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milla1cf Tue, 01/09/2024 - 11:32 January 9, 2024 — Cleerly , the company working to create a new standard of care for the diagnosis of heart disease, announced the launch of Cleerly ISCHEMIA , which recently received U.S. Cleerly ISCHEMIA is a transformative addition poised to reshape the landscape of cardiac care.”
It further reported that these results underscore the strong and positive effect of the Cleerly products on clinical utility for patients with suspected coronaryarterydisease. “We High Diagnostic Accuracy Of AI-Ischemia in Comparison To PET, FFR-CT, SPECT, and Invasive FFR: A PACIFIC Sub-Study. James Min, M.D.
1 Atherosclerosis is a systemic disease that affects multiple vascular regions and is particularly severe in PAD patients, where up to 80 percent suffer from concurrent coronaryarterydisease (CAD), historically linked with a mortality rate exceeding 50 percent within five years. Journal of Vascular Surgery, Mar.
milla1cf Thu, 03/28/2024 - 07:00 March 28, 2024 — Cleerly , the company on a mission to create a new standard of care to aid in the diagnosis of heart disease, shared findings from a study published online in the Journal of the American College of Cardiology: Cardiovascular Imaging on March 13, 2024. J Am Coll Cardiol. 2024.01.007.
Many of the changes seen are reminiscent of LVH with “strain,” and downstream Echo may very well corroborate such a suspicion, but since the ECG isn’t the best tool for definitively establishing the presence of LVH, we must favor a subendocardial ischemia pattern, instead. A large Diagonal artery has subtotal occlusion proximally.
Such a pattern is consistent with significant left main coronaryarterystenosis. Angiography done after initial stabilization showed severe stenosis of distal left main coronaryartery. ST elevation in aVR more than that in V1 is also suggestive of left main disease. References Sen F et al.
This case shows a CT image of subendocardial ischemia. ng/mL (slightly elevated) and his symptoms could not be controlled with nitroglycerin, so he was taken to the cath lab and found to have: --Severe 3 vessel Coronaryarterydisease involving the LM. The image is shown at the bottom after the case presentation.
Background:Myocardial infarction with nonobstructive coronaryarterydisease (MINOCA) is a special syndrome with clear evidence of myocardial ischemia, but no clear stenosis of coronaryartery imaging sign. Circulation, Volume 150, Issue Suppl_1 , Page A4143007-A4143007, November 12, 2024.
milla1cf Wed, 03/06/2024 - 18:48 March 6, 2024 — Cleerly , the company on a mission to create a new standard of care to aid in the diagnosis of heart disease, has been granted Breakthrough Device Designation by the U.S. Food and Drug Administration ( FDA ) for its CoronaryArteryDisease ( CAD ) Staging System.
The diagnostic coronary angiogram identified only minimal coronaryarterydisease, but there was a severely calcified, ‘immobile’ aortic valve. A transthoracic echocardiogram showed an LV EF of less than 15%, critically severe aortic stenosis , severe LVH , and a small LV cavity.
Coronary angiography gives a visual impression about the severity of the stenosis. But it need not imply the actual functional significance of the stenosis in terms of flow physiology. indicates inducible ischemia while an FFR above 0.80 excludes ischemia in 90% of cases. Normal FFR is 1.0 and an FFR below 0.75
Angiogram No obstructive epicardial coronaryarterydisease Cannot exclude non-ACS causes of troponin elevation including coronary vasospasm, stress cardiomyopathy, microvascular disease, etc. Detailed coronaryartery evaluation not performed. This suggests further severe ischemia.
I quickly reviewed the patient’s records and saw that she was a 53 year old woman with a history of BMI 40, but no other identifiable risk factors for coronaryarterydisease. This proves effective treatment of the recurrent ischemia. The patient had no further symptoms of ischemia.
The first task when assessing a wide complex QRS for ischemia is to identify the end of the QRS. The ST segment changes are compatible with severe subendocardial ischemia which can be caused by type I MI from ACS or potentially from type II MI (non-obstructive coronaryarterydisease with supply/demand mismatch).
