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Med Page Today
DECEMBER 26, 2023
(MedPage Today) -- Four new risk factors for young-onset dementia were identified in the prospective U.K. Orthostatic hypotension, vitamin D deficiency, high C-reactive protein (CRP) levels, and social isolation emerged as new risk. Biobank study.
142 
Medical Xpress - Cardiology
JUNE 26, 2024
Dementia risk factors associated with cardiovascular health may have increased over time compared to factors such as smoking and having less education, finds a new study led by UCL researchers.
97 
Science Daily - Stroke
SEPTEMBER 17, 2024
Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.
110 
Dr. Paddy Barrett
AUGUST 9, 2024
More than heart disease or cancer, the risk of dementia often creates much greater anxiety in the patients I see. And given that dementia is routinely in the top 5 leading causes of death, this concern is dually warranted. But can dementia be prevented? 14 Ways To Prevent Dementia. 14 Ways To Prevent Dementia.
105 
Med Page Today
MAY 23, 2024
(MedPage Today) -- Lifestyle and other dementia risk factors were linked with cognitive changes independently of genetic risks for Alzheimer's disease, a French prospective study found. Across nearly 5,200 people in three French cities, worse.
144 
Med Page Today
JULY 31, 2024
(MedPage Today) -- PHILADELPHIA -- The Lancet Commission on dementia prevention, intervention, and care has raised the number of modifiable risk factors definitively linked to cognitive loss to 14, based on research conducted since its last update.
126 
Med Page Today
DECEMBER 14, 2023
(MedPage Today) -- Sleep regularity in midlife and at older ages may be a novel dementia risk factor, data from 88,000 people in Great Britain suggested. Day-to-day consistency in sleep-wake patterns showed a U-shaped association with incident.
128 
Cardiometabolic Health Congress
AUGUST 23, 2024
The 2024 report from the Lancet Standing Commission on Dementia Prevention, Intervention, and Care brings promising developments for healthcare professionals and public health advocates. Key Takeaways: Up to 50% of all dementia cases could potentially be prevented or substantially delayed.
52 
NEJM Journal Watch - Cardiology
OCTOBER 9, 2024
After adjustment for known risk factors, ICAD was associated with elevated dementia risk at 5 years.
75 
Dr. Paddy Barrett
SEPTEMBER 13, 2024
Insulin resistance is a major risk factor for the leading causes of death, the leading one being cardiovascular disease. Understanding where you sit on this continuum is a key part of defining your future risk of heart disease but also dementia, and many cancers. The key is to identify risk much earlier.
95 
Hypertension Journal
SEPTEMBER 21, 2023
Cerebral small vessel disease is common in older adults and increases the risk of stroke, cognitive impairment, and dementia. While often attributed to midlife vascular risk factors such as hypertension, factors from earlier in life may contribute to later small vessel disease risk.
40 
Dr. Sanjay Gupta
JANUARY 17, 2022
However over the past few years there have been several studies which have studied AF patients and discovered patients with AF have a significantly higher prevalence of cognitive impairment and dementia and as we do not have any clinical guidelines as yet, we have to try and work out for ourselves as to why there is this association.
52 
Stroke Journal
FEBRUARY 1, 2024
Background:Individual magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD) are associated with impaired cognition and dementia but may not reflect the overall burden of CSVD. 3.69; p<0.001) and vascular risk factors (HR: 1.76; 95% CI: 1.10-2.81; Over a median follow-up time of 6.4
40 
Journal of the American Heart Association
FEBRUARY 13, 2024
BackgroundIt is uncertain whether rareNOTCH3variants are associated with stroke and dementia in the general population and whether they lead to alterations in cognitive function. For the follow‐up analysis, 1007 participants were included in the stroke analysis, and 870 participants in the dementia analysis.
40 
Science Daily - Heart Disease
OCTOBER 23, 2024
In middle-aged people, having risk factors like blood pressure, blood sugar and cholesterol that are not well-controlled combined with not following certain healthy habits including exercise, diet and sleep, are linked to a higher risk of stroke, dementia or depression later in life, according to a new study.
Hypertension Journal
SEPTEMBER 21, 2023
Recently, some randomized trials, including the SPRINT (Systolic Blood Pressure Intervention Trial), have suggested that improvements in cardiovascular risk factors may also slow cognitive decline and reduce the eventual development of dementia.
