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The Potential Risks of GLP-1s

CardiacWire

Starting with the good news, GLP-1s lowered risks for 42 health outcomes while increasing risks for 19 outcomes. As expected, GLP-1s reduced MI risk by 9%, cardiac arrest by 22%, incident HF by 11%, ischemic stroke by 7%, and hemorrhagic stroke by 14%. The less good news?

Obesity 59
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Abstract WP51: Non-Traumatic Intracranial Hemorrhage and Risk of Incident Dementia

Stroke Journal

The exposure was an incident diagnosis of non-traumatic intracranial hemorrhage, defined as a composite of intracerebral hemorrhage, subarachnoid hemorrhage, or subdural hemorrhage. The outcome was an incident diagnosis of dementia. million patients, 14,775 had a diagnosis of intracranial hemorrhage.

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Non-Traumatic Intracranial Hemorrhage and Risk of Incident Dementia in U.S. Medicare Beneficiaries

Stroke Journal

The exposure was a new diagnosis of non-traumatic intracranial hemorrhage, defined as a composite of intracerebral hemorrhage (ICH), subarachnoid hemorrhage (SAH), and subdural hemorrhage (SDH). The outcome was a first-ever diagnosis of dementia. The cumulative incidence rate of dementia was 8.6% (IQR, 8.1-8.9)

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Spatial Correlates of Dementia and Disability After Intracerebral Hemorrhage

Journal of the American Heart Association

BackgroundDementia and disability are highly prevalent after spontaneous intracerebral hemorrhage (ICH). Previous studies categorizing ICH by large anatomic boundaries have demonstrated that lobar ICH is associated with dementia, while ICH in the basal ganglia is associated with disability. interquartile range, 1.05.8) years and 1.0

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Long-Term Cognitive Decline After Subarachnoid Hemorrhage: Pathophysiology, Management, and Future Directions

Stroke Journal

Subarachnoid hemorrhage is a critical neurological condition accounting for about 5% of all strokes, and survivors experience long-term cognitive deterioration and increased risk of dementia. Stroke, Ahead of Print. Management techniques reviewed include long-term cognitive health, such as endovascular coiling and surgical clipping.

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Abstract TMP92: Dementia and Cognitive Impairment in Stroke: A Systematic Review and Meta-Analysis of Reperfusion Treatment Outcomes

Stroke Journal

Background:Endovascular thrombectomy (EVT) and intravenous thrombolysis (IVT) outcomes are unclear in patients with pre-stroke dementia or cognitive impairment. Primary outcome was defined as favorable 90-day outcome (modified Rankin Scale (mRS) score 0-2). Results:9 articles were included from 825 screened. 95%CI 1.03

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Abstract 83: Prognostic Value of Cortical Superficial Siderosis Among Patients with Cerebral Amyloid Angiopathy-Associated Intracerebral Hemorrhage

Stroke Journal

Clinical and neuroimaging predictors of an unfavorable discharge outcome (modified Rankin score 4) were assessed in univariate and multivariable models.Results:Between 2003 and 2019, 1,791 patients were admitted with non-traumatic ICH. Introduction:The recent update (version 2.0)