Circulation

APRIL 4, 2025

BACKGROUND:Shared genetic and lifestyle risk factors may underlie the development of both coronary artery disease (CAD) and dementia. Primary outcomes were incident all-cause, Alzheimers, and vascular dementia diagnoses obtained from electronic health records. year follow-up. year follow-up.

Coronary Artery Disease 51

Coronary Artery Disease Dementia Risk Factors Outcomes 51

CardiacWire

JANUARY 22, 2025

Starting with the good news, GLP-1s lowered risks for 42 health outcomes while increasing risks for 19 outcomes. GLP-1s also led to an 8% lower risk of dementia and 12% lower risk of Alzheimer’s disease. That said, it could serve as an early look into the long-term health outcomes of using GLP-1s to treat obesity and T2D.

Obesity 59

Obesity Cardiac Arrest Dementia Outcomes 59

Science Daily - Heart Disease

APRIL 22, 2024

This irregular heartbeat is associated with increased risks of heart failure, dementia and stroke. These results pave the way for integration into wearable technologies, allowing early interventions and better patient outcomes. It gives early warnings on average 30 minutes before onset, with an accuracy of around 80%.

Arrhythmia 124

Arrhythmia Atrial Fibrillation Dementia Heart Failure 124

Stroke Journal

FEBRUARY 1, 2024

Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. Primary outcome was defined as favorable 90-day outcome (modified Rankin Scale (mRS) score 0-2). Results:9 articles were included from 825 screened. 95%CI 1.03

Dementia 40

Dementia Outcomes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

The outcome was an incident diagnosis of dementia. The exposure and outcomes were identified using previously validatedICD-9andICD-10-CMdiagnosis codes. In the primary analysis, we used Cox regression to study the risk of dementia after any intracranial hemorrhage, after adjusting for demographics and comorbidities.

Dementia 40

Dementia Hemorrhage Medicare Outpatient 40

Journal of the American Heart Association

FEBRUARY 8, 2025

Previous studies categorizing ICH by large anatomic boundaries have demonstrated that lobar ICH is associated with dementia, while ICH in the basal ganglia is associated with disability. ConclusionsSpecific distribution of ICH lesions is linked to development of dementia and disability after ICH. interquartile range, 1.05.8)

Dementia 40

Dementia Hemorrhage Outcomes Hospital 40

Hypertension Journal

OCTOBER 23, 2023

BACKGROUND:Abnormal orthostatic blood pressure (BP) regulation may result in cerebral hypoperfusion and brain ischemia and contribute to dementia. It may also manifest as early symptoms of the neurodegenerative process associated with dementia. The primary outcome was adjudicated dementia ascertained through 2019.RESULTS:Among

Dementia 40

Dementia Blood Pressure Atherosclerosis Ischemia 40

Stroke Journal

JANUARY 30, 2025

The outcome was a first-ever diagnosis of dementia. The exposure and outcomes were identified using validated ICD-9 and ICD-10-CM diagnosis codes. We excluded patients who had prevalent intracranial hemorrhage or dementia, to ensure that only incident cases were counted in our analyses. Stroke, Ahead of Print.

Dementia 40

Dementia Hemorrhage Medicare Outpatient 40

Physiologically Speaking

DECEMBER 2, 2024

This study emphasizes how exercise intensity and volume contribute differently to physiological adaptations, depending on the desired outcome and the individual’s fitness level. The inevitable conclusion for our training is that we need both low- and high-intensity training to truly reach our peak potential. hours/day), moderate (10.2–11.4

Physiology 59

Physiology Exercise Dementia Genetic predisposition 59

Stroke Journal

JANUARY 30, 2025

Introduction:All-cause dementia remains a significant public health concern, with stroke recognized as a key risk factor. Few studies have applied Machine Learning (ML) models to accurately predict cognitive impairment and dementia, yet none have specifically focused on post-stroke dementia risk prediction. The sample was 48.4%

Dementia 40

Dementia Stroke Strokes Blood Pressure 40

Dr. Paddy Barrett

AUGUST 30, 2024

Poor Sleep Might Eliminate The Benefits Of Exercise & Dementia. High levels of aerobic fitness are closely linked to lower rates of future dementia 1. Regular physical activity is arguably one of the biggest factors preventing dementia. When it comes to preventing dementia, this could not be truer.

Heart Disease 111

Heart Disease Dementia Obesity Heart attacks 111

Stroke Journal

JANUARY 18, 2024

Accumulating evidence supports a link between sleep disorders, disturbed sleep, and adverse brain health, ranging from stroke to subclinical cerebrovascular disease to cognitive outcomes, including the development of Alzheimer disease and Alzheimer disease–related dementias.

Dementia 90

Dementia Cerebrovascular Disease Biomarkers Stroke 90

Stroke Journal

DECEMBER 9, 2024

BACKGROUND:Although the presence of amyloid deposits is associated with a more severe cognitive status in patients with stroke at baseline, its influence on the subsequent cognitive outcome has not been extensively assessed. Patients underwent annually comprehensive clinical and cognitive assessments for 5 years after the PET scan.