40 
Hypertension Journal
SEPTEMBER 21, 2023
Dementia affects almost 50 million adults worldwide, and remains a major cause of death and disability. Hypertension is a leading risk factor for dementia, including Alzheimer disease and Alzheimer disease–related dementias. Hypertension, Ahead of Print.
40 
Physiologically Speaking
NOVEMBER 22, 2024
Insulin resistance and impaired glucose metabolism are risk factors for Alzheimer's disease, hence why the disease is sometimes referred to as ‘type 3 diabetes.’ And while lifestyle factors play a crucial role in mitigating the risk of dementia, our genetic makeup also plays a part. Moderate: 24.1–31.1
107 
Stroke Journal
FEBRUARY 1, 2024
Introduction:Associations between magnetic resonance imaging (MRI) markers of vascular pathology and dementia risk in older adults have been established, but it remains less clear how lifestyle factors may modify this association. years) with ongoing surveillance.
40 
Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
IntroductionPatients with cognitive impairment often have a history of cardiovascular disease (CVD) or multiple cardiovascular risk factors (CRFs) such as hypertension, obesity, and hypercholesterolemia. The literature reports that CVD with CRFs may increase the risk of developing vascular dementia and Alzheimer’s Disease.
40 American College of Cardiology
FEBRUARY 5, 2024
Hypertension represents a major modifiable risk factor for coronary artery disease (CAD), heart failure (HF), stroke, chronic kidney disease (CKD), and dementia.
75 
Journal of the American Heart Association
DECEMBER 29, 2023
The authors tested the hypothesis that suboptimal sleep duration is associated with poorer neuroimaging brain health profiles in asymptomatic middle‐aged adults.Methods and ResultsThe authors conducted a prospective magnetic resonance neuroimaging study in middle‐aged individuals without stroke or dementia enrolled in the UK Biobank.
40 
Dr. Paddy Barrett
JANUARY 23, 2024
The real question is what the Tsimane tribe's risk factor profile looks like. Because if we can understand that, we can attempt to emulate it and also considerably delay the onset of cardiovascular disease and our risk of an early death as a consequence of it. For the Tsimane tribe, dementia is rarely, if ever, an issue.
Dr. Paddy Barrett
AUGUST 30, 2024
Poor Sleep Might Eliminate The Benefits Of Exercise & Dementia. High levels of aerobic fitness are closely linked to lower rates of future dementia 1. Regular physical activity is arguably one of the biggest factors preventing dementia. When it comes to preventing dementia, this could not be truer.
105 
Science Daily - Stroke
DECEMBER 20, 2023
Signs of injury to the brain's white matter called white matter hyperintensities, as seen on brain scans, may be tied more strongly to vascular risk factors, brain shrinkage, and other markers of dementia in former tackle football players than in those who did not play football.
61 
Stroke Journal
OCTOBER 10, 2024
The burden of neurologic diseases, including stroke and dementia, is expected to grow substantially in the coming decades. Emerging evidence shows that the heart and the brain, once considered unrelated organ systems, are interdependent and linked through shared risk factors. Stroke, Ahead of Print.
Journal of Clinical Investigation - Cardiology
JANUARY 2, 2024
Emerging data indicate that central Lewy body diseases — Parkinson disease and dementia with Lewy bodies — can begin in the peripheral nervous system, opening up a therapeutic window before central involvement. In this issue of the JCI, Goldstein et al. In this issue of the JCI, Goldstein et al.
49 
Dr. Paddy Barrett
MARCH 23, 2024
It’s not that they don’t get cardiovascular disease, cancer or dementia; they just get it way later than everyone else. When broken down by disease category, cardiovascular disease, cancer, dementia, stroke, osteoarthritis, hypertension and stroke, the pattern is the same. Aggressively control the risk factors.
102 Journal of Clinical Investigation - Cardiology
JANUARY 2, 2024
In Lewy body diseases (LBDs) Parkinson disease (PD), and dementia with Lewy bodies (DLB), by the time parkinsonism or cognitive dysfunction manifests clinically, substantial neurodegeneration has already occurred. Thirty-four with 3 or more confirmed risk factors underwent serial cardiac 18F-dopamine PET at 1.5-year BACKGROUND.
