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Coronary Artery Disease Diabetes Outcomes 
Cardiology Update
MARCH 25, 2024
Left main coronary artery disease (CAD) and diabetes pose significant challenges in cardiovascular care, often leading to adverse outcomes. Preliminary evidence from trials focusing on patients with multivessel disease has hinted at diabetes as a potential modifier of treatment outcomes.
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Cardiovascular Diabetology
AUGUST 6, 2024
Objective To explore trends in prognosis and use of glucose-lowering drugs (GLD) in patients with diabetes and coronary artery disease (CAD). Information on GLD (dispended 6 months before or after coronary angiography) was collected from the Swedish Prescribed Drug Registry.
American College of Cardiology
APRIL 26, 2024
Since limb events are major drivers of morbidity in diabetic patients with peripheral (PAD) and coronary artery disease (CAD), does the addition of ticagrelor to background therapy of aspirin improve limb events?
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Dr. Paddy Barrett
APRIL 26, 2024
Coronary artery disease is caused by the retention of a cholesterol particle in the artery wall. On the far end of that line is type two diabetes. On the far end of that line is type two diabetes. We also know that WHEN you get type 2 diabetes makes a huge difference. Let me be 100% clear, however.
105 
Cardiovascular Diabetology
FEBRUARY 2, 2024
The outcomes of percutaneous coronary intervention (PCI) in diabetic patients are still suboptimal, and it is unclear if diabetic patients might derive a benefit from the use of drug-coated balloons.
Dr. Paddy Barrett
APRIL 5, 2024
A common feedback I get is that people with existing coronary artery disease feel like it doesn’t apply to them. Arguably, applying the principles of prevention offers more bang for buck in the short term for people WITH coronary artery disease than those without coronary artery disease.
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Cardiovascular Diabetology
JANUARY 5, 2024
The role of triglyceride-glucose (TyG) index, an insulin resistance indicator, in glycemic management for diabetic patients with coronary artery disease (CAD) was still unknown. Therefore, we aimed to explore.
Circulation
MARCH 11, 2024
BACKGROUND:Diabetes may be associated with differential outcomes in patients undergoing left main coronary revascularization with percutaneous coronary intervention (PCI) or coronary artery bypass grafting (CABG). Patients were categorized by diabetes status. PintHR=0.87) diabetes.
Circulation
NOVEMBER 11, 2024
However, the long-term outcomes in patient with an intermediate stenosis received FFR have not yet been investigated comprehensively.Methods:We retrospective included 558 patients underwent both coronary artery angiography (CAG) and FFR. Circulation, Volume 150, Issue Suppl_1 , Page A4144277-A4144277, November 12, 2024.
Circulation
NOVEMBER 11, 2024
Background:Clinical trials have demonstrated that sodium-glucose cotransporter-2 inhibitors (SGLT2i) and glucagon-like peptide-1 receptor agonists (GLP1RA) reduce cardiovascular (CV) risk in patients (pts) with type 2 diabetes (T2D) with or at high risk for CV disease.
Coronary Artery Disease Journal
NOVEMBER 20, 2023
Background: Gender-specific outcomes after percutaneous coronary interventions were studied by a number of research groups with different endpoints and cohorts of different ethnic extractions. Results: Overall, in the unmatched cohorts, accumulated target-lesion revascularization rates did not differ between both genders (2.7%
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Open Heart
JUNE 5, 2024
Background There is increasing awareness that patients without standard modifiable risk factors (SMuRFs; diabetes, hypercholesterolaemia, hypertension and smoking) may represent a unique subset of patients with acute coronary syndrome (ACS). Patients with coronary artery disease were excluded.
MIBHS
FEBRUARY 28, 2025
A family history of heart disease often indicates that genetic factors might be at play. Common Heart Diseases with Genetic Links Coronary Artery Disease (CAD): CAD occurs when the arteries supplying blood to the heart become narrowed or blocked.
DAIC
APRIL 9, 2024
The international ARISE-HF trial was designed to test the effectiveness of the investigational drug AT-001 at stabilizing exercise capacity in patients with diabetic cardiomyopathy. Patients had had Type 2 diabetes for an average of 14 years. Decline in exercise ability is a hallmark of progression to overt heart failure.
Coronary Artery Disease Journal
MAY 13, 2024
Objective To investigate the impact of prior coronary artery bypass grafting (CABG) and coronary lesion complexity on transcatheter aortic valve replacement (TAVR) outcomes for aortic stenosis. 23), which was not associated with better/worse clinical outcomes in patients with prior CABG.
Frontiers in Cardiovascular Medicine
FEBRUARY 23, 2024
Introduction The presence of non-coronary atherosclerosis (NCA) in patients with coronary artery disease is associated with a poor prognosis. We have studied whether NCA is also a predictor of poorer outcomes in patients undergoing coronary artery bypass grafting (CABG). vs. 9%, p < 0.001).
Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
IntroductionThere is a higher prevalence of diabetes mellitus type 2 in Hispanics as compared to other ethnic groups in the United States. Diabetes is a risk factor for acute ischemic stroke and also a poor predictor of outcome for many interventional surgeries. or greater. vs. 20.5%; p = 0.048) and stenting (28.4%
40 
DAIC
MAY 16, 2024
A new joint guideline from the American Heart Association (AHA), the American College of Cardiology (ACC) and nine other medical societies reports early diagnosis and treatment of peripheral artery disease is essential to improve outcomes and reduce amputation risk, heart attack, stroke and death for people with Peripheral Artery Disease (PAD).
Journal of the American Heart Association
FEBRUARY 26, 2025
P=0.006), especially in diabetic patients (Pearsonr=0.58,P<0.001). After multivariate adjustment, every 0.1mmol/L increase in timeaveraged sdLDLC conferred a 1.2fold increased risk of PP.ConclusionsOur findings suggest that sdLDLC is an independent risk factor of PP in patients with coronary artery disease.
56 
Dr. Paddy Barrett
OCTOBER 11, 2024
Inflammation is a key driver of heart disease, specifically coronary artery disease. I have covered this topic previously here , but it is clear that inflammation plays a major role in the initiation and progression of coronary artery disease, and the inflammatory biomarker hsCRP is tightly connected to this process.
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DAIC
JANUARY 23, 2024
Atherosclerotic cardiovascular disease (ASCVD), caused by plaque buildup in arterial walls, is one of the leading causes of disability and death worldwide.1,2 1,2 ASCVD causes or contributes to conditions that include coronary artery disease (CAD), cerebrovascular disease, and peripheral vascular disease (inclusive of aortic aneurysm).3
Frontiers in Cardiovascular Medicine
JANUARY 7, 2024
Introduction The use of contemporary drug-eluting stents (DES) has significantly improved outcomes of patients with coronary artery disease (CAD) undergoing percutaneous coronary intervention (PCI). years, Diabetes mellitus 29%, acute coronary syndrome 67%, chronic total occlusion 9%).
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Stroke Journal
FEBRUARY 1, 2024
Malnutrition is common in stroke patients and leads to worse outcomes. Body mass index (BMI) is a widely available marker of nutrition status, however studies on BMI and post-ICH outcomes are limited and have conflicting results. There was no association between BMI and ICH volume in patients with deep or lobar hemorrhage.
40 
Stroke Journal
JANUARY 30, 2025
Background and Purpose:Whether imaging markers of cerebral small vessel disease on computed tomography (CT-CSVD) relates to early clinical outcomes after intravenous thrombolysis for acute ischemic stroke remains not well understood. 1.02; score 2: OR 0.46, 95%CI 0.26-0.83; 0.83; score 3: OR 0.16, 95%CI 0.03-0.76, 1.95, p = 0.019).Conclusion:This
40 
DAIC
MARCH 13, 2024
Smith Center for Outcomes Research in Cardiology and section chief of Interventional Cardiology at BIDMC. Even with advances in stent technology, patients with coronary in-stent restenosis continue to comprise approximately 10 percent of individuals undergoing angioplasty interventions each year. and Susan F.
116 
Stroke Journal
JANUARY 30, 2025
Migraine with aura(MwA) is associated with an increased risk of stroke and adverse vascular outcomes compared to those with migraine without aura (MwoA). Patients with any adverse vascular outcomes before the index ECG were excluded. The prevalences of all vascular outcomes are summarized in Table 1. p < 001).
Frontiers in Cardiovascular Medicine
DECEMBER 12, 2024
BackgroundCoronary artery bypass grafting (CABG) surgery has been a widely accepted method for treating coronary artery disease. However, its postoperative complications can have a significant effect on long-term patient outcomes.
The British Journal of Cardiology
APRIL 16, 2024
We present the cumulative percutaneous coronary intervention (PCI) data of all comers (stable angina and acute coronary syndromes [ACS]) who presented to Hadi Clinic between January 2018 and December 2020. A total of 567 patients underwent coronary catheterisation for the three-year period between January 2018 and December 2020.
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Cardiology Update
APRIL 9, 2024
The percent change from baseline in fasting triglycerides (TG) at six months served as the primary outcome measure. The percent change from baseline in fasting TG at six months served as the primary outcome measure. Among patients with HFpEF, those who received the shunt experienced poor outcomes than those who did not.
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Coronary Artery Disease Journal
JANUARY 11, 2024
Myocardial infarction (MI) with non-obstructive coronary arteries (MINOCA) covers an expanding group of patients over recent years. Previous studies showed considerable risks of outcomes in this group. In this study, we aimed to investigate the long-term outcomes in very young patients with MINOCA.