After PCI — there was acceptable flow in the LM, LAD and LCx arteries. Angiography : LMCA — 90-99% osteal stenosis. LCx — 50-69% stenosis of the 1st marginal branch; with 100% distal LCx occlusion. There is no definite evidence of acute ischemia. (ie, Some residual ischemia in the infarct border might still be present.
His response: “subendocardial ischemia. History sounds concerning for ACS (could be critical stenosis, triple vessel), but differential also includes dissection, GI bleed, etc. Smith : It should be noted that, in subendocardial ischemia, in contrast to OMI, absence of wall motion abnormality is common. Anything more on history?
Background Untreated multivessel disease (MVD) in acute myocardial infarction (AMI) has been linked to a higher risk of recurrent ischemia and death within one year. The immediate non-IRA PCI is associated with a significantly lower occurrence of unplanned ischemia-driven PCI (OR 0.60; confidence interval [CI] 0.44–0.83)
A 56 year old male with a history of diabetes, dyslipidemia, hypertension, and coronaryarterydisease presented to the emergency department with sudden onset weakness, fatigue, lethargy, and confusion. The patient’s angiogram should have been expedited, but the EKG change was not recognized as recurrence of transmural ischemia.
Post by Smith and Meyers Sam Ghali ( [link] ) just asked me (Smith): "Steve, do left main coronaryartery *occlusions* (actual ones with transmural ischemia) have ST Depression or ST Elevation in aVR?" Here I explain: First, you don't know for certain what the state of the artery was at the time of the ECG.
Diamond and Forrester accomplished this by first establishing the prevalence of coronaryarterydisease based on how clinically likely patients with chest pain symptoms were found to have coronarydisease based on a coronary angiogram. The results of this dataset by age and gender follow. This happens.
Hospital Course The patient was taken emergently to the cath lab which did not reveal any significant coronaryarterydisease, but she was noted to have reduced EF consistent with Takotsubo cardiomyopathy. An apical OMI has the same ultrasound findings as takotsubo, and thus mimics takotsubo. Learning Points: 1.
found that such ECG findings only represented left main ACS in 14% of such ECGs: Only 23% of patients with the aVR STE pattern had any LM disease (fewer if defined as 50% stenosis). Diffuse ST depression with ST elevation in aVR: Is this pattern specific for global ischemia due to left main coronaryarterydisease?
The patient was in his 50s with history of hypertension, diabetes, seizure disorder, and smoking, but no known coronaryarterydisease. If the patient had been "lucky," his symptoms from the prior day might have been due to ischemia prolonged and intense enough to result in small troponin increase.
Women had less coronaryarterydisease: multivessel in 60.0% of invasive‐assigned men, and no ≥50% stenosis in 12.3% 1.14];P=0.49), with no significant sex‐by‐treatment‐group interactions.ConclusionsWomen had less extensive coronaryarterydisease and, therefore, lower revascularization rates in the invasive group.
Written by Pendell Meyers A woman in her 70s with known prior coronaryarterydisease experienced acute chest pain and shortness of breath. One could argue or wonder if there is both subendocardial ischemia AND posterior OMI pattern, since the STD in V4 may be equal or possibly slightly worse proportionally than V6.
BackgroundCoronary ArteryDisease (CAD) is a leading cause of mortality, with an increasing number of patients affected by coronaryarterystenosis each year. Coronary angiography (CAG) is commonly employed as the definitive diagnostic tool for identifying coronaryarterystenosis.
The patient was started on heparin for possible NSTEMI vs demand ischemia. Smith : "decompensation" of aortic stenosis might have initiated this entire cascade. What "initiates" the aortic stenosis cascade? increasing stenosis, ischemia, volume changes, increased blood pressure, atrial fibrillation, etc.)
Watch what happends as the heart recovers from its episode of ischemia. Angiogram: Severe two-vessel coronaryarterydisease of a left dominant system including 70 to 80% stenosis involving the distal left main/bifurcation. The ECG shows inferior ischemia. Are the T-waves in leads I and II hyperacute?
August 2024 Approvals Minima Stent System (P240003) (Approval Date: August 28, 2024) The Minima Stent System is an expandable cobalt-chromium metal mesh tube to reopen blood vessels in neonates, infants, and children with Coarctation of the Aorta and Pulmonary ArteryStenosis, specifically designed to expand as younger patients grow.
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