Stroke Journal

FEBRUARY 1, 2024

Stroke, Volume 55, Issue Suppl_1 , Page AWMP5-AWMP5, February 1, 2024.

Thrombolysis 40

Thrombolysis Outcomes Strokes Stroke 40

Stroke Journal

FEBRUARY 1, 2024

Posterior circulation tandem occlusion was defined as stroke due to intracranial vertebral (V4), basilar, or posterior cerebral artery (PCA) occlusions, with tandem steno-occlusive lesion >70% of the extracranial vertebral artery and impaired distal flow or partial filling of the VA from collaterals.

Circulation 40

Circulation Outcomes Thrombolysis Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Introduction:Large vessel recanalization (LVR) is a well described phenomenon following intravenous thrombolysis (IVT). Better collateral circulation was independently associated with both higher odds of LVR, as well as lower odds of infarct progression. Higher Tan CS was significantly associated with higher odds of LVR (2.95 [95%CI 1.60-5.45],

Thrombolysis 40

Thrombolysis Outcomes Circulation Strokes 40

Stroke Journal

JANUARY 30, 2024

However, tPA is a more complex enzyme than expected, being for instance able to promote thrombolysis, but at the same time, also able to influence neuronal survival and to affect the integrity of the blood-brain barrier. In this context, the impact of endogenous parenchymal tPA is limited.

Circulation 40

Circulation Strokes Stroke Embolism 40

Stroke: Vascular and Interventional Neurology

JANUARY 29, 2024

The retraction has been issued at the authors’ request.Patel et al Anterior Circulation Thrombectomy in Patients With Low National Institutes of Health Stroke Scale Score: Analysis of the National Inpatient Sample. Specifically, the variables for endovascular therapy and intravenous thrombolysis were mistakenly switched. 2023, e000998.

Inpatient 40

Inpatient Circulation Strokes Stroke 40

Stroke: Vascular and Interventional Neurology

FEBRUARY 19, 2024

P < 0.001) and more likelihood of achieving Thrombolysis in Cerebral Infarction 3 (79.5% Use of intravenous tissue‐type plasminogen activator, hypertension, final Thrombolysis in Cerebral Infarction 3, and lower baseline National Institutes of Health Stroke Scale score were independent predictors of functional outcome.

Stents 40

Stents Stent Circulation Strokes 40

EMS 12-Lead

SEPTEMBER 6, 2022

During spontaneous reperfusion -- whether via thrombolysis, or recruitment of collateral circulation -- there exists characteristic ST/T changes on the ECG. Coronary thrombosis is a dynamic process of platelet aggregation and subsequent coagulation. Case Review: [link]

Thrombosis 52

Thrombosis Thrombolysis Circulation 52

Stroke: Vascular and Interventional Neurology

DECEMBER 19, 2024

In the external set, patients with LVO treated with endovascular therapy achieving modified Thrombolysis in Cerebral Infarction score 2b and available baseline NCCT, CT angiography, and CT perfusion were included.RESULTSA total of 2858 studies of patients with stroke alerts were used for training (80%) and internal validation (20%).

Thrombolysis 75

Thrombolysis Strokes Stroke Article 75

Stroke Journal

JANUARY 30, 2025

Background:The effectiveness and safety of intravenous Tirofiban as an adjunct to endovascular therapy (EVT) in posterior circulation patients with tandem lesions (PCTL) remain uncertain.Methods:This study utilized individual patient data pooled from two multicenter observational studies: the BASILAR and the PERSIST registries.

