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We aimed to perform a systematic review and meta-analysis to study the effects of colchicine in patients with symptomatic coronaryarterydisease (CAD) who have undergone PCI. These results were driven mainly by the reduction in repeat vessel revascularisation, stroke and stent thrombosis.
"Clinicians need better tools to guide decision making on the choice of antiplatelet therapy in coronaryarterydisease patients, particularly after coronary stenting. The Prolocor pFCG test will be an important asset as we tailor antiplatelet therapies to balance thrombotic and bleeding risk" said Dominick J.
Stone, MD Mount Sinai Health System tim.hodson Wed, 04/02/2025 - 15:26 March 31, 2025 Using intravascular imaging (IVI) to guide stent implantation during complex stenting procedures is safer and more effective for patients with severely calcified coronaryarterydisease than conventional angiography, the more commonly used technique.
A random-effects model was used for outcomes with high heterogeneity.Results:We included 4 RCTs with 3173 patients comparing FFR-guided CR with culprit-only PCI in patients with STEMI and multivessel coronaryarterydiseases. vs 13.6%), any stent thrombosis (RR=1.42; 95% CI [0.35, 5.72]; p=0.62; 2.2%
Key strategies include: Polygenic Risk Scores: Identifying Risk Early PRS helps identify young adults at high lifetime risk for coronaryarterydisease (CAD). Studies, such as those published in JACC (2022) , show that early identification can lead to targeted interventions, reducing long-term risk.
Background Kounis syndrome is an acute coronary syndrome (ACS) caused by allergic reactions, including coronaryartery spasm (type I) caused by allergies without coronary predisposing factors, pre-existing coronary atherosclerosis, and coronaryarterydisease.
Angiogram No obstructive epicardial coronaryarterydisease Cannot exclude non-ACS causes of troponin elevation including coronary vasospasm, stress cardiomyopathy, microvascular disease, etc. The degree of stenosis is not a great predictor of thrombosis, and culprits may not be visible. Lindahl et al.
Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronaryarterydisease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3
There is increased LV cavity dimensions with an increase in transient ischemic dilation, suggesting Left Main, or 3-vessel coronaryarterydisease. Sudden narrowing of a coronaryartery due to ACS (plaque rupture with thrombosis and/or downstream showering of platelet-fibrin aggregates). Type I ischemia.
Self-reported adherence to cardiovascular medications in patients who have coronaryarterydisease is for the combination of aspirin, beta-blocker and a lipid-lowering agent in surveys.7 Long-Term Adherence to Evidence-Based Secondary Prevention Therapies in CoronaryArteryDisease. J Am Geriatr Soc.
Notably, the Supraflex Cruz stent showed a significant reduction in clinically driven target lesion revascularization (TLR) rates and very low rates of stent thrombosis, despite the fact that the enrolled patients were at substantial risk for bleeding and ischemic events. Principal Investigator, Dr. Pieter C.
Objectives Compare the safety and efficacy of BVS versus DES in patients receiving percutaneous coronary intervention for coronaryarterydisease across a complete range of randomised controlled trial (RCT) follow-up intervals.
That, it was possible to treat atherosclerotic coronaryarterydisease with an updated Andreas Grüntzig’s balloon alone, without the safety net and comfort of implanting a single stent. It was unprecedented, going against received wisdom.
FAME study showed that at one year follow up, rate of major adverse coronary events was reduced by approximately 30% by routinely measuring FFR. Usually a stent is considered in bifurcation disease only if the side branch is large and almost equal in size to the distal vessel. Cut off FFR was 0.8 in the study. J Am Coll Cardiol.
Coronary angiography revealed a tortuous and extremely aneurysmal RCA, as well as multivessel coronaryarterydisease (mvCAD) involving LAD, D1, LCx, OM1. Multislice CT angiography further characterized the RCA, which extends to the coronary sinus (CS) distally forming a coronary cameral fistula (CCF).
Introduction:Subacute stent thrombosis (ST) is related to high rates of cardiac reinfarction. The patient’s chest pain (CP) was not alleviated with initial revascularization of his left circumflex (LCx) ST, requiring PCI to his right coronaryartery (RCA) chronic total occlusion (CTO). We present a case of reinfarction from ST.
