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Circulation Strokes Thrombolysis 
Stroke Journal
JANUARY 4, 2024
Stroke, Ahead of Print. BACKGROUND:The effectiveness of intravenous thrombolysis (IVT) before endovascular treatment (EVT) has been investigated in randomized trials and meta-analyses. These studies mainly concerned anterior circulation occlusions. All patients with a posterior circulation occlusion were included.
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Journal of the American Heart Association
MARCH 8, 2024
ConclusionsIn thrombectomy‐eligible patients with anterior circulation large‐vessel occlusion, IVT improves functional outcome independent of grade of reperfusion and distal thrombus migration. We performed sensitivity analysis using propensity score matching. 0.75];P=0.001). to 0.01];P=0.05).ConclusionsIn
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP13-AWP13, February 1, 2025. Introduction:Strokes affecting the posterior circulation (PCS) account for 20% of all ischemic strokes. The number of stroke mimics presenting with isolated dizziness who received thrombolysis was 11 in 2021, 16 in 2022, 9 in 2023, and 11 in 2024.
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Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionIntracranial atherosclerotic disease (ICAD) is associated with up to 32% of posterior circulation strokes.1 1 ICAD‐related strokes are at high risk for re‐occlusion following MT.
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP253-AWP253, February 1, 2025. Background and Aims:Endovascular treatment (EVT) alone has been confirmed to be non-inferior to intravenous thrombolysis (IVT) followed with EVT in acute ischemic stroke (AIS) due to large-vessel occlusion of the anterior circulation.
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Stroke Journal
JANUARY 30, 2024
Stroke, Ahead of Print. BACKGROUND:Intravenous injection of alteplase, a recombinant tPA (tissue-type plasminogen activator) as a thrombolytic agent has revolutionized ischemic stroke management. However, when associated to tPAWTlittermates, tPANullmice had similar perfusion deficits, but less severe brain infarcts.
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWMP5-AWMP5, February 1, 2024.
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP354-AWP354, February 1, 2025. Background:Circulating neuroinflammatory factors change rapidly in acute stroke, but the association with ischemic lesion size and stroke severity is unknown. Twenty-six (57%) MSU patients were confirmed ischemic stroke (AIS). range 0-171) mL.
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Stroke: Vascular and Interventional Neurology
DECEMBER 19, 2024
Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDA simplified patient selection paradigm with noncontrast computed tomography (NCCT) can reduce the time to reperfusion and widen the eligibility of acute ischemic stroke large vessel occlusions (LVOs) for endovascular therapy. on the internal validation set.
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Stroke: Vascular and Interventional Neurology
JANUARY 29, 2024
Stroke: Vascular and Interventional Neurology, Ahead of Print. The retraction has been issued at the authors’ request.Patel et al Anterior Circulation Thrombectomy in Patients With Low National Institutes of Health Stroke Scale Score: Analysis of the National Inpatient Sample. Stroke: Vascular and Interventional Neurology.
40 Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page A106-A106, February 1, 2024. Background:Circulating interleukin-6 (IL-6) concentrations are elevated in acute stroke but the timing of the IL-6 response in humans is unknown. We used a mobile stroke unit (MSU) to identify IL-6 levels within minutes of symptom onset. pg/mL, respectively.
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP19-ATP19, February 1, 2025. Background:Patients with acute ischemic stroke and a large vessel occlusion (LVO) admitted to primary stroke centers (PSC) often require inter-facility transfer for thrombectomy.
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Stroke: Vascular and Interventional Neurology
FEBRUARY 19, 2024
Stroke: Vascular and Interventional Neurology, Ahead of Print. was considered significant.RESULTSOf 119 posterior stroke patients (99 [83.2%] basilar artery, 16 [13.4%] vertebral artery, and 4 [3.4%] posterior cerebral artery), 110 patients had 90‐day mRS data available on follow‐up. < 0.05 versus 83.3%;P versus 62.1%;P
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A13-A13, February 1, 2025. We included patients with acute ischemic stroke due to PCTLs who were treated with EVT. The patients were divided into two groups based on whether they received adjunctive intravenous Tirofiban therapy or not. 4.03], P=0.19). 0.59], P=0.001).Conclusion:Intravenous
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Stroke: Vascular and Interventional Neurology
JANUARY 31, 2024
Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDPrior studies have shown benefit for endovascular therapy (EVT) in patients with large‐vessel occlusion and severe deficits, as captured by the National Institutes of Health Stroke Scale (NIHSS).