Circulation 40

Circulation Outcomes Strokes Stroke 40

Stroke: Vascular and Interventional Neurology

JANUARY 31, 2024

In multivariable models, intravenous thrombolysis was independently associated with higher odds of routine discharge (adjusted OR, 1.78; 95% CI, 1.57–2.01;P<0.001) Patients treated with intravenous thrombolysis had greater odds of routine discharge. P<0.001) and higher rates of death (adjusted OR, 2.11; 95% CI, 1.20–3.70;P

Inpatient 40

Inpatient Circulation Strokes Stroke 40

Stroke Journal

JANUARY 30, 2025

Twenty-three (88%) patients received IV thrombolysis and 7 (27%) had mechanical thrombectomy. Conclusions:This study found the acute stroke response for circulating inflammatory factors IFN, IL-17 and IL-2 correlated with stroke lesion volume and IFN correlated with severity on the NIHSS. Median lesion volume on MRI was 1.4

Strokes 40

Strokes Stroke Circulation Hospital 40

Stroke Journal

FEBRUARY 1, 2024

Nineteen (68%) MSU patients were diagnosed as stroke, with 17 (61%) confirmed and 2 likely TIA or stroke averted by thrombolysis; 9 were stroke mimics. Median initial NIHSS score was 7 (range 1-22) and 12 (71%) received intravenous thrombolysis with tPA or TNK. IL-6 was independent of lesion volume and NIHSS.

Strokes 40

Strokes Stroke Circulation Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Purpose:Clot Burden Score (CBS) is a semiquantitative measure of thrombus extent on CTA for proximal anterior circulation strokes whose relationship with perfusion metrics has not been fully explored. Final infarct ASPECTS were scored for those without thrombolysis or thrombectomy.

Circulation 40

Circulation Strokes Stroke Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

Clinical outcomes were assessed using uni- and multivariable logistic regression models.Results:A total of 216 patients were included, with target vessels located within the anterior circulation (133; 63.4%) and posterior circulation (79; 36.6%). 10.43, p=0.0325).Conclusions:The

Stents 40

Stents Stent Thrombolysis Angioplasty 40

Dr. S. Venkatesan MD

SEPTEMBER 1, 2024

In this context, we need a movement to revive the pre-hospital thrombolysis. Efficiency of thrombolysis is highly reproducible. Strategy to Reduce Mortality Rates of ST-elevation Acute Myocardial Infarction Using Prehospital Thrombolysis: A Meta-analysis. Circulation 2005;111:761-7. Circulation 2006;114:2019-25

Thrombolysis 52

Thrombolysis Myocardial Infarction Academic STEMI 52

Stroke Journal

JANUARY 30, 2025

Random-effect models in a meta-analysis were employed to get the pooled risk ratios (RRs) and their corresponding 95% confidence intervals (95% CI) for sICH with MT, compared to other reperfusion treatment regimens, including best medical treatment and intravenous thrombolysis (IVT).Results:MT 2.07; P = 0.037). 1.03; P = 0.079).

Hemorrhage 40

Hemorrhage Thrombolysis Circulation Strokes 40

Circulation: Cardiovascular Interventions

JANUARY 23, 2024

Circulation: Cardiovascular Interventions, Ahead of Print. BACKGROUND:It is uncertain whether adjunctive thrombolysis is beneficial for patients with ST-segment–elevation myocardial infarction undergoing percutaneous coronary intervention (PCI) within 120 minutes of presentation. The median symptom to thrombolysis time was 252.5

Myocardial Infarction 40

Myocardial Infarction Thrombolysis Academic Cardiovascular Interventions 40

Stroke Journal

FEBRUARY 1, 2024

We included AIS patients treated with MT for ICA, M1, or M2 occlusion with successful recanalization (modified Thrombolysis in Cerebral Infarction [mTICI] score ≥ 2C) and procedure durations under 60 minutes. FR was defined as successful recanalization with 90-day modified Rankin Scale (mRS) 3-6.

Circulation 40

Circulation Strokes Stroke Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

The primary outcome measure was successful recanalization defined as modified Thrombolysis in Cerebral Ischemia (mTICI) score of 2b or higher. Data from 29 stroke centers for 10,229 AIS patients treated with MT for LVO between January 2010 and December 2022 was investigated.

Circulation 40

Circulation Strokes Stroke Thrombolysis 40

Dr. S. Venkatesan MD

MARCH 3, 2025

Is primary PCI superior to thrombolysis in the first hour of STEMI ? The fact of the matter is, at best, pPCI fights for equipoise in the first hour, but thrombolysis is a clear winner in moral, scientifc & holistic perspective, as it can be administered very early, at a fraction of cost ,independent of expertise and infrastructure.

