2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
Circulation
JANUARY 27, 2025
Circulation, Ahead of Print.
Alteplase for Posterior Circulation Ischemic Stroke at 4.5 to 24 Hours
The New England Journal of Medicine
APRIL 2, 2025
In patients with posterior circulation stroke for whom thrombectomy was not planned, alteplase administered 4.5 to 24 hours after stroke onset resulted in less disability at 90 days than standard treatment.
Circulation 
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68 
Alteplase increases frequency of functional independence after posterior circulation stroke
Medical Xpress - Cardiology
APRIL 4, 2025
For patients with mainly mild posterior circulation ischemic stroke who do not receive thrombectomy, alteplase administered at 4.5
Circulation 52
52 
Blood platelet score detects previously unmeasured risk of heart attack and stroke
Medical Xpress - Cardiology
AUGUST 20, 2024
Platelets are circulating cell fragments known to clump up and form blood clots that stop bleeding in injured vessels.
Heart Attack 103
103 
Patent Foramen Ovale Closure in Patients With and Without Nickel Hypersensitivity: A Randomized Trial
Circulation: Cardiovascular Interventions
MARCH 9, 2025
Circulation: Cardiovascular Interventions, Ahead of Print. No significant differences were observed in documented arrhythmias, bleeding, or stroke. Background:Nickel-containing devices, such as the Amplatzer PFO Occluder and Gore Cardioform Septal Occluder (GSO), are used for transcatheter patent foramen ovale (PFO) closure.
Chest Pain 70
70 
New mechanisms in the development of stroke discovered
Medical Xpress - Cardiology
JUNE 14, 2024
A group of researchers from the University of Tartu and international scientists discovered new mechanisms of how stroke occurs by studying changes in mouse and human cells.
Stroke 90
90 Abstract WP167: Posterior Circulation Stroke is Associated with Increased Risk of Misdiagnosis as Compared to Anterior Circulation Stroke in a Multistate Cohort
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP167-AWP167, February 1, 2025. Background:Small studies have found that patients presenting with posterior circulation ischemic strokes are more likely than patients with anterior circulation strokes to suffer a missed or delayed diagnosis in the ED.
Circulation 40
40 
Novel Risk Score to Predict Poor Outcome After Endovascular Treatment in Anterior Circulation Occlusive Acute Ischemic Stroke
Journal of the American Heart Association
APRIL 10, 2025
BackgroundWe aimed to develop and validate a prognostic score to predict outcomes after endovascular treatment in acute ischemic stroke.MethodsThe prognostic score was developed based on the ACTUAL (Endovascular Treatment for Acute Anterior Circulation Ischemic Stroke) registry. The validation cohort was derived from the Captor trial.
Circulation 40
40 
O2 pulse slope correlates with stroke volume during exercise in patients with a Fontan circulation
Open Heart
NOVEMBER 7, 2023
Background Peak oxygen pulse (O 2 pulse=oxygen consumption/heart rate) is calculated by the product of stroke volume (SV) and oxygen extraction. It has been shown to be reduced in patients with a Fontan circulation. However, in the Fontan population, it may be a poor marker of SV.
Exercise 52
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Early Neurologic Deterioration and Efficacy of Dual Antiplatelet in Anterior Versus Posterior Circulation Stroke
Journal of the American Heart Association
JANUARY 23, 2025
BackgroundAnterior circulation stroke (ACS) differs from posterior circulation stroke (PCS) in several aspects. Primary outcome was occurrence of END at 7 days, defined as 2point increase in National Institutes of Health Stroke Scale score compared with baseline. Median age was 66 years and 35.1% were women.
Circulation 40
40 
Heart Disease and Stroke Could Affect at Least 60% of Adults in U.S. by 2050, According to American Heart Association Advisories
DAIC
JUNE 18, 2024
A projected rise in heart disease and stroke – along with several key risk factors, including high blood pressure and obesity – is likely to triple related costs to $1.8 trillion by 2050, according to two presidential advisories published in the AHA journal Circulation. This includes a doubling of stroke rates. population.
Heart Disease 105
105 Atherogenic circulating lipoproteins in ischemic stroke
Frontiers in Cardiovascular Medicine
DECEMBER 5, 2024
However, the corresponding studies are scarcer in the field of ischemic stroke, despite carotid arteriosclerosis progression underlies at least 20% of ischemic strokes. The present review relates qualitative alterations of LDL and HDL with the development of carotid arteriosclerosis and the occurrence of ischemic stroke.
Circulation 40
40 
Identification of microRNA biomarkers simultaneously expressed in circulating extracellular vesicles and atherosclerotic plaques
Frontiers in Cardiovascular Medicine
APRIL 24, 2024
The early detection of plaques by circulating biomarkers is highly clinically relevant to prevent the occurrence of major complications such as stroke or heart attacks. BackgroundAtherosclerosis is a widespread disorder of the cardiovascular system. EVs were isolated from serum by precipitation.