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP3-AWP3, February 1, 2025. Introduction:Large vessel recanalization (LVR) is a well described phenomenon following intravenous thrombolysis (IVT). LVR patients had lower NIH Stroke Scale (p=0.006) and higher Tan CS (p=0.019). 0.90], p=0.024). 0.63], p<0.001 and OR 0.21 [95%CI 0.09-0.52],
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page A85-A85, February 1, 2024. Intravenous thrombolysis was administered in 55 patients (22.1%) while general anesthesia was used in 94/248 patients (37.9%). Conclusion:EVT seems to be a safe and effective approach for posterior circulation tandem occlusions.
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWP179-AWP179, February 1, 2024. Background:Stent-retriever thrombectomy is the first-line therapy for acute stroke with intracranial large vessel occlusion. In cases of stent-retriever thrombectomy failure, rescue stent angioplasty might be the sole option for achieving permanent recanalization.
40 Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP133-ATP133, February 1, 2024. Purpose:Clot Burden Score (CBS) is a semiquantitative measure of thrombus extent on CTA for proximal anterior circulation strokes whose relationship with perfusion metrics has not been fully explored.
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWP192-AWP192, February 1, 2024. Introduction:Despite comparable outcomes for different frontline techniques in mechanical thrombectomy (MT) for acute ischemic stroke (AIS), there are sparse data regarding if and when to switch techniques if the first pass is unsuccessful.
40 Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP87-ATP87, February 1, 2025. Background:Early prediction of functional outcome after rtPA helps clinicians in prognostic conversations with stroke patients and their families. Data on demographics, clinical presentations, laboratory values, neuroimaging, and stroke metrics were collected.
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWP205-AWP205, February 1, 2024. The aim of this study is to develop and validate a stroke prediction tool for outcome in MT for AIS patients with low ASPECTS using data from an ongoing international multicenter registry, the Stroke Thrombectomy and Aneurysm Registry (STAR).Methods:236
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWP180-AWP180, February 1, 2024. Introduction:Up to 50% of acute ischemic stroke (AIS) patients who undergo successful mechanical thrombectomy (MT) fail to achieve favorable outcomes (futile recanalization).
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Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP140-ATP140, February 1, 2025. Blackground:Due to the narrow therapeutic time window and strict indications, there are still a large number of patients unable to receive thrombolysis and endovascular therapy, resulting in a poor long-term functional prognosis. AUC range:0.65-0.99).Conclusion:We
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Circulation
OCTOBER 19, 2023
Circulation, Ahead of Print. BACKGROUND:The thrombectomy-capable stroke center (TSC) is a recently introduced intermediate tier of accreditation for hospitals at which patients with acute ischemic stroke receive care. Participants were recruited from Get With The Guidelines–Stroke registry.
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWP154-AWP154, February 1, 2024. Prolonged ICU stay were more likely to have higher baseline median NIHSS score (19 vs. 14%, p < 0.0001), posterior circulation stroke (12.6% Patients receiving thrombolysis prior to thrombectomy were less likely to have a prolonged LOS (27.8%
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ECG Cases
JULY 5, 2022
The post Ep 171 Posterior Stroke, EP Lead, HEAR Score, Ketamine for Suicidal Ideation, Peer Support Workers – Highlights from Calgary EM Hodsman Lecture Day appeared first on Emergency Medicine Cases.
52 Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP260-AWP260, February 1, 2025. Background:The mechanisms by which intracranial atherosclerosis (ICAS) contributes to large-vessel occlusion strokes (LVOS) remains unclear. Among patients with lower fibrinogen levels (< 3.2g/L),
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP242-ATP242, February 1, 2025. Background:Symptomatic intracranial hemorrhage (sICH) is the most dreaded complication after reperfusion therapy for acute ischemic stroke. The sICH risk for MT in the posterior circulation (RR: 7.48; 95%CI: 2.27-24.61) 2.07; P = 0.037). 2.07; P = 0.037).
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Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionPosterior circulation strokes account for 20% of ischemic strokes (1). Optimal management for posterior circulation strokes has been studied less than for anterior circulation strokes (2).
