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Orthostatic Blood Pressure Change, Dizziness, and Risk of Dementia in the ARIC Study: Dementia Series

Hypertension Journal

BACKGROUND:Abnormal orthostatic blood pressure (BP) regulation may result in cerebral hypoperfusion and brain ischemia and contribute to dementia. It may also manifest as early symptoms of the neurodegenerative process associated with dementia. The primary outcome was adjudicated dementia ascertained through 2019.RESULTS:Among

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Abstract TP357: Mitochondrial intercellular transfer via platelets after physical training exerts neuro-glial protection against cerebral ischemia.

Stroke Journal

In cases of acute ischemia, training improved complications and reduced glial activation. Our study suggests it could be a promising new treatment for reducing post-stroke complications and vascular dementia. However, treadmill training protected against these damages.

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Abstract TP349: Deleted NLRP3 inflammasome improves functional outcome and improves cerebral blood flow in an experimental model of Vascular Cognitive Impairment and Dementia

Stroke Journal

Background:Inflammation, a key player in both acute and chronic cerebral ischemia, is activated in brain tissues by bilateral carotid stenosis (BCAS)- induced chronic cerebral hypoperfusion. Stroke, Volume 56, Issue Suppl_1 , Page ATP349-ATP349, February 1, 2025.

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Long-Term Cognitive Decline After Subarachnoid Hemorrhage: Pathophysiology, Management, and Future Directions

Stroke Journal

Subarachnoid hemorrhage is a critical neurological condition accounting for about 5% of all strokes, and survivors experience long-term cognitive deterioration and increased risk of dementia. These have emerging treatments that offer promise for the mitigation of effects such as inflammation, iron chelation, and microvascular dysfunction.

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Abstract WMP13: Cardiac Injury Potentially Contributes to Neuroinflammation via Extracellular Vesicles

Stroke Journal

Cardiogenic dementia has been suggested to characterize patients suffering from cognitive decline after heart disease. Clinical and experimental evidence further suggest that 35%-65% of patients with myocardial ischemia are affected by CGI which include memory and global cognitive deficits.

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Abstract TMP119: Suppression of microRNA-145 alleviates the vascular cognitive impairment in a multiple microinfarction model

Stroke Journal

Background:Vascular cognitive impairment (VCI) is the second most frequent subtype of dementia following Alzheimer's disease. MicroRNAs (miRNAs) play critical roles in the pathologies of cerebral ischemia and dementia. However, the underlying mechanism has not been fully understood and there is no effective treatment for VCI.

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Abstract 262: National Trends of 90?day Readmission Rates and Etiologies among Diabetics following Transient Ischemic Attack

Stroke: Vascular and Interventional Neurology

IntroductionTransient Ischemic Attack (TIA) is a common neurologic condition characterized by temporary, focal cerebral ischemia that results in reversible neurological deficits without tissue infarction. Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023.