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Abstract TMP82: First line aspiration versus stent retriever for posterior circulation stroke; A meta-analysis
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATMP82-ATMP82, February 1, 2025. Introduction:Aspiration and stent retriever thrombectomy are the primary approaches for endovascular management of posterior circulation stroke. However, the optimal first-line choice of surgical technique remains unclear.
Stents 40
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Abstract TP132: Optimal CT Perfusion Post-Processing Method in Posterior Circulation Stroke
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP132-ATP132, February 1, 2024. Objective:CT-perfusion (CTP) has revolutionised stroke care by improving diagnostic accuracy and expanding eligibility to acute therapies. CTP parametric maps were generated using five different post-processing methods.
Circulation 40
40 
Collateral Circulation and Rabep2 Polymorphisms in Large Artery Occlusion: Impacts on Short‐ and Long‐Term Prognosis
Journal of the American Heart Association
APRIL 10, 2025
BackgroundIntracranial anterior circulation large artery occlusion (ACLAO) is a predominant cause of ischemic stroke. Although collateral circulation plays a critical role in stroke outcomes, the genetic and environmental factors affecting collateral development are not fully understood.
Circulation 40
40 
Abstract TP119: Predicting Posterior Circulation Stroke During Emergency Triage: Dizzy-7 Project
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP119-ATP119, February 1, 2024. Introduction:“Stroke code” activation is a uniform process to summon healthcare stakeholders to orchestrate the rapid sequential steps for urgent management in patients with possible stroke.
Circulation 40
40 
Abstract TP53: Above Par on the Back Nine: Improving Triage of Posterior Circulation Stroke
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP53-ATP53, February 1, 2024. Background and Purpose:Notoriously difficult to recognize, posterior circulation strokes (PCS) can be some of the most devastating. A triage algorithm was created to capture as many strokes as possible without a glut of false positives.
Circulation 40
40 
Abstract WMP120: Circulating Mucosal-Associated Invariant T Cells Are Associated with Acute Human Ischemic Stroke and Predict Poor Outcome
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWMP120-AWMP120, February 1, 2025. Introduction:We previously demonstrated that Mucosal-associated Invariant T (MAIT) cells were involved in acute ischemic stroke by regulating neuroinflammation (JAHA 2021). 0.15), 0.31% (0.15-0.79), 0.79), 0.31% (0.19-0.80); 0.80); p <0.0001] (Figure 1A).
Circulation 40
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Forecasting the Burden of Cardiovascular Disease and Stroke in the United States Through 2050—Prevalence of Risk Factors and Disease: A Presidential Advisory From the American Heart Association
Circulation
JUNE 4, 2024
Circulation, Ahead of Print. BACKGROUND:Cardiovascular disease and stroke are common and costly, and their prevalence is rising. to 3.8%), stroke (3.9% in 2020 to 61.0% The prevalences of poor diet, inadequate physical activity, and smoking are estimated to improve over time, whereas inadequate sleep will worsen.
Risk Factors 81
81 
Abstract WP354: Neuroinflammatory Factor Response in Acute Ischemic Stroke Correlates with Lesion Volume and Stroke Severity: Circulating Blood from a Mobile Stroke Unit and during Hospitalization
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP354-AWP354, February 1, 2025. Background:Circulating neuroinflammatory factors change rapidly in acute stroke, but the association with ischemic lesion size and stroke severity is unknown. Twenty-six (57%) MSU patients were confirmed ischemic stroke (AIS). range 0-171) mL.
Stroke 40
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2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association
Circulation
JANUARY 24, 2024
Circulation, Ahead of Print.
Forecasting the Economic Burden of Cardiovascular Disease and Stroke in the United States Through 2050: A Presidential Advisory From the American Heart Association
Circulation
JUNE 4, 2024
Circulation, Ahead of Print. Stroke is projected to account for the largest absolute increase in costs. For cardiovascular conditions, annual health care costs are projected to almost quadruple, from $393 billion to $1490 billion, and productivity losses are projected to increase by 54%, from $234 billion to $361 billion.
Abstract TP246: Circadian Variability of the Clot Burden Score in Acute Anterior Circulation Ischemic Stroke
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP246-ATP246, February 1, 2024. The Clot Burden Score (CBS) is a semiquantitative measure on CT angiography (CTA) of thrombus extent in proximal anterior circulation strokes that has been correlated with functional outcome.
