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Physiology Friday #245: Fitness Protects against Neurodegenerative Diseases—Even in Those at the Greatest Risk

Physiologically Speaking

Exercise benefits on Alzheimer’s disease: State-of-the-science - ScienceDirect But could fitness also influence our risk for common diseases of aging like dementia and Alzheimer’s? And while lifestyle factors play a crucial role in mitigating the risk of dementia, our genetic makeup also plays a part. Moderate: 24.1–31.1

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Midlife Choices May Offset Genetic Risk for Dementia, Stroke, Late-Life Depression

Med Page Today

(MedPage Today) -- Healthier lifestyle behaviors in midlife were linked with better outcomes in people with genetic predisposition for age-related brain diseases, longitudinal data from the U.K. Biobank showed. Over about 12 years of follow-up.

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Physiology Friday November Recap

Physiologically Speaking

This study examined the relationship between cardiorespiratory fitness and the risk of developing neurodegenerative diseases, such as dementia and Alzheimer’s, particularly in individuals with a high genetic predisposition.

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Long-Term Cognitive Decline After Subarachnoid Hemorrhage: Pathophysiology, Management, and Future Directions

Stroke Journal

Subarachnoid hemorrhage is a critical neurological condition accounting for about 5% of all strokes, and survivors experience long-term cognitive deterioration and increased risk of dementia. These have emerging treatments that offer promise for the mitigation of effects such as inflammation, iron chelation, and microvascular dysfunction.