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Journal of Cardiothoracic Surgery
NOVEMBER 12, 2024
With an aging population and higher prevalence of dementia, there is a paucity of data regarding dementia patients undergoing cardiovascular surgery. We examined the nationwide trends and outcomes of cardiovas.
105 
Med Page Today
APRIL 17, 2024
(MedPage Today) -- Use of antipsychotics in dementia patients was associated with an increased risk for a wider range of adverse outcomes than previously acknowledged, a population-based matched cohort study from the U.K. In the analysis.
120 
Med Page Today
NOVEMBER 8, 2024
(MedPage Today) -- Healthier lifestyle behaviors in midlife were linked with better outcomes in people with genetic predisposition for age-related brain diseases, longitudinal data from the U.K. Biobank showed. Over about 12 years of follow-up.
Medical Xpress - Cardiology
APRIL 1, 2025
A research team from the University of Minnesota Medical School has identified a strong predictor of ischemic stroke and dementia, a discovery that could lead to improved patient outcomes. The findings were recently published in Stroke.
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Med Page Today
JANUARY 30, 2025
(MedPage Today) -- An online intervention targeting modifiable dementia risk factors improved cognition over 3 years, a randomized controlled trial of 6,100 older adults in Australia showed. The primary outcome of change in global cognitive composite.
113 
Circulation
APRIL 4, 2025
BACKGROUND:Shared genetic and lifestyle risk factors may underlie the development of both coronary artery disease (CAD) and dementia. Primary outcomes were incident all-cause, Alzheimers, and vascular dementia diagnoses obtained from electronic health records. year follow-up. year follow-up.
Cardiometabolic Health Congress
AUGUST 23, 2024
The 2024 report from the Lancet Standing Commission on Dementia Prevention, Intervention, and Care brings promising developments for healthcare professionals and public health advocates. Key Takeaways: Up to 50% of all dementia cases could potentially be prevented or substantially delayed.
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Dr. Paddy Barrett
NOVEMBER 8, 2024
“Statins cause dementia” This one is easy. For a more detailed explanation of why this is the case and why they may, in fact, protect against dementia, you can read a previous post here. But first, let’s address some common concerns about statin therapy. No, they don’t.
130 
CardiacWire
JANUARY 22, 2025
Starting with the good news, GLP-1s lowered risks for 42 health outcomes while increasing risks for 19 outcomes. GLP-1s also led to an 8% lower risk of dementia and 12% lower risk of Alzheimer’s disease. That said, it could serve as an early look into the long-term health outcomes of using GLP-1s to treat obesity and T2D.
59 
Science Daily - Heart Disease
APRIL 22, 2024
This irregular heartbeat is associated with increased risks of heart failure, dementia and stroke. These results pave the way for integration into wearable technologies, allowing early interventions and better patient outcomes. It gives early warnings on average 30 minutes before onset, with an accuracy of around 80%.
120 
Stroke Journal
FEBRUARY 1, 2024
Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. Primary outcome was defined as favorable 90-day outcome (modified Rankin Scale (mRS) score 0-2). Results:9 articles were included from 825 screened. 95%CI 1.03
40 
Stroke Journal
JANUARY 30, 2025
The outcome was an incident diagnosis of dementia. The exposure and outcomes were identified using previously validatedICD-9andICD-10-CMdiagnosis codes. In the primary analysis, we used Cox regression to study the risk of dementia after any intracranial hemorrhage, after adjusting for demographics and comorbidities.
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Physiologically Speaking
DECEMBER 2, 2024
This study emphasizes how exercise intensity and volume contribute differently to physiological adaptations, depending on the desired outcome and the individual’s fitness level. The inevitable conclusion for our training is that we need both low- and high-intensity training to truly reach our peak potential. hours/day), moderate (10.2–11.4
59 
Journal of the American Heart Association
FEBRUARY 8, 2025
Previous studies categorizing ICH by large anatomic boundaries have demonstrated that lobar ICH is associated with dementia, while ICH in the basal ganglia is associated with disability. ConclusionsSpecific distribution of ICH lesions is linked to development of dementia and disability after ICH. interquartile range, 1.05.8)
40 
Hypertension Journal
OCTOBER 23, 2023
BACKGROUND:Abnormal orthostatic blood pressure (BP) regulation may result in cerebral hypoperfusion and brain ischemia and contribute to dementia. It may also manifest as early symptoms of the neurodegenerative process associated with dementia. The primary outcome was adjudicated dementia ascertained through 2019.RESULTS:Among
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Stroke Journal
JANUARY 30, 2025
The outcome was a first-ever diagnosis of dementia. The exposure and outcomes were identified using validated ICD-9 and ICD-10-CM diagnosis codes. We excluded patients who had prevalent intracranial hemorrhage or dementia, to ensure that only incident cases were counted in our analyses. Stroke, Ahead of Print.