Circulation 40
40 
Omega-3 Blood Levels and Stroke Risk: A Pooled and Harmonized Analysis of 183?291 Participants From 29 Prospective Studies
Stroke Journal
DECEMBER 21, 2023
Stroke, Volume 55, Issue 1 , Page 50-58, January 1, 2024. BACKGROUND:The effect of marine omega-3 PUFAs on risk of stroke remains unclear.METHODS:We investigated the associations between circulating and tissue omega-3 PUFA levels and incident stroke (total, ischemic, and hemorrhagic) in 29 international prospective cohorts.
Stroke 74
74 Young adults with migraine, other nontraditional risk factors may have higher stroke risk
Medical Xpress - Cardiology
MARCH 26, 2024
Adults younger than 35 to 45 years old may have a higher risk of developing a stroke from nontraditional risk factors such as migraines than from traditional risks like high blood pressure. That's according to new research published today in Circulation: Cardiovascular Quality and Outcomes.
Risk Factors 66
66 
Abstract WP88: Association of renal biomarkers with fast progressor phenotype and related outcomes in anterior circulation large vessel occlusion stroke
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP88-AWP88, February 1, 2025. Background:The effect of renal dysfunction on early infarct growth rate (IGR) in anterior circulation large vessel occlusion (ACLVO) stroke is not well studied. mg/dL, p < 0.05) and lower median eGFR (66.2 mL/min/1.73m2, p < 0.05).
Biomarkers 40
40 Abstract TP307: Circulating immune cell landscape in ischemic stroke patients with early neurological deterioration
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page ATP307-ATP307, February 1, 2025. Results:A total of 20 peripheral blood PBMC samples were collected from patients with acute ischemic stroke before and after the occurrence of END.
Circulation 40
40 
Link between high levels of niacin -- a common b vitamin -- and heart disease, study suggests
Science Daily - Heart Disease
FEBRUARY 19, 2024
Higher circulating levels of 4PY were strongly associated with development of heart attack, stroke and other adverse cardiac events in large-scale clinical studies. The team discovered a link between 4PY, a breakdown product from excess niacin, and heart disease.
Heart Disease 117
117 
Associations between circulating proteins and cardiometabolic diseases: a systematic review and meta-analysis of observational and Mendelian randomisation studies
Heart BMJ
SEPTEMBER 25, 2024
We aimed to synthesise existing evidence on the observational and genetic associations between circulating proteins and CMD.
Circulation 52
52 
Abstract 13: Intravenous Tirofiban as An Adjunct to Endovascular Therapy for Posterior Circulation Strokes with Tandem Lesions: One-Year Outcomes
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A13-A13, February 1, 2025. We included patients with acute ischemic stroke due to PCTLs who were treated with EVT. The patients were divided into two groups based on whether they received adjunctive intravenous Tirofiban therapy or not. 4.03], P=0.19). 0.59], P=0.001).Conclusion:Intravenous
Circulation 40
40 Abstract TP141: Understanding Potential Limitations of CTP Imaging in Early Window Large Vessel Anterior Circulation Strokes
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP141-ATP141, February 1, 2024. Background:Computerized tomography perfusion (CTP) imaging serves as a valuable modality for the assessment of individuals with a large vessel anterior circulation stroke. The hypoperfusion intensity ratio (HIR) may result in overestimation.
Circulation 40
40 
Predictors of atrial fibrillation detection in embolic stroke of undetermined source patients with implantable loop recorder
Frontiers in Cardiovascular Medicine
MARCH 3, 2024
Background Covert atrial fibrillation (AF) is a predominant aetiology of embolic stroke of undetermined source (ESUS). Conclusion Our study showed that posterior circulation infarcts with brainstem/cerebellum involvement are associated with AF detection in ESUS patients undergoing ILR.
Abstract TP259: Slower Early Mitral Inflow Velocity and Lesion in Anterior Circulation is Associated With Right-to-Left Shunt in Embolic Stroke of Undetermined Source Right-to-Left Shunt in Embolic Stroke of Undetermined Source
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP259-ATP259, February 1, 2024. Background and Purpose:Right-to-left shunt (RLS) is one of the potential embolic sources in embolic stroke of undetermined source (ESUS), but the eligibility of conducting shunt study to detect RLS in ESUS is still unknown. cm/s, p = 0.021).
