Medical Xpress - Cardiology

DECEMBER 11, 2023

Using a novel "organ-on-a-chip" model, Baker Heart & Diabetes Institute researchers have discovered a potential therapeutic target that may slow down vascular aging and reduce heart disease, kidney dysfunction and vascular dementia.

Dementia 75

Dementia Heart Disease Diabetes Research 75

Dr. Paddy Barrett

AUGUST 30, 2024

Poor Sleep Might Eliminate The Benefits Of Exercise & Dementia. High levels of aerobic fitness are closely linked to lower rates of future dementia 1. Regular physical activity is arguably one of the biggest factors preventing dementia. When it comes to preventing dementia, this could not be truer.

Heart Disease 111

Heart Disease Dementia Obesity Heart Attack 111

Stroke Journal

FEBRUARY 1, 2024

Diabetes doubles the risk of VCID but the underlying reasons remain unclear. At 10 weeks after the onset of diabetes, control and diabetic rats received cholesterol crystal ME (40-70 μm) injections and were monitored for 16 weeks. MAG/PLP-1 ratio was even lower in diabetic ME animals (Table 1).

Dementia 40

Dementia Diabetes Cholesterol Stroke 40

Stroke Journal

JANUARY 30, 2025

Diabetes increases the risk of Vascular Contributions to Cognitive Impairment&Dementia (VCID) and stroke further amplifies this effect. Diabetes also dysregulates the Endothelin (ET) system. Male rats underwent 60-min middle cerebral artery occlusion surgery (MCAO) 8 weeks after diabetes onset.

Diabetes 40

Diabetes Dementia Strokes Stroke 40

Journal of the American Heart Association

FEBRUARY 14, 2024

One such syndrome that has been associated with poor outcomes is cognitive frailty: the simultaneous presence of cognitive impairment, without evidence of dementia, and physical frailty, which results in decreased cognitive reserve.

Cardiovascular Disease 73

Cardiovascular Disease Dementia Obesity Risk Factors 73

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

Type 2 Diabetes Mellitus (T2DM) is a rapidly growing global health problem with increasing prevalence. Of those patients, 35.43% (n=273,993) were diabetic and 64.57% (n=151,112) were non‐diabetic. Diabetics were more likely to be younger (70.43 Among diabetics, readmitted patients were more likely to be older (71.87

Diabetes 40

Diabetes Coronary Artery Disease Atrial Fibrillation Dementia 40

Dr. Paddy Barrett

FEBRUARY 13, 2024

A 10 to 15kg weight loss in those who are overweight can reverse diabetes in 57% of patients with diabetes 1. Even in diabetics of normal weight (BMI<27), weight loss can reverse diabetes 2. 2 1184-P: Return to Normal Glucose Control by Weight Loss in Nonobese People with Type 2 Diabetes: The ReTUNE Study.

Diet 105

Diet Diabetes Exercise Kidney Disease 105

Journal of the American Heart Association

DECEMBER 29, 2023

AF increases the risk of stroke, heart failure, dementia, and hospitalization. Obesity significantly increases AF risk, both directly and indirectly, through related conditions, like hypertension, diabetes, and heart failure. ABSTRACTAtrial fibrillation (AF) is the most common cardiac arrhythmia.

Obesity 45

Obesity Atrial Fibrillation Heart Failure Pharmacology 45

Stroke Journal

JANUARY 30, 2025

In univariate analyses, age, hypertension, diabetes, ischemic stroke history, dementia, admission Glasgow Coma Scale (GCS) scores, intubation, external ventricular drain placement, hematoma evacuation, intraventricular extension, and cSS were associated with an unfavorable discharge outcome (allp&lt; 0.05).

Hemorrhage 40

Hemorrhage Dementia Hypertension Outcomes 40

Physiologically Speaking

FEBRUARY 14, 2025

They had lower risks of hypertension, diabetes, dementia, stroke, Parkinson’s disease, obesity, sleep apnea, and other chronic health conditions compared to inactive adults and similar risks compared to adults accruing their weekly exercise in a greater number of days.

Physiology 85

Physiology Exercise Research Dementia 85

Stroke Journal

JANUARY 30, 2025

We previously found that large PFO shunt is associated with increased long-term risk of vascular dementia. This study aims to explore the relationship among PFO shunt, total homocysteine (tHcy) levels and the risk of vascular cognitive impairment and dementia (VCID).Method:A

Dementia 40

Dementia Risk Factors Echocardiogram Circulation 40

Stroke Journal

JANUARY 30, 2025

Introduction:Vascular cognitive impairment and vascular dementia are diagnosed based on brain vascular changes related to strokes. Over half of the subjects with strokes were females (55 (63.2%)), diabetic (44 (50.6%)), hypertensive (58 (66.7%)), and had metabolic syndrome (44 (50.6%)). Subjects with strokes had a mean (sd) age of 61.4

Stroke 40

Stroke Strokes Education Diabetes 40

Cardiometabolic Health Congress

JUNE 7, 2024

He highlighted that cardiovascular health is essential for cognitive health, noting the common occurrence of vascular dementia. Untangling the Statins and Diabetes Link : Dr. Savitha Subtamaniam explored the incidence of diabetes associated with statin use, noting that the mechanism is unclear. Ballantyne, MD, FNLA , Robert A.

