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Med Page Today
DECEMBER 26, 2023
(MedPage Today) -- Four new risk factors for young-onset dementia were identified in the prospective U.K. Orthostatic hypotension, vitamin D deficiency, high C-reactive protein (CRP) levels, and social isolation emerged as new risk. Biobank study.
142 
Science Daily - Stroke
SEPTEMBER 17, 2024
Medical researchers conducted the largest-ever genome-wide association study of all-cause dementia, finding substantial genetic overlap with vascular dementia.
121 
Medical Xpress - Cardiology
JUNE 26, 2024
Dementia risk factors associated with cardiovascular health may have increased over time compared to factors such as smoking and having less education, finds a new study led by UCL researchers.
98 
Med Page Today
MAY 23, 2024
(MedPage Today) -- Lifestyle and other dementia risk factors were linked with cognitive changes independently of genetic risks for Alzheimer's disease, a French prospective study found. Across nearly 5,200 people in three French cities, worse.
144 
Med Page Today
JULY 31, 2024
(MedPage Today) -- PHILADELPHIA -- The Lancet Commission on dementia prevention, intervention, and care has raised the number of modifiable risk factors definitively linked to cognitive loss to 14, based on research conducted since its last update.
126 
Med Page Today
DECEMBER 14, 2023
(MedPage Today) -- Sleep regularity in midlife and at older ages may be a novel dementia risk factor, data from 88,000 people in Great Britain suggested. Day-to-day consistency in sleep-wake patterns showed a U-shaped association with incident.
128 
Physiologically Speaking
NOVEMBER 22, 2024
Insulin resistance and impaired glucose metabolism are risk factors for Alzheimer's disease, hence why the disease is sometimes referred to as ‘type 3 diabetes.’ And while lifestyle factors play a crucial role in mitigating the risk of dementia, our genetic makeup also plays a part. Moderate: 24.1–31.1
111 
Science Daily - Stroke
APRIL 3, 2025
In a new extensive systematic review, researchers identified 17 modifiable risk factors that are shared by stroke, dementia, and late-life depression. Modifying any one of them can reduce your risk of all three conditions. The findings provide evidence to inform novel tools such as the Brain Care Score.
71 
NEJM Journal Watch - Cardiology
OCTOBER 9, 2024
After adjustment for known risk factors, ICAD was associated with elevated dementia risk at 5 years.
75 
Med Page Today
JANUARY 30, 2025
(MedPage Today) -- An online intervention targeting modifiable dementia risk factors improved cognition over 3 years, a randomized controlled trial of 6,100 older adults in Australia showed. The primary outcome of change in global cognitive composite.
123 
Science Daily - Heart Disease
OCTOBER 23, 2024
In middle-aged people, having risk factors like blood pressure, blood sugar and cholesterol that are not well-controlled combined with not following certain healthy habits including exercise, diet and sleep, are linked to a higher risk of stroke, dementia or depression later in life, according to a new study.
123 
Cardiometabolic Health Congress
AUGUST 23, 2024
The 2024 report from the Lancet Standing Commission on Dementia Prevention, Intervention, and Care brings promising developments for healthcare professionals and public health advocates. Key Takeaways: Up to 50% of all dementia cases could potentially be prevented or substantially delayed.
52 
Circulation
APRIL 4, 2025
BACKGROUND:Shared genetic and lifestyle risk factors may underlie the development of both coronary artery disease (CAD) and dementia. Primary outcomes were incident all-cause, Alzheimers, and vascular dementia diagnoses obtained from electronic health records. Circulation, Ahead of Print. year follow-up. year follow-up.
Frontiers in Cardiovascular Medicine
APRIL 3, 2025
OAC users predominantly had cardiovascular disease and risk factors, whereas non-OAC users had higher rates of malignancy and dementia. during the index visit) was linked to lower hospitalization risks compared to those initiating later (29.2% Early OAC initiation (74.9% for all-cause, p-value<0.001 and 1.3%
Science Daily - Stroke
DECEMBER 20, 2023
Signs of injury to the brain's white matter called white matter hyperintensities, as seen on brain scans, may be tied more strongly to vascular risk factors, brain shrinkage, and other markers of dementia in former tackle football players than in those who did not play football.
82 
American College of Cardiology
FEBRUARY 5, 2024
Hypertension represents a major modifiable risk factor for coronary artery disease (CAD), heart failure (HF), stroke, chronic kidney disease (CKD), and dementia.
