Hypertension Journal

NOVEMBER 29, 2023

It is the main cause of lacunar stroke and a major source of vascular contributions to cognitive impairment and dementia. Knowledge gaps include initiating factors, molecular pathogenesis, relationships between arterial pathology and tissue damage, possible reversibility, pharmacological targets, and molecular biomarkers.

Dementia 64

Dementia Hypertension Pharmacology Biomarkers 64

Stroke Journal

JANUARY 30, 2025

Dementia is associated with respiratory dysfunction. In mice models of dementia, there is increased astrogliosis in the brain stem retro-trapezoid nucleus (RTN), which is crucial for breathing control. TGFR2 pharmacological inhibition additionally reduced astrogliosis in the RTN of Tg-2576 mice (drug 53.624.8 vs. 58.25.16, p=.03

Pharmacology 40

Pharmacology Dementia Stroke Strokes 40

Journal of Clinical Investigation - Cardiology

JULY 15, 2024

Pathogenic variants in valosin-containing protein (VCP) cause multisystem proteinopathy (MSP), a disease characterized by multiple clinical phenotypes including inclusion body myopathy, Paget’s disease of the bone, and frontotemporal dementia (FTD). How such diverse phenotypes are driven by pathogenic VCP variants is not known.

Pharmacology 103

Pharmacology Dementia 103

Stroke Journal

JANUARY 30, 2025

SARS-COV-2 causes neurological and cognitive impairments and aggravates Alzheimers Disease-Related Dementia (ADRD). In conclusion,the SARS-CoV-2 spike protein accelerates Alzheimers Disease-Related Dementia through increased cerebrovascular inflammation and deterioration of BBB in hACE2 Mice.

Dementia 40

Dementia COVID-19 Pharmacology Stroke 40

Journal of the American Heart Association

DECEMBER 29, 2023

AF increases the risk of stroke, heart failure, dementia, and hospitalization. However, studies on how obesity affects pharmacologic or interventional AF treatments are limited. Journal of the American Heart Association, Ahead of Print. ABSTRACTAtrial fibrillation (AF) is the most common cardiac arrhythmia.

Obesity 45

Obesity Atrial Fibrillation Heart Failure Pharmacology 45

Stroke Journal

MARCH 4, 2025

Subarachnoid hemorrhage is a critical neurological condition accounting for about 5% of all strokes, and survivors experience long-term cognitive deterioration and increased risk of dementia. These have emerging treatments that offer promise for the mitigation of effects such as inflammation, iron chelation, and microvascular dysfunction.

Hemorrhage 40

Hemorrhage Genetic predisposition Genetic Markers Quality of Life 40

Stroke Journal

FEBRUARY 1, 2024

Background:Blood-brain barrier (BBB) breakdown, reactive astrogliosis, and myelin losses are the key features of vascular contributions to cognitive impairment and dementia (VCID). Stroke, Volume 55, Issue Suppl_1 , Page ATP17-ATP17, February 1, 2024. However, the molecular and cellular mechanisms underlying VCID are not well understood.

Pharmacology 40

Pharmacology Dementia Stenosis Research 40