Cardiovascular Disease 59

Cardiovascular Disease Obesity Heart Disease Risk Factors 59

Stroke Journal

FEBRUARY 1, 2024

Background:White matter hyperintensities (WMH) are associated with risk of dementia and stroke, so are an important therapeutic target for clinical trials. Stroke, Volume 55, Issue Suppl_1 , Page ATP35-ATP35, February 1, 2024.

Dementia 40

Dementia Atherosclerosis Diabetes Hypertension 40

Dr. Paddy Barrett

AUGUST 9, 2024

More than heart disease or cancer, the risk of dementia often creates much greater anxiety in the patients I see. And given that dementia is routinely in the top 5 leading causes of death, this concern is dually warranted. But can dementia be prevented? 14 Ways To Prevent Dementia. 14 Ways To Prevent Dementia.

Dementia 116

Dementia Blood Pressure Obesity Cholesterol 116

Dr. Paddy Barrett

NOVEMBER 8, 2024

“Statins cause dementia” This one is easy. For a more detailed explanation of why this is the case and why they may, in fact, protect against dementia, you can read a previous post here. “Statins cause diabetes” This one is true. No, they don’t. But the devil is in the detail.

Cholesterol 130

Cholesterol Plaque Heart Attack Heart attacks 130

Dr. Sanjay Gupta

JANUARY 17, 2022

However over the past few years there have been several studies which have studied AF patients and discovered patients with AF have a significantly higher prevalence of cognitive impairment and dementia and as we do not have any clinical guidelines as yet, we have to try and work out for ourselves as to why there is this association.

Dementia 52

Dementia Ablation Atrial Fibrillation Risk Factors 52

Dr. Paddy Barrett

FEBRUARY 21, 2025

The reason excess weight is such big issues are the health consequences it confers with increased rates of diabetes, heart disease, osteoarthritis, obstructive sleep apnea, non-alcoholic fatty liver disease and others, just to name a few. Avoiding diabetes and its precursor states inclduing insulin resistance is key. NEJM Nov 13 2024

Obesity 81

Obesity Diabetes Cardiovascular Disease Chronic Disease 81

Dr. Paddy Barrett

OCTOBER 11, 2024

Dementia is a leading cause of death and a major concern for most people as they age. Optimal metabolic health is linked to reduced rates of dementia, but the question again is whether the use of medications such as Ozempic might also delay the onset of dementia. Obstructive Sleep Apnea (OSA). Colorectal Cancer - 46% reduction.

Obesity 84

Obesity Cancer Dementia Coronary Artery Disease 84

Journal of the American Heart Association

MARCH 21, 2025

BackgroundStroke and dementia are leading causes of mortality and can be prevented through risk factor management. We included participants with available data on selfreported and measured hypertension, hypercholesterolemia, diabetes, kidney disease, hearing impairment and overweight.

Risk Factors 40

Risk Factors Dementia Stroke Strokes 40

Stroke Journal

JANUARY 30, 2025

Introduction:Stroke and dementia are among the leading causes of mortality globally. Reliability of self-reported risk factors was high in overweight (F1 0.81) and diabetes (F1 0.71), moderate in hearing impairment (F1 0.59) and hypertension (F1 0.56) and low in hypercholesterolemia (F1 0.49) and kidney disease (F1 0.25).

Risk Factors 40

Risk Factors Dementia Stroke Strokes 40

DAIC

SEPTEMBER 11, 2024

A-Fib, as the condition is commonly known, has been on the rise for at least the past decade, driven by the aging of the population, along with increasing rates of hypertension, diabetes and obesity. Earlier projections had estimated that 3.3 million U.S. The study appears Sept. 11 in the Journal of the American College of Cardiology JACC.

Atrial Fibrillation 92

Atrial Fibrillation Quality of Life Myocardial Infarction Kidney Disease 92

Dr. Paddy Barrett

AUGUST 23, 2024

While I have covered many of these fitness measures individually in previous posts, I wanted to summarise these metrics and how they relate to living longer and preventing major diseases such as cardiovascular disease, cancer and dementia. Those with the very highest levels of fitness have almost nonexistent rates of type 2 diabetes 4.

Exercise 116

Exercise Dementia Cancer Chronic Disease 116

Dr. Paddy Barrett

SEPTEMBER 13, 2024

Everyone sits somewhere on the scale of insulin sensitivity from very insulin sensitive to very insulin resistant at the point of type 2 diabetes. Understanding where you sit on this continuum is a key part of defining your future risk of heart disease but also dementia, and many cancers. Measuring Insulin Resistance. Some complex.

Risk Factors 106

Risk Factors Heart Disease Dementia Cardiovascular Disease 106

Dr. Paddy Barrett

JANUARY 16, 2024

Cardiovascular disease, cancer and dementia account for 60% of all deaths in the US. For those in the ‘Ideal’ category, they were 51% less likely to have either dementia or depression. However, the way they classified this was unusual as they put both type 2 diabetes and thyroid disorders together.