75 
Dr. Paddy Barrett
AUGUST 30, 2024
Poor Sleep Might Eliminate The Benefits Of Exercise & Dementia. High levels of aerobic fitness are closely linked to lower rates of future dementia 1. Regular physical activity is arguably one of the biggest factors preventing dementia. When it comes to preventing dementia, this could not be truer.
111 
Hypertension Journal
SEPTEMBER 21, 2023
Cerebral small vessel disease is common in older adults and increases the risk of stroke, cognitive impairment, and dementia. While often attributed to midlife vascular risk factors such as hypertension, factors from earlier in life may contribute to later small vessel disease risk.
40 
Stroke Journal
FEBRUARY 1, 2024
Background:Individual magnetic resonance imaging (MRI) markers of cerebral small vessel disease (CSVD) are associated with impaired cognition and dementia but may not reflect the overall burden of CSVD. 3.69; p<0.001) and vascular risk factors (HR: 1.76; 95% CI: 1.10-2.81; Over a median follow-up time of 6.4
40 
Journal of the American Heart Association
FEBRUARY 13, 2024
BackgroundIt is uncertain whether rareNOTCH3variants are associated with stroke and dementia in the general population and whether they lead to alterations in cognitive function. For the follow‐up analysis, 1007 participants were included in the stroke analysis, and 870 participants in the dementia analysis.
40 
Stroke Journal
JANUARY 30, 2025
Introduction:All-cause dementia remains a significant public health concern, with stroke recognized as a key risk factor. Few studies have applied Machine Learning (ML) models to accurately predict cognitive impairment and dementia, yet none have specifically focused on post-stroke dementia risk prediction.
40 
Journal of Clinical Investigation - Cardiology
JANUARY 2, 2024
In Lewy body diseases (LBDs) Parkinson disease (PD), and dementia with Lewy bodies (DLB), by the time parkinsonism or cognitive dysfunction manifests clinically, substantial neurodegeneration has already occurred. Thirty-four with 3 or more confirmed risk factors underwent serial cardiac 18F-dopamine PET at 1.5-year BACKGROUND.
95 
Stroke Journal
JANUARY 30, 2025
The risk factors for cerebral MB and cSS and their relationship with cognitive decline are not well known.(2) 2) Objective:This study aimed to explore the risk factors for cerebral MBs and cSS and to examine their impact on cognitive function in a cohort of cognitively impaired patients.(3)
40 
Stroke Journal
JANUARY 30, 2025
Introduction:Covert brain infarcts (CBIs) are associated with risk of stroke and dementia. It is unknown whether surveillance for CBIs and medical management can mitigate this risk. Exclusion criteria: missing information on risk-factor variables. Results:Among 1,290 included patients, 237 (18.4%) had CBI.
40 
Stroke Journal
FEBRUARY 1, 2024
Introduction:Associations between magnetic resonance imaging (MRI) markers of vascular pathology and dementia risk in older adults have been established, but it remains less clear how lifestyle factors may modify this association. years) with ongoing surveillance.
40 
Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
IntroductionPatients with cognitive impairment often have a history of cardiovascular disease (CVD) or multiple cardiovascular risk factors (CRFs) such as hypertension, obesity, and hypercholesterolemia. The literature reports that CVD with CRFs may increase the risk of developing vascular dementia and Alzheimer’s Disease.
40 
Journal of Clinical Investigation - Cardiology
MAY 15, 2024
cSVD accounts for approximately 25% of ischemic strokes and the vast majority of spontaneous intracerebral hemorrhage and is also the most important vascular contributor to dementia. Despite its high prevalence and potentially long therapeutic window, there are still no mechanism-based treatments.
69 Journal of the American Heart Association
DECEMBER 29, 2023
The authors tested the hypothesis that suboptimal sleep duration is associated with poorer neuroimaging brain health profiles in asymptomatic middle‐aged adults.Methods and ResultsThe authors conducted a prospective magnetic resonance neuroimaging study in middle‐aged individuals without stroke or dementia enrolled in the UK Biobank.
40 Journal of the American Heart Association
FEBRUARY 14, 2024
One such syndrome that has been associated with poor outcomes is cognitive frailty: the simultaneous presence of cognitive impairment, without evidence of dementia, and physical frailty, which results in decreased cognitive reserve.
Stroke Journal
JANUARY 30, 2025
Endothelial dysfunction, a key mechanism in COVID-19 illness, is also a major risk factor for vascular dementia (VaD).
