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The principal clinical manifestation of thrombophilia is venous thromboembolism, which is also markedly linked to arterialthrombosis, including myocardialinfarction. This report presents the case of a young man who suffered an acute myocardialinfarction as a result of thrombophilia.
Background Kounis syndrome is an acute coronary syndrome (ACS) caused by allergic reactions, including coronaryartery spasm (type I) caused by allergies without coronary predisposing factors, pre-existing coronary atherosclerosis, and coronaryarterydisease.
Angiogram No obstructive epicardial coronaryarterydisease Cannot exclude non-ACS causes of troponin elevation including coronary vasospasm, stress cardiomyopathy, microvascular disease, etc. The degree of stenosis is not a great predictor of thrombosis, and culprits may not be visible. Lindahl et al.
Hospital Course The patient was taken emergently to the cath lab which did not reveal any significant coronaryarterydisease, but she was noted to have reduced EF consistent with Takotsubo cardiomyopathy. Such cases are classified as MINOCA (MyocardialInfarction with Non-Obstructed CoronaryArteries).
Adverse vascular outcomes used as endpoints include acute ischemic stroke, acute myocardialinfarction, deep vein thrombosis/pulmonary embolism, AF, and carotid artery dissection.A Patients with any adverse vascular outcomes before the index ECG were excluded. The mean age at the time of the index ECG was 44.3
MINOCA: MyocardialInfarction in the Absence of Obstructive CoronaryArteryDisease). Here is my comment on MINOCA: "Non-obstructive coronarydisease" does not necessarily imply "no plaque rupture with thrombus." 2) overlooked obstructive coronarydisease (e.g., What is MINOCA?
Diffuse ST depression with ST elevation in aVR: Is this pattern specific for global ischemia due to left main coronaryarterydisease? Incidence of an acute coronary occlusion. New insights into the use of the 12-lead electrocardiogram for diagnosing acute myocardialinfarction in the emergency department.
Andreas Grüntzig, an ardent angiologist crafted an indeflatable sausage-shaped dual-lumen balloon-catheter, designed its delivery to the heart, launched minimally invasive coronary intervention and taught by beaming live demonstration. Subsequent advances are just incremental tweaks and tinkers around this fully formed framework from 1978.
A random-effects model was used for outcomes with high heterogeneity.Results:We included 4 RCTs with 3173 patients comparing FFR-guided CR with culprit-only PCI in patients with STEMI and multivessel coronaryarterydiseases. vs 13.6%), any stent thrombosis (RR=1.42; 95% CI [0.35, 5.72]; p=0.62; 2.2%
Stone, MD Mount Sinai Health System tim.hodson Wed, 04/02/2025 - 15:26 March 31, 2025 Using intravascular imaging (IVI) to guide stent implantation during complex stenting procedures is safer and more effective for patients with severely calcified coronaryarterydisease than conventional angiography, the more commonly used technique.
Primary end point was a composite of ischemic stroke, myocardialinfarction, or other arterial thrombotic events. Arterial thrombotic events occurred in 169 (9.7%) patients. CONCLUSIONS:Intracerebral hemorrhage survivors are at high long-term risk of arterialthrombosis. Stroke, Ahead of Print.
Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronaryarterydisease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3
Background Untreated multivessel disease (MVD) in acute myocardialinfarction (AMI) has been linked to a higher risk of recurrent ischemia and death within one year. Similarly, all-cause mortality, cardiovascular mortality, stent thrombosis, and acute renal insufficiency did not show significant differences between two groups.
FAME study showed that at one year follow up, rate of major adverse coronary events was reduced by approximately 30% by routinely measuring FFR. They had lower rates of mortality or myocardialinfarction. PCI or coronaryartery bypass surgery rates were also lower, though not statistically significant.
In the early years of percutaneous coronary intervention (PCI), studies indicated a heightened risk of major adverse cardiac events (MACE) in patients with reduced left ventricular ejection fraction (LVEF), involving outcomes such as death, Q-wave myocardialinfarction (MI), stent thrombosis, and repeat revascularization.
Objectives Compare the safety and efficacy of BVS versus DES in patients receiving percutaneous coronary intervention for coronaryarterydisease across a complete range of randomised controlled trial (RCT) follow-up intervals.
EMPACT-MI 1 ( NCT04509674 ) studied the effects of empagliflozin in patients who have experienced myocardialinfarction (MI). Investigators assessed if empagliflozin could lower the risk of hospitalization for heart failure (HF) or death from cardiovascular disease (CVD). Here is our curated list of the top sessions.
Objective Antithrombotic therapy is essential for patients with atrial fibrillation (AF) and stable coronaryarterydisease (CAD) because of the high risk of thrombosis, whereas a combination of antiplatelets and anticoagulants is associated with a high risk of bleeding.
Decedents with acute coronarythrombosis, myocardialinfarction, or other myocardial abnormality were excluded. Journal of the American Heart Association, Ahead of Print. Decedents with either noncardiac death or SAD had similar height, weight, and heart weight. m versus 19.6 m; mean difference, 1.0
BackgroundAcute myocardialinfarction commonly occurs in patients with coronaryarterydisease, but rarely, it can develop under a hypercoagulable state. These thrombotic complications predominantly arise in veins rather than in arteries.
We included major adverse cardiovascular events (MACE), myocardialinfarction (MI), cardiac death and other outcome indicators. Relative ratio (RR) and 95% confidence interval (CI) were used for statistical analysis.ResultsA total of 5,173 subjects were included in 6 randomized control trials.
Angiography was technically challenging as the patient was receiving CPR, but the cardiologist suspected acute stent thrombosis and initiated cangrelor, although no repeat angiography was able to be obtained. Acute myocardialinfarction: an uncommon complication of takotsubo cardiomyopathy. Coronary plaque disruption.
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