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Introduction:SARS-CoV-2 causes various neurological sequelae in COVID-19 survivors including fatigue and cognitive dysfunction. Endothelial dysfunction, a key mechanism in COVID-19 illness, is also a major risk factor for vascular dementia (VaD).
SARS-COV-2 causes neurological and cognitive impairments and aggravates Alzheimers Disease-Related Dementia (ADRD). In conclusion,the SARS-CoV-2 spike protein accelerates Alzheimers Disease-Related Dementia through increased cerebrovascular inflammation and deterioration of BBB in hACE2 Mice.
COVID-19 doubles the risk for acute ischemic stroke in patients with cardiovascular disorders, yet, the molecular mechanisms are unclear and remain unresolved medical challenges. Vascular-induced cognitive function and dementia (VCID) were assessed using a Novel object recognition test. Infarct size was compared using TTC stain.
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