Cancer 97

Cancer Dementia Diabetes Cardiovascular Disease 97

Physiologically Speaking

AUGUST 23, 2024

Cognitive decline, including Alzheimer’s disease and dementia, is one of the largest causes of death and disability around the world (and all data indicate the rates are rising). And let’s not forget about the brain — which I think is often neglected in conversations about health and longevity.

Physiology 122

Physiology Exercise Laboratory Dementia 122

Stroke Journal

FEBRUARY 1, 2024

Those with high mRS were more likely to have high school-only education or a diagnosis of dementia on admission compared to those with low mRS. Those with high school-only education were 2.94 Similarly, those with a diagnosis of dementia on admission, were 6.22 Similarly, those with a diagnosis of dementia on admission, were 6.22

Hemorrhage 40

Hemorrhage Dementia Outcomes Education 40

DAIC

SEPTEMBER 11, 2024

A-Fib, as the condition is commonly known, has been on the rise for at least the past decade, driven by the aging of the population, along with increasing rates of hypertension, diabetes and obesity. Earlier projections had estimated that 3.3 million U.S. The study appears Sept. 11 in the Journal of the American College of Cardiology JACC.

Atrial Fibrillation 52

Atrial Fibrillation Quality of Life Myocardial Infarction Kidney Disease 52

Frontiers in Cardiovascular Medicine

DECEMBER 18, 2023

Results A total of 4,105 ICU-admitted AMI patients were analyzed.

Myocardial Infarction 64

Myocardial Infarction Coronary Artery Bypass Graft Hospital ICU 64

Stroke Journal

JANUARY 30, 2025

They are key indicators of cerebral small vessel disease (CSVD) and are associated with mild cognitive impairment (MCI) and dementia. Multiple linear regression models tested associations between PVS burden and each NP test, adjusting for age, sex, smoking, diabetes, hypertension, and education.Results:Among 3777 participants (mean age 60.6

Dementia 40

Dementia Biomarkers Education Diabetes 40

Stroke Journal

FEBRUARY 1, 2024

Asymptomatic intracranial large artery stenosis (ILAS) has been associated with higher risk of stroke and dementia. In a model adjusted for age, sex, race/ethnicity, hypertension, diabetes, dyslipidemia and smoking, a higher ILAS score was associated with increased levels of NfL (B=0.01 ± 0.004, p=0.007).

Stenosis 40

Stenosis Dementia Hypertension Biomarkers 40

Stroke Journal

DECEMBER 5, 2024

Participants underwent brain magnetic resonance imaging scans every 3 to 4 years between 2005 and 2016. Cerebral blood flow (CBF) was measured through 2-dimensional phase-contrast magnetic resonance imaging; the cerebrovascular resistance index (CVRi) was defined as the ratio of mean arterial blood pressure to total CBF.

Blood Pressure 40

Blood Pressure Dementia Cardiovascular Disease Diabetes 40

Stroke Journal

FEBRUARY 1, 2024

Evidence shows that in diabetic men, intima-media thickness is significantly higher in those with ApoE4 than those with ApoE3. Whether these interactions influence the risk of stroke and dementia should be further investigated. There was no association between ApoE4 carrier and ICAS score (B= 0.08+0.06, 0.20, p=0.01.Conclusion:ApoE4

Stenosis 40

Stenosis Risk Factors Hypertension Dementia 40

Dr. Paddy Barrett

AUGUST 15, 2023

Insulin resistance is a core risk factor for the three leading causes of death: Cardiovascular Disease Cancer Dementia. Just for clarity, type 2 diabetes is when insulin resistance progresses to the point that your body can no longer keep your blood glucose levels under control. Subscribe now Take cardiovascular disease, for example.

Blood Pressure 52

Blood Pressure Risk Factors Diabetes Cholesterol 52

Dr. Paddy Barrett

MAY 3, 2024

It usually takes many years of being exposed to an uncontrolled risk factor such as high blood pressure, high LDL cholesterol or diabetes. For those who have optimised their cardiovascular risk, their future risk of dementia and many cancers is also likely to reduce. The same applies to high blood pressure, smoking, diabetes, etc.

Heart Attack 105

Heart Attack Heart attacks Blood Pressure Risk Factors 105

Cardiometabolic Health Congress

APRIL 12, 2024

Providers like you require more tools in your arsenal.

Myocardial Infarction 64

Myocardial Infarction Cardiovascular Disease Heart Attack Heart attacks 64

Physiologically Speaking

DECEMBER 15, 2023

Blood glucose control Resistance exercise training can reduce fasting glucose by 2–5 mg/dL in adults with prediabetes and type 2 diabetes but doesn’t seem to reduce blood glucose in healthy adults (not surprising). a higher metabolism). It’s never too late to start — but the earlier you start the better.

Physiology 52

Physiology Exercise Blood Pressure Risk Factors 52