Hospital 40

Hospital Angioplasty Myocardial Infarction Thrombolysis 40

Stroke Journal

FEBRUARY 1, 2024

The bootstrap resampling method was considered internal validation of the model.Results:Age (< 70 years), premorbid status (mRS 0), National Institutes of Health Stroke Scale (NIHSS) (< 20), and recanalization status after the MT (modified Thrombolysis in Cerebral Ischemia [mTICU] ≥2b) were related to 90-day mRS 0-3.

Circulation 40

Circulation Strokes Stroke Outcomes 40

Stroke Journal

JANUARY 30, 2025

12% of the cohort (n=34) had posterior circulation stroke. Area under the receiver operating characteristic curve (AUC) with its 95% confidence interval was calculated for each prognostic model.Results:A total of 279 patients were included in this study. Of those, 43% (n=119) were male. Median age (IQR) was 69 (57-80) years.

Thrombolysis 40

Thrombolysis Strokes Stroke Outcomes 40

Frontiers in Cardiovascular Medicine

JANUARY 3, 2024

Trichosanthes pericarpium is a well-known Chinese traditional herb described with the effect of activating blood circulation to dissipate blood stasis and improve blood circulation. However, its effects on microcirculation in patients with AMI after primary PCI remain unknown.

Myocardial Infarction 59

Myocardial Infarction Outcomes Cardiac Function Thrombolysis 59

Circulation: Cardiovascular Imaging

MARCH 24, 2025

Circulation: Cardiovascular Imaging, Ahead of Print. Linear regression identified prepercutaneous coronary intervention Thrombolysis in Myocardial Infarction flow (=3.35,P<0.001) Early gadolinium enhancement (EGE) emerges as an alternative for measuring the area at risk. P<0.001) and microvascular obstruction (=11.92,P<0.001)

Myocardial Infarction 40

Myocardial Infarction STEMI Thrombolysis Cardiovascular Imaging 40

Stroke Journal

FEBRUARY 1, 2024

Prolonged ICU stay were more likely to have higher baseline median NIHSS score (19 vs. 14%, p < 0.0001), posterior circulation stroke (12.6% Patients receiving thrombolysis prior to thrombectomy were less likely to have a prolonged LOS (27.8% p = 0.0002), not receiving IV thrombolysis (OR 2.3, vs. 1.9%, p = 0.0109).

ICU 40

ICU Thrombolysis Strokes Stroke 40

Circulation: Cardiovascular Interventions

FEBRUARY 27, 2024

Circulation: Cardiovascular Interventions, Ahead of Print. Background:The role of advanced therapies (systemic thrombolysis, catheter-based treatment, and surgical thrombectomy) for the management of right heart thrombus is poorly defined. Younger age (odds ratio, 0.98 [95% CI, 0.96–0.99])

Outcomes 40

Outcomes Thrombolysis Embolism Pulmonary 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionDespite technical advances in mechanical thrombectomy (MT), failure to achieve recanalization in the posterior circulation remains a significant challenge. Rescue strategies to increase MT success in the posterior circulation have been explored. Admission National Institutes of Health Stroke Scale (NIHSS) 20.

Stents 40

Stents Stent Thrombosis Thrombolysis 40

Stroke Journal

JANUARY 30, 2025

Blackground:Due to the narrow therapeutic time window and strict indications, there are still a large number of patients unable to receive thrombolysis and endovascular therapy, resulting in a poor long-term functional prognosis. Stroke, Volume 56, Issue Suppl_1 , Page ATP140-ATP140, February 1, 2025.

Biomarkers 40

Biomarkers Strokes Stroke Technology 40

Circulation

OCTOBER 19, 2023

Circulation, Ahead of Print. Study end points included timeliness of intravenous thrombolysis and EVT, successful reperfusion, discharge destination, discharge mortality, and functional independence at discharge.RESULTS:Among 84 903 patients, 48 682 received EVT, of whom 73% were treated at CSCs, 22% at PSCs, and 4% at TSCs.