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Stroke Journal
JANUARY 30, 2025
Introduction:All-cause dementia remains a significant public health concern, with stroke recognized as a key risk factor. Few studies have applied Machine Learning (ML) models to accurately predict cognitive impairment and dementia, yet none have specifically focused on post-stroke dementia risk prediction. The sample was 48.4%
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Dr. Paddy Barrett
AUGUST 30, 2024
Poor Sleep Might Eliminate The Benefits Of Exercise & Dementia. High levels of aerobic fitness are closely linked to lower rates of future dementia 1. Regular physical activity is arguably one of the biggest factors preventing dementia. When it comes to preventing dementia, this could not be truer.
111 
Stroke Journal
FEBRUARY 1, 2024
Background:The aging of the population is associated with an increasing number of stroke patients with pre-existing dementia. However, the association between pre-stroke dementia and functional outcome after acute ischemic stroke (AIS) has not been fully investigated. women), 86 (17.4%) had PED. vs. 57.0%, P < 0.0001).
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Stroke Journal
JANUARY 18, 2024
Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease–related dementias.
90 
Dr. Paddy Barrett
AUGUST 23, 2024
While I have covered many of these fitness measures individually in previous posts, I wanted to summarise these metrics and how they relate to living longer and preventing major diseases such as cardiovascular disease, cancer and dementia. Fitness & Dementia This relationship is also clearly evident when it comes to rates of dementia.
116 
Stroke Journal
DECEMBER 9, 2024
BACKGROUND:Although the presence of amyloid deposits is associated with a more severe cognitive status in patients with stroke at baseline, its influence on the subsequent cognitive outcome has not been extensively assessed. Patients underwent annually comprehensive clinical and cognitive assessments for 5 years after the PET scan.
40 Stroke Journal
JANUARY 30, 2025
Background:Around one in three strokes are experienced by people living with disability or dementia (PLWD), yet there is currently no consensus to guide physicians in evaluating baseline status in this patient population and determining goals of care. Stroke, Volume 56, Issue Suppl_1 , Page ATP123-ATP123, February 1, 2025.
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Dr. Paddy Barrett
OCTOBER 11, 2024
Dementia is a leading cause of death and a major concern for most people as they age. Optimal metabolic health is linked to reduced rates of dementia, but the question again is whether the use of medications such as Ozempic might also delay the onset of dementia. Obstructive Sleep Apnea (OSA). Sci Rep 13 , 20998 (2023).
79 
CardioBrief
JULY 26, 2018
It’s “breakthrough” time again. News reports out of the Alzheimer’s Association International Conference (AAIC) this week have been relentlessly upbeat and positive about findings from the NIH’s SPRINT MIND study. The message: aggressive blood pressure control can help protect the brain.
Dr. Paddy Barrett
MARCH 23, 2024
It’s not that they don’t get cardiovascular disease, cancer or dementia; they just get it way later than everyone else. When broken down by disease category, cardiovascular disease, cancer, dementia, stroke, osteoarthritis, hypertension and stroke, the pattern is the same. J Gerontol A Biol Sci Med Sci.
106 
Dr. Paddy Barrett
JANUARY 16, 2024
Cardiovascular disease, cancer and dementia account for 60% of all deaths in the US. For those in the ‘Ideal’ category, they were 51% less likely to have either dementia or depression. And less diabetes means less of a driver of the three main leading causes of death - cardiovascular disease, cancer and dementia.
94 
Journal of the American Heart Association
FEBRUARY 14, 2024
One such syndrome that has been associated with poor outcomes is cognitive frailty: the simultaneous presence of cognitive impairment, without evidence of dementia, and physical frailty, which results in decreased cognitive reserve.
Stroke Journal
FEBRUARY 1, 2024
We excluded participants with stroke, dementia, or late-life depression (LLD) at baseline. The outcome of interest was a composite of stroke, dementia, or LLD. The outcome of interest was a composite of stroke, dementia, or LLD.
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JAMA Cardiology
JANUARY 28, 2025
Blood pressure control among individuals with hypertension in both high-income and in low-income and middle-income countries (LMICs) is low, resulting in avoidable and expensive strokes, heart attacks, kidney failure, dementia, and other negative health outcomes.
