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Angiogram No obstructive epicardial coronaryarterydisease Cannot exclude non-ACS causes of troponin elevation including coronary vasospasm, stress cardiomyopathy, microvascular disease, etc. The degree of stenosis is not a great predictor of thrombosis, and culprits may not be visible. Lindahl et al.
Background Kounis syndrome is an acute coronary syndrome (ACS) caused by allergic reactions, including coronaryartery spasm (type I) caused by allergies without coronary predisposing factors, pre-existing coronary atherosclerosis, and coronaryarterydisease.
There is increased LV cavity dimensions with an increase in transient ischemic dilation, suggesting Left Main, or 3-vessel coronaryarterydisease. Sudden narrowing of a coronaryartery due to ACS (plaque rupture with thrombosis and/or downstream showering of platelet-fibrin aggregates).
Hospital Course The patient was taken emergently to the cath lab which did not reveal any significant coronaryarterydisease, but she was noted to have reduced EF consistent with Takotsubo cardiomyopathy. To prove there is no plaque rupture, you need to do intravascular ultrasound (IVUS). It can only be seen by IVUS.
If the arrest was caused by acute MI due to plaque rupture, then the diagnosis is MINOCA. MINOCA: Myocardial Infarction in the Absence of Obstructive CoronaryArteryDisease). Here is my comment on MINOCA: "Non-obstructive coronarydisease" does not necessarily imply "no plaque rupture with thrombus."
You can easily imagine this patient getting one of several diagnoses -- vasospasm, MINOCA , pericarditis, or maybe even no diagnosis at all beyond "non-obstructive coronaryarterydisease." Smith comment : a very high proportion of MINOCA are ruptured plaque with lysed thrombus. Most plaque is outside the lumen!!
Diffuse ST depression with ST elevation in aVR: Is this pattern specific for global ischemia due to left main coronaryarterydisease? Incidence of an acute coronary occlusion. Diffuse ST depression with ST elevation in aVR: Is this pattern specific for global ischemia due to left main coronaryarterydisease?
Stone, MD Mount Sinai Health System tim.hodson Wed, 04/02/2025 - 15:26 March 31, 2025 Using intravascular imaging (IVI) to guide stent implantation during complex stenting procedures is safer and more effective for patients with severely calcified coronaryarterydisease than conventional angiography, the more commonly used technique.
Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 7 Research has shown inflammation plays a significant role in the development of atherosclerosis and ASCVD,8-10 and even the formation of plaque.11 4 In the U.S.
The primary non-inferiority endpoint was MACCE (a composite of cardiac death, MI, ischaemic stroke, stent thrombosis, or target vessel revascularisation). These patients were identified to have non-flow-limiting vulnerable coronaryplaques through intracoronary imaging.
Decedents with acute coronarythrombosis, myocardial infarction, or other myocardial abnormality were excluded. Journal of the American Heart Association, Ahead of Print. Decedents with either noncardiac death or SAD had similar height, weight, and heart weight. Moreover, decedents with SAD had lower cardiomyocyte width (mean, 18.6
Angiography was technically challenging as the patient was receiving CPR, but the cardiologist suspected acute stent thrombosis and initiated cangrelor, although no repeat angiography was able to be obtained. Mechanisms of plaque formation and rupture. Coronaryplaque disruption. She was defibrillated perhaps 25 times.
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