Arterial Thrombosis: Present and Future
Circulation
SEPTEMBER 15, 2024
Circulation, Volume 150, Issue 12 , Page 905-907, September 17, 2024.
Abstract 4142998: Optimizing Transcatheter Aortic Valve Design to Mitigate Subclinical Leaflet Thrombosis
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4142998-A4142998, November 12, 2024. Introduction:Subclinical leaflet thrombosis is an increasingly recognized complication in patients undergoing transcatheter aortic valve replacement (TAVR).
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Pathology of Self-Expanding Transcatheter Aortic Bioprostheses and Hypoattenuated Leaflet Thickening
Circulation: Cardiovascular Interventions
FEBRUARY 17, 2025
Circulation: Cardiovascular Interventions, Volume 18, Issue 2 , Page e014523, February 1, 2025. BACKGROUND:Hypoattenuated leaflet thickening (HALT) is believed to reflect leaflet thrombosis; however, no systematic histological examination of HALT has ever been performed.
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Aspirin Plus Rivaroxaban Versus Rivaroxaban Alone for the Prevention of Venous Stent Thrombosis Among Patients With Post-Thrombotic Syndrome: The Multicenter, Multinational, Randomized, Open-Label ARIVA Trial
Circulation
JANUARY 27, 2025
Circulation, Volume 151, Issue 12 , Page 835-846, March 25, 2025. The risk of stent thrombosis is particularly increased during the first 6 months after intervention. Key exclusion criteria included <18 or >75 years of age, contraindications to anticoagulant use, or acute venous thrombosis <3 months.
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Abstract TP268: Xylitol, Xylose, and MicroRNAs Associated with Thrombosis and the Clotting Cascade in a Multi-Omics Cross-Sectional Study of Adults at Risk for Type 2 Diabetes and Stroke
Stroke Journal
JANUARY 30, 2025
Introduction:Xylitol, a sugar alcohol with a global market estimated at 161,500 metric tons, has been linked to increased thrombosis and risk of stroke and heart attack. Xylitol metabolite concentration was not associated with any miRs in our sample, suggesting that circulating xylose may be a better indicator of clotting risk.
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Correction to: Differential Associations of Cigar, Pipe, and Smokeless Tobacco Use Versus Combustible Cigarette Use With Subclinical Markers of Inflammation, Thrombosis, and Atherosclerosis: The Cross-Cohort Collaboration–Tobacco Working Group
Circulation
APRIL 6, 2025
Circulation, Volume 151, Issue 14 , Page e922-e922, April 8, 2025.
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Cave Under the Aortic Valve: The Rare Left Ventricular Outflow Tract Pseudoaneurysm With Thrombosis
Circulation: Cardiovascular Imaging
JANUARY 17, 2025
Circulation: Cardiovascular Imaging, Ahead of Print.
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Disseminated Intracardiac Thrombosis Due to Long-Standing, Asymptomatic Ventricular Fibrillation Under Left Ventricular Assist Device Support
Circulation: Heart Failure
FEBRUARY 21, 2025
Circulation: Heart Failure, Ahead of Print.
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Early Reperfusion
EMS 12-Lead
SEPTEMBER 6, 2022
Coronary thrombosis is a dynamic process of platelet aggregation and subsequent coagulation. During spontaneous reperfusion -- whether via thrombolysis, or recruitment of collateral circulation -- there exists characteristic ST/T changes on the ECG. Case Review: [link]
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What does the angiogram show? The Echo? The CT coronary angiogram? How do you explain this?
Dr. Smith's ECG Blog
NOVEMBER 15, 2023
MINOCA may be due to: coronary spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis/emboli , and coronary dissection; myocardial disorders, including myocarditis, takotsubo cardiomyopathy, and other cardiomyopathies. Circulation [Internet] 2017;135(16):1481–9. Circulation.
1 hour of CPR, then ECMO circulation, then successful defibrillation.
Dr. Smith's ECG Blog
MAY 19, 2020
Coronary thrombosis or embolism can result in MINOCA, either with or without a hypercoagulable state. The gold standard technique for diagnosing coronary spasm is administration of high-dose intracoronary acetylcholine boluses with the response evaluated by invasive contrast angiography.
Prospective Multicenter International Registry of Ultrasound-Facilitated Catheter-Directed Thrombolysis in Intermediate-High and High-Risk Pulmonary Embolism (KNOCOUT PE)
Circulation: Cardiovascular Interventions
JANUARY 24, 2024
Circulation: Cardiovascular Interventions, Ahead of Print. Principal safety outcomes were independently adjudicated International Society on Thrombosis and Haemostasis major bleeding at 72 hours post-treatment and mortality within 12 months of treatment.