Embolism 40
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Abstract TP252: Forward Head Posturing as a Significant Risk Factor for Posterior Circulation Infarcts
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP252-ATP252, February 1, 2024. Objective:Forward head posturing (FHP) has been associated with chronic anatomic vertebral artery disturbances possibly leading to posterior circulation ischemia. Information on demographics and comorbidities were also collected. degrees higher C2 tilt and 8.1
Risk Factors 40
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Predictors of Good Functional Outcomes in Posterior Circulation Stroke After Mechanical Thrombectomy With Stent Retrievers: An Individual Patient?Data Pooled Analysis From the TRACK and NASA Registries
Stroke: Vascular and Interventional Neurology
FEBRUARY 19, 2024
Stroke: Vascular and Interventional Neurology, Ahead of Print. was considered significant.RESULTSOf 119 posterior stroke patients (99 [83.2%] basilar artery, 16 [13.4%] vertebral artery, and 4 [3.4%] posterior cerebral artery), 110 patients had 90‐day mRS data available on follow‐up. < 0.05 versus 83.3%;P versus 62.1%;P
Stents 40
40 Abstract 106: Circulating Interleukin-6 Levels Early During Active Stroke Estimate Time of Stroke Onset: Potential New Clinical Biomarker Tool From a Mobile Stroke Unit
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page A106-A106, February 1, 2024. Background:Circulating interleukin-6 (IL-6) concentrations are elevated in acute stroke but the timing of the IL-6 response in humans is unknown. We used a mobile stroke unit (MSU) to identify IL-6 levels within minutes of symptom onset. pg/mL, respectively.
Stroke 40
40 
Cardiovascular and Metabolic Effects of Modulating Circulating Ketone Bodies With 1,3‐Butanediol in Patients With Heart Failure With Reduced Ejection Fraction
Journal of the American Heart Association
DECEMBER 24, 2024
Secondary end points were stroke volume, heart rate, left ventricular ejection fraction, circulating 3hydroxybutyrate, and free fatty acids. BD treatment provided significant increase in circulating 3hydroxybutyrate by 1400 mol/L (95% CI, 12621538 mol/L,P<0.001) and increased cardiac output by 0.9 L/min (95% CI, 0.71.1
Abstract 70: Machine Learning for Identification of Fast Progressors of Acute Anterior Circulation Ischemic Strokes in the Early Window Without CT Perfusion
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page A70-A70, February 1, 2025. Purpose:Fast progressors (FP) of infarct growth in anterior circulation occlusions at 0-6 hours from onset (early window) have been associated with reduced rates of favorable outcome post endovascular thrombectomy (EVT).
Circulation 40
40 
Transcatheter PFO closure for cryptogenic stroke: current approaches and future considerations
Frontiers in Cardiovascular Medicine
MAY 19, 2024
Although generally considered a benign anatomic variant, a PFO may facilitate passage of a thrombus from the venous to arterial circulation, thereby resulting in cryptogenic stroke or systemic embolization.
Stroke 52
52 
Inflammatory Type Focal Cerebral Arteriopathy of the Posterior Circulation in Children: A Comparative Cohort Study
Stroke Journal
MARCH 6, 2024
Stroke, Ahead of Print. BACKGROUND:Inflammatory type focal cerebral arteriopathy (FCA-i) in the anterior circulation (AC) is well characterized, and the focal cerebral arteriopathy severity score (FCASS) reflects the severity of the disease. interquartile range, 2.7–8.2 15.6]; 20 male; 57.1%) years with FCA-i were identified.
Circulation 40
40 Abstract 153: First Pass Effect in Mechanical Thrombectomy for Anterior Circulation Acute Ischemic Stroke is Modified by Procedure Time: Proposal of a New Measure for Thrombectomy Procedures
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page A153-A153, February 1, 2024. Objective:To determine whether first pass effect (FPE) after mechanical thrombectomy (MT) for anterior circulation large vessel occlusion acute ischemic stroke (LVO-AIS) is modified by procedural time (PT).Methods:The
Circulation 40
40 
Abstract TP133: Clot Burden Score Correlates Best With Hypoperfusion Volume and Predicts Final Infarct ASPECTS<=3 in Anterior Circulation Ischemic Strokes
Stroke Journal
FEBRUARY 1, 2024
Stroke, Volume 55, Issue Suppl_1 , Page ATP133-ATP133, February 1, 2024. Purpose:Clot Burden Score (CBS) is a semiquantitative measure of thrombus extent on CTA for proximal anterior circulation strokes whose relationship with perfusion metrics has not been fully explored.
Circulation 40
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Abstract WP306: Exploring the Cardiovascular Effect and Downstream Proteomic Signature of Pharmacologic Targeting of Circulating Adiponectin Levels in a Drug-Target Mendelian Randomization Framework
Stroke Journal
JANUARY 30, 2025
Stroke, Volume 56, Issue Suppl_1 , Page AWP306-AWP306, February 1, 2025. variants in the vicinity (300 kb) of theADIPOQgene from a GWAS of circulating adiponectin levels (n=~38,600). 0.98; p=0.006) risk, but not ischemic stroke/subtypes (all p-values > 0.05). We selected genome-wide, independent (r2<0.1)
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