs) Parkinson disease (PD), and dementia with Lewy bodies (DLB), by the time parkinsonism or cognitive dysfunction manifests clinically, substantial neurodegeneration has already occurred. Thirty-four with 3 or more confirmed risk factors underwent serial cardiac 18F-dopamine PET at 1.5-year BACKGROUND.
92 
Dr. Paddy Barrett
MAY 3, 2024
It usually takes many years of being exposed to an uncontrolled risk factor such as high blood pressure, high LDL cholesterol or diabetes. Even if they have controlled all of their known risk factors. However, it just happens way less often to those who have controlled their risk factors. Manage Risk.
104 
Stroke Journal
JANUARY 30, 2025
Introduction:Covert brain infarcts (CBIs) are associated with risk of stroke and dementia. It is unknown whether surveillance for CBIs and medical management can mitigate this risk. Exclusion criteria: missing information on risk-factor variables. Results:Among 1,290 included patients, 237 (18.4%) had CBI.
40 
Stroke Journal
FEBRUARY 1, 2024
Introduction:Associations between magnetic resonance imaging (MRI) markers of vascular pathology and dementia risk in older adults have been established, but it remains less clear how lifestyle factors may modify this association. years) with ongoing surveillance.
40 
Stroke Journal
OCTOBER 10, 2024
The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Emerging evidence shows that the heart and the brain, once considered unrelated organ systems, are interdependent and linked through shared risk factors. Stroke, Ahead of Print.
Dr. Paddy Barrett
FEBRUARY 21, 2025
Type 2 Diabetes When it comes to the increasing the risk of major chronic diseases such as cardiovascular disease, many cancers and dementia, type 2 diabetes plays a huge role. As a risk factor for cardiovascular disease and many of the major chronic diseases that result in an early death, avoiding type 2 diabetes is key.
77 
Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
IntroductionPatients with cognitive impairment often have a history of cardiovascular disease (CVD) or multiple cardiovascular risk factors (CRFs) such as hypertension, obesity, and hypercholesterolemia. The literature reports that CVD with CRFs may increase the risk of developing vascular dementia and Alzheimer’s Disease.
40 
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
cSVD accounts for approximately 25% of ischemic strokes and the vast majority of spontaneous intracerebral hemorrhage and is also the most important vascular contributor to dementia. Despite its high prevalence and potentially long therapeutic window, there are still no mechanism-based treatments.
68 Journal of the American Heart Association
DECEMBER 29, 2023
The authors tested the hypothesis that suboptimal sleep duration is associated with poorer neuroimaging brain health profiles in asymptomatic middle‐aged adults.Methods and ResultsThe authors conducted a prospective magnetic resonance neuroimaging study in middle‐aged individuals without stroke or dementia enrolled in the UK Biobank.
40 Journal of the American Heart Association
FEBRUARY 14, 2024
One such syndrome that has been associated with poor outcomes is cognitive frailty: the simultaneous presence of cognitive impairment, without evidence of dementia, and physical frailty, which results in decreased cognitive reserve.
Stroke Journal
JANUARY 30, 2025
Endothelial dysfunction, a key mechanism in COVID-19 illness, is also a major risk factor for vascular dementia (VaD).
40 Stroke Journal
NOVEMBER 15, 2024
As awareness of dementia increases, more individuals with minor cognitive complaints are requesting clinical assessment. Neuroimaging studies frequently identify incidental white matter hyperintensities, raising patient concerns about their brain health and future risk for dementia. Stroke, Ahead of Print.
40 
Dr. Paddy Barrett
JANUARY 16, 2024
Cardiovascular disease, cancer and dementia account for 60% of all deaths in the US. Yes, many external factors impact these factors, but ultimately, you have significant control over all of these. Let’s look at what happens to NCD risk when these risk factors are optimised. These are NCD’s.
95 
Journal of Clinical Investigation - Cardiology
JANUARY 2, 2024
Emerging data indicate that central Lewy body diseases — Parkinson disease and dementia with Lewy bodies — can begin in the peripheral nervous system, opening up a therapeutic window before central involvement. In this issue of the JCI, Goldstein et al. In this issue of the JCI, Goldstein et al.
46 
Dr. Paddy Barrett
JULY 5, 2024
As a risk factor for death, high blood pressure is responsible for more deaths than any other risk factor, including smoking. High blood pressure is the risk factor associated with the most early deaths compared to any other risk factor. And if it’s not, your risk of: Heart disease.
105 Journal of the American Heart Association
FEBRUARY 14, 2025
The cohort included 119 participants diagnosed with subjective cognitive impairment, mild cognitive impairment, and ADrelated dementia, as well as individuals without cognitive complaints. ConclusionsThis raises the suggestion that a decreased neurovascular coupling in the disease process of AD is related to comorbid small vessel disease.
40
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