Dementia 40

Dementia Outcomes Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Background:Around one in three strokes are experienced by people living with disability or dementia (PLWD), yet there is currently no consensus to guide physicians in evaluating baseline status in this patient population and determining goals of care. Stroke, Volume 56, Issue Suppl_1 , Page ATP123-ATP123, February 1, 2025.

Dementia 40

Dementia Stroke Strokes Best Practices 40

CardioBrief

JULY 26, 2018

It’s “breakthrough” time again. News reports out of the Alzheimer’s Association International Conference (AAIC) this week have been relentlessly upbeat and positive about findings from the NIH’s SPRINT MIND study. The message: aggressive blood pressure control can help protect the brain.

Blood Pressure 52

Blood Pressure Dementia Outcomes 52

Journal of the American Heart Association

FEBRUARY 14, 2024

One such syndrome that has been associated with poor outcomes is cognitive frailty: the simultaneous presence of cognitive impairment, without evidence of dementia, and physical frailty, which results in decreased cognitive reserve.

Cardiovascular Disease 73

Cardiovascular Disease Dementia Obesity Risk Factors 73

Stroke Journal

FEBRUARY 1, 2024

We excluded participants with stroke, dementia, or late-life depression (LLD) at baseline. The outcome of interest was a composite of stroke, dementia, or LLD. The outcome of interest was a composite of stroke, dementia, or LLD.

Outcomes 40

Outcomes Dementia Blood Pressure Public Health 40

HeartRhythm

APRIL 30, 2024

However, the data on neurological outcomes including cerebrovascular disease (CVA) and dementia remain a controversy. Catheter ablation (CA) of atrial fibrillation (AF) has been proved to benefit patient with symptomatic AF and heart failure.

Atrial Fibrillation 40

Atrial Fibrillation Ablation Cerebrovascular Disease Dementia 40

Stroke Journal

JANUARY 30, 2025

Stroke, Volume 56, Issue Suppl_1 , Page ATP349-ATP349, February 1, 2025. Background:Inflammation, a key player in both acute and chronic cerebral ischemia, is activated in brain tissues by bilateral carotid stenosis (BCAS)- induced chronic cerebral hypoperfusion.

Dementia 40

Dementia Ischemia Stenosis Outcomes 40

Stroke Journal

FEBRUARY 1, 2024

Background:Anecdotal cases of rapidly progressing dementia in patients with dural arteriovenous fistulas (dAVFs) and cortical venous drainage have been reported in small series. Post-treatment outcomes were analyzed.Results:A total of 60 patients with dAVFs-CI and 60 control dAVFs were included.

Outcomes 40

Outcomes Dementia Hypertension Stenosis 40

JAMA Cardiology

JANUARY 28, 2025

Blood pressure control among individuals with hypertension in both high-income and in low-income and middle-income countries (LMICs) is low, resulting in avoidable and expensive strokes, heart attacks, kidney failure, dementia, and other negative health outcomes.

Blood Pressure 54

Blood Pressure Hypertension Heart attacks Heart Attack 54

Stroke Journal

MARCH 4, 2025

Subarachnoid hemorrhage is a critical neurological condition accounting for about 5% of all strokes, and survivors experience long-term cognitive deterioration and increased risk of dementia. Genetic predispositions have been associated with post-subarachnoid hemorrhage cognitive outcomes and emphasize a role for personalized care strategies.

Hemorrhage 40

Hemorrhage Genetic predisposition Genetic Markers Quality of Life 40

Stroke Journal

JANUARY 30, 2025

Clinical and neuroimaging predictors of an unfavorable discharge outcome (modified Rankin score 4) were assessed in univariate and multivariable models.Results:Between 2003 and 2019, 1,791 patients were admitted with non-traumatic ICH. Patients who met the diagnostic criteria for CAA were selected for inclusion in this study.

Hemorrhage 40

Hemorrhage Dementia Hypertension Outcomes 40

Journal of the American Heart Association

JANUARY 17, 2025

Linear, zeroinflated Poisson, and logistic regression were employed for continuous, count, and binary outcomes, respectively. Cortical CMIs may partly explain the relationship between concentric LV hypertrophy and cognitive function.ConclusionsConcentric LV hypertrophy was associated with cortical CMIs and dementia.

Dementia 40

Dementia Risk Factors Heart Disease Outcomes 40

Journal of the American Heart Association

DECEMBER 29, 2023

AF increases the risk of stroke, heart failure, dementia, and hospitalization. In this review, we discuss mechanisms by which obesity mediates AF and treatment outcomes, aiming to provide insight into obesity‐drug interactions and guide personalized treatment for this patient subgroup.