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Winning the Battle Against Atherosclerosis: Practical, Proactive Solutions
Cardiometabolic Health Congress
JANUARY 16, 2025
A 2022 study published in Circulation demonstrated that earlier LDL-C reduction leads to compounded cardiovascular benefits over time. Studies, such as those published in JACC (2022) , show that early identification can lead to targeted interventions, reducing long-term risk.
Immunothrombosis in Acute Ischemic Stroke
Stroke Journal
OCTOBER 31, 2024
Thrombosis is the main pathological process of stroke and is therefore an important therapeutic target in stroke prevention. Circulating immune cells have been found to induce immunothrombosis, and they actively participate in the formation of the thrombus by promoting platelet recruitment and thrombin activation.
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Abstract TMP96: The Use of Direct Oral Anticoagulants in Pediatric Arterial Ischemic Stroke
Stroke Journal
JANUARY 30, 2025
Direct oral anticoagulants (DOACs) are approved in many countries for the treatment and prevention of pediatric venous thrombosis but its use in pediatric arterial thrombosis is less established. Patients treated for concomitant venous thrombosis and/or without follow up imaging were excluded. Data was de-identified and SAS 8.3
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Dynamic OMI ECG. Negative trops and negative angiogram does not rule out coronary ischemia or ACS.
Dr. Smith's ECG Blog
SEPTEMBER 18, 2024
5 We are aware that the current consensus is that the propensity for plaques to rupture is independent of plaque size; however, in our opinion, the hypothesis that small atherosclerotic plaques are the most likely to rupture, with resulting occlusive thrombosis, is unproven. These are typical findings at sites of plaque rupture.
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SMT Publishes Trial Results for Supraflex Cruz Stent
DAIC
OCTOBER 16, 2024
16, 2024 — Sahajanand Medical Technologies (SMT) recently announced the publication of the COMPARE 60/80 HBR trial results in Circulation: Cardiovascular Interventions , a journal of The American Heart Association. tim.hodson Wed, 10/16/2024 - 09:00 Oct. Led by Dr. Pieter C.
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52 Abstract 4141755: New internet-based warfarin anticoagulation management approach after mechanical heart valve replacement: prospective, multicenter, randomized controlled trial
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4141755-A4141755, November 12, 2024. However, it subjects patients to lifelong warfarin therapy after MHVR, with the attendant risk of bleeding and thrombosis. Background:Mechanical heart valve replacement (MHVR) is an effective method for the treatment of severe heart valve disease.
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Bivalirudin in Extracorporeal Membrane Oxygenation
Journal of Cardiovascular Pharmacology
SEPTEMBER 5, 2024
Heparin, the most utilized anticoagulant, carries concerns for heparin-induced thrombocytopenia and possible resistance given its dependence on co-factors and circulating proteins to exert its pharmacologic effect.
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40 Abstract 4142117: First Reported Case of Massive Gastrointestinal Bleeding Linked to Piperacillin-Tazobactam in a Patient on Rivaroxaban: A Comprehensive Case Review
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4142117-A4142117, November 12, 2024. Introduction:The management of patients with Venous thromboembolism (VTE) receiving anticoagulant therapy is complicated by potential interactions with other medications, including antibiotics.
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Abstract 123: First Off?Label Use of the XIENCE Skypoint Stent for Mechanical Thrombectomy Rescue
Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
IntroductionDespite technical advances in mechanical thrombectomy (MT), failure to achieve recanalization in the posterior circulation remains a significant challenge. Rescue strategies to increase MT success in the posterior circulation have been explored. The off‐label use of DES for intracranial pathologies continues to expand.
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40 Abstract 4137144: Return to Cath Lab: Chest Pain Resolution after Right Coronary Artery Chronic Total Occlusion Intervention
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4137144-A4137144, November 12, 2024. Introduction:Subacute stent thrombosis (ST) is related to high rates of cardiac reinfarction. He had CCS Class IV CP despite medical therapy and returned for re-look CA with TIMI-3 flow in the left-sided circulation without thrombus (Fig 1b).
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40 From the Member Sections | Tackling the Polypharmacy Pandemic in CV Care
American College of Cardiology
FEBRUARY 1, 2025
7 The use of antiplatelet agents to prevent stent thrombosis, moderate- to high-dose statin therapy after acute coronary syndromes, or antihypertensive agents in asymptomatic patients may all be perceived by patients as not providing benefit because they may not feel the effects.8 Circulation. Circulation. BMC Med2015;13(74).
Abstract WP260: The Role of Fibrinogen in the Pathogenesis of Intracranial Atherosclerosis-Related Large Vessel Occlusion Strokes
Stroke Journal
JANUARY 30, 2025
Compared to AF-LVOS, ICAS-LVOS patients exhibited associations with younger age (OR: 0.947; P = 0.043), previous stroke (OR: 4.749; P = 0.017), posterior circulation involvement (OR: 6.417; P = 0.017), higher fibrinogen levels (OR: 2.049; P = 0.023), and higher triglyceride levels (OR: 2.905; P = 0.019).
