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It encompasses a range of conditions, including coronaryarterydisease, heartfailure and arrhythmias. While lifestyle factors such as diet, exercise and smoking play a significant role in the development of heartdisease, genetics also contribute substantially.
The female-specific positive association of PGSMDwith CAD risk was replicated in BioVU.CONCLUSIONS:Genetic predisposition to MD confers a greater risk of CVDs in females versus males, even in the absence of any depression diagnosis.
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Coronary Artery Disease 
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