Hospital Course The patient was taken emergently to the cath lab which did not reveal any significant coronaryarterydisease, but she was noted to have reduced EF consistent with Takotsubo cardiomyopathy. The degree of stenosis is not a great predictor of thrombosis, and culprits may not be visible. Lindahl et al.
Adverse vascular outcomes used as endpoints include acute ischemic stroke, acute myocardial infarction, deep vein thrombosis/pulmonary embolism, AF, and carotid artery dissection.A Patients with any adverse vascular outcomes before the index ECG were excluded. The mean age at the time of the index ECG was 44.3
In the early years of percutaneous coronary intervention (PCI), studies indicated a heightened risk of major adverse cardiac events (MACE) in patients with reduced left ventricular ejection fraction (LVEF), involving outcomes such as death, Q-wave myocardial infarction (MI), stent thrombosis, and repeat revascularization.
Data were extracted from published reports and quality assessment was performed per Cochrane recommendations. Statistical analysis was performed using Review Manager (Cochrane collaboration).
The primary non-inferiority endpoint was MACCE (a composite of cardiac death, MI, ischaemic stroke, stent thrombosis, or target vessel revascularisation). The results advocate for considering PCI as a treatment option for such plaques, potentially expanding the indications for PCI in coronaryarterydisease management.
Although there is a favorable trend for major adverse cardiovascular and cerebrovascular events (MACCE), nonfatal AMI, cerebrovascular events, and major bleeding in the immediate non-culprit artery (-ies) PCI, those were statistically non-significant.
Old ‘NSTEMI’ A history of coronaryarterydisease and a stent to the same territory further increases pre-test likelihood of acute coronary occlusion, including in-stent thrombosis.
MINOCA: Myocardial Infarction in the Absence of Obstructive CoronaryArteryDisease). Here is my comment on MINOCA: "Non-obstructive coronarydisease" does not necessarily imply "no plaque rupture with thrombus." 2) overlooked obstructive coronarydisease (e.g., What is MINOCA? myocarditis).
Diffuse ST depression with ST elevation in aVR: Is this pattern specific for global ischemia due to left main coronaryarterydisease? Incidence of an acute coronary occlusion. Diffuse ST depression with ST elevation in aVR: Is this pattern specific for global ischemia due to left main coronaryarterydisease?
You can easily imagine this patient getting one of several diagnoses -- vasospasm, MINOCA , pericarditis, or maybe even no diagnosis at all beyond "non-obstructive coronaryarterydisease." Smith comment : a very high proportion of MINOCA are ruptured plaque with lysed thrombus. That plaque is at risk of thrombosing again.
Andreas Grüntzig, an ardent angiologist crafted an indeflatable sausage-shaped dual-lumen balloon-catheter, designed its delivery to the heart, launched minimally invasive coronary intervention and taught by beaming live demonstration. Subsequent advances are just incremental tweaks and tinkers around this fully formed framework from 1978.
Objective Antithrombotic therapy is essential for patients with atrial fibrillation (AF) and stable coronaryarterydisease (CAD) because of the high risk of thrombosis, whereas a combination of antiplatelets and anticoagulants is associated with a high risk of bleeding.
Primary end point was a composite of ischemic stroke, myocardial infarction, or other arterial thrombotic events. Arterial thrombotic events occurred in 169 (9.7%) patients. CONCLUSIONS:Intracerebral hemorrhage survivors are at high long-term risk of arterialthrombosis. Stroke, Ahead of Print.
BackgroundAcute myocardial infarction commonly occurs in patients with coronaryarterydisease, but rarely, it can develop under a hypercoagulable state. These thrombotic complications predominantly arise in veins rather than in arteries. These thrombotic complications predominantly arise in veins rather than in arteries.
0.85, P = 0.004), target vessel revascularization (TVR) (P = 0.01), target lesion revascularization (TLR) (P = 0.03) and stent thrombosis (ST) (P = 0.002) in the experimental group (IVUS-guidance) was lower than that in the control group (non-IVUS-guidance). The results showed that the incidence of MACE (RR: 0.63, 95% CI: 0.49–0.82,
Angiography was technically challenging as the patient was receiving CPR, but the cardiologist suspected acute stent thrombosis and initiated cangrelor, although no repeat angiography was able to be obtained. Circumstances attending 100 sudden deaths from coronaryarterydisease with coroners necropsies. & Dewar, H.
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