40 Stroke: Vascular and Interventional Neurology
DECEMBER 19, 2023
Stroke: Vascular and Interventional Neurology, Ahead of Print. Baseline characteristics were comparable, with the exception of baseline National Institutes of Health Stroke Scale score (MSU median 19 [interquartile range 13, 23] versus emergency medical services 16 [11, 20],P= 0.002) and study site. in MSU group and 0.51±0.41
40 Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionCurrent evidence supports endovascular therapy (EVT) for eligible patients with acute ischemic stroke in the anterior and posterior circulation. I2 = 31%) and the difference was not also evident for posterior circulation (48.8%
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWP10-AWP10, February 1, 2024. Introduction:While observational data suggest that dexmedetomidine may have neuroprotective effects on ischemic brain, its clinical use in acute ischemic stroke is limited due to concerns about cerebral vasoconstriction. vs. 28.8%; p=0.24).
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Stroke: Vascular and Interventional Neurology
NOVEMBER 28, 2023
Stroke: Vascular and Interventional Neurology, Ahead of Print. BACKGROUNDIn patients with acute ischemic stroke secondary to large vessel occlusion, achieving modified Thrombolysis in Cerebral Infarction (mTICI) 2c/3 (excellent recanalization) over mTICI 2b is associated with improved functional outcomes. P=0.012).
40 Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionDespite technical advances in mechanical thrombectomy (MT), failure to achieve recanalization in the posterior circulation remains a significant challenge. Admission National Institutes of Health Stroke Scale (NIHSS) 20.
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Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP212-ATP212, February 1, 2024. Background:Endovascular thrombectomy (EVT) for treatment of acute ischemic stroke (AIS) in the proximal cerebrovasculature has, since its inception, become part of the standard of care when addressing AIS.
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Stroke: Vascular and Interventional Neurology
SEPTEMBER 28, 2023
Stroke: Vascular and Interventional Neurology, Volume 3, Issue 6 , November 1, 2023. BackgroundEndovascular thrombectomy (EVT) is limited to comprehensive stroke centers (CSCs), with patients who first present to primary stroke centers (PSCs) transferred for treatment by road ambulance or helicopter emergency medical services (HEMS).
40 Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page AWP182-AWP182, February 1, 2024. Background:Atrial fibrillation (AF) has been shown to be associated with better procedural outcomes in patients with anterior circulation large vessel occlusion (aLVO) undergoing endovascular therapy (EVT). In the NOAC group, 59.5%
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP188-ATP188, February 1, 2024. Here, we investigate the association of middle cerebral artery(MCA) tortuosity on radiographic and functional outcome.Methods:The Analysis of Revascularization in Ischemic Stroke with EmboTrap II was utilized to identify patients with anterior circulation stroke.
Circulation: Genomic and Precision Medicine
JANUARY 23, 2025
Circulation: Genomic and Precision Medicine, Ahead of Print. The end point of interest was time to first myocardial infarction, stroke/TIA, or coronary revascularization. The data source was the Nashville Biosciences Lp(a) data set, which includes clinical data from the Vanderbilt University Health System. mg/dL, of whom 23.7%
Circulation
OCTOBER 18, 2023
Circulation, Volume 148, Issue 24 , Page 1919-1928, December 12, 2023. The primary efficacy outcome was a composite of acute limb ischemia, major amputation of a vascular pathogenesis, myocardial infarction, ischemic stroke, or cardiovascular death. There was a consistent benefit for rivaroxaban regardless of background clopidogrel.
Stroke: Vascular and Interventional Neurology
NOVEMBER 9, 2023
Stroke: Vascular and Interventional Neurology, Volume 3, Issue S2 , November 1, 2023. IntroductionMechanical thrombectomy (MT) often fails to achieve successful reperfusion in up to 20% of acute ischemic stroke (AIS) patients with large vessel occlusion (LVO) [1, 2].
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DAIC
JANUARY 22, 2024
The International Stroke Conference 2024 will be held Feb. According to program planners with the American Stroke Association, a division of the American Heart Association, findings from late-breaking science will include multiple high profile randomized clinical trials like RESILIENT-Extend, EMBOLISE, STEM, ZODIAC, among many others.
100 Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP175-ATP175, February 1, 2025. Background and Purpose:Acute ischemic stroke (AIS) may present with an estimated core of 0 ml on CT perfusion imaging without a visible decrease in cerebral blood flow (CBF) maps. 2.25, p=0.04).Conclusions:Stroke
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