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Stem cell-derived cardiomyocytes expressing a dominant negative pacemaker HCN4 channel do not reduce the risk of graft-related arrhythmias

Frontiers in Cardiovascular Medicine

BackgroundHuman pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) show tremendous promise for cardiac regeneration following myocardial infarction (MI), but their transplantation gives rise to transient ventricular tachycardia (VT) in large-animal MI models, representing a major hurdle to translation.

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Best Cardiology EHRs for a Small Practice in 2024

GEMMS

Key features include: Compliance Under Appropriate Use Criteria (AUC) – GEMMS ONE meets CMS standards and requirements by including an AUC orders module, part of its integrated system. This enables early intervention, minimizes hospital admissions, and helps improve patient outcomes.