Strokes 40

Strokes Stroke Thrombolysis Certification 40

Stroke Journal

FEBRUARY 1, 2024

Background:Atrial fibrillation (AF) has been shown to be associated with better procedural outcomes in patients with anterior circulation large vessel occlusion (aLVO) undergoing endovascular therapy (EVT). Forty-four percent of the no AC group received intravenous thrombolysis (IVT). In the NOAC group, 59.5%

Atrial Fibrillation 40

Atrial Fibrillation Outcomes Thrombolysis Hemorrhage 40

Stroke Journal

JANUARY 30, 2025

Compared to AF-LVOS, ICAS-LVOS patients exhibited associations with younger age (OR: 0.947; P = 0.043), previous stroke (OR: 4.749; P = 0.017), posterior circulation involvement (OR: 6.417; P = 0.017), higher fibrinogen levels (OR: 2.049; P = 0.023), and higher triglyceride levels (OR: 2.905; P = 0.019).

Atherosclerosis 40

Atherosclerosis Strokes Stroke Atrial Fibrillation 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionCurrent evidence supports endovascular therapy (EVT) for eligible patients with acute ischemic stroke in the anterior and posterior circulation. 1.56, P= 0.28; I2 = 26%, Figure A) and the results of the anterior circulation subgroup showed non‐statistically significant difference (OR = 1.22, 95% CI: 0.90–1.67,

Strokes 40

Strokes Stroke Circulation Thrombolysis 40

Circulation

OCTOBER 18, 2023

Circulation, Volume 148, Issue 24 , Page 1919-1928, December 12, 2023. The principal safety end point was Thrombolysis in Myocardial Infarction major bleeding. Thrombolysis in Myocardial Infarction major bleeding was significantly higher for the rivaroxaban and aspirin group for the endovascular cohort (HR, 1.66 [95% CI, 1.06–2.59])

Peripheral Arterial Disease 40

Peripheral Arterial Disease Myocardial Infarction Thrombolysis Ischemia 40

Circulation: Genomic and Precision Medicine

JANUARY 23, 2025

Circulation: Genomic and Precision Medicine, Ahead of Print. BACKGROUND:Established risk models may not be applicable to patients at higher cardiovascular risk with a measured Lp(a) (lipoprotein[a]) level, a causal risk factor for atherosclerotic cardiovascular disease.METHODS:This was a model development study. mg/dL, of whom 23.7%

Myocardial Infarction 40

Myocardial Infarction Risk Factors Thrombolysis Circulation 40

Circulation: Cardiovascular Interventions

JANUARY 20, 2025

Circulation: Cardiovascular Interventions, Volume 18, Issue 1 , Page e014499, January 1, 2025. years; 44% women; 29% catheter-directed thrombolysis; 68% mechanical thrombectomy; and 3% both). Inverse probability of treatment weighting was used to balance covariates.RESULTS:A total of 133 patients were included (mean age, 58.3

Embolism 40

Embolism Pulmonary Outcomes Cardiac Arrest 40

Circulation

NOVEMBER 11, 2024

Circulation, Volume 150, Issue Suppl_1 , Page A4141279-A4141279, November 12, 2024. Background:Slow flow phenomenon is impaired coronary flow during percutaneous coronary intervention (PCI) in absence of mechanical obstruction, and it is associated with deteriorated outcome.

STEMI 40

STEMI Myocardial Infarction Kidney Disease Thrombolysis 40

Stroke: Vascular and Interventional Neurology

NOVEMBER 9, 2023

IntroductionPosterior circulation strokes account for 20% of ischemic strokes (1). Optimal management for posterior circulation strokes has been studied less than for anterior circulation strokes (2). Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. He was continued on Aspirin monotherapy.

Strokes 40

Strokes Stroke Embolism Hemorrhage 40