40 Stroke Journal
NOVEMBER 15, 2024
As awareness of dementia increases, more individuals with minor cognitive complaints are requesting clinical assessment. Neuroimaging studies frequently identify incidental white matter hyperintensities, raising patient concerns about their brain health and future risk for dementia. Stroke, Ahead of Print.
40 
Journal of Clinical Investigation - Cardiology
JANUARY 2, 2024
Emerging data indicate that central Lewy body diseases — Parkinson disease and dementia with Lewy bodies — can begin in the peripheral nervous system, opening up a therapeutic window before central involvement. In this issue of the JCI, Goldstein et al. In this issue of the JCI, Goldstein et al.
49 Journal of the American Heart Association
FEBRUARY 14, 2025
The cohort included 119 participants diagnosed with subjective cognitive impairment, mild cognitive impairment, and ADrelated dementia, as well as individuals without cognitive complaints. ConclusionsThis raises the suggestion that a decreased neurovascular coupling in the disease process of AD is related to comorbid small vessel disease.
40 
Stroke Journal
FEBRUARY 1, 2024
The 21-point Brain Care Score (BCS) is a novel tool designed to motivate individuals and care providers to take action to reduce the risk of stroke and dementia by motivating lifestyle changes (Fig 1).
40 
Stroke Journal
JANUARY 30, 2025
Background:Patent foramen ovale (PFO) is an independent risk factor for neurovascular injury such as stroke. We previously found that large PFO shunt is associated with increased long-term risk of vascular dementia. Stroke, Volume 56, Issue Suppl_1 , Page AWP44-AWP44, February 1, 2025.
40 Journal of the American Heart Association
JANUARY 17, 2025
As a novel magnetic resonance imaging marker of cerebral small vessel disease and a risk factor for cognitive dysfunction, cortical cerebral microinfarcts (CMIs) have been associated with heart disease through mechanisms including cardioembolism and cerebral hypoperfusion.
40 Hypertension Journal
JANUARY 4, 2024
BACKGROUND:Hypertension is one of the main risk factors for dementia and cognitive impairment.METHODS:We used the model of transverse aortic constriction to induce chronic pressure overload in mice. Hypertension, Ahead of Print. We characterized brain injury by advanced translational applications of magnetic resonance imaging.
49 
Hypertension Journal
APRIL 18, 2025
BACKGROUND:Hypertension and advanced age are risk factors for arteriosclerotic cerebral small vessel disease (cSVD), a common cause of vascular dementia in elderly individuals. Circulating IGF-1 (insulin-like growth factor 1) levels decrease with age and are linked to age-related cognitive impairment.
40 Circulation
NOVEMBER 11, 2024
Background:Cognitive decline and dementia are significant global health concerns, with hypertension being a major risk factor. Moreover, the relationship between blood pressure (BP) components, particularly diastolic BP (DBP) and pulse pressure (PP), and the risk of cognitive decline or dementia remains complex.
40 Journal of the American Heart Association
MARCH 8, 2024
Whether hs‐cTn is associated with domain‐specific cognitive decline and SVD burden in patients with stroke remains unknown.Methods and ResultsWe analyzed patients with acute stroke without premorbid dementia from the prospective multicenter DEMDAS (DZNE [German Center for Neurodegenerative Disease]‐Mechanisms of Dementia after Stroke) study.
40 
Cardiometabolic Health Congress
JUNE 7, 2024
He highlighted that cardiovascular health is essential for cognitive health, noting the common occurrence of vascular dementia. ” She emphasized the importance of measuring Lp(a) levels and addressing them by optimizing risk factor reduction. She noted that certain risk factors for heart disease change during this time.
Dr. Paddy Barrett
AUGUST 22, 2023
Being a carrier of the APOE4 gene variant is associated with higher rates of the most common type of dementia, late-onset dementia. Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant 1. Of those with late-onset dementia, up to 65% are carriers of the APOE4 gene variant 1. What to do?
52 
Stroke Journal
FEBRUARY 1, 2024
Introduction:Stroke and transient ischemic attack (TIA) increase risk for cognitive impairment and dementia. Statistical analyses were performed using Spearman’s rank correlation and Mann Whitney U test.Results:Our subjects were split based on CVA status and matched according to vascular risk factors. pg/mL and 5337.0
40 
Stroke Journal
FEBRUARY 1, 2024
Background:Mild manifestations of individual cerebral small vessel disease (CSVD) markers are common and may not denote increased risk, but high CSVD burden identifies individuals at increased risk of stroke and dementia.
40
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