Abstract 4145271: Systemic Lupus Erythematosus-Induced Libman-Sacks Endocarditis Complicated by Multiple Embolic Episodes and Atypical Secondary Valve Involvement
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4145271-A4145271, November 12, 2024. A 42-year-old female with SLE, lupus cerebritis with related seizure disorder, and mesenteric venous thrombosis on warfarin initially presented for syncope. Acute stroke workup was negative, and syncope was attributed to possible brief seizure.
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Why we need continuous 12-lead ST segment monitoring in Wellens' syndrome
Dr. Smith's ECG Blog
NOVEMBER 15, 2013
Circulation 1991;84:1454-1455. It is important to recognize that coronary thrombosis is dynamic , with spontaneous opening and lysing of the thrombus in the infarct-related artery (we all have endogenous tPA and plasmin to lyse thrombi). Consequences of reocclusion after successful reperfusion therapy in acute myocardial infarction.
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52 Abstract 4146624: Computational Fluid Dynamics-Based Investigation and Development of an Axial-Flow Ventricular Assist Device Incorporating a Toroidal Blade Geometry for Improved Hemodynamics
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4146624-A4146624, November 12, 2024. However, complications – such as hemolysis, thrombosis, degradation of the von Willebrand factor, and gastrointestinal bleeding – stand in the way of their widespread application.
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Abstract 4142012: Ectasias of Multiple Coronary Arteries and a Coronary Cameral Fistula Between Right Coronary Artery and Coronary Sinus
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4142012-A4142012, November 12, 2024. At the time of discharge, LV systolic function improved to 39% and there were no findings concerning for coronary artery thrombosis or fistula repair failure. No murmur or extra heart sound were heard, and the lung sounds were normal.
Abstract WP154: Factors Associated With Prolonged Length of Intensive Unit Stay Following Mechanical Thrombectomy for Acute Ischemic Stroke
Stroke Journal
FEBRUARY 1, 2024
Prolonged ICU stay were more likely to have higher baseline median NIHSS score (19 vs. 14%, p < 0.0001), posterior circulation stroke (12.6% vs. 6.1%, p = 0.0002), deep vein thrombosis (7.3 vs. 5.7%, p = 0.0200), intubation for the procedure (86.7% vs. 69.3%, p = 0.0001), complications including pneumonia (18.5%
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Abstract 139: Regional Disparities in Mechanical Thrombectomy Utilization for Treatment of Acute Ischemic Stroke in the United States
Stroke Journal
FEBRUARY 1, 2024
We determined the number of patients who were admitted with AIS due to thrombosis or embolism of anterior circulation arteries and those who received MT in a particular region/state based on the State Inpatient Database of NIS.
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Upon arrival to the emergency department, a senior emergency physician looked at the ECG and said "Nothing too exciting."
Dr. Smith's ECG Blog
NOVEMBER 30, 2022
MINOCA may be due to: coronary spasm, coronary microvascular dysfunction, plaque disruption, spontaneous coronary thrombosis/emboli , and coronary dissection. link] We know that most type 1 acute MI due to plaque rupture and thrombosis occurs in lesions that are less than 50% (see Libby reference). Circulation.
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Taskforce Develops New Standards to Monitor Adults with Heart Valve Disease
DAIC
FEBRUARY 18, 2025
tim.hodson Tue, 02/18/2025 - 16:41 Feb. The dataset suggests tracking clinic-reported outcome measures at six months within the first year after diagnosis and annually thereafter, and patient-reported outcomes annually, with more frequent tracking advised for patients who undergo either a surgical or transcatheter procedure.
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Abstract WP302: Different Clot Characteristics According to the Clot Volume: A Microscopic Analysis of Clot Composition
Stroke Journal
FEBRUARY 1, 2024
Background and Objectives:Understanding the mechanisms of thrombosis is crucial for the future advancement in treating ischemic stroke. After adjusting for potential confounders including posterior circulation occlusion, serum hemoglobin levels, serum albumin levels, and the presence of active cancer (all p<0.05
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Coronary Angiography, Intravascular Ultrasound, and Optical Coherence Tomography in the Guidance of Percutaneous Coronary Intervention: A Systematic Review and Network Meta-Analysis.
Circulation
FEBRUARY 12, 2024
Circulation, Ahead of Print. The secondary outcomes included ischemia-driven target lesion revascularization, target vessel myocardial infarction, death, cardiac death, target vessel revascularization, stent thrombosis, and major adverse cardiac events. Frequentist random-effects network meta-analyses were conducted.