Stroke Journal
FEBRUARY 1, 2024
Studies have reported racial disparities in young stroke patients and less desired outcomes of minorities. Socioeconomic status, risk factors, stroke etiology, acute interventions and short-term outcomes were accessed. Compared to White, black and Hispanic had higher rate of Diabetes, Hypertension and prior stroke (p<0.001).
40 Stroke Journal
JANUARY 30, 2025
At baseline, prevalence of comorbidities was high (hypertension 66% and 84%, hyperlipidemia 53% and 75%, coronary artery disease 18% and 31%, diabetes 25% and 38% in MarketScan and CDM, respectively). Introduction:Patients suffering from transient ischemic attack (TIA) are at high risk of ischemic stroke (IS).
European Journal of Heart Failure
SEPTEMBER 26, 2023
diabetes, hypertension, coronary artery disease), underlying the development of cardiac dysfunction and further increased risk. Overall, understanding and utilizing NT-proBNP levels will lead to earlier and more accurate diagnoses of heart failure ultimately improving patient outcomes and reducing healthcare costs.
Dr. Paddy Barrett
OCTOBER 31, 2023
An elevated Lp(a) is a common genetic factor that is independently and causally related to premature coronary artery disease. The occurrence of disease in this instance is probabilistic, not deterministic. An elevated Lp(a) does increase the risk of early cardiovascular disease, but that risk is not set in stone.
Dr. Anish Koka
MAY 16, 2023
Soviet biologist Trofim Lysenko famously rejected the objective reality of Mendelian genetics because it clashed with the Marxist philosophy that the environment, not genetics, was the primary determinant of outcomes. This particular passage references the fact women and men commonly complain of chest pain.
52 Stroke Journal
DECEMBER 8, 2023
The primary outcome was ischemic stroke; the secondary outcome was combined cardiovascular events (ischemic stroke, myocardial infarction, and cardiovascular death). The plaque-related risk of outcomes was also analyzed according to the presence of statin treatment.
40 
Circulation
NOVEMBER 11, 2024
The outcome measure was peri-procedural complications defined as a composite of perioperative death, major bleeding, contrast nephropathy, myocardial infarction, ischemic stroke, and major amputation. Notable comorbidities included diabetes mellitus at 60.6% A history of coronary artery disease was noted in 40.7%
Stroke Journal
FEBRUARY 1, 2024
We compared demographics, hospital traits, comorbidities, and outcomes. In-hospital mortality, our primary outcome, was analyzed through multivariate logistic regression using STATA 18.Results:Incorporating to 2.26) and liver disease (OR 2.20, p < 0.01, CI 1.27
40 
Dr. Paddy Barrett
MAY 17, 2024
Regardless of what is driving the effect, it is clear that experiencing high levels of stress is associated with worse outcomes. 24% increased risk of coronary artery disease. While studies attempt to correct for these influences, it can be very hard to do. These findings have been replicated multiple times.
104 
European Journal of Heart Failure
SEPTEMBER 15, 2023
A prior history of the following comorbidities was considered: episodic or persistent atrial fibrillation ( n = 920), coronary artery disease ( n = 3732), diabetes ( n = 2171), and hypertension ( n = 3353). Patients were classified into three groups based on the number of comorbidities: 0, 1–2, or ≥3.
Dr. Smith's ECG Blog
SEPTEMBER 25, 2024
A 56 year old male with a history of diabetes, dyslipidemia, hypertension, and coronary artery disease presented to the emergency department with sudden onset weakness, fatigue, lethargy, and confusion. This is another case sent by the undergraduate (who is applying to med school) who works as an EKG tech.
120 Stroke Journal
JANUARY 30, 2025
SPRINT originally randomized 9,361 hypertensive individuals without diabetes into two groups: intensive treatment (SBP<120 mmHg, n=4,678) and standard treatment (SBP<140 mmHg, n=4,683). We selected participants meeting SPRINTs criteria and used a validated polygenic risk score for SBP to emulate treatment effects.
Cardiometabolic Health Congress
AUGUST 2, 2024
Blood Sugar Management: For individuals with or at risk of diabetes, precision nutrition offers tailored strategies to manage blood glucose levels by identifying individual responses to different foods. This is particularly beneficial in managing conditions like hypertension, where precise control of dietary sodium intake is crucial.
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Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
Outcomes of interest included symptomatic intracerebral hemorrhage (ICH), asymptomatic ICH, hemorrhagic transformation, mass effect and death. Median LDL was higher (94 vs 67, p=0.01) and there was a higher rate of diabetes (55.2% Baseline demographics and clinical characteristics were compared. vs 26.6%, p=0.01).
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