96 
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
cSVD accounts for approximately 25% of ischemic strokes and the vast majority of spontaneous intracerebral hemorrhage and is also the most important vascular contributor to dementia. Despite its high prevalence and potentially long therapeutic window, there are still no mechanism-based treatments.
90 
Journal of the American Heart Association
FEBRUARY 14, 2024
One such syndrome that has been associated with poor outcomes is cognitive frailty: the simultaneous presence of cognitive impairment, without evidence of dementia, and physical frailty, which results in decreased cognitive reserve.
Circulation
NOVEMBER 11, 2024
Background:Cognitive decline and dementia are significant global health concerns, with hypertension being a major risk factor. Moreover, the relationship between blood pressure (BP) components, particularly diastolic BP (DBP) and pulse pressure (PP), and the risk of cognitive decline or dementia remains complex.
40 Stroke Journal
FEBRUARY 1, 2024
The 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by motivating lifestyle changes (Fig 1).
40 
Dr. Paddy Barrett
MAY 3, 2024
It usually takes many years of being exposed to an uncontrolled risk factor such as high blood pressure, high LDL cholesterol or diabetes. Even if they have controlled all of their known risk factors. However, it just happens way less often to those who have controlled their risk factors. Manage Risk.
93 Journal of the American Heart Association
MARCH 8, 2024
Whether hs‐cTn is associated with domain‐specific cognitive decline and SVD burden in patients with stroke remains unknown.Methods and ResultsWe analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]‐Mechanisms of Dementia after Stroke) study.
40 
Stroke Journal
FEBRUARY 1, 2024
Introduction:Stroke and transient ischemic attack (TIA) increase risk for cognitive impairment and dementia. Statistical analyses were performed using Spearman’s rank correlation and Mann Whitney U test.Results:Our subjects were split based on CVA status and matched according to vascular risk factors. pg/mL and 5337.0
40 Hypertension Journal
JANUARY 4, 2024
BACKGROUND:Hypertension is one of the main risk factors for dementia and cognitive impairment.METHODS:We used the model of transverse aortic constriction to induce chronic pressure overload in mice. Hypertension, Ahead of Print. We characterized brain injury by advanced translational applications of magnetic resonance imaging.
49 
Stroke Journal
FEBRUARY 1, 2024
Background:Mild manifestations of individual cerebral small vessel disease (CSVD) markers are common and may not denote increased risk, but high CSVD burden identifies individuals at increased risk of stroke and dementia.
40 
Dr. Paddy Barrett
JANUARY 16, 2024
Cardiovascular disease, cancer and dementia account for 60% of all deaths in the US. Yes, many external factors impact these factors, but ultimately, you have significant control over all of these. Let’s look at what happens to NCD risk when these risk factors are optimised. These are NCD’s.
81 
Dr. Paddy Barrett
JULY 5, 2024
As a risk factor for death, high blood pressure is responsible for more deaths than any other risk factor, including smoking. High blood pressure is the risk factor associated with the most early deaths compared to any other risk factor. And if it’s not, your risk of: Heart disease.
Journal of the American Heart Association
DECEMBER 1, 2023
BackgroundBrain arterial diameters (BADs) are novel imaging biomarkers of cerebrovascular disease, cognitive decline, and dementia. Journal of the American Heart Association, Volume 12, Issue 23 , December 5, 2023.
Dr. Paddy Barrett
AUGUST 22, 2023
Being a carrier of the APOE4 gene variant is associated with higher rates of the most common type of dementia, late-onset dementia. Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant 1. Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant 1. What to do?
52 
Journal of the American Heart Association
NOVEMBER 28, 2023
BackgroundCerebral small vessel disease (cSVD) is a major contributing factor to ischemic stroke and dementia. However, longitudinal investigations into vascular stiffness and regulatory function as possible risk factors for cSVD remain warranted. However, the vascular pathologies of cSVD remain inconclusive.
40 
Cardiometabolic Health Congress
JUNE 7, 2024
He highlighted that cardiovascular health is essential for cognitive health, noting the common occurrence of vascular dementia. ” She emphasized the importance of measuring Lp(a) levels and addressing them by optimizing risk factor reduction. She noted that certain risk factors for heart disease change during this time.
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