Obesity 45

Obesity Atrial Fibrillation Heart Failure Pharmacology 45

Circulation

NOVEMBER 11, 2024

Background:Cognitive decline and dementia are significant global health concerns, with hypertension being a major risk factor. Moreover, the relationship between blood pressure (BP) components, particularly diastolic BP (DBP) and pulse pressure (PP), and the risk of cognitive decline or dementia remains complex. 23, p=0.005).

Pacemaker 40

Pacemaker Blood Pressure Dementia Risk Factors 40

Stroke Journal

JANUARY 30, 2025

Background:Vascular cognitive impairment (VCI) is the second most frequent subtype of dementia following Alzheimer's disease. MicroRNAs (miRNAs) play critical roles in the pathologies of cerebral ischemia and dementia. However, the underlying mechanism has not been fully understood and there is no effective treatment for VCI.

Dementia 40

Dementia Cholesterol Ischemia Stroke 40

Stroke Journal

JANUARY 30, 2025

Diabetes increases the risk of Vascular Contributions to Cognitive Impairment&Dementia (VCID) and stroke further amplifies this effect. There is emerging evidence that ETB receptor agonism improves outcomes in patients with cerebral ischemic stroke, but long-term effects, especially in diabetes, are unknown.

Diabetes 40

Diabetes Dementia Stroke Strokes 40

Journal of the American Heart Association

DECEMBER 14, 2024

We used regression models to investigate associations between BACE1 and imaging and blood markers as well as clinical outcomes in CSVD. During 2year followup, BACE1 activity was independently related to dementia conversion (odds ratio, 17.72;P=0.001) Plasma BACE1 activity was significantly higher in CSVD (median 862.0 RFU, 438.3662.1,P<0.001)

Dementia 40

Dementia Biomarkers Hemorrhage Hypertension 40

Journal of Cardiovascular Electrophysiology

OCTOBER 23, 2023

The concept of AF burden has more recently been used as a clinical endpoint in clinical trials as a more clinically relevant endpoint compared to AF-related symptoms or time to first recurrence, but its correlation with symptoms and other clinical outcomes remains unclear.

Atrial Fibrillation 40

Atrial Fibrillation Dementia Heart Failure Arrhythmia 40

Stroke Journal

FEBRUARY 1, 2024

BHe was a composite of stroke, dementia and late-life depression. Stage 1 entailed testing for association between BHe prior to 2016 (exposure) and epigenetic age (outcome). Stage 2 entailed testing for association between epigenetic age (exposure) and BHe occurring after 2016 (outcome).

Dementia 40

Dementia Stroke Strokes Outcomes 40

Stroke Journal

JANUARY 30, 2025

The main outcome was a first-documented, isolated, non-traumatic SDH; we did not count SDH cases with a concurrent traumatic brain injury. The exposures and outcome were identified using previously validatedICD-10-CMdiagnosis codes. million hospitalized patients, 2,335 had CAA and 600,646 had other cerebrovascular disease.

Hemorrhage 40

Hemorrhage Cerebrovascular Disease Dementia Hospital 40

Stroke Journal

FEBRUARY 1, 2024

Global cognition (primary outcome), executive function, and memory were harmonized across studies and standardized as T-scores (mean [SD], 50 [10]); a 1-point difference represents a 0.1-SD Linear mixed-effects models were used to estimate longitudinal changes in cognition after incident stroke. SD difference in cognition.

Stroke 40

Stroke Strokes Hemorrhage Atherosclerosis 40

Stroke Journal

FEBRUARY 1, 2024

Background:Cerebrovascular disease is a common cause of vascular cognitive impairment (VCI) and may progress to vascular dementia at a relatively fast rate. Before the intervention and at the end of the first and second months of the intervention, executive function was assessed as the primary outcome using the Trail-Making Test (TMT)-A/B.

Outpatient 40

Outpatient Dementia Outcomes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

While the epsilon (ε) 4 variants within theAPOEgene have been extensively investigated as a risk factor for dementia and stroke,APOEε4 carriers have not been thoroughly studied as an at-risk population. Our outcome was a composite of stroke, TIA or MI.

Myocardial Infarction 40

Myocardial Infarction Blood Pressure Dementia Diet 40

Stroke Journal

FEBRUARY 1, 2024

Participants ≥18 years with incident stroke and free of dementia were included (52% female and 39% Black). Repeated cognitive tests were administered in person or by telephone by trained cohort staff. Median (IQR) follow-up was 4.1 (1.8,

Education 40

Education Stroke Strokes Dementia 40

Stroke Journal

FEBRUARY 1, 2024

CAA may lead to dementia and stroke; however effective options currently are very limited to treat or halt CAA progression. Pharmacological inhibition of EZH2 improved cognitive outcomes in CAA mice, suggesting a possible therapeutic target. Stroke, Volume 55, Issue Suppl_1 , Page AWMP114-AWMP114, February 1, 2024.

Pharmacology 40

Pharmacology Dementia Stroke Strokes 40