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Optical Coherence Tomography vs. Angiography Alone to Guide PCI for Complex Lesions: A Meta-Analysis of Randomized Controlled Trials
Circulation: Cardiovascular Interventions
MARCH 30, 2025
Circulation: Cardiovascular Interventions, Ahead of Print. Endpoints included major adverse cardiovascular events (MACE), cardiac death, myocardial infarction (MI), periprocedural MI, all-cause mortality, stent thrombosis (definite or probable), and target vessel revascularization (TVR). 0.76; p=0.003), MI (RR 0.75; 95%CI 0.59-0.96;
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40 Abstract 4145424: 30-Day Outcomes of Dual vs Triple Antithrombotic Therapy After PCI
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4145424-A4145424, November 12, 2024. The outcome was any 30-day event defined as death, stent thrombosis, major bleeding events, and composites of ischemic and bleeding events. 41% patients were treated with immediate dual therapy, and 59% were discharged on triple therapy.
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40 Circulating Sex-Specific Markers of Plaque Instability in Women and Men With Severe Carotid Atherosclerosis
Stroke Journal
JANUARY 21, 2024
BACKGROUND:Sex-specific differences in plaque composition and instability underscore the need to explore circulating markers for better prediction of high-risk plaques. Antagonistic interactions between sex and white blood cell (WBC) counts, basophil-to-WBC ratio, and platelet counts influenced plaque instability.
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The Texas Heart Institute Collaborates on Multi-institutional DOD Grant to Develop Novel Left Ventricular Assist Device
DAIC
MARCH 8, 2024
As an alternative therapeutic option, LVAD heart pumps have been implanted to help patients with end-stage heart failure sustain blood circulation in the body. However, there are shortcomings associated with LVAD implantation: complications include infection, blood clotting (thrombosis), stroke and bleeding.
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98 An Aspirin-Free Versus Dual Antiplatelet Strategy for Coronary Stenting: STOPDAPT-3 Randomized Trial
Circulation
NOVEMBER 23, 2023
Circulation, Ahead of Print. 3.30]) and subacute definite or probable stent thrombosis (0.58% and 0.17%; hazard ratio, 3.40 [95% CI, 1.26–9.23]) mg/day) monotherapy or to DAPT with aspirin (81–100 mg/day) and prasugrel (3.75 mg/day) after loading of 20 mg of prasugrel in both groups. years; men, 76.6%; acute coronary syndrome, 75.0%).
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Racial Disparities in Long-Term Outcomes After Endovascular Aortic Aneurysm Repair in Black and White Medicare Beneficiaries
Circulation
APRIL 7, 2025
Circulation, Ahead of Print. Black patients had higher rates of medical complications in the perioperative period, including acute renal failure (subdistribution HR, 1.18 [95% CI, 1.011.38]), dialysis initiation (subdistribution HR, 2.75 [95% CI, 2.033.7]), and deep vein thrombosis (subdistribution HR, 1.54 [95% CI, 1.052.26]).
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Lowering Atherosclerotic Cardiovascular Disease Events by Treating Residual Inflammatory Risk
DAIC
JANUARY 23, 2024
Inflammation driven by signaling cytokines, circulating immune cells, adhesion molecules, and oxidized low-density lipoprotein cholesterol (LDL-C) leads to atherosclerotic plaque development, plaque progression, and eventual rupture.14,15 2019 Sep 10;140(11):e649-e650] [published correction appears in Circulation. Circulation.
Abstract 4139677: A rare case of ventriculobronchial fistula caused by an epicardial defibrillator patch
Circulation
NOVEMBER 11, 2024
Circulation, Volume 150, Issue Suppl_1 , Page A4139677-A4139677, November 12, 2024. She had idiopathic ventricular fibrillation in 1992, treated with an EPD (Picture 1A), later replaced by a transvenous ICD.She was diagnosed with left femoral deep venous thrombosis and bilateral pulmonary embolism and started on therapeutic anticoagulation.
Moyamoya Angiopathy and Antiphospholipid Antibodies: A Coincidental Association?
Stroke Journal
DECEMBER 9, 2024
Anticardiolipin antibodies, anti-2-glycoprotein I antibodies, and lupus anticoagulant were assessed using the guidelines of the International Society on Thrombosis and Haemostasis.RESULTS:aPL prevalence was 22% in patients with MMA and 25% in controls (P=0.74) with no differences in aPL subtypes between the 2 groups.
Abstract TP7: Comparison of inflammatory clot markers in higher and lower shear stress environments: is there really that big of a difference?
Stroke Journal
JANUARY 30, 2025
Introduction:Venous thromboembolism (VTE)manifesting as deep vein thrombosis (DVT) and pulmonary embolus (PE) and arterial thromboembolism (ATE) manifesting as acute ischemic stroke (AIS) result in ~1 million US deaths annually. Stroke, Volume 56, Issue Suppl_1 , Page ATP7-ATP7, February 1, 2025.
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