HeartRhythm
APRIL 30, 2024
However, the data on neurological outcomes including cerebrovascular disease (CVA) and dementia remain a controversy. Catheter ablation (CA) of atrial fibrillation (AF) has been proved to benefit patient with symptomatic AF and heart failure.
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP349-ATP349, February 1, 2025. Background:Inflammation, a key player in both acute and chronic cerebral ischemia, is activated in brain tissues by bilateral carotid stenosis (BCAS)- induced chronic cerebral hypoperfusion.
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Stroke Journal
FEBRUARY 1, 2024
Background:Anecdotal cases of rapidly progressing dementia in patients with dural arteriovenous fistulas (dAVFs) and cortical venous drainage have been reported in small series. Post-treatment outcomes were analyzed.Results:A total of 60 patients with dAVFs-CI and 60 control dAVFs were included.
40 
DAIC
SEPTEMBER 11, 2024
Fortunately, atrial fibrillation is preventable, and early detection and appropriate treatment can substantially reduce its adverse outcomes,” he said.
The British Journal of Cardiology
JUNE 11, 2024
Nonagenarians constitute an expanding proportion of pacemaker recipients, yet data on device selection and outcomes are limited, especially in emergency situations. In nonagenarians with emergent CHB, we compared the clinical characteristics and outcomes of patients receiving VVI versus DDD pacemakers. vs. 50.7% ± 10.1, vs. 4.3 ± 1.1,
40 
Stroke Journal
MARCH 4, 2025
Subarachnoid hemorrhage is a critical neurological condition accounting for about 5% of all strokes, and survivors experience long-term cognitive deterioration and increased risk of dementia. Genetic predispositions have been associated with post-subarachnoid hemorrhage cognitive outcomes and emphasize a role for personalized care strategies.
40 
Stroke Journal
JANUARY 30, 2025
Clinical and neuroimaging predictors of an unfavorable discharge outcome (modified Rankin score 4) were assessed in univariate and multivariable models.Results:Between 2003 and 2019, 1,791 patients were admitted with non-traumatic ICH. Patients who met the diagnostic criteria for CAA were selected for inclusion in this study.
40 
Journal of the American Heart Association
JANUARY 17, 2025
Linear, zeroinflated Poisson, and logistic regression were employed for continuous, count, and binary outcomes, respectively. Cortical CMIs may partly explain the relationship between concentric LV hypertrophy and cognitive function.ConclusionsConcentric LV hypertrophy was associated with cortical CMIs and dementia.
40 Journal of the American Heart Association
DECEMBER 29, 2023
AF increases the risk of stroke, heart failure, dementia, and hospitalization. In this review, we discuss mechanisms by which obesity mediates AF and treatment outcomes, aiming to provide insight into obesity‐drug interactions and guide personalized treatment for this patient subgroup.
45 
Circulation
NOVEMBER 11, 2024
Background:Cognitive decline and dementia are significant global health concerns, with hypertension being a major risk factor. Moreover, the relationship between blood pressure (BP) components, particularly diastolic BP (DBP) and pulse pressure (PP), and the risk of cognitive decline or dementia remains complex. 23, p=0.005).
40 
Cardiometabolic Health Congress
APRIL 12, 2024
This endorsement is based on positive CLEAR Outcomes data , including indications for cardiovascular risk reduction and extended LDL-C reduction in primary and secondary prevention patients. Providers like you require more tools in your arsenal. Over a median duration of 3.4
Stroke Journal
JANUARY 30, 2025
Background:Vascular cognitive impairment (VCI) is the second most frequent subtype of dementia following Alzheimer's disease. MicroRNAs (miRNAs) play critical roles in the pathologies of cerebral ischemia and dementia. However, the underlying mechanism has not been fully understood and there is no effective treatment for VCI.
40 Stroke Journal
JANUARY 30, 2025
Diabetes increases the risk of Vascular Contributions to Cognitive Impairment&Dementia (VCID) and stroke further amplifies this effect. There is emerging evidence that ETB receptor agonism improves outcomes in patients with cerebral ischemic stroke, but long-term effects, especially in diabetes, are unknown.
40 
Journal of the American Heart Association
DECEMBER 14, 2024
We used regression models to investigate associations between BACE1 and imaging and blood markers as well as clinical outcomes in CSVD. During 2year followup, BACE1 activity was independently related to dementia conversion (odds ratio, 17.72;P=0.001) Plasma BACE1 activity was significantly higher in CSVD (median 862.0 RFU, 438.3662.1,P<0.001)
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